scholarly journals Kinetic spectrophotometric determination of Co(II) ion by the oxidation of ponceau 4R by hydrogen peroxide

2006 ◽  
Vol 71 (2) ◽  
pp. 189-196 ◽  
Author(s):  
Zora Grahovac ◽  
Snezana Mitic ◽  
Emilija Pecev ◽  
Snezana Tosic
Keyword(s):  
Hydrogen Peroxide ◽  
Kinetic Method ◽  
Calibration Graph ◽  
Borate Buffer ◽  
Linear Calibration ◽  
Reaction Conditions ◽  
Ponceau 4R ◽  
Optimum Reaction ◽  
Kinetic Spectrophotometric

Anew, sensitive and simple kinetic method has been developed for the determination of traces of Co(II) ions based on their catalytic effect in the oxidation of trisodium-2-hydroxy-1-(4-sulphonato-1-naphthylazo)naphthalene-6,8-disulphonate (red artificial color Ponceau 4R) by hydrogen peroxide in borate buffer. The reaction was followed spectrophotometrically by tracing the oxidation product at 478.4 nm within 1 min after the initiation of the reaction. The optimum reaction conditions are: borate buffer (pH 10.50), Ponceau 4R (8 x10-6 mol/dm3), H2O2 (3 x10-2 mol/dm3) at 22 ?C. Following this procedure, Co(II) can be determined with a linear calibration graph up to 1.17 ng/cm3 and a detection limit of 0.20, based on the 3??criterion. The relative error ranges between 4.80-3.25 % for the concentration interval of Co(II) ions 1.76-17.61 ng/cm3. The effects of certain foreign ions on the reaction rate were determined for an assessment of the selectivity of the method. The method was applied for the determination of Co(II) in pharmaceutical samples.

scholarly journals SPECTROFLUORIMETRIC DETERMINATION OF EOSIN CHEMILUMINESCENCE SYSTEM FOR THE ANALYSIS OF DABIGATRAN IN PHARMACEUTICAL FORMULATIONS

2019 ◽  
pp. 104-108
Author(s):  
DHANAPAL Y ◽  
SRUDHIVINOD V ◽  
MOHAMAD WASEEM A
Keyword(s):  
Method Development ◽  
Pharmaceutical Formulations ◽  
Calibration Graph ◽  
Eosin Y ◽  
Linear Calibration ◽  
Reaction Conditions ◽  
Quenching Effect ◽  
Spectrofluorimetric Determination ◽  
Optimum Reaction

Objectives: The objectives of this study were to develop a rapid, simple, and economical spectrofluorometric method for quantification of dabigatran from marketed formulation and its principle involved based on the protonated process of a binary mixture complex formation with eosin Y. Methods: A simple and precise spectrofluorometric technique was applied for the method development. It depends on measuring the quenching effect of the drug on the native fluorescence of eosin at excitation under the optimum reaction conditions. Results: The reaction linear calibration graph constructed between the fluorescence quenching valves flouresence intensity (ΔF) and the concentration ranges of 5–50 μg/ml. Spectrofluorometric analytical performance was validated by accuracy, precision, and specificity, and the results were satisfactory. Conclusion: This method was to develop a fast, simple, and economically applied successfully for the assay, and qualification of dabigatran tablet contains drug, also with different coformulated pharmaceutical formulations.

Study of the Catalytic Effects of Trace Titanium on Oxidation of Pyronin B with Hydrogen Peroxide and its Application

2012 ◽  
Vol 602-604 ◽  
pp. 1233-1237
Author(s):  
Zhi Rong Zhou ◽  
Li Zhen Zhang
Keyword(s):  
Hydrogen Peroxide ◽  
Reaction Medium ◽  
Reaction Conditions ◽  
Relative Standard ◽  
Extraction Separation ◽  
Optimum Reaction ◽  
Kinetic Spectrophotometric ◽  
Replicate Measurements ◽  
Catalytic Effects

A simple and sensitive kinetic spectrophotometric method for the determination of trace amounts titanium (IV), based on the catalytic effect of Ti (IV) on the oxidation pyronin B with hydrogen peroxide in 0.02 mol/L sulfuric acid, is described. The reaction rate is monitored spectrophotometrically by measuring the decrease in absorbance of pyronin B at 555 nm. The detection limit of the method is 0.017 μg/L, and the linear range is 0.055–1.0 µg/L. The influences of reaction medium and acidity, concentrations of reactants, reactive temperature and foreign ions is also discussed. The optimum reaction conditions were established. The relative standard deviation for 11 replicate measurements of 0.010 and 0.020 μg/25mL of titanium (IV) were 2.8 % and 2.3 %, respectively. In combination with solvent extraction separation, the method has been successfully applied to the determination of trace titanium (IV) in rock samples. The results are in good agreement with the certified volumes with the relative standard deviations (RSD) of 1.6 %–3.6 %.

