scholarly journals Function of the left ventricular myocardium in patients with systemic sclerosis

2010 ◽  
Vol 63 (3-4) ◽  
pp. 163-169
Author(s):  
Marina Deljanin-Ilic ◽  
Stevan Ilic ◽  
Bojana Stamenkovic
Keyword(s):  
Cardiovascular Disease ◽  
Systemic Sclerosis ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Ventricular Myocardium ◽  
Tissue Doppler ◽  
Left Ventricular ◽  
Doppler Imaging ◽  
Left Ventricular Myocardium ◽  
Female Patients

Deposits of myocardial fibrosis are the principal cause of myocardial dysfunction and poor prognosis in the patients with systemic sclerosis. Our aim was to assess whether there are changes in regional function of the left ventricular myocardium in female patients with systemic sclerosis without clinical signs and symptoms of cardiovascular disease. The study included 23 female patients with systemic sclerosis (without cardiovascular disease and with normal global systolic and diastolic function of the left ventricle) and 21 healthy female controls. In both groups, pulsed wave tissue Doppler imaging was done at rest and during exercise stress test echocardiography. The myocardial function was assessed from the basal segments in systola and diastola. The level achieved and duration of exercise tests were significantly reduced in the patients with systemic sclerosis compared to the controls (P<0.001 for both). The patients had significantly lower baseline regional systolic (P<0.02) and diastolic (P<0.001) myocardial functions, which became even more evident after the exercise test. During the test, those with systemic sclerosis demonstrated a smaller increase of systolic (20.6%) and diastolic (6.5%) function compared to the controls (systolic by 32.3% and diastolic by 25.0%). Quantification of regional function of the left ventricular myocardium using pulsed wave tissue Doppler imaging demonstrated an impaired systolic and diastolic myocardial function in the female patients with systemic sclerosis who had no clinical signs and symptoms of a cardiovascular disease.

Abstract 1247: Heart Function is Transiently Sustained Despite a Near Loss of SERCA2 Protein in Cardiomyocyte-specific Serca2 null Mice

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Kristin B Andersson ◽  
Alexandra V Finsen ◽  
Ivar Sjaastad ◽  
Yibin Wang ◽  
Ju Chen ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiac Output ◽  
Diastolic Pressure ◽  
Heart Function ◽  
Clinical Signs ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Lung Weight ◽  
Adult Mice

The SERCA2 Ca 2+ ATPase is of central importance for refilling of the sarcoplasmic reticulum (SR) Ca 2+ store and cardiac contractility. Reduced SERCA2 function is associated with heart failure. We hypothesized that loss of SERCA2 would result in immediate severe myocardial contractile dysfunction and death. Transgenic mice were generated with a Cre-loxP strategy in which tamoxifen induces Serca2 ( Atp2a2 ) gene excision in the cardiomyocytes (SERCA2KO) of adult mice. In SERCA2KO mice, SERCA2 protein was rapidly reduced in left ventricular myocardium with a half-life < 3 days. After 4 weeks, SERCA2 protein was reduced to < 5% of control values. In isolated cardiomyocytes, SERCA2a, SERCA2b, SERCA1 and SERCA3 proteins were not detectable. Strikingly, SERCA2KO mice did not present clinical signs of circulatory failure at 4 weeks. Fractional shortening was preserved, and cardiac output was reduced to 80% of control values. The left atrial diameter, lung weight and left ventricular end-diastolic pressure (LVEDP) were slightly increased in SERCA2KO mice compared with controls, and the maximal rates of pressure development and decline in the left ventricle were affected with a prolongation of the ventricular relaxation time. After seven weeks, SERCA2KO mice developed severe congestive heart failure with dilated chambers, elevated LVEDP and pronounced increases in lung and atrial weights. Cardiac output was reduced to 70% of control values. There were no indications of major cardiomyocyte disarray in the myocardium at the 4 or 7 week timepoints. The abundance of Na + ,Ca 2+ exchanger, L-type Ca 2+ channel 1c and alpha2delta1 subunit proteins and Pmca1 mRNA were all increased at 4 and 7 weeks. The expression of calsequestrin protein and Ryr2 mRNA were unchanged. L-type Ca 2+ channel alpha2delta1 subunit and PMCA1 expression were further enhanced at 7 weeks in SERCA2KO mice. Thus, cardiac function is supported in SERCA2KO mice for several weeks despite the near absence of SERCA2 protein. Alterations in the expression of Ca 2+ transporting proteins suggest that Ca 2+ transients are generated over the plasma membrane rather than the SR. However, the adaptations induced by loss of SERCA2 are not sufficient for long-term support of heart function in adult mice.

