scholarly journals Synthesis, characterization and antimicrobial activity of cobalt metal complex against multi drug resistant bacterial and fungal pathogens

2009 ◽  
Vol 7 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Subhasish Saha ◽  
Dharumadurai Dhanasekaran ◽  
Sarvanan Chandraleka ◽  
Annamalai Panneerselvam
Keyword(s):  
Antifungal Activity ◽  
Metal Complex ◽  
Cobalt Complex ◽  
Fungal Genome ◽  
Klebsiella Pneumonia ◽  
Cobalt Metal ◽  
Antibacterial And Antifungal Activity ◽  
In Silico Docking ◽  
Antibacterial And Antifungal

Cobalt complex with histidine ligand was synthesized and physico-chemically characterized by solubility testing, melting point, UV-spectra and FTIR. The synthesized metal complex was evaluated for in-vitro antibacterial and antifungal activity against the multidrug resistant pathogens, such as Pseudomonas aeruginosa, Vibrio cholerae, Salmonella typhi, E. coli, Klebsiella pneumonia, Staphylococcus aureus, Aspergillus niger, Aspergillus flavus and Candida albicans. The metal complex showed the significant antibacterial and antifungal activity comparison with commercial antibiotics. Further work can be extended through In-silico docking of this metal complex and bacterial, fungal genome which can be given a better idea about genome metal interaction in molecular level.

scholarly journals Antibacterial and antifungal activities of hydroalcoholic hands products sold in Côte d’Ivoire during covid-19

2021 ◽  
Vol 16 (2) ◽  
pp. 297-305
Author(s):  
Andrée Emmanuelle Sika ◽  
Ollo Kambiré ◽  
Bertin Tiekoura ◽  
Florent N’Guessan ◽  
Rose Koffi-Nevry ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Cote D'ivoire ◽  
Côte D’Ivoire ◽  
Microbial Load ◽  
Klebsiella Pneumonia ◽  
Antibacterial And Antifungal Activity ◽  
Cote D’Ivoire ◽  
Côte D'ivoire ◽  
Antibacterial And Antifungal

In the midst of the COVID-19 pandemic, hydroalcoholic products are widely used for hand disinfection. Côte d'Ivoire has also opted for this barrier measure. Ivorian markets and supermarkets have been filled with new hydroalcoholic products of various compositions and colors, certified or not by the Ivorian standardization agency. It was important to verify the antimicrobial efficacy of these hydroalcoholic products. To do this, we tested 16 hydroalcoholic products collected from supermarkets in Abidjan. The microbial load on the hands of 144 volunteers was determined before and after hand rubbing. These hydroalcoholic products were also tested for antibacterial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Proteus mirabilis; and antifungal activity against Aspergillus fumigatus and Penicillium chrysogenum. The results of this study showed that hydroalcoholic products tested significantly reduced the microbial load on the hands after friction. The germ inhibition rate was between 94.99 and 99.97%. Of the 16 hydroalcoholic products, only 3 showed antibacterial and antifungal activity on all indicator strains. In contrast, 4 showed no antibacterial and antifungal activity on these strains. The low efficacy of hydroalcoholic products tested in vitro is an indicator of the lack of quality control of these products. Some of them could not therefore guarantee the health security of the populations.

scholarly journals Chemical constituents, in vitro antibacterial and antifungal activity of Mentha×Piperita L. (peppermint) essential oils

2019 ◽  
Vol 31 (4) ◽  
pp. 528-533 ◽  
Author(s):  
Nagarjuna Reddy Desam ◽  
Abdul Jabbar Al-Rajab ◽  
Mukul Sharma ◽  
Mary Moses Mylabathula ◽  
Ramachandra Reddy Gowkanapalli ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Essential Oils ◽  
Chemical Constituents ◽  
Mentha Piperita ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal

scholarly journals SYNTHESIS, IN VITRO ANTIOXIDANT AND ANTIMICROBIAL EVALUATION OF 3-HYDROXY CHROMONE DERIVATIVES

2018 ◽  
Vol 11 (3) ◽  
pp. 259
Author(s):  
Pallavi Kamble ◽  
Sailesh Wadher
Keyword(s):  
Antioxidant Activity ◽  
Double Bond ◽  
Antifungal Activity ◽  
Phenolic Hydroxyl ◽  
Hydroxyl Group ◽  
Antibacterial And Antifungal Activity ◽  
Activity Data ◽  
Group 4 ◽  
Antibacterial And Antifungal

