scholarly journals Treatment of gestational trophoblastic disease: A 10-year experience

2012 ◽  
Vol 65 (5-6) ◽  
pp. 244-246 ◽  
Author(s):  
Biljana Lazovic ◽  
Vera Milenkovic ◽  
Spomenka Djordjevic
Keyword(s):  
World Health Organization ◽  
Pulmonary Metastases ◽  
Descriptive Study ◽  
Gestational Trophoblastic Disease ◽  
World Health ◽  
Trophoblastic Disease ◽  
Multiple Factors ◽  
Invasive Mole ◽  
Health Organization ◽  
Epidemiological Characteristics

A retrospective descriptive study about the presence of metastases, epidemiological characteristics and treatment of 104 patients suffering from gestational trophoblastic disease was performed in the period from 1st Jan, 2000 to 31st December, 2010. Of eleven patients who were found to have metastases (10.6%), 72.7% had pulmonary metastases, 27.3 had vaginal, and one patient had both pulmonary and brain metastases. The average age was 33.9. Antecedent molar pregnancy was recorded in 63.6% patients. Invasive mole was more frequent than choriocarcinoma (63.6%). According to the World Health Organization criteria, 7 patients (63.6%) had high risk score (the average World Health Organization score was 8.4). All patients were treated by chemotherapy, the average number of courses being 1.8. Complete remission was achieved in all patients. Treatment of metastatic disease depends on multiple factors. However, combined chemotherapy is the universally accepted treatment. If chemotherapy is individualized and applied on time, the prognosis is good, even in cases with cerebral metastases.

scholarly journals Practices suggested in social media for birth plans

2020 ◽  
Vol 73 (5) ◽  
Author(s):  
Victória Prates Pasqualotto ◽  
Mariene Jaeger Riffel ◽  
Virgínia Leismann Moretto
Keyword(s):  
Social Media ◽  
World Health Organization ◽  
Thematic Analysis ◽  
Descriptive Study ◽  
World Health ◽  
Production Of Knowledge ◽  
The World ◽  
Means Of Transmission ◽  
Health Organization ◽  
E Mail

ABSTRACT Objective: To describe and analyze the practices suggested in social media for the elaboration of Birth Plans, available on Blogs/Sites and not included in the WHO recommendations. Method: Qualitative, exploratory, descriptive study with thematic analysis. A total of 41 e-mail addresses were selected for analysis among the 200 web addresses previously identified between March and July 2016. Three web addresses were in Portugal and the others in Brazil. Results: 48 practices not included in the recommendations of the World Health Organization (WHO) were identified. Conclusion: Blogs/Websites, as means of transmission, circulation and production of knowledge, enable the horizontal expression of values, encourage women to plan the events considered important for their deliveries and put childbirth decisions on the hands of women, which has caused controversy in the discourse of humanization of childbirth.

scholarly journals Epidemiological Surveillance To Establish Thresholds For Influenza Among Children In Satellite Cities Of A metropolitan area of Tokyo, Japan

2021 ◽  
Author(s):  
Ayako Matsuda ◽  
Kei Asayama ◽  
Taku Obara ◽  
Naoto Yagi ◽  
Takayoshi Ohkubo
Keyword(s):  
World Health Organization ◽  
Metropolitan Area ◽  
Seasonal Influenza ◽  
Type A ◽  
World Health ◽  
Epidemiological Surveillance ◽  
Influenza Epidemic ◽  
The World ◽  
Health Organization ◽  
Epidemiological Characteristics

