scholarly journals Microwave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity

2015 ◽  
Vol 80 (3) ◽  
pp. 305-313 ◽  
Author(s):  
Dongamanti Ashok ◽  
Bommidi Lakshmi ◽  
Sidda Ravi ◽  
Arram Ganesh
Keyword(s):  
Antimicrobial Activity ◽  
Sodium Acetate ◽  
Pathogenic Bacteria ◽  
Conventional Heating ◽  
Microwave Assisted Synthesis ◽  
Good Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Microwave Assisted ◽  
Bacteria And Fungi

A series of pyrazolines 4a-g have been synthesized by Michael addition of chalcones 3a-g with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation. Structures of the newly synthesized chalcones 3a-g and pyrazolines 4a-g have been established on the basis of IR, 1H & 13C NMR and mass spectral data. All the synthesized compounds were screened for their antimicrobial activity. Some of the compounds shown very good activity compared to standard drugs against all pathogenic bacteria and fungi.

scholarly journals Microwave assisted synthesis of 1H-tetrazole-based flavonoid derivatives and their antimicrobial activity

2018 ◽  
Vol 83 (12) ◽  
pp. 1305-1313
Author(s):  
Dongamanti Ashok ◽  
Nalaparaju Nagaraju ◽  
Madderla Sarasija ◽  
Vijaya Lakshmi
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Pathogenic Bacteria ◽  
Microwave Assisted Synthesis ◽  
Good Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Microwave Assisted ◽  
Bacteria And Fungi

A series of novel tetrazole scaffolds containing chalcones 4a?e and aurones 5a?e were synthesized under conventional and microwave irradiation conditions. All the newly synthesized compounds were characterized by IR, NMR and mass spectral data. Furthermore, the title compounds were screened in vitro for their antimicrobial activity against bacteria, such as Staphylococus aureus, Bacillus subtilis, Klebsiella pneumoniae and Escherichia coli, as well as fungi, such as Aspergillus niger, A. flavus and Fusarium oxysporum. Some of the compounds showed very good activity compared to standard drugs against all the tested pathogenic bacteria and fungi.

scholarly journals Microwave assisted synthesis of 2-(2-(tetrazolo[1,5-a]quinolin-4-yl)-2,3-dihydro-1h-benzo[b][1,4]diazepin-4-yl) substituted phenols and evaluation of their antimicrobial activity

2016 ◽  
Vol 81 (8) ◽  
pp. 851-858 ◽  
Author(s):  
Dongamanti Ashok ◽  
Velagapuri Rao ◽  
Rangu Kavitha
Keyword(s):  
Antimicrobial Activity ◽  
Microwave Irradiation ◽  
13C Nmr ◽  
Sodium Acetate ◽  
Conventional Heating ◽  
Microwave Assisted Synthesis ◽  
Substituted Phenols ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Microwave Assisted

A series of new benzodiazepines 4a-h have been synthesized by Michael addition of chalcones 3a-h with o-phenylenediamine (OPDA) in presence of sodium acetate under conventional heating and microwave irradiation. Structures of the newly synthesized benzodiazepines 4a-h have been established on the basis of IR, 1H & 13C NMR and mass spectral data and tested for antimicrobial activity.

scholarly journals Microwave-assisted synthesis of 2,8-di(alkyl/aryl)-4,6-dichloro-2H,8H-pyrano[3,2-g] chromene-3,7-dicarbaldehydes and their antimicrobial activity

2019 ◽  
Vol 84 (4) ◽  
pp. 355-364
Author(s):  
Rupireddy Venkataramana ◽  
Venkata Chittireddy ◽  
Dongamanti Ashok ◽  
Kudle Rao
Keyword(s):  
Antimicrobial Activity ◽  
Pathogenic Bacteria ◽  
Aromatic Aldehydes ◽  
Conventional Heating ◽  
Microwave Assisted Synthesis ◽  
Good Activity ◽  
One Pot ◽  
Alkyl Aryl ◽  
Microwave Assisted ◽  
Bacteria And Fungi

A series of 2,8-di(alkyl/aryl)-substituted bischromanone derivatives were synthesized in one pot from 4,6-diacetylresorcinol and aliphatic/aromatic aldehydes in the presence of pyrrolidine/piperidine under conventional heating and microwave irradiation. The 2,8-di(alkyl/aryl)-substituted bischromanones were converted into a new series of 4,6-dichloro-3,7-diformyl-2,8-di(alkyl/aryl)-substituted bischromenes using the Vilsmeier?Haack reagent. The structures of the compounds were established based on elemental analysis, IR, 1H-NMR, 13C- -NMR and LC?MS spectral data. All the synthesized compounds were evaluated for their antimicrobial activity. Some of the compounds showed very good activity compared to standard drugs against all the tested pathogenic bacteria and fungi.

