scholarly journals Systematic analysis of trimazolin hydrochloride as adrenergic vasoconstrictor

2008 ◽  
Vol 62 (2) ◽  
pp. 69-77 ◽  
Author(s):  
Goran Nikolic ◽  
Ivana Savic ◽  
Vladimir Bankovic
Keyword(s):  
Physicochemical Characterization ◽  
Second Phase ◽  
Spectroscopic Methods ◽  
Systematic Analysis ◽  
Rp Hplc ◽  
Patent Literature ◽  
Degree Of Certainty ◽  
Pharmacologically Active

Trimazolin-hydrochloride, which is used as a pharmaceutically active component (adrenergic vasoconstrictor) for the production of decongestive preparations, was investigated in this paper by performing systematic analysis. In domestic and foreign pharmacopoeias, as well as in scientific and patent literature, there are no data on trimazolin and the methods of its investigation. Systematic analysis involves two investigation phases. A complete physicochemical characterization of the synthesized substance was done by previous investigation. In the second phase, a chemical structure of the synthesized pharmacologically active substance was confirmed to a certain degree of certainty by using the absorption spectroscopic methods (FTIR, UV-VIS, 1H-NMR). The spectroscopic methods used proved to be successful at identifying and investigating the purity of trimazolin hydrochloride. Liquid (RP-HPLC) chromatography was used for the analysis of trimazolin hydrochloride in the nasal preparation (Adrianol). The method of titrimetric analysis was developed with the aim of quantitative determination of trimazolin hydrochloride in decongestive preparations.

scholarly journals Chemical and Physicochemical Characterization of Faveleria (Cnidoscolus phyllacanthus) Oil - It Use of Determination of Enzymatic Activity of Extract of Fungi rhizopus sp.

2020 ◽  
Vol 12 (5) ◽  
pp. 1319-1333
Author(s):  
Carla Verônica Rodarte de Moura ◽  
Haroldo Luis Sousa Neres ◽  
Edmilson Miranda de Moura ◽  
Maria Christina Sanches Muratori ◽  
Tiago Linus Silva Coelho ◽  
...  
Keyword(s):  
Enzymatic Activity ◽  
Physicochemical Characterization ◽  
It Use ◽  
Rhizopus Sp

scholarly journals Development and validation of stability-indicating RP-HPLC method for determination of Olmesartan medoxomile in pharmaceutical dosage form and identification, characterization of alkaline degradation impurity of Olmesartan medoxomile drug substance as well as drug product

2012 ◽  
Vol 18 (4-1) ◽  
pp. 595-604 ◽  
Author(s):  
P.S. Jain ◽  
A.J. Chaudhari ◽  
S.J. Surana
Keyword(s):  
Degradation Product ◽  
Drug Product ◽  
Olmesartan Medoxomil ◽  
Hplc Method ◽  
Drug Substance ◽  
Alkaline Degradation ◽  
Stability Indicating ◽  
Rp Hplc

Olmesartan Medoxomil (OLME) belongs to a group of angiotensin II receptor blockers used as an antihypertensive agent and is currently being used for prevention of Hypertension. This paper describes the Validation and development of stability indicating RP-HPLC method for the determination of OLME in the presence of its degradation products generated from forced degradation study and characterization of degradation product (impurity). The assay involved gradient elution of OLME on An LC GC BDS C18 column (250 ? 4.5mm, 5-?m particle size) was employed for loading the sample. The mobile phase A consists of 7 ml Triethylamine in 1000 ml water (pH adjusted to 3.0 with orthophosphoric acid) and B contains acetonitrile. Quantification was achieved with photodiode array detection at 257 nm. The chromatographic separation was obtained with a retention time of 6.72 min, and the method was linear in the range 50-150 ?g/ml. The method was validated according to the ICH guidelines with respect to linearity, precision, accuracy, limit of detection (LOD), limit of quantification (LOQ), specificity and robustness. Impurity found in stressed and stability studies of Olmesartan Medoxomil in both drug substance and drug product are described. This degradation product is identified as 1-(biphenyl-4-ylmethyl)-1H-imidazole-5-carboxylic acid. An Alkaline degradation pathway of Olmesartan medoxomil, for the formation of this degradation product, has been proposed and degradation product was characterized.