Abstract Background: Few reports have longitudinally investigated seasonal influenza epidemiological surveillance data of pediatric populations in the metropolitan areas of Japan. We aimed to provide descriptive characteristics of circulating influenza and to investigate the usefulness of setting thresholds for influenza in children (0–15 years old) in two satellite cities of a metropolitan area of Tokyo, Japan, for five consecutive seasons of the influenza epidemic.Methods: The survey was conducted annually during the influenza season, from 2014 to 2018 (ending March 2019), at preschools (kindergartens and nursery schools), elementary schools, and junior high schools located in Toda and Warabi cities, Saitama prefecture. We investigated the epidemiological characteristics and established thresholds using the World Health Organization method.Results: Of the 108,362 children (21,024 to 22,088 throughout five seasons) who received the questionnaire, 76,753 (70.8%; 14,652 to 15,808) responded. After exclusion of responses without basic information, 64,586 children were included in the analysis, of which 13,754 (21.3%) had tested positive for influenza. Influenza type A was generally dominant, whereas type B was responsible for a substantial share of all influenza cases (>40% in seasons 2015 and 2017, when type A circulated with low incidence). The weeks when the influenza epidemic peaked had no clear seasonal pattern among the surveyed years, i.e., the peaks appeared at week 51 (mid-December) or later, whereas the World Health Organization methods reported that the median period when a peak was observed was at 3 weeks (mid-January), regardless of school age group.Conclusions: The present information obtained from the epidemiological survey regarding seasonal influenza in children would be useful for general practitioners, health policymakers, and planners who establish prevention and control methods against influenza.

scholarly journals KEBUTUHAN PERAWATAN ORTHODONSI BERDASARKAN INDEX OF ORTHODONTIC TREATMENT NEED PADA SISWA SMP NEGERI 1 TARERAN

e-GIGI ◽  
2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Liefany Anastasia Wilar ◽  
A. J. M. Rattu ◽  
Ni Wayan Mariati
Keyword(s):  
World Health Organization ◽  
Orthodontic Treatment ◽  
Emotional Health ◽  
Dental Health ◽  
Descriptive Study ◽  
World Health ◽  
Sampling Frame ◽  
Treatment Need ◽  
Health Organization

Abstract: Malocclusion according to World Health Organization (WHO) is a defect or functional distruption that can be a hampered to a physical and emotional health from patient who needs treatment. The aim of this study is to know the needs of orthodontic treatment of students in SMPN 1 Tareran ages 13-14 years old according to IOTN. Index of Orthodontic Treatment Need consisted of two parts which are Aesthetic Component (AC) and Dental Health Component (DHC). This is a descriptive study, has done in SMPN 1 Tareran Rumoong village on March 2014. The population of this study is all the students of SMPN 1 Tareran ages 13-14 years old totaled 155 students and only 61 students included in the sampling frame. These sample observed using AC and DHC according to IOTN. The result of the study showed that according to AC (73,77%) don’t need treatment or need minor treatment, (22,95%) need a borderline treatment and (3,28%) really need treatment. According to DHC (16,39%) don’t need treatment or need minor treatment, (18,04%) need a borderline treatment and (65,57%) really need treatment. Keywords: Malocclusion, Index of Orthodontic Treatment Need, Aesthetic Component, Dental Health Component.     Abstrak: Maloklusi menurut World Health Organization (WHO) adalah cacat atau gangguan fungsional yang dapat menjadi hambatan bagi kesehatan fisik maupun emosional dari pasien yang memerlukan perawatan. Tujuan penelitian ini untuk mengetahui kebutuhan perawatan orthodonsi siswa SMP Negeri 1 Tareran usia 13-14 tahun berdasarkan IOTN. Index of Orthodontic Treatment Need terdiri dari dua bagian yaitu Aesthetic Component (AC) dan Dental Health Component (DHC). Penelitian ini bersifat deskriptif, dilakukan di SMP Negeri 1 Tareran desa Rumoong pada bulan Maret 2014. Populasi penelitian ini yaitu seluruh siswa SMP Negeri 1 Tareran usia 13-14 tahun yang berjumlah 155 siswa dan hanya 61 siswa yang termasuk dalam sampling frame. Sampel kemudian diperiksa menggunakan AC dan DHC berdasarkan IOTN. Hasil penelitian menunjukkan bahwa berdasarkan AC (73,77%) tidak atau butuh perawatan ringan, (22,95%) butuh perawatan borderline dan (3,28%) sangat butuh perawatan. Berdasarkan DHC (16,39%) tidak atau butuh perawatan ringan, (18,04%) butuh perawatan borderline dan (65,57%) sangat butuh perawatan. Kata kunci: Maloklusi, Index of Orthodontic Treatment Need, Aesthetic Component, Dental Health Component.

