Role of maternal and paternal age in an assisted reproductive program

2002 ◽  
Vol 55 (11-12) ◽  
pp. 535-538
Author(s):  
Dunja Tabs ◽  
Nebojsa Radunovic
Keyword(s):  
Assisted Reproduction ◽  
Ovarian Reserve ◽  
Maternal Age ◽  
Low Dose ◽  
Reproductive Age ◽  
Paternal Age ◽  
Parental Age ◽  
Younger Women ◽  
Poor Ovarian Reserve

Introduction Many infertile couples try to become parents spontaneously, neglecting the possibility to conceive artificially, so they seek medical help in their late reproductive age. Maternal age Major aspects of maternal age in regard to assisted reproduction consider oocytes, ovaries and endometrium. Also, some habits and maternal diseases associated with aging may have an impact on fertility (smoking, atherosclerosis, previous gynecological operations etc.). Even though estimating the ovarian reserve is the most objective test in assessing female fertility, it has a limited predictive value in younger women. A short protocol of ovulation induction showed best results in women with poor ovarian reserve, but recent studies recommend low-dose gonadotropin-releasing hormone agonists in these cases. Paternal age With aging, sperm parameters become worse, which points to the neglected role of the father in assisted reproduction. Conclusion Thus, parental age plays an important role in assisted reproductive programs.

Parental Age and Schizophrenia

1966 ◽  
Vol 112 (490) ◽  
pp. 899-905 ◽  
Author(s):  
K. L. Granville-Grossman
Keyword(s):  
Maternal Age ◽  
Age Effect ◽  
Age Effects ◽  
Paternal Age ◽  
Considerable Importance ◽  
Parental Age ◽  
Advanced Paternal Age ◽  
Older Parents ◽  
Maternal Age Effect ◽  
Environmental Causes

Reports that schizophrenics have older parents than non-schizophrenics (Barry, 1945; Goodman, 1957; Johanson, 1958; Gregory, 1959) are of considerable importance. If valid, they provide evidence for environmental causes of schizophrenia, and by analogy with other conditions where parental age effects have been noted may give some indication of the nature of these causes. There are, however, inconsistencies in these studies: thus Johanson and Gregory found a significant association between advanced paternal age and schizophrenia, but failed to confirm the maternal age effect noted by Barry and Goodman. These differences indicate the need for further investigation and this paper describes such a study.

Mitochondrial SIRT5 is present in follicular cells and is altered by reduced ovarian reserve and advanced maternal age

2014 ◽  
Vol 26 (8) ◽  
pp. 1072 ◽  
Author(s):  
Leanne Pacella-Ince ◽  
Deirdre L. Zander-Fox ◽  
Michelle Lane
Keyword(s):  
Follicular Fluid ◽  
Ovarian Reserve ◽  
Protein Function ◽  
Maternal Age ◽  
Cumulus Cells ◽  
Advanced Maternal Age ◽  
Oocyte Quality ◽  
Carbamoyl Phosphate ◽  
Protein Activity

Women with reduced ovarian reserve or advanced maternal age have an altered metabolic follicular microenvironment. As sirtuin 5 (SIRT5) senses cellular metabolic state and post-translationally alters protein function, its activity may directly impact on oocyte viability and pregnancy outcome. Therefore, we investigated the role of SIRT5 in relation to ovarian reserve and maternal age. Women (n = 47) undergoing routine IVF treatment were recruited and allocated to one of three cohorts based on ovarian reserve and maternal age. Surplus follicular fluid, granulosa and cumulus cells were collected. SIRT5 mRNA, protein and protein activity was confirmed in granulosa and cumulus cells via qPCR, immunohistochemistry, western blotting and desuccinylation activity. The presence of carbamoyl phosphate synthase I (CPS1), a target of SIRT5, was investigated by immunohistochemistry and follicular-fluid ammonium concentrations determined via microfluorometry. Women with reduced ovarian reserve or advanced maternal age had decreased SIRT5 mRNA, protein and desuccinylation activity in granulosa and cumulus cells resulting in an accumulation of follicular-fluid ammonium, presumably via alterations in activity of a SIRT5 target, CPS1, which was present in granulosa and cumulus cells. This suggests a role for SIRT5 in influencing oocyte quality and IVF outcomes.