Characterization of Different Nanostructured Bone Substitute Biomaterials

2014 ◽  
Vol 936 ◽  
pp. 695-700 ◽  
Author(s):  
Nelson Levandowski ◽  
Nelson H.A. Camargo ◽  
Daiara F. Silva ◽  
Gisele M.L. Dalmônico ◽  
Priscila F. Franczak
Keyword(s):  
Tricalcium Phosphate ◽  
Physicochemical Characterization ◽  
Bone Substitutes ◽  
Second Phase ◽  
State University ◽  
Transformation Kinetics ◽  
Beta Tricalcium Phosphate ◽  
Molecular Events ◽  
Kinetics Of

The present research paper centers on physicochemical characterization of six nanostructured alloplastic bone substitutes developed at Santa Catarina State University (UDESC Brazil). In addition to identifying the main phases, the focus was to measure the morphological and microstructural features, which are believed to be crucial for controlling and guiding biological and molecular events. The studied samples exhibited rounded granules measuring 200μm 10(PO4)6(OH)2] was found as main phase for HAp, BCP and HAp/Al2O3 biomaterials. For HAp/TiO2n, HAp/SiO2n and β-TCP, the major phase was beta tricalcium phosphate [Ca3(PO4)2-β]. The results demonstrate that the presence of a second phase of nanometer order, at a hydroxyapatite bioceramic matrix, may modify the surface diffusion of the grains and the phase transformation kinetics of hydroxyapatite and beta tricalcium phosphate at temperatures up to 1100°C.

scholarly journals Design and Molecular Modeling of Abiraterone-Functionalized Gold Nanoparticles

Nanomaterials ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 641 ◽  
Author(s):  
Elżbieta Stolarczyk ◽  
Marta Łaszcz ◽  
Andrzej Leś ◽  
Marek Kubiszewski ◽  
Krzysztof Kuziak ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Density Functional ◽  
Essential Feature ◽  
Physicochemical Characterization ◽  
Basic Study ◽  
Functional Theory ◽  
The Density Functional Theory ◽  
Charged Nanoparticles ◽  
Pharmacologically Active

The aim of our work was the synthesis and physicochemical characterization of a unique conjugate consisting of gold nanoparticles (AuNPs) and a pharmacologically active anticancer substance abiraterone (AB). The direct coupling of AB with gold constitutes an essential feature of the unique AuNPs–AB conjugate that creates a promising platform for applications in nanomedicine. In this work, we present a multidisciplinary, basic study of the obtained AuNPs–AB conjugate. Theoretical modeling based on the density functional theory (DFT) predicted that the Aun clusters would interact with abiraterone preferably at the N-side. A sharp, intense band at 1028 cm−1 was observed in the Raman spectra of the nanoparticles. The shift of this band in comparison to AB itself agrees well with the theoretical model. AB in the nanoparticles was identified by means of electrochemistry and NMR spectroscopy. The sizes of the Au crystallites measured by XRPD were about 9 and 17 nm for the nanoparticles obtained in pH 7.4 and 3.6, respectively. The size of the particles as measured by TEM was 24 and 30 nm for the nanoparticles obtained in pH 7.4 and pH 3.6, respectively. The DLS measurements revealed stable, negatively charged nanoparticles.

scholarly journals Rapid determination of flavonoids and phenolic acids in grape juices and wines by RP-HPLC/DAD: Method validation and characterization of commercial products of the new Brazilian varieties of grape

2017 ◽  
Vol 228 ◽  
pp. 106-115 ◽  
Author(s):  
Carla Valéria da Silva Padilha ◽  
Gabriela Aquino Miskinis ◽  
Marcelo Eduardo Alves Olinda de Souza ◽  
Giuliano Elias Pereira ◽  
Débora de Oliveira ◽  
...  
Keyword(s):  
Method Validation ◽  
Phenolic Acids ◽  
Rapid Determination ◽  
Commercial Products ◽  
Rp Hplc ◽  
Grape Juices

scholarly journals Potentials for commercial production of biogas from domestic food waste generated in Benin Metropolis, Nigeria

2016 ◽  
Vol 20 (2) ◽  
pp. 369-373
Author(s):  
E.P. Akhator ◽  
D.I. Igbinomwanhia ◽  
A.I. Obanor
Keyword(s):  
Solid Waste ◽  
Food Waste ◽  
Solid Waste Management ◽  
Biogas Production ◽  
Second Phase ◽  
Biodegradable Waste ◽  
Daily Food ◽  
Two Phases

The work reported in this paper investigated the potentials of commercial biogas production from biodegradable waste in Benin metropolis. The study was carried out in two phases. The first phase involved characterization of solid waste generated and determination of the quantity of potential feed stock for biogas production in Benin metropolis and the second phase was determination of the amount of biogas obtainable from biodegradable waste. The results from the study showed that an average daily generation rate of 0.358kg per person per day (ppd.) of solid waste is generated in study area. Food waste accounted for about 78.49% of the generated solid waste representing 0.281kg per person per day (ppd.) and a total daily food waste generation of 305.075tonnes. Based on this value for food waste the obtainable biogas was estimated to be 28,836.91m3 of biogas in Benin metropolis per day. This volume of biogas can provide cooking gas for about 24,076.91 families per month in Benin metropolis or alternatively can be utilised to generate about 49.023MW of electricity per day.Keywords: Solid waste management, food waste, anaerobic digestion, biogas

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