Conservative Chemotherapy in Gestational Trophoblastic Disease: Experience With Etoposide, Methotrexate, and Dactinomycin Chemotherapy

2016 ◽  
Vol 26 (4) ◽  
pp. 790-795 ◽  
Author(s):  
Seung Won Byun ◽  
Tae Chul Park ◽  
Seog Nyeon Bae
Keyword(s):  
High Risk ◽  
Gestational Trophoblastic Disease ◽  
Low Risk ◽  
The Other ◽  
World Health ◽  
Who Grade ◽  
Trophoblastic Disease ◽  
Group A ◽  
Group B ◽  
Health Organization

ObjectiveThe goal of this study was to evaluate the efficacy, toxicity, and survival of patients in our institution treated by EMA (etoposide, methotrexate [MTX], and dactinomycin) chemotherapy for 3 groups of patients: ones that had low-risk gestational trophoblastic disease (GTD) that was resistant to MTX (group A), those with high-risk GTD (group B), and the group having low-risk GTD but the cancer being metastatic (group C).MethodsThe medical records of 58 patients who received EMA chemotherapy in groups A, B, and C in the 2000 to 2012 period at St Mary’s Hospital were examined. Clinical characteristics, chemotherapy responses, causes of treatment failure, and cases of drug toxicity were analyzed retrospectively.ResultsTreatment with the EMA regimen resulted in primary remission in 52 (96%) of 54 patients and resistance in 2 of the patients (3%). In the resistance group, one belonged to group B and was treated with etoposide, MTX, and actinomycin D with cyclophosphamide and vincristine (EMA-EP) and the other belonged to group A and died of refractory disease. World Health Organization (WHO) grade 4 leukocytopenia and thrombocytopenia with the EMA regimen occurred in 6% and 0.4% of the cycles, respectively; the other toxic effects were acceptable and manageable. Median cycles of EMA chemotherapy during the treatment were 7, 8, and 8 in groups A, B, and C, respectively. There was some reduction in total chemo cycle and toxicity, as compared with a previously reported study using the alternative cyclophosphamide and vincristine regimen. Among the EMA treated patients, 1 patient with a second malignancy of breast cancer was documented. In addition, 5 child births for the treated patients were recorded during the follow-up period of mostly 10 years.ConclusionsThe EMA chemotherapy seemed to reduce treatment duration and the relapse rate without increasing the adverse effects in patients with MTX resistance and low-risk GTD, but having confirmed metastatic lesions. Although this study had some limitations regarding the high-risk GTD, our findings will provide a basis for the use of EMA chemotherapy when cyclophosphamide and vincristine is contraindicated due to toxicity.

scholarly journals Tingkat Akseptabilitas dan Tolerabilitas Cairan Pencuci Tangan Formula World Health Organization (WHO) yang Digunakan Mahasiswa Kepaniteraan Klinik Senior di RSUD Arifin Achmad Provinsi Riau

2017 ◽  
Vol 9 (1) ◽  
pp. 27
Author(s):  
Dewi Anggraini ◽  
Insan Fitriyani ◽  
Tuti Restuastuti
Keyword(s):  
Hand Hygiene ◽  
World Health Organization ◽  
Descriptive Study ◽  
Ease Of Use ◽  
World Health ◽  
Good Tolerability ◽  
Mortality And Morbidity ◽  
Overall Evaluation ◽  
Health Care Associated Infection ◽  
Health Organization

Health Care Associated Infection (HCAI) is one of the leading cause of mortality and morbidity in hospital and otherhealth care facilitiy. Hand hygiene is the main way to reduce incidence of HCAI. World Health Organization (WHO)recommends alcohol-based handrub because it is more acceptable and tolerable than other hand hygiene products.WHO has identified formulations for the local preparation. This was a descriptive study aimed to determine theacceptability and tolerability of WHO recommended handrub formulation. The subjects of the study were 40 seniorclerkships in Arifin Achmad Hospital, Riau Province, from Surgery, Obstetrics and Gynecology, and Internal MedicineDepartment. Each respondent was given WHO-recommended handrub formulation used for three days. On the firstday, the observer distributed handrubs being tested. After 3 days of consecutive use of the product, participantscompleted the questionnaire and the observer evaluate the condition of participants’ hands. We used WHO’squestionnaire to evaluate acceptability and tolerability level. The results of this study showed that WHO-recommendedhandrub formulation had good acceptability for its application, colour, smell, irritation, ease of use, speed of drying,and overall evaluation but had a less rate of acceptability for its textures and drying effect. WHO-recommendedhandrub formulation had good tolerability.