Parental Age Differences

1974 ◽  
Vol 6 (1) ◽  
pp. 93-106 ◽  
Author(s):  
William H. James
Keyword(s):  
Social Class ◽  
Age Differences ◽  
Neonatal Death ◽  
Maternal Age ◽  
Perinatal Death ◽  
Paternal Age ◽  
Age Difference ◽  
Parental Age ◽  
Biological Phenomena ◽  
Mother’S Age

SummaryData are presented on a representative sample of legitimate live-born first infants in England, Scotland and Wales. When they are categorized simultaneously by paternal age, maternal age and social class of the father, it is found that:(1) Mean parental age difference (father's age — mother's age) is higher in upper class births than in other births.(2) If a man is younger than his wife, he is probably more likely than otherwise to come from the lower social classes, though this conclusion becomes less secure as the age difference increases in this direction.(3) Mean parental age difference increases with paternal age and decreases with maternal age.(4) For a given paternal age, parental age difference increases with a decline in social class, and for a given maternal age, parental age difference increases with a rise in social class.(5) In general, young parents have smaller mean parental age differences than old parents.If such mating patterns are characteristic of white North Americans one would infer:(1) that the risks of neonatal death and stillbirth previously reported in association with aged paternity are the result of biological rather than sociological phenomena, and(2) that the risks of neonatal death and stillbirth previously reported in association with youthful paternity are the result of sociological rather than biological phenomena.In general, it seems that mean parental age difference is unlikely to be a fruitful clue to the aetiologies of pathological conditions unless there are simultaneous controls on the age of at least one parent and on social class.The question is raised whether age disparity between spouses is associated with childlessness as well as with perinatal death and congenital malformations.

scholarly journals Paternal but not maternal age influences early-life performance of offspring in a long-lived seabird

2016 ◽  
Vol 283 (1828) ◽  
pp. 20152318 ◽  
Author(s):  
Rémi Fay ◽  
Christophe Barbraud ◽  
Karine Delord ◽  
Henri Weimerskirch
Keyword(s):  
Maternal Age ◽  
Paternal Age ◽  
Parental Age ◽  
Fitness Component ◽  
Offspring Performance ◽  
Offspring Quality ◽  
Delayed Effects ◽  
Offspring Fitness ◽  
Demographic Traits ◽  
Iteroparous Species

Variability in demographic traits between individuals within populations has profound implications for both evolutionary processes and population dynamics. Parental effects as a source of non-genetic inheritance are important processes to consider to understand the causes of individual variation. In iteroparous species, parental age is known to influence strongly reproductive success and offspring quality, but consequences on an offspring fitness component after independence are much less studied. Based on 37 years longitudinal monitoring of a long-lived seabird, the wandering albatross, we investigate delayed effects of parental age on offspring fitness components. We provide evidence that parental age influences offspring performance beyond the age of independence. By distinguishing maternal and paternal age effects, we demonstrate that paternal age, but not maternal age, impacts negatively post-fledging offspring performance.

The role of maternal age in assisted reproduction

1995 ◽  
Vol 10 (suppl 1) ◽  
pp. 165-173 ◽  
Author(s):  
Z. Rosenwaks ◽  
O. K. Davis ◽  
M. A. Damario
Keyword(s):  
Assisted Reproduction ◽  
Maternal Age

scholarly journals Anti-MüLlerian Hormone as a Marker of Ovarian Reserve: An Update

2008 ◽  
Vol 4 (2) ◽  
pp. 137-141 ◽  
Author(s):  
David M Robertson
Keyword(s):  
Assisted Reproduction ◽  
Ovarian Reserve ◽  
Ovarian Response ◽  
Müllerian Inhibiting Substance ◽  
Oocyte Yield ◽  
Reproductive Processes ◽  
Assisted Reproduction Treatment ◽  
Mullerian Inhibiting Substance

