scholarly journals Ni(II), Pd(II) and Pt(II) complexes with ligand containing thiosemicarbazone and semicarbazone moiety: Synthesis, characterization and biological investigation

2008 ◽  
Vol 73 (7) ◽  
pp. 727-734 ◽  
Author(s):  
Sulekh Chandra ◽  
Monika Tyagi
Keyword(s):  
Chelating Agents ◽  
Fungal Species ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Biological Investigation ◽  
Square Planar ◽  
New Compounds

The synthesis of nickel(II), palladium(II) and platinum(II) complexes with thiosemicarbazone and semicarbazone of p-tolualdehyde are reported. All the new compounds were characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements, mass, 1H-NMR, IR and electronic spectral studies. Based on the molar conductance measurements in DMSO, the complexes may be formulated as [Ni(L)2Cl2] and [M(L)2]Cl2 (where M = Pd(II) and Pt(II)) due to their non-electrolytic and 1:2 electrolytic nature, respectively. The spectral data are consistent with an octahedral geometry around Ni(II) and a square planar geometry for Pd(II) and Pt(II), in which the ligands act as bidentate chelating agents, coordinated through the nitrogen and sulphur/oxygen atoms. The ligands and their metal complexes were screened in vitro against fungal species Alternaria alternata, Aspergillus niger and Fusarium odum, using the food poison technique. .

scholarly journals Synthesis, characterization and antimicrobial Studies of complexes of some metal ions with 5(2-hydroxy benzylidine) -2-thio ether -1, 3, 4-thiadiazole

2010 ◽  
Vol 7 (1) ◽  
pp. 585-592
Author(s):  
Baghdad Science Journal
Keyword(s):  
Iron Complex ◽  
Octahedral Geometry ◽  
Planar Geometry ◽  
In Vitro Tests ◽  
Conductivity Measurements ◽  
Antimicrobial Studies ◽  
Square Planar ◽  
Escherchia Coli ◽  
Complex Display

A new series of Fe (III) , Co (II) , Ni (II) and Cu (II) complexes of the Schiff base, 5 (2-hydroxy benzylidine) -2-thio ether -1, 3, 4-thiadiazole were prepared and characterized .The imine behaves as a bidentate. The nature of bonding and the stereochemistry of the complexes were deduced from metal analyses, infrared, electronic spectra,magnetic susceptibility and conductivity measurements, an octahedral geometry was suggested for all complexes except the copper complex has a square planar geometry .preliminary in vitro tests for antimicrobial activity show that all the prepared compounds except iron complex display good activity to gram positive Staphelococcus aures and gram negative Escherchia coli.

scholarly journals Synthesis, Characterization, and Biological Activity of Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) Complexes of N-Thiophenoyl-N′-Phenylthiocarbohydrazide

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
M. Yadav ◽  
Debasis Behera
Keyword(s):  
Magnetic Susceptibility ◽  
Biological Activity ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Tetradentate Ligand ◽  
Tetrahedral Geometry ◽  
Square Planar ◽  
Infrared Spectral ◽  
Bacteria And Fungi

Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) complex of N-thiophenoyl -N′-phenylthiocarbohydrazide (H2TPTH) have been synthesized and characterized by elemental analysis, magnetic susceptibility measurements, infrared, NMR, electronic, and ESR spectral studies. The complexes were found to have compositions [Mn(H TPTH)2], [Co(TPTH) (H2O)2], [Ni(TPTH) (H2O)2], [Cu(TPTH)], [Zn(H TPTH)], [Cd(H TPTH)2], and [Fe(H TPTH)2(EtOH)]. The magnetic and electronic spectral studies suggest square planar geometry for [Cu(TPTH)], tetrahedral geometry for [Zn(TPTH)] and [Cd(H TPTH)2], and octahedral geometry for rest of the complexes. The infrared spectral studies of the 1 : 1 deprotonated complexes suggest bonding through enolic oxygen, thiolato sulfur, and both the hydrazinic nitrogens. Thus, H2TPTH acts as a binegative tetradentate ligand. H2TPTH and its metal complexes have been screened against several bacteria and fungi.