scholarly journals Microwave assisted synthesis and antimicrobial activity of some novel pyrimidine derivatives

2007 ◽  
Vol 72 (2) ◽  
pp. 109-117 ◽  
Author(s):  
S.J. Vaghasia ◽  
V.H. Shah
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Activities ◽  
Microwave Assisted Synthesis ◽  
Mass Spectral Data ◽  
Pyrimidine Derivatives ◽  
Plate Method ◽  
Mass Spectral ◽  
Microwave Assisted ◽  
New Compounds

The synthesis of thiazolo[5,4-d]pyrimidines can be achieved from different 5- thiazolidinones, 2-butyl-1H-imidazole-5-carbaldehyde and thiourea using microwave irradiation within 5 min. The structures of the products were supported by FTIR, PMR and mass spectral data. The in vitro antimicrobial activity of the synthesized thiazolo[5,4-d]pyrimidines 1a-j, having substituents at the 1- and 3-positions, were determined by the cup-plate method against several standard strains chosen to define the spectrum and potency of the new compounds. The antimicrobial activities of the thiazolo[5,4-d]pyrimidines 1a-j are compared with those of known chosen standard drugs, viz. ampicillin, chloramphenicol, ciprofloxacin, norfloxacin and griseofulvin. .

scholarly journals Microwave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-ols

2019 ◽  
Vol 84 (3) ◽  
pp. 237-244
Author(s):  
Dongamanti Ashok ◽  
Rangu Kavitha ◽  
Srinivas Gundu ◽  
Madderla Sarasija
Keyword(s):  
Antimicrobial Activity ◽  
Microwave Irradiation ◽  
Sodium Acetate ◽  
Analytical Data ◽  
Conventional Heating ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Structural Assignment ◽  
Antimicrobial Evaluation ◽  
Antimicrobial Potency

A new series of 6-[3-aryl-1-phenyl-4?,5?-dihydro[4,5?-bi-1H-pyrazol]-3?-yl]-2H-chromen-5-ol derivatives was synthesized by Michael addition of chalcones 5a?j with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation. Structural assignment of the products was confirmed based on IR, 1H-NMR, 13C-NMR, MS and analytical data. All the synthesized compounds 6a?j were screened for their antimicrobial activity against various bacterial and fungal strains. Most of the compounds exhibited variable range of antimicrobial activity and compounds 6c?f and 6i showed promising antimicrobial potency.

scholarly journals Microwave assisted synthesis of substituted 4-chloro-8-methyl-2-(1,3-diphenyl-1H-pyrazol-4-yl)-1,5-dioxa-2H-phenanthren-6-ones and their antimicrobial activity

2017 ◽  
Vol 82 (2) ◽  
pp. 117-125 ◽  
Author(s):  
Dongamanti Ashok ◽  
Reddy Vanaja ◽  
Mdderla Sarasija ◽  
Vijaya Lakshmi
Keyword(s):  
Antimicrobial Activity ◽  
Pathogenic Bacteria ◽  
Microwave Assisted Synthesis ◽  
Vilsmeier Reaction ◽  
Microwave Assisted ◽  
Antibacterial And Antifungal Activities ◽  
Bacteria And Fungi ◽  
Antibacterial And Antifungal ◽  
Microwave Assisted Method

Due to the potential antimicrobial activity of pyranochromenones and pyrazolines moieties, hybrid compounds containing both, substituted 4-Chloro-8-methyl-2-(1,3-diphenyl- -1H-pyrazol-4-yl)-1,5-dioxa-2H-phenanthren-6-ones (4a-g), have been synthesized from substituted (E)-1-(7-Hydroxy-4-methyl-8-coumarinyl)-3-(1,3-diphenyl -1H-pyrazol-4-yl)-2-propen-1-ones (3a-g) in good yield using the Vilsmeier reaction, by microwave-assisted method. The structures of all the compounds have been established on the basis of analytical and spectral data. All the synthesized compounds were tested in vitro for their antibacterial and antifungal activities. Some of the compounds have shown very good activity compared to standard drugs against all pathogenic bacteria and fungi.

scholarly journals Microwave Assisted Synthesis and Characterization of Schiff Base of 2-Amino Benzimidazole

