scholarly journals Bimetallic Cd(II) and Hg(II) complexes of 1, 4-bis-(5-H/methyl/chloro-1H-benzimidazol- 2-yl)-1, 2, 3, 4-butanetetraols

2005 ◽  
Vol 70 (8-9) ◽  
pp. 1067-1073 ◽  
Author(s):  
Aydin Tavman
Keyword(s):  
Nmr Spectroscopy ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Metal Ion ◽  
1H Nmr Spectroscopy ◽  
Imidazole Ring ◽  
Molar Conductivity ◽  
Hydroxyl Groups ◽  
Hydroxyl Oxygen ◽  
Oxygen Atoms

The bimetallic complexes of 1,4-bis-(5-H/methyl/chloro-1H-benzimidazol 2-yl)-1,2,3,4-butanetetraols (L1?L3) with CdCl2 and HgCl2 were synthesized and characterized by elemental analysis, molar conductivity, as well as IR and 1H-NMR spectroscopy. The ligands coordinate to the metal ion through all of the hydroxyl oxygen atoms as tetradentate in the Hg(II) complexes of L1?L3 and in the Cd(II) complexes of L2 and L3. In theCd2(L1)Cl4 complex, the ligand acts as tetradentate through the benzimidazole nitrogen atoms and the two oxygen atoms of the hydroxyl groups near the imidazole ring.

SYNTHESIS AND PROPERTIES OF INTERACTION PRODUCTS OF TRIS[TRI(BUTOXY)TITANATE]BORON AND ALIPHATIC FLUORINATED ALCOHOLS

2018 ◽  
Vol 59 (1) ◽  
pp. 75 ◽  
Author(s):  
N.Ya. Kuzmenko ◽  
S.N. Kuzmenko ◽  
O.V. Skrinnik ◽  
V.V. Bugrym
Keyword(s):  
Nmr Spectroscopy ◽  
Molecular Mass ◽  
1H Nmr ◽  
Elemental Analysis ◽  
1H Nmr Spectroscopy ◽  
Alkoxy Group ◽  
Partial Substitution ◽  
Fluorinated Alcohols ◽  
Analysis Determination

Synthesis and properties of products based on tris[[tri(butoxy)titanate]boron with complete or partial substitution of butoxy groups linked with titanium by fluorinated alkoxy group were described. Extracted products were liquid or solid substances which are high soluble in aliphatic-, aromatic- chloraromatic- and chlorinated hydrocarbons, low alcohols, and ketone. Their structure was confirmed by elemental analysis, determination of molecular mass, IR and 1H NMR spectroscopy.

SYNTHESIS AND EVALUATION OF SOME NEWER QUINAZOLINONYL SUBSTITUTED BENZOXAZEPINYL / BENZOTHIAZEPINYL INDOLES AS POTENT ANTICONVULSANT AGENTS

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (03) ◽  
pp. 18-24
Author(s):  
Archana ◽  
Keyword(s):  
Nmr Spectroscopy ◽  
Acute Toxicity ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Anticonvulsant Activity ◽  
1H Nmr Spectroscopy ◽  
Standard Drug ◽  
Anticonvulsant Agents ◽  
Phenytoin Sodium

new series of 3-[3-amino-2-methyl-6-substituted quinazolin-4(3H)-onyl chalconyl)-2-substituted indoles (3-8), 3-[3-Amino-2-methyl-6- substituted quinazolin-4(3H) -onyl-benzoxazepin/benzo -thiazepin- 2-yl] -2-substituted indoles (9-20) and 3-[3-amino-2-methyl-6-substituted quinazolin-4(3H) -onyl-3- (sub-stituted phenylaminomethylene) -benzoxazepin/benzothizepin-2-yl] -2-substitutedindoles (21-44) were synthesised and evaluated for anticonvulsant activity. All these compounds were screened in vivo, for their anticonvulsant activity and acute toxicity. Coumpund 44 , 3-[3-amino-2-methyl-6-bromoquinazolin- 4(3H)-onyl-3- (chlorophenylaminomethylene)-benzothiazepine-2-yl]-2-chloroindole, was found to be most potent compound of this series , more potent than standard drug phenytoin sodium. The homogeneity of all the compounds have been established by elemental analysis, IR and 1H-NMR spectroscopy.

scholarly journals 4,4′-Di-tert-butyl-2,2′-bipyridinium Trifluoromethanesulfonate

