scholarly journals Evaluation of the constructed 3D models of RNAs: A review

2020 ◽  
Vol 18 (1) ◽  
pp. 39-45
Author(s):  
Biljana Arsic ◽  
Boris Furtula ◽  
Marjan Randjelovic
Keyword(s):  
Electron Spectroscopy ◽  
3D Models ◽  
Structural Features ◽  
Experimental Techniques ◽  
Evaluation Scores ◽  
Insight Into

The development of new experimental techniques, such as cryo-electron spectroscopy, enables insight into the structural features inside cells. However, in specific cases, it is still not possible to get the cryo images. Therefore, the development of the scores for the evaluation of the quality of the constructed RNAs, similarly to the proteins, is a prerequisite for the investigation of the diseases caused by the organisms not well investigated. Here, we are providing a summary of the evaluation scores in use for the prediction of the quality of the constructed 3D models of the RNAs.

Gluten protein functionality in wheat flour processing: a review

2001 ◽  
Vol 52 (12) ◽  
pp. 1311 ◽  
Author(s):  
P. W. Gras ◽  
R. S. Anderssen ◽  
M. Keentok ◽  
F. Békés ◽  
R. Appels
Keyword(s):  
Structural Features ◽  
Protein Functionality ◽  
Gluten Protein ◽  
Physical Processes ◽  
Naturally Occurring ◽  
Wheat Flours ◽  
Insight Into

Gluten protein functionality remains the basis of any understanding of the end-product quality of wheat flours. Information about this functionality has been obtained by both in vivo and in vitro studies. Recent advances include structure/function studies of deletion mutants and transformed genotypes, where the genes incorporated were both naturally occurring genes and genes which have been desired to provide specific structural features. The contributions of these specific changes in structure to the rheology of the resulting doughs allow insight into the underlying physical processes that determine dough and end-product properties.

scholarly journals Improving the Outer Shell of the Form Using the Characteristics of Human Skin

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Faezeh Tafreshi ◽  
Babak Alemi
Keyword(s):  
Human Skin ◽  
Structural Features ◽  
The Body ◽  
Outer Shell ◽  
Internal Organs ◽  
External Shell ◽  
Building Form ◽  
Insight Into ◽  
Biological Organisms

Context: Biomimetics is a novel field of science that takes inspiration from nature and biological organisms to create and design forms. This knowledge can help improve the conditions of a building form. The form is the manifestation of architecture, and the initial insight into a form is figured out by observing its external shell. Therefore, the composition and the type of interactions of a shell with its surrounding forces determine the quality of this important element in construction. Evidence Acquisition: One of the most obvious patterns that have similar features with the outer shell of the building is the human skin, so the structural features of the skin can be used as a source of inspiration in production or improvement of the form’s outer shell. The skin is a vital and the widest living organ of the body. It is one of the most complex and active organs with such capabilities in transforming the human body as an efficient microclimate that can favor the situation of its internal organs and plays an important role in self-repair, energy absorption, and thermal insulation. Conclusions: In this study, we tried to use the structural features of the skin to provide suitable ideas for improving and upgrading the outer shell of the building form. Applying these capabilities in the structure of a building form would lead to the creation of a smart, usable, and expandable architecture with a favorable geometrical performance that will adapt to the surrounding environmental conditions, including climate, pressure, etc.

Skeletal elements of crinoid echinoderms: High-resolution structural and microanalytical results

1983 ◽  
Vol 41 ◽  
pp. 194-195
Author(s):  
D. F. Blake ◽  
L. F. Allard ◽  
D. R. Peacor
Keyword(s):  
High Resolution ◽  
Marine Invertebrates ◽  
Sea Urchins ◽  
Structural Features ◽  
Sea Stars ◽  
High Resolution Tem ◽  
Relationship Of ◽  
The Relationship ◽  
Insight Into

