scholarly journals Signal amplification for sumatriptan sensing based on polymeric surface decorated with Cu nanoparticles

2018 ◽  
Vol 83 (4) ◽  
pp. 449-462
Author(s):  
Ghasem Karim-Nezhad ◽  
Samane Khanaliloo ◽  
Zeynab Khorablou ◽  
Seyed Dorraji
Keyword(s):  
Signal Amplification ◽  
Biological Fluids ◽  
Differential Pulse ◽  
Cu Nanoparticles ◽  
Linear Calibration ◽  
Polymeric Surface ◽  
Sensitive Determination ◽  
Pulse Voltammetry ◽  
Uniform Deposition

A new nanocomposite, Cu NPs/poly-melamine, was deposited on a glassy carbon electrode by cyclic voltammetry. The uniform deposition of the nanocomposite was observed by the field emission scanning electron microscopy. The electron transfer characteristics of the drug sumatriptan (SUM), was greatly improved on the modified electrode. The prepared electrode was used for the sensitive determination of SUM by the differential pulse voltammetry. Linear calibration curve was obtained in the concentration ranges of 0.08?0.58 and 0.58?6.5 ?M, and the detection limit of 0.025 ?M. The proposed method was evaluated by the determination of SUM in human biological fluids such as urine and blood plasma with satisfactory results (recovery > 99 %).

Sensitive Determination of Epinephrine in the Presence of Ascorbic Acid at Poly(diphenylamine sulfonic acid) Modified Sensor

2020 ◽  
Vol 18 (4) ◽  
pp. 253-258
Author(s):  
Gamze Erdoğdu
Keyword(s):  
Ascorbic Acid ◽  
Sulfonic Acid ◽  
Limit Of Detection ◽  
Phosphate Buffer Solution ◽  
Differential Pulse ◽  
Buffer Solution ◽  
Sensitive Determination ◽  
Pulse Voltammetry ◽  
Modified Sensor

A sensitive and simple modified sensor was prepared by electrodeposition of diphenylamine sulfonic acid (DPSA) to the glassy carbon electrode surface by cyclic voltammetry (CV) technique. The electrooxidation of epinephrine (EP) was accomplished by CV and differential pulse voltammetry at poly(DPSA) modified sensor. As a result of the findings, the current values were enhanced and both substances were separated at the modified sensor compared to the bare electrode. There was linearly between the oxidation current and concentration of EP from 0.2 to 100 μM in phosphate buffer solution at pH 7.0. The limit of detection was 5.0 nM and the sensitivity was 0.4205 μA/μM. The determination of EP was successfully and satisfactorily carried out in real samples such as human blood serum and urine at the poly(DPSA) sensor. To the best knowledge of this work, this is the first study that detect the EP in the presence of ascorbic acid at poly(DPSA) sensor in the literature.

scholarly journals Utility of Activated Glassy Carbon and Pencil Graphite Electrodes for Voltammetric Determination of Nalbuphine Hydrochloride in Pharmaceutical and Biological Fluids

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Hoda M. Elqudaby ◽  
Hassan A. M. Hendawy ◽  
Eglal R. Souaya ◽  
Gehad G. Mohamed ◽  
Ghada M. G. Eldin
Keyword(s):  
Glassy Carbon ◽  
Biological Fluids ◽  
Differential Pulse ◽  
Pencil Graphite Electrode ◽  
Buffer Solution ◽  
Graphite Electrodes ◽  
Diffusion Controlled ◽  
Pulse Voltammetry ◽  
Voltammetric Peak

This work compares voltammetric response of nalbuphine hydrochloride (NP·HCl) at both activated glassy carbon and pencil graphite electrodes. The electrochemical oxidation of the drug was studied using cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV) techniques. For analytical purpose a well-resolved irreversible diffusion controlled voltammetric peak was established in Britton-Robinson (B-R) buffer solution of pH 6.00 using pencil graphite electrode (PGE). Using activated glassy carbon electrode (GCE) a well-resolved irreversible diffusion controlled voltammetric peak was obtained at pH 7.00 using the same buffer solution. According to the linear relationship between the peak current and NP·HCl concentration, DPV and SWV methods were developed for their quantitative determination in pharmaceutical and human biological fluids. The linear response was obtained in the range from1.6×10-5to1.5×10-4 mol L−1using PGE and from12.5×10-6to13.75×10-5 mol L−1using a GC electrode, respectively. Precision and accuracy of the developed method were checked by recovery studies.