scholarly journals Spectroscopic and Biological Studies on Newly Synthesized Cobalt (II) and Nickel (II) Complexes with 2-Acetyl Coumarone Semicarbazone and 2-Acetyl Coumarone Thiosemicarbazone

2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
Sanjay Goel ◽  
Sulekh Chandra ◽  
Sudhanshu Dhar Dwivedi
Keyword(s):  
Magnetic Susceptibility ◽  
Metal Complexes ◽  
Antioxidant Activities ◽  
Molar Conductance ◽  
Metal Salts ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Square Planar ◽  
Biological Studies ◽  
Infrared Spectral

Co(II) and Ni(II) complexes of general composition ML2X2(M = Co(II), Ni(II); X = Cl−,NO3 −) were synthesized by the condensation of metal salts with semicarbazone/thiosemicarbazone derived from 2-acetyl coumarone. The ligands and metal complexes were characterized by NMR, elemental analysis, molar conductance, magnetic susceptibility measurements, IR, and atomic absorption spectral studies. On the basis of electronic, molar conductance and infrared spectral studies, the complexes were found to have square planar geometry. The Schiff bases and their metal complexes were tested for their antibacterial and antioxidant activities.

scholarly journals Spectral, NLO, Fluorescence, and Biological Activity of Knoevenagel Condensate of β-Diketone Ligands and Their Metal(II) Complexes

2011 ◽  
Vol 2011 ◽  
pp. 1-8
Author(s):  
S. Sumathi ◽  
C. Anitha ◽  
P. Tharmaraj ◽  
C. D. Sheela
Keyword(s):  
Metal Complexes ◽  
Second Harmonic ◽  
Biological Activities ◽  
Analytical Data ◽  
Structural Features ◽  
Considerable Effect ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Planar Geometry

Transition metal complexes of various acetylacetone-based ligands of the type ML (where M=  Cu(II), Ni(II), Co(II); L=  3-(aryl)-pentane-2,4-dione) have been synthesized. The structural features have been derived from their elemental analysis, magnetic susceptibility, molar conductance, IR, UV-Vis, H1NMR, mass and ESR spectral studies. Conductivity measurements reveal that all the complexes are nonelectrolytic in nature. Spectroscopic and other analytical data of the complexes suggest square planar geometry for copper(II), cobalt(II), and nickel(II) complexes of 3-(3-phenylallylidene)pentane-2,4-dione and octahedral geometry for other metal(II) complexes. The redox behaviors of the copper(II) complexes have been studied by cyclic voltammetry. The free ligands and their metal complexes have been screened for their in vitro biological activities against bacteria and fungus. The metal(II) complexes are found to possess increased activities compared to those of the free ligands. All synthesized compounds may serve as potential photoactive materials as indicated from their characteristic fluorescence properties. The second harmonic generation (SHG) efficiency of the ligands was found to have considerable effect compared to that of urea and KDP.

scholarly journals Spectroscopic and biological approach in the characterization of Cr(III), Mn(II) and Co(II) complexes with a novel hexaazamacrocyclic ligand derived from semicarbazide

2009 ◽  
Vol 74 (12) ◽  
pp. 1413-1422 ◽  
Author(s):  
Sulekh Chandra ◽  
Archana Gautam
Keyword(s):  
Antimicrobial Agents ◽  
Macrocyclic Ligand ◽  
Free Ligand ◽  
Pathogenic Fungi ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Plant Pathogenic Fungi

