scholarly journals The qualitative determination of oseltamivir phosphate in Tamiflu® capsule by cyclic voltammetry

2011 ◽  
Vol 65 (1) ◽  
pp. 87-91 ◽  
Author(s):  
Milka Avramov-Ivic ◽  
Slobodan Petrovic ◽  
Dusan Mijin ◽  
Katica Drljevic-Djuric
Keyword(s):  
Cyclic Voltammetry ◽  
Electrochemical Method ◽  
Gold Electrode ◽  
Cyclic Voltammogram ◽  
Carbon Electrode ◽  
Experimental Conditions ◽  
Concentration Dependency ◽  
Oseltamivir Phosphate ◽  
Qualitative Determination

A gold electrode was applied in the voltammetric determination of oseltamivir phosphate standard in 0.05 M NaHCO3. Oseltamivir phosphate as a standard and as a component of Tamiflu? capsule exhibited the identical cyclic voltammogram. The peaks originated from excipients in capsule do not appear under the applied electrochemical conditions. The electrochemical method for the qualitative determination of oseltamivir phosphate in Tamiflu? capsule by cyclic voltammetry was developed. The presence of oseltamivir phosphate as standard and as a content of Tamiflu? capsule in electrolyte as well as their concentrations were simultaneously checked by HPLC. The lack of the current/concentration dependency was established. The not pretreated glassy carbon electrode cannot be used for the determination of oseltamivir phosphate under identical experimental conditions presented for gold electrode.

Determination of Cyanuric Acid by Electrochemical Cyclic Voltammetry Method Using CuGeO3 Nanowires as Modified Electrode Materials

2013 ◽  
Vol 4 (3) ◽  
Author(s):  
L. Z. Pei ◽  
Y. K. Xie ◽  
Y. Q. Pei ◽  
Z. Y. Cai ◽  
C. G. Fan
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Method ◽  
Electrode Materials ◽  
Cyanuric Acid ◽  
Cyclic Voltammogram ◽  
Carbon Electrode ◽  
Scan Rate ◽  
Cyclic Voltammetry Method

A simple electrochemical method for the determination of cyanuric acid (CA) has been developed based on a CuGeO3 nanowire modified glassy carbon electrode. The dense CuGeO3 nanowire film can be formed on the surface of the glassy carbon electrode. The roles of scan rate, CA concentration, and electrolytes with different pH values on the electrochemical responses of CA have also been analyzed. The intensities of two anodic peaks vary linearly with the increase of the scan rate from 25 to 200 mVs−1. The intensity of the electrochemical CV peak increases with the increase of the acidity of the electrolytes. The two anodic peak currents are linear with the CA concentration in the range of 0.005–2 mM. The linear correlation coefficient is 0.984 and 0.980 for the cyclic voltammogram peaks (cvp) cvp1 and cvp2, respectively. The detection limit is 4.3 μM and 2.1 μM for cvp1 and cvp2, respectively. The proposed electrochemical method is convenient and effective sensing of CA.

scholarly journals Electrochemical characterization and determination of carbamazepine as pharmaceutical standard and tablet content on gold electrode

2014 ◽  
Vol 68 (2) ◽  
pp. 207-212 ◽  
Author(s):  
Nemanja Trisovic ◽  
Bojan Bozic ◽  
Slobodan Petrovic ◽  
Svetlana Tadic ◽  
Milka Avramov-Ivic
Keyword(s):  
Cyclic Voltammetry ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Phosphate Buffer ◽  
Bovine Serum ◽  
Gold Electrode ◽  
Anticonvulsant Drug ◽  
Voltammetric Techniques ◽  
Anodic Behaviour

The anodic behaviour of carbamazepine (CBZ), an anticonvulsant drug, has been studied on gold electrode in 0.1 mol dm-3 phosphate buffer of pH 7.0 by using cyclic voltammetry. It has been found that the value of the oxidative current of pure CBZ at +0.90 V is a linear function of the concentration in a range from 1.0?10-7 to 1.0?10?4 mol dm?3. The detection of CBZ in the concentration of 1.0?10-8 mol dm-3 is among the lowest that have been reported for this drug using voltammetric techniques. CBZ as a content of tablet Galepsine? has been quantitatively determined. It has also been demonstrated that the modification of gold electrode with bovine serum albumin (BSA) results in a decrease of the oxidative peak current due to the binding of the drug to BSA.