A novel kinetic-spectrophotometric method for determination of nitrites in water

2009 ◽  
Vol 63 (4) ◽  
Author(s):  
Zenovia Moldovan
Keyword(s):  
Kinetic Method ◽  
Calibration Graph ◽  
Linear Calibration ◽  
Nitrite Concentration ◽  
Experimental Conditions ◽  
Sulfuric Acid Medium ◽  
Relative Standard ◽  
Kinetic Spectrophotometric ◽  
Drinking Water Samples

AbstractA simple, selective and sensitive kinetic method for the determination of nitrite in water was developed. The method is based on the catalytic effect of nitrite on the oxidation of methylene blue (MB) with bromate in a sulfuric acid medium. During the oxidation process, absorbance of the reaction mixture decreases with the increasing time, inversely proportional to the nitrite concentration. The reaction rate was monitored spectrophotometrically at λ = 666 nm within 30 s of mixing. Linear calibration graph was obtained in the range of 0.005–0.5 μg mL−1 with a relative standard deviation of 2.09 % for six measurements at 0.5 μg mL−1. The detection limit was found to be 0.0015 μg mL−1. The effect of different factors such as acidity, time, bromate concentration, MB concentration, ionic strength, and order of reactants additions is reported. Interference of the most common foreign ions was also investigated. The optimum experimental conditions were: 0.38 mol L−1 H2SO4, 5 × 10.4 mol L−1 KBrO3, 1.25 × 10.5 mol L−1 MB, 0.3 mol L−1 sodium nitrate, and 25°C. The proposed method was conveniently applied for the determination of nitrite in spiked drinking water samples.

scholarly journals Kinetic spectrophotometric determination of Bi(III) based on its catalytic effect on the oxidation of phenylfluorone by hydrogen peroxide

2009 ◽  
Vol 74 (8-9) ◽  
pp. 977-984
Author(s):  
Sofija Rancic ◽  
Snezana Nikolic-Mandic
Keyword(s):  
Hydrogen Peroxide ◽  
Spectrophotometric Determination ◽  
Reaction Rate ◽  
Catalytic Effect ◽  
Limit Of Detection ◽  
Kinetic Method ◽  
Limit Of Quantification ◽  
Kinetic Spectrophotometric ◽  
Good Agreement

A new reaction was suggested and a new kinetic method was elaborated for determination of Bi(III) in solution, based on its catalytic effect on the oxidation of phenyl-fluorone (PF) by hydrogen peroxide in ammonia buffer. By application of spectrophotometric technique, a limit of quantification (LQ) of 128 ng cm-3 was reached, and the limit of detection (LD) of 37 ng cm-3 was obtained, where LQ was defined as the ratio signal: noise = 10:1 and LD was defined as signal 3:1 against the blank. The RSD value was found to be in the range 2.8-4.8 % for the investigated concentration range of Bi(III). The influence of some ions upon the reaction rate was tested. The method was confirmed by determining Bi(III) in a stomach ulcer drug ('Bicit HP', Hemofarm A.D.). The obtained results were compared to those obtained by AAS and good agreement of results was obtained.

scholarly journals Kinetic Spectrophotometric Method for the Determination of Ranitidine and Nizatidine in Pharmaceuticals

2002 ◽  
Vol 85 (6) ◽  
pp. 1316-1323 ◽  
Author(s):  
Mohamed I Walash ◽  
Fathalla Belal ◽  
Fawzia Ibrahim ◽  
Mohamed Hefnawy ◽  
Manal Eid
Keyword(s):  
Spectrophotometric Method ◽  
Reaction Pathway ◽  
Kinetic Method ◽  
Fixed Time ◽  
Borate Buffer ◽  
The Other ◽  
Average Recovery ◽  
Kinetic Spectrophotometric ◽  
Good Agreement

Abstract An accurate and simple kinetic method is described for the determination of ranitidine and nizatidine in pure form and in pharmaceuticals. The method is based on the reaction of the compounds with 7-chloro-4-nitrobenz-2-oxa-1,3-diazole in pH 7.4 borate buffer at 60°C for a fixed time of 25 min for both compounds. The absorbance of the reaction product is measured at 495 nm for ranitidine and nizatidine. Calibration graphs were linear over the concentration range of 2–20 μg/mL, with limits of detection of 0.13 (3.7 × 10−7M) and 0.25 μg/mL (7.5 × 10−7M) for ranitidine and nizatidine, respectively. The proposed method was applied successfully to the determination of ranitidine in tablets and ampoules with average recoveries of 100.26 ± 0.69 and 100.29 ± 0.59%, respectively, and to the determination of nizatidine in capsules with an average recovery of 104.26 ± 0.44%. The results obtained are in good agreement with those obtained by the other methods used for comparison. A proposal of the reaction pathway is also presented.