Evaluation of the Diastolic Function of the Left Ventricular by Means of Tissue Doppler

10.12737/2729 ◽  
2013 ◽  
Vol 20 (4) ◽  
pp. 57-61 ◽  
Author(s):  
Смоленский ◽  
A. Smolenskiy ◽  
Татаринова ◽  
A. Tatarinova ◽  
Михайлова ◽  
...  
Keyword(s):  
Blood Flow ◽  
Diastolic Function ◽  
Tissue Doppler ◽  
Left Ventricular ◽  
Doppler Imaging ◽  
Left Ventricular Myocardium ◽  
Lateral Part ◽  
Functional Evaluation ◽  
Doppler Study ◽  
Function Impairment

The results of the morphological and functional evaluation of the left ventricular in athletes of different sports disciplines are presented in this paper. The aim of the study was to assess morphological and functional condition of the left ventricular in athletes with the emphasis on the evaluation of the diastolic function including the use of tissue Doppler. Methods: 231 athletes of different sports disciplines were examined. All athletes included in this study underwent comprehensive transthoracal echocardiography by means of Doppler study and tissue Doppler. Results: This study revealed the difference in heart morphology between athletes of different sports disciplines. Parameters of the diastolic function of the left ventricular are not significantly differ between athletes of different sports disciplines. The diastolic function was not impaired in athletes with mild hypertrophy of the left ventricular. Violation of diastolic function occur in athletes with complaints of extreme fatigue after exercise. Method of tissue Doppler allows to detect signs of diastolic function impairment in athletes with formally &#34;normal&#34; mitral blood flow. Conclusions: 1. In athletes with small and border myocardial hypertrophy of the left ventricle is not observed violations of diastolic function of the left ventricular myocardium, which indicates the adaptive nature of the appearance of a small hypertrophy. 2. The authors suggest that the impairment of the diastolic function of the left ventricular is linked with the chronic overload of cardiovascular system. 3. The use of tissue Doppler allows to determine the signs of diastolic function impairment in athletes with visually normal mitral blood flow. 4. The authors consider enough check tissue Doppler imaging speed of displacement of the lateral part of the mitral annulus, since the check in other segments rarely gives new information, significantly extending the time of the study. 5. The authors also suggest that it is necessary to assess diastolic function by means of tissue Doppler in athletes with the E/A ratio less than 1.5.

scholarly journals Cardiomyopathy in Captive African Hedgehogs (Atelerix Albiventris)

2000 ◽  
Vol 12 (5) ◽  
pp. 468-472 ◽  
Author(s):  
James T. Raymond ◽  
Michael M. Garner
Keyword(s):  
Clinical Signs ◽  
Myocardial Edema ◽  
Ventricular Myocardium ◽  
Extramedullary Hematopoiesis ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Tubular Necrosis ◽  
Study Population ◽  
Renal Tubular ◽  
Passive Congestion

From 1994 to 1999, 16 captive African hedgehogs ( Atelerix albiventris), from among 42 necropsy cases, were diagnosed with cardiomyopathy. The incidence of cardiomyopathy in this study population was 38%. Fourteen of 16 hedgehogs with cardiomyopathy were males and all hedgehogs were adult (>1 year old). Nine hedgehogs exhibited 1 or more of the following clinical signs before death: heart murmur, lethargy, icterus, moist rales, anorexia, dyspnea, dehydration, and weight loss. The remaining 7 hedgehogs died without premonitory clinical signs. Gross findings were cardiomegaly (6 cases), hepatomegaly (5 cases), pulmonary edema (5 cases), pulmonary congestion (4 cases), hydrothorax (3 cases), pulmonary infarct (1 case), renal infarcts (1 case), ascites (1 case), and 5 cases showed no changes. Histologic lesions were found mainly within the left ventricular myocardium and consisted primarily of myodegeneration, myonecrosis, atrophy, hypertrophy, and disarray of myofibers. All hedgehogs with cardiomyopathy had myocardial fibrosis, myocardial edema, or both. Other common histopathologic findings were acute and chronic passive congestion of the lungs, acute passive congestion of the liver, renal tubular necrosis, vascular thrombosis, splenic extramedullary hematopoiesis, and hepatic lipidosis. This is the first report of cardiomyopathy in African hedgehogs.