Anodic Voltammetric Behavior of Lincomycin and its Electroanalytical Determination in Pharmaceutical Dosage form and Urine at Gold Electrode

2017 ◽  
Vol 231 (5) ◽  
Author(s):  
Jyothi C. Abbar ◽  
Manjunath D. Meti ◽  
Sharanappa T. Nandibewoor
Keyword(s):  
Gold Electrode ◽  
Dosage Form ◽  
Oxidation Process ◽  
Linear Sweep Voltammetry ◽  
Linear Sweep ◽  
Experimental Conditions ◽  
Pharmaceutical Dosage Form ◽  
Antibiotic Drug ◽  
Voltammetric Behavior

AbstractThe anodic voltammetric behavior of an antibiotic drug, lincomycin hydrochloride (LIN) at gold electrode (GE) has been investigated using cyclic and linear sweep voltammetry. The dependence of the current on pH, concentration and scan rate were investigated to optimize the experimental conditions for the determination of lincomycin. The anodic peak was characterized and the process was adsorption-controlled. The number of electrons transferred in the oxidation process was calculated. In the range of 8.0×10

scholarly journals Electrocatalytic Study of Paracetamol at a Single-Walled Carbon Nanotube/Nickel Nanocomposite Modified Glassy Carbon Electrode

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Koh Sing Ngai ◽  
Wee Tee Tan ◽  
Zulkarnain Zainal ◽  
Ruzniza Mohd Zawawi ◽  
Joon Ching Juan
Keyword(s):  
Cyclic Voltammetry ◽  
Carbon Nanotube ◽  
Glassy Carbon Electrode ◽  
Modified Electrode ◽  
Glassy Carbon ◽  
Carbon Electrode ◽  
Single Walled Carbon Nanotube ◽  
Paracetamol Concentration ◽  
Single Walled Carbon

A rapid, simple, and sensitive method for the electrochemical determination of paracetamol was developed. A single-walled carbon nanotube/nickel (SWCNT/Ni) nanocomposite was prepared and immobilized on a glassy carbon electrode (GCE) surface via mechanical attachment. This paper reports the voltammetry study on the effect of paracetamol concentration, scan rate, pH, and temperature at a SWCNT/Ni-modified electrode in the determination of paracetamol. The characterization of the SWCNT/Ni/GCE was performed by cyclic voltammetry. Variable pressure scanning electron microscopy (VPSEM) and energy dispersive X-ray (EDX) spectrometer were used to examine the surface morphology and elemental profile of the modified electrode, respectively. Cyclic voltammetry showed significant enhancement in peak current for the determination of paracetamol at the SWCNT/Ni-modified electrode. A linear calibration curve was obtained for the paracetamol concentration between 0.05 and 0.50 mM. The SWCNT/Ni/GCE displayed a sensitivity of 64 mA M−1and a detection limit of 1.17 × 10−7 M in paracetamol detection. The proposed electrode can be applied for the determination of paracetamol in real pharmaceutical samples with satisfactory performance. Results indicate that electrodes modified with SWCNT and nickel nanoparticles exhibit better electrocatalytic activity towards paracetamol.

A Simple and Rapid Electrochemical Method for Determination of Ascorbic Acid

2013 ◽  
Vol 341-342 ◽  
pp. 866-869 ◽  
Author(s):  
Yu Fang Sha ◽  
Mei Zhao ◽  
Fei Guo ◽  
Man Zhao ◽  
Ming Quan Yang
Keyword(s):  
Ascorbic Acid ◽  
Electrochemical Method ◽  
Multiwall Carbon Nanotubes ◽  
Carbon Electrode ◽  
Redox Polymer ◽  
Real Samples ◽  
Screen Printed Carbon Electrode ◽  
Response Current ◽  
Multiwall Carbon

This paper introduced a simple and rapid electrochemical method for determination of ascorbic acid (AA). A screen-printed carbon electrode modified by multilayer films containing multiwall carbon nanotubes (MWNTs) and redox polymer. The modified electrode exhibited good stability and high electrocatalytic activity towards AA in the presence of uric acid and dopamine even in the real samples. The response current revealed a good linear relationship with the concentration of AA in the range of 5×10-7M~7×10-5M and the detection limit was 3×10-7M.

Determination of isoniazid content via cysteic acid/graphene modified glassy carbon electrode

2015 ◽  
Vol 7 (2) ◽  
pp. 793-798 ◽  
Author(s):  
Xiaojing Si ◽  
Lin Jiang ◽  
Xinyue Wang ◽  
Yaping Ding ◽  
Liqiang Luo
Keyword(s):  
Detection Limit ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Method ◽  
Cysteic Acid ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode

The electrodeposited graphene (EGR) and cysteic acid (CA) composite (CA/EGR) was fabricated through an electrochemical method for the modification of glassy carbon electrode (GCE). The obtained detection linearity of isoniazid at the CA/EGR/GCE ranged from 0.1 to 200 μM with the detection limit of 0.03 μM (S/N = 3).

A voltammetric sensor based on eosin Y film modified glassy carbon electrode for simultaneous determination of hydroquinone and catechol

2014 ◽  
Vol 6 (16) ◽  
pp. 6494-6503 ◽  
Author(s):  
Jiahong He ◽  
Ri Qiu ◽  
Wenpo Li ◽  
Shaohua Xing ◽  
Zhongrong Song ◽  
...  
Keyword(s):  
Cyclic Voltammetry ◽  
Simultaneous Determination ◽  
Glassy Carbon Electrode ◽  
Modified Electrode ◽  
Glassy Carbon ◽  
Eosin Y ◽  
Carbon Electrode ◽  
Voltammetric Sensor ◽  
Modified Glassy Carbon Electrode

By using cyclic voltammetry, eosin Y film was electrodeposited on the surface of glassy carbon electrode (GCE) to obtain the modified electrode (denoted as eosin Y/GCE).

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