scholarly journals The most frequent causes of ischemic stroke in young adults

2011 ◽  
Vol 64 (5-6) ◽  
pp. 331-335 ◽  
Author(s):  
Mirjana Jovicevic ◽  
Ivana Divjak ◽  
Petar Slankamenac ◽  
Ksenija Bozic ◽  
Tamara Rabi-Zikic ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Young Adults ◽  
Ischemic Stroke ◽  
Magnetic Resonance ◽  
Diagnostic Procedures ◽  
Doppler Imaging ◽  
Conventional Angiography ◽  
Stroke Treatment ◽  
Stroke In Young Adults ◽  
Stroke In Young

Introduction. Pathogenesis of ischemic stroke in young adults is heterogeneous, thus making differential diagnosis very broad. Material and methods. The study comprised 60 ischemic stroke patients of both sexes aged 15-45 years who were treated at the Department of Neurology of the Clinical Centre of Vojvodina. Information about sex and age, detailed history, risk factors for ischemic stroke were obtained for all patients who underwent neurological examination as well. Diagnostic procedures applied in all patients included brain computed tomography and/or magnetic resonance imaging, routine laboratory tests, Doppler imaging of extra and endocranial blood vessels and coagulation tests. Contrast and/ or transesophageal echocardiography, immunological blood assays, magnetic resonance angiography and/or computed tomography angiography and/or conventional angiography, immunological tests, assessment of levels of natural coagulation inhibitors, toxicological examination, etc. were performed in selected patients. Results. Causes of ischemic stroke were determined according to the Trial of ORG 10172 in Acute Stroke Treatment criteria. The most frequent were the so called other causes of ischemic stroke, which were found in 26.7% patients. The second most frequent cause was cardiac embolisation, found in 25%. The cause of ischemic stroke remained undetermined in 21.7% of all patients. Conclusion. Aetiology of ischemic stroke in young adults is diverse and demands thorough diagnostic evaluation.

Subclinical Vascular Brain Lesions in Young Adults With Acute Ischemic Stroke

Stroke ◽  
2021 ◽  
Author(s):  
Valeria De Giuli ◽  
Mario Grassi ◽  
Michele Besana ◽  
Marialuisa Zedde ◽  
Andrea Zini ◽  
...  
Keyword(s):  
Young Adults ◽  
Ischemic Stroke ◽  
Magnetic Resonance ◽  
Odds Ratio ◽  
White Matter Hyperintensities ◽  
Hazard Ratio ◽  
Brain Lesions ◽  
End Point ◽  
Stroke In Young Adults ◽  
Stroke In Young

Background and Purpose: Subclinical vascular brain lesions are highly prevalent in elderly patients with stroke. Little is known about predisposing factors and their impact on long-term outcome of patients with stroke at a young age. Methods: We quantified magnetic resonance-defined subclinical vascular brain lesions, including lacunes and white matter hyperintensities, perivascular spaces and cerebral microbleeds, and assessed total small-vessel disease (SVD) score in patients with first-ever acute ischemic stroke aged 18 to 45 years, and followed them up, as part of the multicentre Italian Project on Stroke in Young Adults. The primary end point was a composite of ischemic stroke, transient ischemic attack, myocardial infarction, or other arterial events. We assessed the predictive accuracy of magnetic resonance features and whether the addition of these markers improves outcome prediction over a validated clinical tool, such as the Italian Project on Stroke in Young Adults score. Results: Among 591 patients (males, 53.8%; mean age, 37.5±6.4 years), 117 (19.8%) had subclinical vascular brain lesions. Family history of stroke was associated with lacunes (odds ratio, 2.24 [95% CI, 1.30–3.84]) and total SVD score (odds ratio, 2.06 [95% CI, 1.20–3.53] for score≥1), hypertension with white matter hyperintensities (odds ratio, 2.29 [95% CI, 1.22–4.32]). After a median follow-up of 36.0 months (25th–75th percentile, 38.0), lacunes and total SVD score were associated with primary end point (hazard ratio, 2.13 [95% CI, 1.17–3.90] for lacunes; hazard ratio, 2.17 [95% CI, 1.20–3.90] for total SVD score ≥1), and the secondary end point brain ischemia (hazard ratio, 2.55 [95% CI, 1.36–4.75] for lacunes; hazard ratio, 2.61 [95% CI, 1.42–4.80] for total SVD score ≥1). The predictive performances of the models, including magnetic resonance features were comparable to those of the random model. Adding individual magnetic resonance features to the Italian Project on Stroke in Young Adults score did not improve model prediction. Conclusions: Subclinical vascular brain lesions affect ≈2 in 10 young adults with ischemic stroke. Although lacunes and total SVD score are associated with thrombotic recurrence, they do not improve accuracy of outcome prediction over validated clinical predictors.