Echinodermata is a phylum of marine invertebrates which has been extant since Cambrian time (c.a. 500 m.y. before the present). Modern examples of echinoderms include sea urchins, sea stars, and sea lilies (crinoids). The endoskeletons of echinoderms are composed of plates or ossicles (Fig. 1) which are with few exceptions, porous, single crystals of high-magnesian calcite. Despite their single crystal nature, fracture surfaces do not exhibit the near-perfect {10.4} cleavage characteristic of inorganic calcite. This paradoxical mix of biogenic and inorganic features has prompted much recent work on echinoderm skeletal crystallography. Furthermore, fossil echinoderm hard parts comprise a volumetrically significant portion of some marine limestones sequences. The ultrastructural and microchemical characterization of modern skeletal material should lend insight into: 1). The nature of the biogenic processes involved, for example, the relationship of Mg heterogeneity to morphological and structural features in modern echinoderm material, and 2). The nature of the diagenetic changes undergone by their ancient, fossilized counterparts. In this study, high resolution TEM (HRTEM), high voltage TEM (HVTEM), and STEM microanalysis are used to characterize tha ultrastructural and microchemical composition of skeletal elements of the modern crinoid Neocrinus blakei.

A Systematic Review on Popularity, Application and Characteristics of Protein Secondary Structure Prediction Tools

2019 ◽  
Vol 16 (2) ◽  
pp. 159-172 ◽  
Author(s):  
Elaheh Kashani-Amin ◽  
Ozra Tabatabaei-Malazy ◽  
Amirhossein Sakhteman ◽  
Bagher Larijani ◽  
Azadeh Ebrahim-Habibi
Keyword(s):  
Systematic Review ◽  
Secondary Structure ◽  
Structure Prediction ◽  
Web Of Science ◽  
Secondary Structure Prediction ◽  
Structural Information ◽  
Protein Secondary Structure ◽  
Structural Features ◽  
Prediction Tools ◽  
Insight Into

Background: Prediction of proteins’ secondary structure is one of the major steps in the generation of homology models. These models provide structural information which is used to design suitable ligands for potential medicinal targets. However, selecting a proper tool between multiple Secondary Structure Prediction (SSP) options is challenging. The current study is an insight into currently favored methods and tools, within various contexts. Objective: A systematic review was performed for a comprehensive access to recent (2013-2016) studies which used or recommended protein SSP tools. Methods: Three databases, Web of Science, PubMed and Scopus were systematically searched and 99 out of the 209 studies were finally found eligible to extract data. Results: Four categories of applications for 59 retrieved SSP tools were: (I) prediction of structural features of a given sequence, (II) evaluation of a method, (III) providing input for a new SSP method and (IV) integrating an SSP tool as a component for a program. PSIPRED was found to be the most popular tool in all four categories. JPred and tools utilizing PHD (Profile network from HeiDelberg) method occupied second and third places of popularity in categories I and II. JPred was only found in the two first categories, while PHD was present in three fields. Conclusion: This study provides a comprehensive insight into the recent usage of SSP tools which could be helpful for selecting a proper tool.

Attitudes of Elderly People in the South Moravian Region to Further Education

2014 ◽  
Vol 4 (2) ◽  
pp. 54-78
Author(s):  
Petr Adamec ◽  
Marián Svoboda
Keyword(s):  
Quality Of Life ◽  
Elderly People ◽  
Further Education ◽  
The South ◽  
The Third ◽  
Interesting Insight ◽  
Survey Results ◽  
Insight Into ◽  
Demographic Features

This paper deals with the results of sociological survey focused on identification of the attitudes of elderly people to further education. The research was carried out in September 2010. Experience of elderly people with further education, their readiness (determination) for further education as well as their motivation and barriers in further education were also subjects of this research. Detecting elderly population’s awareness of universities of the third age and finding out their further education preferences were an integral part of the research. Research sample consisted of citizens over 55 years living in the South Moravian region. The survey results are structured by socio-demographic features e.g.: age, sex, educational attainment etc. and provide an interesting insight into the attitudes of the target group to one of the activities that contributes to improvement of their quality of life.