Sensitive Determination of Semicarbazide in Flour by Differential Pulse Voltammetry

2019 ◽  
Vol 74 (9) ◽  
pp. 913-919
Author(s):  
Yudan Zhu ◽  
Yiping Hang ◽  
Xiaoshan Huang ◽  
Chenglong Song
Keyword(s):  
Differential Pulse Voltammetry ◽  
Differential Pulse ◽  
Sensitive Determination ◽  
Pulse Voltammetry

Pulse Polarographic Trace Determination of Bismuth in Natural Waters and Biological Materials

1992 ◽  
Vol 29 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Rajendra P Namdeo ◽  
K S Pitre
Keyword(s):  
Natural Waters ◽  
Biological Fluids ◽  
Supporting Electrolyte ◽  
Saturated Calomel Electrode ◽  
Differential Pulse ◽  
Biological Materials ◽  
Trace Determination ◽  
Linear Calibration ◽  
Half Wave

A convenient and accurate analytical procedure has been developed for the trace determination of bismuth(III) in natural waters and biological fluids. Bismuth gives a well-defined, diffusion-controlled cathodic wave in 1 M HCl with a half wave potential of −0·21 V with reference to a saturated calomel electrode. Trace amounts of Bi(III) have been determined by normal pulse and differential pulse polarographic techniques in a 1 M HCl supporting electrolyte with linear calibration plots. The determination of Bi(III) has been achieved in the presence of metals with which it is commonly associated. This is illustrated with bismuth measurements in the presence of copper and zinc. Suitable methods of preparing the samples for analysis have also been suggested. The method may also be used for the determination of Bi(III) in different natural water samples and biological materials such as blood and urine samples with lowest detection limit of 0·02 μg/L.

Graphene Modified Molecular Imprinting Electrochemical Sensor for Determining the Content of Dopamine

2019 ◽  
Vol 15 (6) ◽  
pp. 628-634
Author(s):  
Rong Liu ◽  
Jie Li ◽  
Tongsheng Zhong ◽  
Liping Long
Keyword(s):  
Electrochemical Sensor ◽  
Molecular Imprinting ◽  
Neurological Disorders ◽  
Room Temperature ◽  
Low Cost ◽  
Differential Pulse ◽  
Current Response ◽  
Specific Selectivity ◽  
Pulse Voltammetry

Background: The unnatural levels of dopamine (DA) result in serious neurological disorders such as Parkinson’s disease. Electrochemical methods which have the obvious advantages of simple operation and low-cost instrumentation were widely used for determination of DA. In order to improve the measurement performance of the electrochemical sensor, molecular imprinting technique and graphene have always been employed to increase the selectivity and sensitivity. Methods: An electrochemical sensor which has specific selectivity to (DA) was proposed based on the combination of a molecular imprinting polymer (MIP) with a graphene (GR) modified gold electrode. The performance and effect of MIP film were investigated by differential pulse voltammetry (DPV) and cyclic voltammetry (CV) in the solution of 5.0 ×10-3 mol/L K3[Fe(CN)6] and K4[Fe(CN)6] with 0.2 mol/L KCl at room temperature. Results: This fabricated sensor has well repeatability and stability, and was used to determine the dopamine of urine. Under the optimized experiment conditions, the current response of the imprinted sensor was linear to the concentration of dopamine in the range of 1.0×10-7 ~ 1.0×10-5 mol/L, the linear equation was I (µA) = 7.9824+2.7210lgc (mol/L) with the detection limit of 3.3×10-8 mol/L. Conclusion: In this work, a highly efficient sensor for determination of DA was prepared with good sensitivity by GR and great selectivity of high special recognization ability by molecular imprinting membrane. This proposed sensor was used to determine the dopamine in human urine successfully.