Complexes of Cr(III), Mn(II) and Co(II) with a novel 5,7,12,14-tetraphenyl- 1,2,4,8,10,11-hexaazacyclotetradecane-3,9-dione macrocyclic ligand, THTD (L), were synthesized and characterized by elemental analysis, molar conductance and magnetic susceptibility measurements, as well as by mass, 1H-NMR, IR, electronic and EPR spectral studies. Based on the spectral studies, an octahedral geometry was assigned for the Cr(III), Mn(II) and Co(II) complexes. The ligand and its complexes were screened in vitro against some species of bacteria and plant pathogenic fungi. The metal complexes were found to be more active antimicrobial agents than the free ligand from which they were derived.

scholarly journals SYNTHESIS, SPECTROSCOPIC, IN-VITRO ANTIBACTERIAL ACTIVITIES OF A 4-NITROPHENOL LIGAND AND ITS METAL (II) COMPLEXES

2020 ◽  
Vol 3 (2) ◽  
pp. 249-256
Author(s):  
Olubunmi Adewusi ◽  
Keyword(s):  
Magnetic Susceptibility ◽  
Antimicrobial Agents ◽  
Magnetic Moments ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Planar Geometry ◽  
Antimicrobial Studies ◽  
Square Planar

Novel Schiff base 2-((E)-(1H-indol-5-ylimino)methyl)-4-nitrophenol ligand and its Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Pd(II) complexes were synthesized by the stoichiometric reactions between the metal (II) ions and ligand in molar ratio M:L (1:1). The synthesized compounds were characterized using melting point, solubility, molar conductance, room temperature magnetic susceptibility, infra-red and electronic spectroscopies. The assignments of four-coordinate tetrahedral/square planar geometries and the bidentate nature to the complexes was corroborated by IR, electronic spectroscopies, and magnetic moments. The Pd(II) complex however was assigned an octahedral geometry. The in-vitro antimicrobial studies revealed the potential of some of the compounds as antimicrobial agents. The ligand and its metal complexes exhibited good to moderate antimicrobial activity against tested bacteria with selective inactivity against P. mirabilis and P. aureginosa. Keywords: 2-((E)-(1H-indol-5-ylimino)methyl)-4-nitrophenol, magnetic susceptibility, square planar geometry, inhibitory zone.

scholarly journals Novel (N4) Macrocyclic Metal Complexes: Synthesis, Characterization, Spectral Studies and Anticancer Activity

2018 ◽  
Vol 5 (1) ◽  
pp. 51-63 ◽  
Author(s):  
Hanaa A. El-Boraey ◽  
Ohyla A. EL-Gammal
Keyword(s):  
Condensation Reaction ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Human Breast ◽  
Nitrogen Ligand ◽  
Pyramidal Geometry ◽  
Square Planar ◽  
Square Pyramidal Geometry ◽  
Mcf 7

Introduction:A new series of mononuclear Fe(II), Co(II), Ni(II), Cu(II) and Pd(II) complexes correspond to tetradentate macrocyclic nitrogen ligandi.e.naphthyl-3,4:10,11-dibenzo,7-methylene,8-methyl,6-phenyl-1,5,9,13-tetraazacyclohexadecane-5,8-diene-2,12-dione metal(II) complexes, have been synthesized by the template condensation reaction.Methods:The complexes have been characterized by elemental analysis, spectral (IR, UV–Vis, and ESR, molar conductivity, and magnetic as well as thermal analysis measurements.Results:On the basis of above studies, an octahedral geometry has been proposed for all complexes except Cu(II) nitrate complex that adopt square pyramidal geometry, and square planar geometry for Pd(II) chloride complex, respectively.Conclusion:The thermal behavior and the kinetic parameters of degradation were determined using Coats-Redfern and Horowitz-Metzger methods. Moreover, thein vitroantitumor activity of the some synthesized complexes against human breast and human hepatocarcinoma cell lines (MCF-7) and (HePG2), respectively has been studied.

scholarly journals Antifungal and Spectral Studies of Cr(III) and Mn(II) Complexes Derived from 3,3′-Thiodipropionic Acid Derivative

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Sulekh Chandra ◽  
Amit Kumar Sharma
Keyword(s):  
Magnetic Susceptibility ◽  
Acid Derivative ◽  
Elemental Analysis ◽  
Fungicidal Activity ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Bonding Parameters ◽  
Metal Ligand

