scholarly journals Phytochemical analysis and gastroprotective activity of an olive leaf extract

2009 ◽  
Vol 74 (4) ◽  
pp. 367-377 ◽  
Author(s):  
Dragana Dekanski ◽  
Snezana Janicijevic-Hudomal ◽  
Vanja Tadic ◽  
Goran Markovic ◽  
Ivana Arsic ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Defense Mechanism ◽  
Mucosal Injury ◽  
Control Group ◽  
Phytochemical Analysis ◽  
Gastric Lesions ◽  
Olive Leaf ◽  
Gastroprotective Activity ◽  
Reference Drug ◽  
Olive Leaf Extract

Some medicinal features of olive leaf have been known for centuries. It has been traditionally used as an antimicrobial and to prevent and treat diabetes mellitus and heart disease. Whether olive leaf, a natural antioxidant, influences the gastric defense mechanism and exhibits gastroprotection against experimentally-induced gastric lesions remains unknown. In this study, the content of total phenols, total flavonoids and tannins in olive leaf extract (OLE) were determined. Seven phenolic compounds were identified and quantified (oleuropein, caffeic acid, luteolin, luteolin-7-O-glucoside, apigenin-7-O-glucoside, quercetin, and chryseriol). Furthermore, the protective activity of the OLE in gastric mucosal injury induced by a corrosive concentration of ethanol was investigated. In relation to the control group, pretreatment with OLE (40, 80 and 120 mg kg-1) significantly (p < 0.001) attenuated the gastric lesions induced by absolute ethanol. The protective effect of the OLE was similar to that obtained with a reference drug, ranitidine. The results obtained indicate that OLE possesses significant gastroprotective activity, and that the presence of compounds with antioxidative properties would probably explain this effect.

scholarly journals Effects of Olive Leaf Extract on Prevention of Molecular, Histopathological, and Enzymatic Changes in Chicken Carbon Tetrachloride-Induced Liver Damage

2019 ◽  
Vol 8 ◽  
pp. 1204
Author(s):  
Nazila Vahidi-Eyrisofla ◽  
Vida Hojati ◽  
Mohammad-Reza Yazdian ◽  
Morteza Zendehdel ◽  
Hooman Shajiee
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Leaf Extract ◽  
Production Efficiency ◽  
B Cell Lymphoma ◽  
Control Group ◽  
Olive Leaf ◽  
Control Groups ◽  
Olive Leaf Extract ◽  
High Doses

Background: Today, the use of additives such as antibiotics and growth hormones that increase production efficiency in breeding broiler chickens has become inevitable. However, the use of such additives and antibiotics associated with side effects such as liver damage. Oxidative stress occurs due to an imbalance between oxidants and antioxidants. Studies have shown that olive leaves have an antioxidant effect on free radicals. This study was to evaluate the possible effect of olive leaf extract on carbon tetrachloride (CCL4)-induced liver damage (molecular and tissue) and changes of enzymes in chickens. Materials and Methods: A total of 50 chickens were used and classified into5 groups. Treatment groups received 0.5, 1, and 1.5 mg/kg of the olive leaf extract from day 21 of the experiment. Two control groupshealthy and poisoneddid not receive any extract. On the day 35 of the experiment, 1cc of CCL4 was dissolved with olive oil and injected intraperitoneally into the experimental and poisoned control groups. Blood and liver tissue sampling were performed. Results: The histopathology results showed that at high doses of olive leaf extract, the cells and vessels were regularly curable, and sinusoids were healthy. The expression of B-cell lymphoma 2 (BCL2) increased, and that of BH3 interacting domain death agonist (BID)decreased. Enzymatic tests, including serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, alkaline phosphatase, gamma-glutamyl transpeptidase, showed a reduction in BID expression in the experimental group compared with the control group(P<0.005). Conclusion: We concluded that olive leaf extract boosts the BCL2—an antiapoptotic gene—and reduces BID—an apoptosis gene—in the liver of chicken. It prevents the liver cells from disintegrating and destroys sinusoids and liver blood vessels. The high doses of the olive leaf extract caused liver resistance to CCL4 toxicity in chicken. [GMJ.2019;8:e1204]

scholarly journals The Hepatoprotective Effect of Olive Leaf Extract on Diabetic Pregnant Mice and Their Fetuses