The Oxford Handbook of the Brazilian Economy

2018 ◽  
Keyword(s):  
Direct Investment ◽  
Global Economy ◽  
Iron Ore ◽  
Structural Features ◽  
Economic Importance ◽  
Closed Economy ◽  
Current Characteristics ◽  
Insight Into ◽  
Contemporary Context ◽  
Over Time

Brazil constitutes a globally vital but troubled economy. It accounts for the largest GDP in Latin America and ranks among the world’s largest exporters of critical commodities including iron ore, soya, coffee, and beef. In recent years Brazil’s global economic importance has been magnified by a surge in both outward and inward foreign direct investment. This has served to further internationalize what has been historically a relatively closed economy. The purpose of this Handbook is to offer real insight into the Brazil’s economic development in contemporary context, understanding its most salient characteristics and analyzing its structural features across various dimensions. At a more granular level, this volume accomplishes the following tasks. First, it provides an understanding of the economy’s evolution over time and the connection of its current characteristics to this evolution. Second, it analyzes Brazil’s broader place in the global economy, and considers the ways in which this role has changed, and is likely to change, over coming years. Third, reflecting contemporary concerns, the volume offers an understanding, not only of how one of the world’s key economies has developed and transformed itself, but also of the ways in which this process has yet to be completed. The volume thus analyzes the current challenges facing the Brazilian economy and the kinds of issues that need to be tackled for these to be addressed.

scholarly journals Comparisons among rainbow trout, Oncorhynchus mykiss, populations of maternal transcript profile associated with egg viability

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Gregory M. Weber ◽  
Jill Birkett ◽  
Kyle Martin ◽  
Doug Dixon ◽  
Guangtu Gao ◽  
...  
Keyword(s):  
Rainbow Trout ◽  
Egg Quality ◽  
Transcript Abundance ◽  
Differentially Expressed ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Analysis Group ◽  
Maternal Transcripts ◽  
Single Batch ◽  
Insight Into

Abstract Background Transcription is arrested in the late stage oocyte and therefore the maternal transcriptome stored in the oocyte provides nearly all the mRNA required for oocyte maturation, fertilization, and early cleavage of the embryo. The transcriptome of the unfertilized egg, therefore, has potential to provide markers for predictors of egg quality and diagnosing problems with embryo production encountered by fish hatcheries. Although levels of specific transcripts have been shown to associate with measures of egg quality, these differentially expressed genes (DEGs) have not been consistent among studies. The present study compares differences in select transcripts among unfertilized rainbow trout eggs of different quality based on eyeing rate, among 2 year classes of the same line (A1, A2) and a population from a different hatchery (B). The study compared 65 transcripts previously reported to be differentially expressed with egg quality in rainbow trout. Results There were 32 transcripts identified as DEGs among the three groups by regression analysis. Group A1 had the most DEGs, 26; A2 had 15, 14 of which were shared with A1; and B had 12, 7 of which overlapped with A1 or A2. Six transcripts were found in all three groups, dcaf11, impa2, mrpl39_like, senp7, tfip11 and uchl1. Conclusions Our results confirmed maternal transcripts found to be differentially expressed between low- and high-quality eggs in one population of rainbow trout can often be found to overlap with DEGs in other populations. The transcripts differentially expressed with egg quality remain consistent among year classes of the same line. Greater similarity in dysregulated transcripts within year classes of the same line than among lines suggests patterns of transcriptome dysregulation may provide insight into causes of decreased viability within a hatchery population. Although many DEGs were identified, for each of the genes there is considerable variability in transcript abundance among eggs of similar quality and low correlations between transcript abundance and eyeing rate, making it highly improbable to predict the quality of a single batch of eggs based on transcript abundance of just a few genes.

A Study on the Mineral Depletion of the Foods Available to us as a Nation over the Period 1940 to 1991

2003 ◽  
Vol 17 (2) ◽  
pp. 85-115 ◽  
Author(s):  
David Thomas
Keyword(s):  
Mineral Content ◽  
Dietary Habits ◽  
Medical Research Council ◽  
Significant Loss ◽  
King's College ◽  
Compare And Contrast ◽  
Insight Into ◽  
Mineral Constituents ◽  
Mineral Depletion