Molbank ◽  
10.3390/m1261 ◽  
2021 ◽  
Vol 2021 (3) ◽  
pp. M1261
Author(s):  
Shintaro Kodama ◽  
Kazuki Bunno ◽  
Akihiro Nomoto ◽  
Akiya Ogawa
Keyword(s):  
Nmr Spectroscopy ◽  
1H Nmr ◽  
Diethyl Ether ◽  
Elemental Analysis ◽  
1H Nmr Spectroscopy ◽  
Trifluoromethanesulfonic Acid ◽  
Simple Method ◽  
Tert Butyl ◽  
Ft Ir ◽  
Direct Use

4,4′-di-tert-butyl-2,2′-bipyridinium trifluoromethanesulfonate was synthesized by stirring 4,4′-di-tert-butyl-2,2′-bipyridine with scandium(III) trifluoromethanesulfonate in acetonitrile, followed by precipitation with diethyl ether. The structure of the new compound was characterized by FT-IR, 1H, 13C{1H} and 19F{1H} NMR spectroscopy and CHN elemental analysis. This is a safe and simple method to obtain mono-protonated bipyridinium trifluoromethanesulfonate without the direct use of trifluoromethanesulfonic acid.

scholarly journals New ferrocense containing tiophene derivatives

2019 ◽  
Vol 487 (6) ◽  
pp. 626-629
Author(s):  
E. N. Rodlovskaya ◽  
V. A. Vasnev
Keyword(s):  
Nmr Spectroscopy ◽  
Magnetic Materials ◽  
Schiff Bases ◽  
1H Nmr ◽  
Elemental Analysis ◽  
1H Nmr Spectroscopy

A new 2-amino-4-ferrocenyl-thiophene-3-carbonitrile was synthesized by the Gevald reaction and Schiff bases, precursors for new optoelectronic and magnetic materials, were obtained on its basis. The structures of the synthesized compounds were determined by elemental analysis, IR and 1H NMR spectroscopy.

scholarly journals PRODUCTS OF INTERACTION BETWEEN 2,5-DIAMINO- 1,3,4-THIADIAZOLE AND p-AMINOBENZALDEHYDE

2018 ◽  
Vol 59 (5) ◽  
pp. 16 ◽  
Author(s):  
Marina A. Tyutina ◽  
Tatyana V. Kudayarova ◽  
Elena A. Danilova
Keyword(s):  
Mass Spectrometry ◽  
Nmr Spectroscopy ◽  
Quantum Chemistry ◽  
1H Nmr ◽  
Elemental Analysis ◽  
1H Nmr Spectroscopy ◽  
Geometrical Structure

5-Amino-2N-benzylidene-4'-amino-1,3,4-thiadiazole and 2,5 bis (N-benzylidene-4'-amino) - 1,3,4-thiadiazole was synthesized by interaction between 2,5-diamino-1,3,4-thiadiazole and p –ami-nobenzaldehyde in ethanol environment. The structure was established on data of mass spectrometry, the elemental analysis, UV-Vis, IR, 1H NMR spectroscopy. An electronic and geometrical structure of the synthesized compounds was studied by methods of quantum chemistry.

scholarly journals SYNTHESIS AND STUDY OF Zn COMPLEXES WITH N'-ACYL-SALICYLHYDRAZIDES

2019 ◽  
Vol 62 (9) ◽  
pp. 27-32
Author(s):  
Gulnar H. Gondolova
Keyword(s):  
Nmr Spectroscopy ◽  
Nitrogen Atom ◽  
13C Nmr ◽  
Metal Ion ◽  
13C Nmr Spectroscopy ◽  
Zinc Ion ◽  
Amide Group ◽  
Water Molecules ◽  
Hydroxyl Oxygen ◽  
Oxygen Atoms

Zn complexes with potentially tridentate (carbonyl and hydroxyl oxygen atoms of the salicylic fragment and nitrogen atom of the amide group) were synthesized by the ligand N'-phthalimido-salicylamide (H2L) and potentially heptadentate (carbonyl and hydroxyl oxygen atoms of the salicylic fragment, two nitrogen atoms of the hydrazide moiety and two oxygen atoms of the carbonyl and carboxyl groups of the maleic fragment) with the ligand N'-maleoal-salicylhydrazide (H4L) with 78% and 86% yield, respectively. The structural features of the N'-phthalimido-salicylamide (H2L) and N'-maleoyl-salicylhydrazide (H4L) obtained were established by IR and 1H and 13C NMR spectroscopy. In the 1H NMR spectra, signals from proton-containing groups are detected in the expected region. Also the structure of the ligands confirms 13C NMR spectroscopy. The yield of ligands is 92% and 95%, respectively. It was found that both ligands, in the conducted synthesis reactions, behave as bidentate, are in the enol form. Ligand-N- (salicylamide) -phthalimide is coordinated with zinc ion through the oxygen atoms of the phenol and nitrogen amide groups. The N’-maleoyl-salicylhydrazide ligand is coordinated with the zinc ion through the oxygen atoms of the salicylic residue and the nitrogen atom of the amide group of the maleic residue. The structures of synthesized Zn coordination compounds with H2L and H4L have been studied by IR and electronic absorption spectrometry, elemental analysis and thermogravimetry. These analyzes helped to establish that the metal ion in complex compounds is bound to two water molecules by a hydrogen bond and forms a distorted octahedral geometry. Coordination with water molecules is also confirmed by the TG curves, in which the first and second stages of weight loss are attributed to the removal of solvent molecules — coordinated water molecules and DMF.