In recent years there has been an increasing interest in the role of anti-Müllerian hormone or Müllerian-inhibiting substance as a marker of ovarian reserve during assisted reproduction treatment and other reproductive processes. It is concluded that anti-Müllerian hormone is superior to other markers in predicting oocyte yield in IVF and appears useful in monitoring ovarian response in a range of reproductive states and disorders. This article reviews the literature published during 2006 and 2007.

scholarly journals Role of Hormones in Unexplained Infertility

2016 ◽  
Vol 20 (1) ◽  
pp. 34-37 ◽  
Author(s):  
Manju Puri ◽  
Dipti C Ekka
Keyword(s):  
Ovarian Reserve ◽  
Unexplained Infertility ◽  
Infertile Couple ◽  
Female Reproductive System ◽  
Hormonal Interaction ◽  
Important Marker ◽  
Stimulation Of ◽  
Poor Ovarian Reserve ◽  
Fertile Women

ABSTRACT Unexplained infertility is a term applied to an infertile couple whose standard infertility investigations and workup are normal. The aim of the study is to assess the role of hormones in women with unexplained infertility. The female reproductive system is regulated by a balanced hormonal interaction between the hypothalamus, anterior pituitary, and ovaries. Follicle stimulating hormone (FSH) and luteinizing hormone (LH) are important for ovulation and stimulation of secretion of estradiol and progesterone from the ovaries. Anti-Müllerian hormone (AMH) is an important marker to predict the ovarian reserve. The primary function of the ovary is the production of a mature and viable oocyte capable of fertilization, embryo development, and implantation. Fifty women diagnosed with unexplained infertility were enrolled as cases. These were age matched with 50 healthy fertile women volunteers. Body mass index (BMI) was found to be significantly higher in women with unexplained infertility. Serum FSH, LH, and estradiol were significantly higher in cases. LH:FSH ratio and serum AMH were significantly lower in cases as compared to controls. To conclude, serum AMH, FSH, and LH:FSH ratio indicated poor ovarian reserve in women with unexplained infertility. How to cite this article Ekka DC, Jain A, Puri M. Role of Hormones in Unexplained Infertility. Indian J Med Biochem 2016;20(1):34-37.

scholarly journals Measuring IGF-1 and IGFBP-3 profiles in women seeking assisted reproduction; relationship to ovarian reserve parameters, namely AFC and AMH (study 2).

2020 ◽  
Vol 13 (2) ◽  
pp. 035-054
Author(s):  
John L Yovich ◽  
Syeda Zaidi ◽  
Minh DK Nguyen ◽  
Peter M Hinchliffe
Keyword(s):  
Older Women ◽  
Assisted Reproduction ◽  
Ovarian Reserve ◽  
Age Groups ◽  
Antral Follicle ◽  
Serum Levels ◽  
Antral Follicle Count ◽  
Younger Women ◽  
Two Parameters ◽  
Igfbp 3

This is the second of five studies undertaken on women preparing for assisted reproduction, to sequentially examine the relevance of the insulin-like growth factor (IGF) profile (IGF-1, IGFBP-3 and the IGFBP-3/ IGF-1 ratio) which, in children, provides the essential criteria to identify the GH-deficient individual. Whilst our first, published study, focussed on clinical parameters, this study examines its relevance to the two parameters which define the ovarian reserve. The first, that of the antral follicle count (AFC), shows highly significant, sequential changes across 4 age groups ranging from high counts in the younger women <35 years and low counts in the older women, namely those aged 35-39 years, those aged 40-44 years and those aged ≥45 years (p<0.0001). Similarly, the serum levels of anti-Mullerian hormone (AMH), a later introduced marker of ovarian reserve, also showed highly significant sequential changes across the 4 age groups with high levels recorded in the young women and low counts in the older women (p<0.0001). At the higher AFC range, concordance between AFC groups and AMH groups was high at r=0.79 for precise matching and r=0.95 when neighbouring groups were included. The correlation was also clear with inter-quartile AMH levels ranging 27 pmol/L to 50 pmol/L across the higher AFC groups and 8 pmol/L to 10 pmol/L in the lowest groupings. However, IGF profiles showed no significant variations across the entire range, neither for the AFC nor for the AMH groups. Our next study will report on the relevance of the IGF profile to clinical outcomes.

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