Risk Factors, Etiology, and Clinical Outcome of Ischemic Stroke in Young Adults Admitted in a Tertiary Care Hospital in India

2019 ◽  
Vol 2 (1) ◽  
pp. 32-39
Author(s):  
Madhavi Karri ◽  
Balakrishnan Ramasamy
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Ischemic Stroke ◽  
Clinical Outcome ◽  
Tertiary Care ◽  
Care Hospital ◽  
Diagnostic Challenge ◽  
Stroke Treatment ◽  
Stroke In Young Adults ◽  
Stroke In Young

Background: Ischemic stroke in young adults is becoming a rising concern with the increase in vulnerability to traditional risk factors and changing lifestyles. Aim: An overview of risk factors, classification, and clinical outcome of ischemic stroke in young adults (19 to 45 years) has been presented. Methods: Data fulfilling the study criteria from the stroke registry between June 2014 and June 2017 were collected, and a detailed proforma was taken that included history, clinical examination, and routine investigations. Selective investigations such as prothrombotic workup and 24-hour Holter monitoring were performed. Stroke was subclassified using the Trial of Org 10172 in Acute Stroke Treatment criteria. National Institute of Health Stroke Scale (NIHSS) scores at baseline and the modified Rankin score (mRS) scoring after 3 months of patients’ admission were calculated. Results: Out of 223 identified cases of ischemic stroke in young adults, 186 (83.4%) were taken for analysis, constituting 7.3% of the total stroke population of 3,059. Among the cases taken for analysis, 137 were males and 49 were females. A total of 150 patients were among the age group of 36 to 45 years. Dyslipidemia, smoking, and alcohol consumption were prevalent in the study group. Atherosclerotic strokes were predominant in the study population. NIHSS scores at admission had a significant impact on mRS scores after 3 months. In this study, only 4% reported the recurrence of stroke, whereas mortality was about 0.02%. Conclusions: Workup required for ischemic stroke in young adults has always been a diagnostic challenge for physicians who treat the stroke patients, and this must be optimized in all health care centers. Despite extensive workup, 23.66% participants were found to be cryptogenic in this study. The clinical outcome was good in this study with less mortality observed.

scholarly journals Non-atherosclerotic arteriopathy as the cause of ishemic stroke among young adults

2010 ◽  
Vol 63 (5-6) ◽  
pp. 324-332 ◽  
Author(s):  
Mirjana Jovicevic ◽  
Ivana Divjak ◽  
Petar Slankamenac ◽  
Aleksandar Jovanovic ◽  
Svetlana Ruzicka ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Magnetic Resonance ◽  
Systemic Vasculitis ◽  
Age Groups ◽  
Diagnostic Procedures ◽  
Carotid Artery Dissection ◽  
Doppler Imaging ◽  
Artery Dissection ◽  
Conventional Angiography ◽  
Clinical Center

The study comprised 100 ischemic stroke patients of both sexes aged 15-45 years who were treated at the Clinic of Neurology of the Clinical Center of Vojvodina in the period January 2001 - September 2004. All study subjects were divided into three age groups: 15-25, 26-35 and 36-45 years. Sex, age and risk factors for cerebrovascular disease were determined in all patients. Diagnostic procedures applied in all patients included brain computed tomography and/or magnetic resonance imaging, routine laboratory tests, Doppler imaging of extra and endocranial blood vessels and coagulation tests. Contrast and/or transesophageal echocardiography, immunological blood assays, magnetic resonance angiography and/or computed tomography angiography and/or conventional angiography, trombophilia markers, antiphospholipid antibodies and toxicological examination, etc. were performed in selected patients. Non-atherosclerotic arteriopathies were found in 8% of all study subjects, and were the most frequent cause of stroke in the age group 15-25. Carotid artery dissection was the most frequent diagnosis overall, found in 6% of all patients. Fibromuscular dysplasia and systemic vasculitis were diagnosed in one patient each. Moyamoya disease, Takayasu disease, infectious and isolated vasculitis of the CNS were not found in our patients.