Clinical and epidemiological profile of the mother–neonate binomy with microcefalia and suspected infection by zika viruses in the gestation: a sectional study

2020 ◽  
Vol 11 (4) ◽  
pp. 257-265
Author(s):  
Manoel Alfredo Curvelo Sarno ◽  
Luciana Carla Belém dos Santos ◽  
Priscila Pinheiro Ribeiro Lyra ◽  
Carlos Mauricio Cardeal Mendes ◽  
Patrícia Ribeiro de Oliveira ◽  
...  
Keyword(s):  
Virus Infection ◽  
Pregnant Women ◽  
World Health Organization ◽  
Zika Virus ◽  
World Health ◽  
Sectional Study ◽  
Zika Virus Infection ◽  
Epidemiological Profile ◽  
Health Organization ◽  
Epidemiological Characteristics

Introduction: The association between the increased incidence of microcephaly and the epidemic outbreak of Zika virus infection (ZIKV) in Brazil between 2015 and 2016 was observed by many authors. World Health Organization declared it as a public health emergency of international concern. Maternal infection with the Zika virus can be transmitted vertically and lead to Congenital Zika Syndrome (CZS) in infants. So that it is important to investigate the clinical-epidemiological profile of the mothers and their newborns. Aims: To characterize the clinical- epidemiological profile of pregnant women associated with presumed ZIKV in pregnancy and their newborns diagnosed with microcephaly at birth and associated with CZS. Methods: A sectional study, using medical record data, between September 2015 and June 2016. Results: 82 cases of microcephaly were reported in maternity during this period. Of these, 32 cases were excluded because they did not fit the new microcephaly criteria according to the World Health Organization (WHO) and the Ministry of Health of Brazil. The mean maternal age was 25 years, varying from 13 and 43 years old; exanthema was the only symptom related to Zika virus infection and it was observed in 60% (27/45) of the pregnancies, which occurred predominantly during the first or the second trimester of pregnancy. Other mothers were asymptomatic. Related to the newborns, 62% (31/50) were female; 32% (16/50) were low weight; 2% (1/50) were premature. Neonatal brain ultrasound showed 70,4% (31/44) of the neonates with abnormal findings, mainly calcifications that occurred in 87% (27/31). 29 newborns were submitted to fundoscopy examinations and 38% (11/29) were abnormal. Conclusion: Despite the majority of pregnant women did not have classic symptoms of arboviruses and because of this the suspicion and confirmation of Zika viruses infection through serologies are difficult in clinical practice, it is important to understand clinical and epidemiological characteristics related to Zika viruses infection and the CZS to allow mapping where preventive measures should be directed and better investigated as well as to offer an adequate follow-up to the infected neonates according to their outcomes.

scholarly journals Rapid review of early status of COVID-19 infection in South Korea

2020 ◽  
Vol 63 (8) ◽  
pp. 504-511
Author(s):  
Miyoung Choi ◽  
Ho Gyun Shin ◽  
Yan Jin ◽  
Joo Youn Kim ◽  
Kwang Hyub Han
Keyword(s):  
South Korea ◽  
Disease Control ◽  
World Health Organization ◽  
Infection Rate ◽  
World Health ◽  
Rapid Review ◽  
Reproduction Rate ◽  
Public Data ◽  
Health Organization ◽  
Epidemiological Characteristics