scholarly journals Clinical-laboratory Manifestations of Myocarditis in Dogs

2019 ◽  
Author(s):  
Valeriy Shumakov ◽  
Ludmila Kletikova ◽  
Alexanderx Martynov ◽  
Victoria Khrushcheva
Keyword(s):  
Blood Pressure ◽  
Mitral Valve ◽  
Left Ventricle ◽  
Left Atrium ◽  
Blood Pressure Reduction ◽  
Clinical Signs ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Electrocardiographic Study

The leading clinical signs of myocarditis in dogs were the sudden development of signs of disease, refusal to eat, dyspnea at rest, rapid fatigue. At the diagnostic stage, the position of animals forced, lying, increased breathing speed up to 60-72 movements per minute, pale visible mucous membranes and conjunctiva, weak filling of pulse, rapid filling of capillaries, high blood pressure, increase in the number of leukocytes up to 25–27×109/l, SRS up to 15,4–17,4 mg/l, troponin up to 3,85–4,2 ng/ml. Electrocardiographic study established sinus or ectopic rhythm, heart rate 133– 198 oz/min, conductivity disturbance and deceleration. ECHOKG showed moderate expansion of the left ventricle, moderate expansion of the left atrium. Sealing of the mitral valve leaves, regurgitation on the mitral valve of the first degree. Left ventricular myocardium is inhomogeneous, wall echogenicity is increased. Fraction of contractility 16–18 %. After establishment of a dietary regime and correction of conditions of the maintenance, to dogs strictly with a twelve-hour interval twice a day are appointed vedmedin (0,25 mg/kg), sotalol (1,5 mg/kg), sinulox (20 mg/kg), mexidol-vet (1 table), verospheron (1 mg/kg). As a result of four-week monitoring of patients’ condition positive results were noted: lack of dyspnea, normalization of pulse rate and blood pressure, reduction of capillary filling rate up to 1 second, leukocyte concentration up to 12,6–15,7 ×109/l, SRS up to 1,3–1,4 mg/l, troponin up to 0,09–0,17 ng/ml. The electrocardiographic study showed a decrease in the height of teeth R and P, increase in the intervals P-Q and Q-T. The sinus rhythm is irregular. Echokg showed expansion of the left ventricle, moderate expansion of the left atrium. Sealing of mitral valve leaves, regurgitation on mitral valve of the first degree. Left ventricular myocardium is less heterogeneous, wall echogenicity is increased. Fraction of contractility 23–24 %. It is difficult to predict the outcome of the disease at this stage, as the age of dogs is 7–12 years, and in many respects the quality of life will be provided by their owners.

scholarly journals Effects of Supraphysiological Doses of Steroids on the Left Ventricle of Sedentary Mice: Morphometric Analysis

2019 ◽  
Vol 36 (02) ◽  
pp. 091-096 ◽  
Author(s):  
Érika Larissa Poscidônio de Souza ◽  
Rodrigo Leandro Dias ◽  
Raíssa Santiago Rios ◽  
Tânia Martins Vieira ◽  
Bruno Damião ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Anabolic Steroids ◽  
Signs And Symptoms ◽  
Ventricular Myocardium ◽  
Optical Microscope ◽  
Left Ventricular ◽  
Left Ventricular Cavity ◽  
Control Group ◽  
Left Ventricular Myocardium ◽  
Androgenic Steroids

AbstractAnabolic androgenic steroids (AAS) are synthetic compounds derived from testosterone, which are widely used in supraphysiological doses by people seeking an aesthetic effect. The objective of the present experiment was to evaluate the possible morphometric changes in the cardiac left ventricle caused by the administration of supraphysiological doses of the anabolic steroids testosterone cypionate and stanozolol in the hearts of young sedentary mice, to serve as a comparative parameter with young mice that were submitted to exercise. We have used 60 hearts of sedentary young Swiss mice, aged ∼ 90 days old (young-adult), with a body weight between 40 and 50 g. The animals were divided into three groups: the control group, the testosterone cypionate group, and the stanozolol group. For the analysis, 10 distinct sections of the apex, of the middle region, and of the base of the heart were selected, followed by an optical microscope measurement with a 2.5x magnification. The results obtained show an increase in both myocardial thickness and left ventricular cavity diameter in the two groups of male animals in relation to the control group; however, in females, an increase in the thickness of the left ventricular myocardium was observed only for the stanozolol group. These results suggest that the cardiac alterations observed in the present study may be directly related to some signs and symptoms already described in the literature, such as hypertension, arrhythmias, infarction, sudden death, and other cardiovascular diseases.

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