Determination of platinum in biological material by differential pulse polarography: Analysis in urine, plasma and tissue following sample combustion

1983 ◽  
Vol 48 (10) ◽  
pp. 2903-2908 ◽  
Author(s):  
Viktor Vrabec ◽  
Oldřich Vrána ◽  
Vladimír Kleinwächter
Keyword(s):  
Biological Material ◽  
Biological Fluid ◽  
Mercury Electrode ◽  
Differential Pulse ◽  
Differential Pulse Polarography ◽  
Linear Calibration ◽  
Catalytic Current ◽  
Pulse Polarography ◽  
Dropping Mercury Electrode

A method is described for determining total platinum content in urine, blood plasma and tissues of patients or experimental animals receiving cis-dichlorodiamineplatinum(II). The method is based on drying and combustion of the biological material in a muffle furnace. The product of the combustion is dissolved successively in aqua regia, hydrochloric acid and ethylenediamine. The resulting platinum-ethylenediamine complex yields a catalytic current at a dropping mercury electrode allowing to determine platinum by differential pulse polarography. Platinum levels of c. 50-1 000 ng per ml of the biological fluid or per 0.5 g of a tissue can readily be analyzed with a linear calibration.

Polarographic and voltammetric determination of 6-mercaptopurine and 6-thioguanine

1986 ◽  
Vol 51 (11) ◽  
pp. 2466-2472 ◽  
Author(s):  
Jiří Barek ◽  
Antonín Berka ◽  
Ludmila Dempírová ◽  
Jiří Zima
Keyword(s):  
Detection Limit ◽  
Differential Pulse Voltammetry ◽  
Detection Limits ◽  
Differential Pulse ◽  
Voltammetric Determination ◽  
Differential Pulse Polarography ◽  
Hanging Mercury Drop Electrode ◽  
Pulse Polarography ◽  
Pulse Voltammetry

Conditions were found for the determination of 6-mercaptopurine (I) and 6-thioguanine (II) by TAST polarography, differential pulse polarography and fast-scan differential pulse voltammetry at a hanging mercury drop electrode. The detection limits were 10-6, 8 . 10-8, and 6 . 10-8 mol l-1, respectively. A further lowering of the detection limit to 2 . 10-8 mol l-1 was attained by preliminary accumulation of the determined substances at the surface of a hanging mercury drop.

The polarographic and voltammetric determination of 2,6-dicyano-4-nitro-2'-acetylamino-4'-diethylaminoazobenzene

1990 ◽  
Vol 55 (6) ◽  
pp. 1508-1517 ◽  
Author(s):  
Jiří Barek ◽  
Dagmar Civišová ◽  
Ashutosh Ghosh ◽  
Jiří Zima
Keyword(s):  
Azo Dye ◽  
Differential Pulse ◽  
Differential Pulse Polarography ◽  
Determination Limit ◽  
Polarographic Reduction ◽  
Hanging Mercury Drop Electrode ◽  
Optimal Conditions ◽  
Pulse Polarography ◽  
Pulse Voltammetry

The polarographic reduction of the title azo dye was studied and optimal conditions were found for its analytical utilization in the concentration range 1 . 10-6 - 1 . 10-7 mol l-1 using differential pulse polarography and 1 . 10-6 - 1 . 10-8 mol l-1 using fast scan differential pulse voltammetry or linear scan voltammetry at a hanging mercury drop electrode. When the latter technique is combined with adsorptive accumulation of the studied substance on the surface of the hanging mercury drop, the determination limit can be further decreased to 3 . 10-9 mol l-1.

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