2018 ◽  
Vol 10 (4) ◽  
Author(s):  
Garima Shrivastava ◽  
Manjul Shrivastava
Keyword(s):  
Schiff Base ◽  
Spectral Data ◽  
Aromatic Aldehyde ◽  
Synthesis And Characterization ◽  
Microwave Assisted Synthesis ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Microwave Assisted

New Schiff base (2-[(1H-benzimidazol-2-ylimino) methyl]-4,6- diiodophenol) was synthesized by the condensation of aryl/hetero aromatic aldehyde (3,5diiodosalicylaldehyde) with 2- amino benzimidazole under conventional and microwave conditions and characterized through IR, HNMR and Mass spectral data and CHN analysis

scholarly journals A Novel and Efficient Synthesis of [1,2,3]-Triazolyl Substituted Benzo[c]Coumarins and Evaluation of their Antimicrobial Activity

2016 ◽  
Vol 70 ◽  
pp. 1-11
Author(s):  
Neha N. Gohil ◽  
Kaushik N. Kundaliya ◽  
Dinkar I. Brahmbhatt
Keyword(s):  
Antimicrobial Activity ◽  
Fungal Pathogens ◽  
Sodium Acetate ◽  
Efficient Synthesis ◽  
Mass Spectral Data ◽  
Pyridinium Bromide ◽  
Mass Spectral ◽  
H Nmr ◽  
Anti Fungal ◽  
C Nmr

A series of novel [1,2,3]-triazolyl substituted benzo [c] coumarins have been synthesized by reacting various 3-coumarinoyl methyl pyridinium bromide salts with 1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl) ethanones in the presence of sodium acetate in refluxing acetic acid. The structures of the synthesized compounds have been elucidated by IR,1H-NMR,13C-NMR and Mass spectral data. All the synthesized compounds have been screened for theirinvitroanti-bacterial and anti-fungal activities. Some of the compounds have been found to be active against some bacterial and fungal pathogens compared to standard drugs.

scholarly journals Synthesis and Antimicrobial Activity of (2-Methoxy/2-Amino)-6-{4'-[(4'''-Chlorophenyl) (Phenyl) Methyl Amino] Phenyl}-4-Aryl Nicotinonitrile

2015 ◽  
Vol 49 ◽  
pp. 99-103
Author(s):  
J.V. Guna ◽  
V.N. Bhadani ◽  
H.D. Purohit ◽  
Dipak M. Purohit
Keyword(s):  
Antimicrobial Activity ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Spectral Data ◽  
Elemental Analysis ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Bacteria And Fungi ◽  
Layer Chromatography

2- Methoxy – 6 - {4' - [(4'''- Chlorophenyl) (phenyl) methyl amino] phenyl} - 4 - aryl nicotinonitrile (3a-3l) and 2-Amino-6-{4'-[(4'''-Chlorophenyl)(phenyl)methyl amino]phenyl}-4-aryl nicotinonitrile (4a-4l) have been synthesized. The products have been assayed for their antimicrobial activity against Gram +ve, Gram -ve bacteria and fungi. The structure of the products has been elucidated by IR, 1H-NMR, mass spectral data, elemental analysis and thin layer chromatography.

scholarly journals Microwave-Assisted Synthesis of 2-(5-(5-(4-Substituted phenyl)-2-(5-methoxy- 2H-chromen-3-yl)-1H-imidazol-1-yl)alkyl)-1H-benzo[de]isoquinoline- 1,3(2H)-dione Derivatives and their Antimicrobial Activity

2020 ◽  
Vol 32 (4) ◽  
pp. 839-844
Author(s):  
D. Ashok ◽  
K. Ramakrishna ◽  
Nalaparaju. Nagaraju ◽  
Ravinder Dharavath ◽  
M. Ram Reddy ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Microwave Irradiation ◽  
Conventional Heating ◽  
Microwave Assisted Synthesis ◽  
Klebsiella Pneumonia ◽  
Green Solvents ◽  
Microwave Irradiation Method ◽  
Reaction Conditions ◽  
Mass Spectral

A method for the synthesis of several imidazoles containing isoquinoline scaffolds under conventional and microwave irradiation methods. In the microwave irradiation method gives higher yields with in shorter reaction time as compared to conventional heating method, using green solvents and eco-friendly reaction conditions. All the synthesized derivatives were characterized by IR, NMR and Mass spectral analysis. Furthermore, the title compounds were screened for their in vitro antimicrobial activity against bacteria such as Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumonia as well as fungi such as Aspergillus niger, Aspergillus flavus and Fusarium oxysporum. The compounds 8a, 8d, 8e and 8h exhibited better antimicrobial activity against all organisms.

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