Predictive value of pro- and anti-inflammatory cytokines in assessing severity and outcome of acute pancreatitis

2005 ◽  
Vol 24 (4) ◽  
pp. 253-257 ◽  
Author(s):  
Darko Mirkovic ◽  
Maja Surbatovic ◽  
Nikola Filipovic ◽  
Sonja Radakovic
Keyword(s):  
Acute Pancreatitis ◽  
Inflammatory Cytokines ◽  
Predictive Value ◽  
Anti Inflammatory

Plasma anti‐inflammatory cytokines and monocyte human leucocyte antigen‐DR expression in patients with acute pancreatitis

2004 ◽  
Vol 39 (2) ◽  
pp. 178-187 ◽  
Author(s):  
P. Mentula ◽  
M.‐L. Kylänpää ◽  
E. Kemppainen ◽  
S.‐E. Jansson ◽  
S. Sarna ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Inflammatory Cytokines ◽  
Human Leucocyte Antigen ◽  
Anti Inflammatory

High plasma levels of the pro-inflammatory cytokine IL-22 and the anti-inflammatory cytokines IL-10 and IL-1ra in acute pancreatitis

Pancreatology ◽  
2014 ◽  
Vol 14 (6) ◽  
pp. 465-469 ◽  
Author(s):  
Philippe Vasseur ◽  
Iris Devaure ◽  
Jacques Sellier ◽  
Adriana Delwail ◽  
Carine Chagneau-Derrode ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Inflammatory Cytokines ◽  
Plasma Levels ◽  
Inflammatory Cytokine ◽  
High Plasma ◽  
Anti Inflammatory

Role of Daphnetin in Rat Severe Acute Pancreatitis Through the Regulation of TLR4/NF-κB Signaling Pathway Activation

2016 ◽  
Vol 44 (01) ◽  
pp. 149-163 ◽  
Author(s):  
Zhiyong Liu ◽  
Jiao Liu ◽  
Kailiang Zhao ◽  
Qiao Shi ◽  
Teng Zuo ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Signaling Pathway ◽  
Inflammatory Cytokines ◽  
Severe Acute Pancreatitis ◽  
Sodium Taurocholate ◽  
Neutrophil Infiltration ◽  
Sod Activity ◽  
Molecular Analyses ◽  
Pathway Activation ◽  
Anti Inflammatory

Severe acute pancreatitis (SAP) often results in multiple-organ dysfunction syndrome with high mortality. There is no effective clinical therapy for SAP, yet daphnetin, a coumarin extracted from Dracaena marginata, has analgesic and anti-inflammatory effects, and has been used clinically in several diseases. The objective of this study was to investigate the role and underlying mechanisms of daphnetin in a rat SAP model. Male Wistar rats were pretreated with daphnetin via intraperitoneal injection, 30[Formula: see text]min before retrograde infusion of 5% sodium taurocholate into the biliopancreatic duct. Twelve hours after sodium taurocholate administration, rats were sacrificed and tissues and blood were harvested. Then, histological, chemical, and molecular analyses were performed. Daphnetin treatment reduced the levels of serum alanine transaminase and creatinine (CR), increased superoxide dismutase(SOD) activity, and decreased neutrophil infiltration and cell apoptosis of the pancreatic tissues in rat SAP. Daphnetin treatment significantly decreased expression of pro-inflammatory cytokines and increased expression of anti-inflammatory cytokines in rat SAP. Molecular analyses revealed that daphnetin reduced TLR4 expression and inhibited NF-[Formula: see text]B signaling pathway activation. These findings demonstrate that daphnetin attenuates acute pancreatic injury by regulating the TLR4/NF-[Formula: see text]B signaling pathway and inflammation in rat SAP model. Daphnetin may be a potential therapeutic agent for SAP.

Increased viability of cardiomyocytes after exposure of anti-inflammatory cytokines

2008 ◽  
Vol 56 (S 1) ◽  
Author(s):  
W Rees ◽  
T Kubin ◽  
J Pöling ◽  
S Hein ◽  
H Warnecke ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Anti Inflammatory

VALUE OF COMBINATION OF HAP SCORE AND BISAP SCORE IN PREDICTING SEVERITY IN PATIENTS OF ACUTE PANCREATITIS

2019 ◽  
pp. 96-100
Author(s):  
Thi Ngoc Suong Le ◽  
Pham Chi Tran ◽  
Van Huy Tran
Keyword(s):  
Acute Pancreatitis ◽  
Positive Predictive Value ◽  
Roc Curve ◽  
Predictive Value ◽  
Prognostic Value ◽  
Acute Inflammation ◽  
Clinical Symptoms ◽  
Mortality Rates ◽  
Multiple Organ ◽  
Central Hospital

Acute pancreatitis (AP) is an acute inflammation of the pancreas, usually occurs suddenly with a variety of clinical symptoms, complications of multiple organ failure and high mortality rates. Objectives: To determine the value of combination of HAP score and BISAP score in predicting the severity of acute pancreatitis of the Atlanta 2012 Classification. Patients and Methods: 75 patients of acute pancreatitis hospitalized at Hue Central Hospital between March 2017 and July 2018; HAP and BISHAP score is calculated within the first 24 hours. The severity of AP was classified by the revised Atlanta criteria 2012. Results: When combining the HAP and BISAP scores in predicting the severity of acute pancreatitis, the area under the ROC curve was 0,923 with sensitivity value was 66.7%, specificity value was 97.1%; positive predictive value was 66.7%, negative predictive value was 97.1%. Conclusion: The combination of HAP and BISAP scores increased the sensitivity, predictive value, and prognostic value in predicting the severity of acute pancreatitis of the revised Atlanta 2012 classification in compare to each single scores. Key words: HAPscore, BiSAP score, acute pancreatitis, predicting severity

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