The involvement of the factor V G1691A gene on recurrent ischemic stroke in young adults

2021 ◽  
Vol 429 ◽  
pp. 118692
Author(s):  
Lamia Mbarek ◽  
Salma Sakka ◽  
Fatma Megdich ◽  
Khadija Sonda Moalla ◽  
Nadia Bouattour ◽  
...  
Keyword(s):  
Young Adults ◽  
Ischemic Stroke ◽  
Factor V ◽  
Stroke In Young Adults ◽  
Factor V G1691a ◽  
Stroke In Young

Abstract WMP53: Traditional Vascular Risk Factors Account for Different Proportions of Ischemic Stroke Within Different Gender and Race Groups

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Elizabeth M Aradine ◽  
Yan Hou ◽  
Kathleen A Ryan ◽  
Prachi Mehndiratta ◽  
Michael S Phipps ◽  
...  
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Ischemic Stroke ◽  
Black Men ◽  
White Men ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Odds Ratios ◽  
Stroke In Young Adults ◽  
Stroke In Young

Introduction: Few studies have compared the proportion of ischemic strokes attributable to traditional vascular risk factors (population-attributable risk percent or PAR%) between genders and races. The PAR% is a function of the population prevalence and strength of association of a risk factor. Methods: A population-based case-control study of ischemic stroke in young adults ages 18-49 in the Baltimore-Washington region was used to study the prevalence, odds ratios, and PAR% of hypertension, diabetes, and smoking among blacks and whites. Logistic regression was used to calculate age-adjusted odds ratios. All analyses were stratified by gender. Results: There were 1044 cases and 1099 controls. Of the cases, 47% were black, 54% were women. Roughly a quarter to a third of all strokes in women were attributable to smoking. Due to the higher prevalence of hypertension and a higher odds ratio for hypertension in black men (OR 3.9, 95% CI 2.6-5.9) compared to white men (OR 1.8, 95% CI 1.3-2.6), there was a much higher PAR% for hypertension among black men than white men. See Table 1 for prevalence and Table 2 for PAR% stratified by gender and race. Conclusion: Traditional vascular risk factors have the potential to explain a high proportion of ischemic stroke in young adults. The high proportion of strokes in women attributable to smoking underscores the need for targeted smoking cessation interventions in this population. Diabetes and, especially, hypertension are important contributors to the excess population burden of ischemic stroke among blacks. These findings support the value of early screening and treatment for hypertension in young blacks.

Epidemiology and Etiology of Ischemic Stroke in Young Adults Aged 18 to 44 Years in Northern Sweden

Stroke ◽  
1997 ◽  
Vol 28 (9) ◽  
pp. 1702-1709 ◽  
Author(s):  
Bo Kristensen ◽  
Jan Malm ◽  
Bo Carlberg ◽  
Birgitta Stegmayr ◽  
Christer Backman ◽  
...  
Keyword(s):  
Young Adults ◽  
Ischemic Stroke ◽  
Northern Sweden ◽  
Stroke In Young Adults ◽  
Stroke In Young

scholarly journals Obesity Increases Risk of Ischemic Stroke in Young Adults

Stroke ◽  
2015 ◽  
Vol 46 (6) ◽  
pp. 1690-1692 ◽  
Author(s):  
Andrew B. Mitchell ◽  
John W. Cole ◽  
Patrick. F. McArdle ◽  
Yu-Ching Cheng ◽  
Kathleen A. Ryan ◽  
...  
Keyword(s):  
Young Adults ◽  
Ischemic Stroke ◽  
Stroke In Young Adults ◽  
Stroke In Young

scholarly journals Acute ischemic stroke in young adults with tuberculous meningitis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Liming Zhang ◽  
Xiaoyu Zhang ◽  
Huaqiang Li ◽  
Gang Chen ◽  
Meijia Zhu
Keyword(s):  
Young Adults ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Tuberculous Meningitis ◽  
Stroke In Young Adults ◽  
Stroke In Young

Ischemic stroke in young adults in Bogota, Colombia: a cross-sectional study

2020 ◽  
Author(s):  
Maria Paula Aguilera-Pena ◽  
Andres Felipe Cardenas-Cruz ◽  
Ivan Baracaldo ◽  
Elkin Garcia-Cifuentes ◽  
Maria Isabel Ocampo-Navia ◽  
...  
Keyword(s):  
Young Adults ◽  
Ischemic Stroke ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Stroke In Young Adults ◽  
Stroke In Young
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