Since the confirmation of the first coronavirus disease 2019 (COVID-19) patient on January 20 2020, COVID-19 infection rate ramped up between February and March in South Korea. This study aimed to provide information on the characteristics of the first two months of COVID-19 prevalence in South Korea and attempted to comprehend preliminary evidence from various sources. We used public data available from the Korea Center for Disease Control and Prevention and situation reports from the World Health Organization from February to March 2020. For additional information, health utilization data from the Organization for Economic Co-operation and Development was used for subgroup analysis. A proportion of meta-analysis was performed. We searched literatures from PubMed, KoreaMed, and CNKI (China National Knowledge Infrastructure) for identifying epidemiological characteristics of COVID-19 and treatment strategies. We monitored domestic and global disease control institutions’ recommendations. The search results and reports were updated every two weeks. In South Korea, the ratio of confirmed cases is divided into two groups; before and after the occurrence of a large cluster infection explosion on February 17 2020 from a religious group called the Shincheonji Church. After the global pandemic announcement by World Health Organization on March 11 2020, the fatality rate of COVID-19 seems to be related to the number of beds and general hospitals. From the literature review, we identified a strong reproduction rate, asymptomatic period or infection, rate of exacerbation, and current treatments. The COVID-19 pandemic in South Korea was inevitable, but the early explosion of infection showed the decline curve afforded by the rigorous tracing, widespread testing, and well-organized health care system.

The role of neurosurgery in the treatment of cerebral metastases from choriocarcinoma: a report of two cases

2004 ◽  
Vol 14 (1) ◽  
pp. 157-161
Author(s):  
P. L. Semple ◽  
L. Denny ◽  
M. Coughlan ◽  
R. Soeters ◽  
L. Van Wijk
Keyword(s):  
Prognostic Indicator ◽  
Gestational Trophoblastic Disease ◽  
Cerebral Metastases ◽  
Classification Systems ◽  
World Health ◽  
Trophoblastic Disease ◽  
The World ◽  
Health Organization ◽  
Figo Classification

Cerebral metastases from choriocarcinoma are a poor prognostic indicator of outcome in both the World Health Organization and FIGO classification systems. However, with the increased experience with chemotherapy and radiotherapy the prognosis of this group of patients has improved substantially. Neurosurgery remains an option for selected patients. We present two patients who underwent craniotomy as part of their management of choriocarcinoma, and review the role of neurosurgery in the treatment of gestational trophoblastic disease.

Salvage surgery for chemorefractory gestational trophoblastic disease.

1994 ◽  
Vol 12 (12) ◽  
pp. 2737-2742 ◽  
Author(s):  
E Lehman ◽  
D M Gershenson ◽  
T W Burke ◽  
C Levenback ◽  
E G Silva ◽  
...  
Keyword(s):  
Salvage Surgery ◽  
Complete Response ◽  
Gestational Trophoblastic Disease ◽  
World Health ◽  
Cancer Center ◽  
University Of Texas ◽  
Trophoblastic Disease ◽  
Health Organization ◽  
The University

PURPOSE To investigate and define better the role of salvage surgery for patients with chemorefractory gestational trophoblastic disease (GTD). PATIENTS AND METHODS A retrospective review of medical records at The University of Texas M.D. Anderson Cancer Center identified 33 patients with chemorefractory GTD who underwent salvage surgery between 1962 and 1991. The end points selected for analysis were serologic response and survival. RESULTS Initial salvage procedures consisted of 29 hysterectomies, four thoracotomies, and one nephrectomy (in conjunction with a hysterectomy). Fourteen patients (42%) had a serologic complete response (CR) to surgery (normalization of human chorionic gonadotropin [hCG]), 10 (30%) had a partial response (> 50% decrease in hCG level), and nine had no response (< or = 50% decrease in hCG level). Of 19 patients who received further chemotherapy, eight (42%) attained a CR. Four patients underwent a second salvage surgery: two thoracotomies, one craniotomy, and one partial hepatectomy. All achieved a CR. The probability of achieving a CR was influenced by the time from diagnosis to surgery, number of preoperative disease sites, preoperative World Health Organization (WHO) score, and histologic type. Survival was influenced by the type of antecedent pregnancy, number of preoperative regimens, number of preoperative disease sites, time from diagnosis to surgery, and preoperative WHO score. CONCLUSION Based on the findings of this study, it appears that a select subset of patients with chemorefractory GTD who have a limited number of clinically detectable tumor foci may benefit from salvage surgery.

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