scholarly journals Hypertriglyceridemia and atherogenic lipoprotein phenotype: Triglycerides and atherosclerosis

2002 ◽  
Vol 55 (3-4) ◽  
pp. 85-88 ◽  
Author(s):  
Mirjana Djeric
Keyword(s):  
Atherogenic Lipoprotein ◽  
Atherogenic Lipoprotein Phenotype ◽  
Lipoprotein Phenotype

scholarly journals Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype

2002 ◽  
Vol 43 (6) ◽  
pp. 979-985 ◽  
Author(s):  
Syrah Khan ◽  
Anne-Marie Minihane ◽  
Philippa J. Talmud ◽  
John W. Wright ◽  
Margaret C. Murphy ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Atherogenic Lipoprotein ◽  
Lpl Gene ◽  
Atherogenic Lipoprotein Phenotype ◽  
Lipoprotein Phenotype ◽  
Long Chain

Effects of troglitazone on atherogenic lipoprotein phenotype in coronary patients with insulin resistance

1999 ◽  
Vol 146 (1) ◽  
pp. 187-193 ◽  
Author(s):  
Satoshi Sunayama ◽  
Yoshiro Watanabe ◽  
Hirotoshi Ohmura ◽  
Masato Sawano ◽  
Kazunori Shimada ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Atherogenic Lipoprotein ◽  
Coronary Patients ◽  
Atherogenic Lipoprotein Phenotype ◽  
Lipoprotein Phenotype

scholarly journals The Correlation between Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Insulin Resistance and the Components of Atherogenic Lipoprotein Phenotype in Males with Central Obesity

2010 ◽  
Vol 2 (3) ◽  
pp. 137
Author(s):  
Yusmiati Yusmiati ◽  
Burhanuddin Bahar ◽  
Andi Wijaya
Keyword(s):  
Insulin Resistance ◽  
Linear Correlation ◽  
Central Obesity ◽  
Proprotein Convertase ◽  
Apo B ◽  
Atherogenic Lipoprotein ◽  
Positive Linear Correlation ◽  
Atherogenic Lipoprotein Phenotype ◽  
Lipoprotein Phenotype

BACKGROUND: Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) promotes the degradation of LDL receptor in hepatocytes. in vitro studies have proven that insulin increases the expression of PCSK9. Insulin resistance, a common condition in central obesity is characterized by dyslipidemia called Atherogenic Lipoprotein Phenotype (ALP). This study aimed to investigate the correlation between insulin resistance (HOMA-IR) and PCSK9, and to analyze whether this condition is related to the development of ALP in central obesity.METHODS: This is an observational study with crosssectional design. The subjects consisted of 62 male adults with central obesity, aged 30-60 years old. ELISA was used to measure plasma PSCK9.RESULTS: The mean plasma PCSK9 concentration of the samples was 283.7 ng/mL. PCSK9 had positive linear correlation with HOMA-IR (r=0.225, p=0.045) and Apo B (r=0.245, p=0.055). After controlling of HOMA-IR, PCSK9 had positive linear correlation with triglycerides (r=0.352, p=0.045). In population with HOMA-IR >2, crosstabs analysis showed that PCSK9 had significant correlation with triglycerides and Apo B with an odd ratio of 6,125 (r=0.376, p=0.037). Triglyceride showed significant negative correlation with HDL cholesterol and ratio of LDL/Apo B, but neither HOMA-IR nor PCSK9 did.CONCLUSION: In males with central obesity, PCSK9 is one of the factors mediating the occurence of ALP in insulin resistance.KEYWORDS: PCSK9, insulin resistance, atherogenic lipoprotein phenotype

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