2017 ◽  
Vol 8 (2) ◽  
pp. 70
Author(s):  
Sultan Ahmad ◽  
Shah Dawran ◽  
Islam Uddin ◽  
Sajid Ali ◽  
Hazrat Bilal ◽  
...  
Keyword(s):  
Oral Dose ◽  
Leaf Extract ◽  
Diabetic Group ◽  
Hepatoprotective Effect ◽  
Control Group ◽  
Olive Leaf ◽  
Daily Oral Dose ◽  
Olive Leaf Extract ◽  
Pregnant Mice ◽  
Liver Tissues

Gestational diabetes mellitus (GDM) is a disease with hyperglycemia, insulin resistance and fetal abnormality development. This study was designed to evaluate the hypoglycemic effect and hepatoprotective properties of olive leaves extract.The experimental mice divided into not diabetic group, the control group (GI), and the diabetic pregnant mice were divided into: the diabetic pregnant group (GII) single intraperitoneal injected by streptozotocine (STZ, 240mg/Kg b.wt.). The pregnant mice were given a daily oral dose of olive leaf extract (OLE) only (100 mg/kg) from day 1 to 18 of gestation group (GIII). The diabetic pregnant mice were given daily oral dose of olive leaf extract from day 1 to day 18 of gestation, group (GIV). The STZ-induced diabetic group(GII) exhibited a significant (p<0.05) hyperglycemia, accompanied with a significant increase in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), enzyme activitieswhen compared with control group. This result is confirmed with extreme histopathological changes in liver tissues and decreased in glutathione peroxidase (GPx) expression. A significant improvement in glucose level, serum AST and ALT enzyme activities showed in (GIV). Also, OLE succeeded to minimize the severe changes in liver tissues of diabetic pregnant mice and their fetuses. Furthermore, level of (GPx) was returned to near normal level. The findings suggest that OLE have a hepatoprotective effect on pregnant diabetic mice and their fetus. 

scholarly journals Gastroprotection of Calein D against Ethanol-Induced Gastric Lesions in Mice: Role of Prostaglandins, Nitric Oxide and Sulfhydryls

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 622 ◽  
Author(s):  
María Sánchez-Mendoza ◽  
Yaraset López-Lorenzo ◽  
Leticia Cruz-Antonio ◽  
Audifás-Salvador Matus-Meza ◽  
Yolanda Sánchez-Mendoza ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Methyl Ester ◽  
Oral Treatment ◽  
Control Group ◽  
Peptic Ulcers ◽  
Gastric Lesions ◽  
Gastroprotective Activity ◽  
Reference Drug ◽  
Sulfhydryl Compounds

Peptic ulcers are currently treated with various drugs, all having serious side effects. The aim of this study was to evaluate the gastroprotective activity of calein D (from Calea urticifolia), a sesquiterpene lactone with a germacrane skeleton. Gastric lesions were induced in mice by administering ethanol (0.2 mL) after oral treatment with calein D at 3, 10 and 30 mg/kg, resulting in 13.15 ± 3.44%, 77.65 ± 7.38% and 95.76 ± 2.18% gastroprotection, respectively, to be compared with that of the control group. The effect found for 30 mg/kg of calein D was not reversed by pretreatment with NG-nitro-l-arginine methyl ester (l-NAME, 70 mg/kg, ip), indomethacin (10 mg/kg, sc) or N-ethylmaleimide (NEM, 10 mg/kg, sc). Hence, the mechanism of action of calein D does not involve NO, prostaglandins or sulfhydryl compounds. Calein D was more potent than carbenoxolone, the reference drug. The findings for the latter are in agreement with previous reports.

The Hepatoprotective Effect of Olive Leaf Extract on Diabetic Pregnant Mice and Their Fetuses

2017 ◽  
Vol 8 (2) ◽  
pp. 85
Author(s):  
Hend. A. Mohammed ◽  
Mohammed. S. Aleissaa ◽  
Aziza. H. Mohamady ◽  
Mona. A. Ibrahim ◽  
Nahid M. Emam
Keyword(s):  
Oral Dose ◽  
Leaf Extract ◽  
Diabetic Group ◽  
Hepatoprotective Effect ◽  
Control Group ◽  
Olive Leaf ◽  
Daily Oral Dose ◽  
Olive Leaf Extract ◽  
Pregnant Mice ◽  
Liver Tissues