Sensitive and simple detection of trace hydrogen peroxide based on a resonance light scattering assay

2015 ◽  
Vol 7 (20) ◽  
pp. 8750-8756 ◽  
Author(s):  
Ningli Tang ◽  
Yaqi Shan ◽  
Ronghui Zhang ◽  
Xinglong Meng
Keyword(s):  
Hydrogen Peroxide ◽  
Light Scattering ◽  
Resonance Light Scattering ◽  
Influential Factors ◽  
New Method ◽  
Reaction Conditions ◽  
Simple Detection ◽  
Optimum Reaction

A new method for the resonance light scattering determination of hydrogen peroxide has been developed, and the optimum reaction conditions, influential factors and applications were investigated.

Kinetic Spectrophotometric Determination of Ascorbic Acid in Pharmaceutical Samples by Oxidation of Ponceau 4R by Hydrogen Peroxide

2008 ◽  
Vol 55 (1) ◽  
pp. 137-142 ◽  
Author(s):  
Zora M. Grahovac ◽  
Snežana S. Mitić ◽  
Todor G. Pecev ◽  
Emilija T. Pecev ◽  
Aleksandra N. Pavlović
Keyword(s):  
Hydrogen Peroxide ◽  
Ascorbic Acid ◽  
Spectrophotometric Determination ◽  
Pharmaceutical Samples ◽  
Ponceau 4R ◽  
Kinetic Spectrophotometric

scholarly journals Kinetic determination of morin nanoamounts

2004 ◽  
Vol 69 (6) ◽  
pp. 477-484 ◽  
Author(s):  
Danijela Kostic ◽  
Snezana Mitic ◽  
Gordana Miletic
Keyword(s):  
Reaction Rate ◽  
Limit Of Detection ◽  
Kinetic Equations ◽  
Calibration Graph ◽  
Linear Calibration ◽  
Kinetic Determination ◽  
Concentration Interval ◽  
Kinetic Spectrophotometric ◽  
The Given

kinetic-spectrophotometric method is proposed for the determination of morin. The method is based on the inhibition effect of morin on the oxidation of C6H5COON aby hydrogen peroxide in the presence of the complex Fe(II)-AA(ascorbic acid),which acts as a catalyst. The concentration range for the determination of morin is one of the lowest achieved so far (a linear calibration graph was obtained for morin from 2.255?22.55 ng cm-3). The limit of detection of the method is 0.28 ng cm-3. The relative error ranges between 1.42 to 5.10% for the given concentration interval. Kinetic equations are proposed for the investigated process. The effects of certain foreign ions upon the reaction rate were determined in order to assess the selectivity of the method. The major advantages of this kinetic-spectrophotometric assay are its sensitivity, selectivity, reproducibility, speed and simplicity.

scholarly journals Kinetic determination of ultramicro amounts of Cu(II) ion in solution

2003 ◽  
Vol 68 (3) ◽  
pp. 219-226 ◽  
Author(s):  
Zora Grahovac ◽  
Snezana Mitic ◽  
Emilija Pecev
Keyword(s):  
Hydrogen Peroxide ◽  
Detection Limit ◽  
Reaction Rate ◽  
Catalytic Effect ◽  
Kinetic Method ◽  
Kinetic Equations ◽  
Kinetic Determination ◽  
Concentration Interval ◽  
Ponceau 4R

A new kinetic method is described for the determination of ultramicro amounts of Cu(II) based on its catalytic effect on the oxidation of trisodium-2-hydroxy 1-(4-sulphonato-1-naphthylazo)naphthalene-6,8-disulphonato (red artificial color PONCEAU 4R) by hydrogen peroxide in borate buffer (B.B). The detection limit given by Perez-Bendito is 0.8 ng/cm3, but the detection limit that we experimentaly determined is 3.8 ng/cm3. The relative error ranges between 7.77 and 2.09%for the concentration interval 3.8 to 50.1 ng/cm3. Kinetic equations are proposed for the investigated process. The effects of certain foreign ions upon the reaction rate were determined for an assessment of the selectivity of the method. The method was applied for the determination of Cu(II) ions in samples of alloy.

scholarly journals Determination of lisinopril in pharmaceuticals by a kinetic spectrophotometric method

2012 ◽  
Vol 77 (10) ◽  
pp. 1437-1442 ◽  
Author(s):  
Mira Cakar ◽  
Gordana Popovic
Keyword(s):  
Hydrogen Peroxide ◽  
Spectrophotometric Method ◽  
Nile Blue ◽  
Borate Buffer ◽  
Nile Blue A ◽  
Tangent Method ◽  
Kinetic Spectrophotometric ◽  
Detection And Quantification

A kinetic spectrophotometric method for determination of lisinopril in pharmaceuticals has been developed. The method is based on activator action of lisinopril on Cu(II) ions catalysing the oxidation of nile blue A with hydrogen peroxide in borate buffer (pH 9.3). A decrease of the absorbance was recorded at 635 nm for 5 min at 25?C. The linearity was established applying the tangent method within the concentration range of lisinopril from 0.8-6.4 ?g mL-1, the detection and quantification limits being 0.158 ?g mL-1 and 0.480 ?g mL-1, respectively. The method has been successfully applied in three brands of tablets containing lisinopril alone or in combination with hydrochlorothiazide.

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