scholarly journals Damage to proximal tubular epithelial cells in type 2 diabetes mellitus

2007 ◽  
Vol 60 (5-6) ◽  
pp. 272-276 ◽  
Author(s):  
Vlastimir Vlatkovic ◽  
Biljana Stojimirovic ◽  
Radmila Obrenovic ◽  
Spomenka Nogic
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Control Group ◽  
Tubular Damage ◽  
Gamma Glutamyl Transferase ◽  
Irreversible Damage ◽  
Proximal Tubular ◽  
Glutamyl Transferase

Introduction: Kidney damage from diabetes mellitus is called diabetic nephropathy. At the beginning it is a functional disorder, but later it results in an irreversible damage. The aim of this research was to establish damage to proximal tubular cells in patients with type 2 diabetes mellitus, and various degrees of proteinuria by determining the urinary N-acetyl-b-D-glucose-aminidase and g-glutamyl-transferase; to compare obtained results with the results in healthy examinees; to establish the correlation between these enzymes, and to investigate their sensitivity. Material and methods Patients with type 2 diabetes mellitus and creatinine clearence >80 ml/min were included in the research. Patients were divided into three groups, according to the degree of proteinuria. The first group included diabetics without microalbuminuria; the second - patients with proteinuria <300 mg/24h and microalbuminuria >20 mg/24h, and the third group included patients with proteinuria >300 mg/24h. Healthy examinees were the control group. Results: Values of the urinary N-acetyl-b-D-glucosaminidase activity were elevated before microalbuminuria was observed. The highest values were detected in the group of patients with microalbuminuria. Differences among the examined groups were statistically significant, which implies that this enzyme has a high diagnostic importance. Enzyme g-glutamyl-transferase was less sensitive in this research. The activity of this enzyme was increased only in the group of patients with proteinuria >300 mg/24h, where values increased with diabetes mellitus duration. Conclusion The increased activity of urinary N-acetyl-b-D-glucosaminidase points to early tubular damage, and can be used as a sensitive parameter in its early detection. On the other hand, gamma-glutamyl-transferase was a less sensitive damage indicator.

Correlation between Lipid parameters and gamma glutamyl transferase in type 2 diabetes mellitus

2016 ◽  
Vol 3 (3) ◽  
pp. 299
Author(s):  
Sangappa Virupaxappa Kashinakunti ◽  
Pampareddy B. Kollur ◽  
Manjula Rangappa ◽  
Gurupadappa Shantappa Kallaganada
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase ◽  
Lipid Parameters

scholarly journals Non-linear relationship between gamma-glutamyl transferase and type 2 diabetes mellitus risk: secondary analysis of a prospective cohort study

2020 ◽  
Vol 48 (7) ◽  
pp. 030006052093791
Author(s):  
Hao Wang ◽  
Lixia Li ◽  
Shouyan Zhang
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Linear Relationship ◽  
Secondary Analysis ◽  
Gamma Glutamyl Transferase ◽  
Non Linear ◽  
Glutamyl Transferase ◽  
Study Participants

Objective To investigate the association between gamma-glutamyl transferase (GGT) and type 2 diabetes mellitus (T2DM) risk. Methods This was a secondary analysis based on a publicly available DRYAD dataset that included 15 444 study participants that received medical examinations at a single centre in Japan between 2004 and 2015. Crude, minimally-adjusted and fully-adjusted regression models were used to evaluate the relationship between GGT levels and T2DM risk. Results The study participants (mean ± SD age of 43.72 ± 8.90 years; 8415 of 15 444 [54.49%] were male) were followed-up for a median of 1968 days (5.39 years). After adjusting for potential covariates, a non-linear relationship between the baseline GGT level and T2DM incidence was observed. The inflection point for T2DM risk was 10 IU/l GGT; below this point, the T2DM incidence increased by 1.18-fold per unit change in GGT. Above this point, the association between GGT and the incidence rate of T2DM became nonsignificant. Conclusion Baseline GGT exhibited a non-linear association with T2DM incidence. Elevated GGT levels should be incorporated into routine screening for individuals at high risk of T2DM, allowing for early intervention targeting GGT to potentially reduce T2DM-related morbidity.

scholarly journals Urinary brush border enzymes for early diagnosis of tubular dysfunction in patients with type 2 diabetes mellitus

2019 ◽  
Vol 7 (6) ◽  
pp. 2015 ◽  
Author(s):  
Sasikala T. ◽  
Aparna R. Bitla ◽  
Alok Sachan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Renal Dysfunction ◽  
Tubular Dysfunction ◽  
Gamma Glutamyl Transferase ◽  
Group 3 ◽  
Group 2 ◽  
Glutamyl Transferase

Background: Diabetic nephropathy is a major cause of premature morbidity and mortality in type 1 and type 2 diabetes mellitus (T2DM) and hence new markers with better sensitivities are being investigated. The study was taken up to investigate whether urinary activities of N-acetyl-β-D-glycosaminidase (NAG), alkaline phosphatase (ALP), lactate dehydrogenase LDH) and Gamma glutamyl transferase (γ-GT) can be used as screening markers of renal dysfunction in patients suffering from T2DM.Methods: One hundred and four patients with T2DM along with 30 age- and gender-matched healthy individuals were included in the study. Patients were divided into three groups based on their u-MA levels i.e. normoalbuminuric (group1), micro albuminuric (group 2) and macroalbuminuric (group 3).Results: Urinary enzymes activity was significantly higher in patients with T2DM compared to controls (p<0.05). NAG, ALP, LDH, and GGT were significantly higher in group 3 compared to group1 and group 2 (p<0.0001). NAG, ALP, LDH and GGT showed significant positive correlation with MA (p=0.0001, r=0.308; p=0.0001, r=0.369; p=0.002, r=0.304, p=0.044, r=0.202 respectively). GGT and LDH showed highest sensitivity (86.21%, 84.00% respectively) and specificity (78.57%,53.49% respectively) for diagnosing renal dysfunction in patients with normoalbuminuria.Conclusions: The study suggests that u-GGT and LDH can be useful markers for assessing renal dysfunction in T2DM patients even before microalbuminuria manifests.

ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Shah Namrata Vinubhai ◽  
Pardeep Agarwal ◽  
Bushra Fiza ◽  
Ramkishan Jat
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Serum Ferritin ◽  
Inflammatory Marker ◽  
Control Group ◽  
Diabetic Patients ◽  
Positive Correlation

Background: Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM. Methodology: The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin. Results: A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control. Conclusion: The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control. Keywords: Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.

Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Rheumatoid Factor ◽  
Serum Uric Acid ◽  
Control Group ◽  
Healthy Male ◽  
Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

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