The Cr(III) and Mn(II) complexes with a ligand derived from 3,3′-thiodipropionic acid have been synthesized and characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements, IR, UV, and EPR spectral studies. The complexes are found to have [Cr(L)X]X2 and [Mn(L)X]X, compositions, where L = quinquedentate ligand and X=NO3−, Cl− and OAc−. The complexes possess the six coordinated octahedral geometry with monomeric compositions. The evaluated bonding parameters, Aiso and β, account for the covalent type metal-ligand bonding. The fungicidal activity of the compounds was evaluated in vitro by employing Food Poison Technique.

Synthesis, Spectral and Antimicrobial Investigation of 2-(Naphthalenel-ylamino)-2- Phenylacetonitrile and 1, 10-Phenanthroline with Five Divalent Transition Metal Ions

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Mohammed Al-Amery1 ◽  
Ashraf Saad Rasheed ◽  
Dina A. Najeeb
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Transition Metal Ions ◽  
Molar Conductance ◽  
Octahedral Geometry ◽  
Mixed Ligand ◽  
Gram Negative Bacteria ◽  
Magnetic Studies ◽  
Gram Positive Bacteria

Five new mixed ligand metal complexes have been synthesized by the reaction of divalent transition metal ions (Hg, Ni, Zn, Cu and Cd) with 2-(naphthalen-l-ylamino)-2-phenylacetonitrile (L1 ) and 1,10-phenanthroline (L2). The coordination likelihood of the two ligands toward metal ions has been suggested in the light of elemental analysis, UV-Vis spectra, FTIR, 1H-NMR, flam atomic absorption, molar conductance and magnetic studies. Results data suggest that the octahedral geometry for all the prepared complexes. Antibacterial examination of synthesized complexes in vitro was performed against four bacterias. Firstly, Gram-negative bacteria namely, Pseudomonas aerugin and Escherichia. Secondly, Gram-positive bacteria namely, Bacillus subtilis, Staphylococcuaurouss. Results data exhibit that the synthesized complexes exhibited more biological activity than tetracycline pharmaceutical.

New Platinum (II) Ternary Complexes of Formamidine and Pyrophosphate: Synthesis, Characterization and DFT Calculations and In vitro Cytotoxicity

2020 ◽  
Vol 23 (7) ◽  
pp. 611-623
Author(s):  
Ahmed A. Soliman ◽  
Fawzy A. Attaby ◽  
Othman I. Alajrawy ◽  
Azza A.A. Abou-hussein ◽  
Wolfgang Linert
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Theoretical Calculations ◽  
Thermal Analyses ◽  
Cancer Cell Line ◽  
Cellular Growth ◽  
Planar Geometry ◽  
Square Planar ◽  
Vis Spectroscopy

Aim and Objective: Platinum (II) and platinum (IV) of pyrophosphate complexes have been prepared and characterized to discover their potential as antitumor drugs. This study was conducted to prepare and characterize new ternary platinum (II) complexes with formamidine and pyrophosphate as an antitumor candidate. Materials and Methods: The complexes have been characterized by mass, infrared, UV-Vis. spectroscopy, elemental analysis, magnetic susceptibility, thermal analyses, and theoretical calculations. They have been tested for their cytotoxicity, which was carried out using the fastcolorimetric assay for cellular growth and survival against MCF-7 (breast cancer cell line), HCT- 116 (colon carcinoma cell line), and HepG-2 (hepatocellular cancer cell line). Results: All complexes are diamagnetic, and the electronic spectral data displayed the bands due to square planar Pt(II) complexes. The optimized complexes structures (1-4) indicated a distorted square planar geometry where O-Pt-O and N-Pt-N bond angles were 82.04°-96.44°, respectively. Conclusion: The complexes showed noticeable cytotoxicity and are considered as promising antitumor candidates for further applications.

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