Gestational diabetes mellitus (GDM) defined as is a disease with hyperglycemia, insulin resistance and fetal abnormality development. This study was designed to evaluate the hypoglycemic effect and hepatoprotective properties of olive leaves extract.The experimental mice divided into, the control group GI (not diabetic group), and the diabetic pregnant mice groups were divided into: the diabetic pregnant group (GII) single intraperitoneal injected by streptozotocine (STZ, 240mg/Kg b.wt.). The pregnant mice were given a daily oral dose of olive leaf extract (OLE) only (100 mg/kg) from day 1 to 18 of gestation group (GIII). The diabetic pregnant mice were given daily oral dose of olive leaf extract from day 1 to day 18 of gestation, group (GIV). The STZ-induced diabetic group(GII) exhibited a significant (p<0.05) hyperglycemia, accompanied with a significant increase in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), enzyme activitieswhen compared with control group. This result is confirmed with extreme histopathological changes in liver tissues and decreased in glutathione peroxidase (GPx) expression. A significant improvement in glucose level, serum AST and ALT enzyme activities showed in (GIV). Also, OLE succeeded to minimize the severe changes in liver tissues of diabetic pregnant mice and their fetuses. Furthermore, level of (GPx) was returned to near normal level. The findings suggest that OLE have a hepatoprotective effect on pregnant diabetic mice and their fetus.

scholarly journals Evaluation of the Protective Effect of Olive Leaf Extract on Cisplatin-Induced Testicular Damage in Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Rafa S. Almeer ◽  
Ahmed E. Abdel Moneim
Keyword(s):  
Leaf Extract ◽  
Serum Testosterone ◽  
Control Group ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Testicular Damage ◽  
Olive Leaf ◽  
Beneficial Effects ◽  
Olive Leaf Extract ◽  
Nitrite Nitrate

In the present investigation, the effect of olive leaf extract (OLE) on testicular damage induced in rats by an intraperitoneal injection of cisplatin (cis-diamminedichloroplatinum (CDDP)) at a dose of 5 mg/kg was tested. Rats were randomly divided into 4 groups: control, CDDP, OLE, and OLE + CDDP. After 5 days of CDDP treatment, body and testicular weights, histopathological alteration, and serum male sex hormone levels were determined. In addition to the biochemical and immunohistochemical changes in the testes, CDDP caused the disorganization of germinal epithelium and apoptosis by inducing Bax and inhibiting Bcl-2 protein expression. Testicular weights, catalase, serum testosterone, testicular enzymatic (including glutathione peroxidase, glutathione reductase, and superoxide dismutase) along with nonenzymatic (glutathione) antioxidants, and levels of luteinizing and follicle-stimulating hormones were significantly reduced in addition to a significant increase in testicular malondialdehyde and nitrite/nitrate levels when compared with the control group. OLE treatment markedly attenuated both biochemical and histopathological changes. The reproductive beneficial effects of OLE were mediated, at least partly, by inducing the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway.

scholarly journals Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Toshio Mikami ◽  
Jimmy Kim ◽  
Jonghyuk Park ◽  
Hyowon Lee ◽  
Pongson Yaicharoen ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Exercise Capacity ◽  
Endurance Exercise ◽  
Leaf Extract ◽  
Metabolic Diseases ◽  
Olive Leaf ◽  
Olive Leaf Extract ◽  
Hypoxic Conditions ◽  
G Protein Coupled ◽  
Antioxidant Effects

AbstractObesity is a risk factor for development of metabolic diseases and cognitive decline; therefore, obesity prevention is of paramount importance. Neuronal mitochondrial dysfunction induced by oxidative stress is an important mechanism underlying cognitive decline. Olive leaf extract contains large amounts of oleanolic acid, a transmembrane G protein-coupled receptor 5 (TGR5) agonist, and oleuropein, an antioxidant. Activation of TGR5 results in enhanced mitochondrial biogenesis, which suggests that olive leaf extract may help prevent cognitive decline through its mitochondrial and antioxidant effects. Therefore, we investigated olive leaf extract’s effects on obesity, cognitive decline, depression, and endurance exercise capacity in a mouse model. In physically inactive mice fed a high-fat diet, olive leaf extract administration suppressed increases in fat mass and body weight and prevented cognitive declines, specifically decreased working memory and depressive behaviors. Additionally, olive leaf extract increased endurance exercise capacity under atmospheric and hypoxic conditions. Our study suggests that these promising effects may be related to oleanolic acid’s improvement of mitochondrial function and oleuropein’s increase of antioxidant capacity.

scholarly journals Olive leaf extract impairs mitochondria by pro-oxidant activity in MDA-MB-231 and OVCAR-3 cancer cells

2021 ◽  
Vol 134 ◽  
pp. 111139
Author(s):  
Reyes Benot-Dominguez ◽  
Maria Grazia Tupone ◽  
Vanessa Castelli ◽  
Michele d’Angelo ◽  
Elisabetta Benedetti ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Leaf Extract ◽  
Olive Leaf ◽  
Olive Leaf Extract
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