scholarly journals AFM studies of DNA structures extracted from adriamycin treated and non-treated Erlich tumor cells

2005 ◽  
Vol 70 (6) ◽  
pp. 823-831 ◽  
Author(s):  
M. Avramov-Ivic ◽  
Slobodan Petrovic ◽  
E. Kalman ◽  
T. Milosavljevic ◽  
I. Reljin ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Chromatin Structure ◽  
Ehrlich Tumor ◽  
Dna Structures ◽  
Force Microscopy ◽  
Atomic Force ◽  
Bond Scission ◽  
Ehrlich Tumor Cells

Atomic force microscopy (AFM), a unique tool to investigate drug treatment of cancer cells, was used to analyze the anti-neoplastic activity of adriamycin by comparing DNA structures of non-treated and adriamycin-treated Ehrlich tumor cells. The non-treated cells exhibited a highly branched intact chromatin structure, related to the intensive DNA replication in cancer cells. Images from adriamycin-treated tumor cells showed that the DNA chains were broken and the chromatin structure had been destroyed. Possible explanations for these effects of adriamycin are considered: breakage of hydrogen bonding, oxidation and intercalation effects, as well as the poisoning of topoisomerase enzyme. DNA fractal and multifractal analyses performed in order to evaluate the degree of bond scission, showed that the treated DNA had become more fractal compared to non-treated DNA.

Study of NSCLC cell migration promoted by NSCLC-Derived Extracellular Vesicle using atomic force microscopy

2021 ◽  
Author(s):  
Shuwei Wang ◽  
Jiajia Wang ◽  
Tuoyu Ju ◽  
Kaige Qu ◽  
Fan Yang ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Cell Migration ◽  
Cancer Cells ◽  
Extracellular Vesicles ◽  
Extracellular Vesicle ◽  
Cancer Microenvironment ◽  
Biological Processes ◽  
Force Microscopy ◽  
Atomic Force ◽  
Cellular Components

Extracellular Vesicles (EVs) secreted by cancer cells have a key role in the cancer microenvironment and progression. Previous studies have mainly focused on molecular functions, cellular components and biological processes...

scholarly journals Stretched DNA structures observed with atomic force microscopy

1994 ◽  
Vol 22 (20) ◽  
pp. 4224-4228 ◽  
Author(s):  
Thomas Thundat ◽  
David P. Allison ◽  
Robert J. Warmack
Keyword(s):  
Atomic Force Microscopy ◽  
Dna Structures ◽  
Force Microscopy ◽  
Atomic Force

Viscoelastic properties of doxorubicin-treated HT-29 cancer cells by atomic force microscopy: the fractional Zener model as an optimal viscoelastic model for cells

2019 ◽  
Vol 19 (3) ◽  
pp. 801-813 ◽  
Author(s):  
Maricela Rodríguez-Nieto ◽  
Priscila Mendoza-Flores ◽  
David García-Ortiz ◽  
Luis M. Montes-de-Oca ◽  
Marco Mendoza-Villa ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Cancer Cells ◽  
Viscoelastic Properties ◽  
Viscoelastic Model ◽  
Zener Model ◽  
Force Microscopy ◽  
Atomic Force ◽  
Fractional Zener Model ◽  
Ht 29

Quantitative Measurements of Intercellular Adhesion Strengths between Cancer Cells with Different Malignancies Using Atomic Force Microscopy

2019 ◽  
Vol 91 (16) ◽  
pp. 10557-10563 ◽  
Author(s):  
Hyonchol Kim ◽  
Kenta Ishibashi ◽  
Kosuke Matsuo ◽  
Atsushi Kira ◽  
Tomoko Okada ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Cancer Cells ◽  
Intercellular Adhesion ◽  
Force Microscopy ◽  
Quantitative Measurements ◽  
Atomic Force

scholarly journals Evaluation of 5-fluorouracil-treated lung cancer cells by atomic force microscopy

2019 ◽  
Vol 11 (39) ◽  
pp. 4977-4982 ◽  
Author(s):  
Xiaolin Jiang ◽  
Ke Ma ◽  
Cuihua Hu ◽  
Mingyan Gao ◽  
Jiashuo Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Atomic Force Microscopy ◽  
Cancer Cells ◽  
Side Effect ◽  
Drug Efficacy ◽  
Small Cell ◽  
Lung Cancer Cells ◽  
Small Cell Lung ◽  
Force Microscopy ◽  
Atomic Force

The drug efficacy and side-effect of 5-fluorouracil for non-small cell lung cancer cells were studied by atomic force microscopy.

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