N-Heterocyclic Carbene-facilated Condensation of 3-Methylphenylboronic Acid to the Boroxine

2013 ◽  
Vol 68 (5-6) ◽  
pp. 453-457 ◽  
Author(s):  
Dongxiang Zhang ◽  
Jie Li ◽  
Xiao Dong ◽  
Xing Zhou ◽  
Zhi Yang ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Single Crystal ◽  
1H Nmr ◽  
Elemental Analysis ◽  
1H Nmr Spectroscopy ◽  
Phenylboronic Acid ◽  
X Ray Diffraction ◽  
X Ray

The adduct of (3-MeC6H4)3B3O3 with an N-heterocyclic carbene (NHC=1,3-diethyl-4,5- dimethylimidazol-2-ylidene) was prepared by reacting 2.5 equiv. of 3-methylphenylboronic acid with 1 equiv. of the NHC. This reaction shows a novel carbene-facilitated condensation of substituted phenylboronic acid monomers. The structure of the compound (3-MeC6H4)3B3O3(NHC) (1) has been characterized by 1H NMR spectroscopy, elemental analysis, and single-crystal X-ray diffraction studies

scholarly journals Synthesis and study of the anticancer activity of some new 7H-[1,2,4]triazolo [3,4-b][1,3,4]thiadiazines

2021 ◽  
Vol 14 (3) ◽  
pp. 320-327
Author(s):  
I. I. Myrko ◽  
T. I. Chaban ◽  
V. V. Ohurtsov ◽  
I. V. Drapak ◽  
V. S. Matiichuk
Keyword(s):  
Nmr Spectroscopy ◽  
Anticancer Activity ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Anticancer Agents ◽  
1H Nmr Spectroscopy ◽  
Analysis Data ◽  
Elemental Analysis Data ◽  
Tumor Cell Death ◽  
Secondary Stage

The problem of finding effective low-toxic anticancer agents is one of the most important in modern medicine and pharmacy. Despite a large selection of anticancer drugs and a variety of mechanisms of their action, the effectiveness of existing drugs continues to be insufficient. Among the numerous natural and synthetic heterocyclic compounds that exhibit anticancer activity, 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives, which are able to initiate different pathways of tumor cell death. Based on this, the synthesis of new derivatives of this class of compounds and the study of their anticancer properties is relevant. The aim of the work is to synthesis of new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and study their anticancer activity. Materials and methods. It was used methods of organic synthesis, physical and chemical methods of analysis organic compounds (1H NMR spectroscopy, elemental analysis). Results. In order to obtain new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines, the interaction implemented of 4-amino-4H-[1,2,4]triazole-3-thiols with the corresponding bromoacetophenones. The reaction proceeds by heating the above reagents in alcohol with the closure of the thiadiazine ring and the formation of 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine systems. The structure of all synthesized compounds was confirmed by 1H NMR spectroscopy and elemental analysis data. The study of the anticancer activity of the synthesized compounds was carried out in the framework of the international scientific program DTP (Developmental Therapeutics Program) of the National Cancer Institute (NCI, Bethesda, Maryland, USA). It was found that the synthesized compounds exhibited different levels of anticancer activity. The most active among the tested substances was compound 3j with an average GP value of 28.73. The most sensitive to it were the lines of melanoma MDA-MB-435 and SK-MEL-2, kidney cancer A498 and RXF 393, CNS cancer SNB-75, and non-small cell lung cancer NCI-H522. The secondary stage of studies of this compound confirmed its high anticancer activity against most cancer cell lines. Conclusions. As a result of the interaction of 4-amino-4H-[1,2,4]triazole-3-thiols with the relevant bromoacetophenones, a series of new triazolo[3,4-b][1,3,4]thiadiazines was not described in the literature was synthesized. Testing the synthesized compounds for the antitumor activity made it possible to isolate 1 highly active compound with a pronounced anticancer effect, which in terms of activity approaches or exceeds the known drugs 5-fluorouracil (5-FU) and cisplatin, as well as an anticancer agent, curcumin.  

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