In 1927 a study at King's College, University of London, of the chemical composition of foods was initiated by Dr McCance to assist with diabetic dietary guidance. The study evolved and was then broadened to determine all the important organic and mineral constituents of foods, it was financed by the Medical Research Council and eventually published in 1940. Over the next 51 years subsequent editions reflected changing national dietary habits and food laws as well as advances in analytical procedures. The most recent (5th Edition) published in 1991 has comprehensively analysed 14 different categories of foods and beverages. In order to provide some insight into any variation in the quality of the foods available to us as a nation between 1940 and 1991 it was possible to compare and contrast the mineral content of 27 varieties of vegetable, 17 varieties of fruit, 10 cuts of meat and some milk and cheese products. The results demonstrate that there has been a significant loss of minerals and trace elements in these foods over that period of time. It is suggested that the results of this study cannot be taken in isolation from recent dietary, environmental and disease trends. These trends are briefly mentioned and suggestions are made as to how the deterioration in the micronutrient quality of our food intake may be arrested and reversed.

scholarly journals Dialogical research to open up new narrative patterns among young women living with severe anxiety

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
L Cantarero Arevalo ◽  
S Fejfer Olsen
Keyword(s):  
Young Women ◽  
Population Group ◽  
Patient Experiences ◽  
Constructivist Approach ◽  
Patient’S Perspective ◽  
Healthcare Needs ◽  
Narrative Patterns ◽  
Severe Anxiety ◽  
Insight Into

Abstract Background 16,889 new cases of severe anxiety (SA) were diagnosed in Denmark in 2019. Incidence rate is highest among 16 to 24 year-old women, a population group with 64% risk of being diagnosed with SA. Experiences of stigma and shame are common among this group, affecting negatively their quality of life and opportunity to recover. The aim is 1) to gain insight into the digital narratives young women with SA share through social networking websites, and 2) to open up the possibility to develop new narrative patterns using dialogical research as a method rooted in Bakhtin (1895-1975) and further developed by Frank (2005). Methods Netnography of four large Facebook groups focused on anxiety was used to gain insight into the patients' narratives and to build guiding themes for the off-line dialogical interviews (DI). Biographical narrative patterns were analyzed in light of a narrative-constructivist approach. Participants were invited to sign an informed consent prior to the DI and received ample information about the project aims and their rights. Results 8 young women diagnosed with SA participated in the off-line DI. They had experienced stress, loss, betrayal or violation against them prior to the trigger of SA. All had constructed a narrative that explained why they were suffering from SA. Patient experiences were dominated by the struggle to control intrusive thoughts and to live in a threatening world. Some felt stigmatized and tried to hide their condition from colleagues, friends and family. They had different preferences regarding healthcare needs and were active in their search for alternative ways to cope with SA. Conclusions Participants perceived DI as beneficial. It thus has the potential to not only explore the patient's perspective in depth, but also serve as therapy during the process of inquiry. Key messages Dialogical research has the potential to not only explore the patient’s perspective in depth, but also serve as therapy during the process of inquiry. Young women suffering with severe anxiety experience shame and stigma, which worsen their condiction and hinder their opportunity to recover.

scholarly journals Cryo-EM structure of amyloid fibrils formed by the entire low complexity domain of TDP-43

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Qiuye Li ◽  
W. Michael Babinchak ◽  
Witold K. Surewicz
Keyword(s):  
Amyloid Fibrils ◽  
Low Complexity ◽  
Structural Features ◽  
Protein Fragments ◽  
Hydrophobic Residues ◽  
Backbone Conformation ◽  
Hydrophobic Amino Acids ◽  
Insight Into ◽  
Lateral Sclerosis

AbstractAmyotrophic lateral sclerosis and several other neurodegenerative diseases are associated with brain deposits of amyloid-like aggregates formed by the C-terminal fragments of TDP-43 that contain the low complexity domain of the protein. Here, we report the cryo-EM structure of amyloid formed from the entire TDP-43 low complexity domain in vitro at pH 4. This structure reveals single protofilament fibrils containing a large (139-residue), tightly packed core. While the C-terminal part of this core region is largely planar and characterized by a small proportion of hydrophobic amino acids, the N-terminal region contains numerous hydrophobic residues and has a non-planar backbone conformation, resulting in rugged surfaces of fibril ends. The structural features found in these fibrils differ from those previously found for fibrils generated from short protein fragments. The present atomic model for TDP-43 LCD fibrils provides insight into potential structural perturbations caused by phosphorylation and disease-related mutations.

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