 Objective: The objective of the present study was to synthesize a series of 3-hydroxychromone derivatives and to evaluate its in vitro antioxidant and antimicrobial activities.Methods: 3-hydroxy chromones were synthesized using an algar flynn oyamada method which includes oxidative cyclization of 2-hydroxy chalcones in basic solution by hydrogen peroxide. 2-hydroxy chalcones were synthesized by Claisen-Schmidt condensation of substituted 2-hydroxy acetophenones with substituted aromatic aldehydes using polyethylene glycol-400 as a recyclable solvent. The synthesized compounds were evaluated for in vitro antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. In addition, these compounds were also screened for in vitro antibacterial and antifungal activity by agar cup method and Poison plate method, respectively.Results: The structures of the synthesized compounds were characterized by infrared, 1H nuclear magnetic resonance and mass spectroscopy. The antioxidant activity data revealed that all the synthesized derivatives exhibited good activity due to the presence of phenolic hydroxyl group, 4-oxo group and 2,3-double bond. Further, the activity increased with the introduction of a more phenolic hydroxyl group and adjacent methoxy group in the structure. The antimicrobial activity data showed that the compounds possess better antibacterial and antifungal activity which is attributed to the presence of phenolic hydroxyl group and 4-oxo group in the structure.Conclusions: The use of inexpensive, eco-friendly and readily available reagents, easy work-up and high purity of products makes the procedure a convenient and robust method for the synthesis of title compounds. The presence of phenolic hydroxyl group, 4-oxo group, and 2,3-double bond in the structure is responsible for their good antioxidant and antimicrobial activities.

Synthesis and Antimicrobial Evaluation of Some New 2-(6-Oxo-5,6- dihydro[1,3]thiazolo[3,2-b]-2-aryloxymethyl-1,2,4-triazol-5-yl)-Narylacetamides

2010 ◽  
Vol 65 (5) ◽  
pp. 617-624 ◽  
Author(s):  
Prajwal L. Lobo ◽  
Boja Poojary ◽  
Kumsi Manjunatha ◽  
Nalilu Suchetha Kumari
Keyword(s):  
Acetic Acid ◽  
Antifungal Activity ◽  
Spectral Data ◽  
Good Yield ◽  
Antibacterial And Antifungal Activity ◽  
Acid Media ◽  
Antimicrobial Evaluation ◽  
Antibacterial And Antifungal

A series of 2-(6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b]-2-aryloxymethyl-1,2,4-triazol-5-yl)-Narylacetamides 6 were synthesized in good yield by condensing 5-aryloxymethyl-4H-1,2,4-triazole- 3-thiol 5 with various substituted N-phenyl-maleimides in acetic acid media. The newly synthesized compounds were characterized by spectral data and tested for their in vitro antibacterial and antifungal activity against a variety of microorganisms.

scholarly journals In Vitro Antibacterial and Antifungal Activity of Lavandula x intermedia Emeric ex Loisel. ‘Budrovka’

Molecules ◽  
2011 ◽  
Vol 16 (5) ◽  
pp. 4241-4253 ◽  
Author(s):  
Biljana Blazekovic ◽  
Gordana Stanic ◽  
Stjepan Pepeljnjak ◽  
Sanda Vladimir-Knezevic
Keyword(s):  
Antifungal Activity ◽  
Antibacterial And Antifungal Activity ◽  
Antibacterial And Antifungal

scholarly journals In Vitro Evaluation of Portuguese Propolis and Floral Sources for Antiprotozoal, Antibacterial and Antifungal Activity

2013 ◽  
Vol 28 (3) ◽  
pp. 437-443 ◽  
Author(s):  
Soraia I. Falcão ◽  
Nuno Vale ◽  
Paul Cos ◽  
Paula Gomes ◽  
Cristina Freire ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Antibacterial And Antifungal Activity ◽  
In Vitro Evaluation ◽  
Antibacterial And Antifungal

scholarly journals Synthesis of some new 6-aryl-3-(4-isopropylphenyl)[1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles and its anti-microbial study

2021 ◽  
Vol 10 (4) ◽  
pp. 479-488 ◽  
Author(s):  
K. A. Joshi ◽  
J. M. Dhalani ◽  
H. B. Bhatt ◽  
K. M. Kapadiya
Keyword(s):  
Antifungal Activity ◽  
Spectroscopic Techniques ◽  
Aromatic Acids ◽  
Reference Standard ◽  
Antibacterial And Antifungal Activity ◽  
Essential Step ◽  
Step Procedure ◽  
Antibacterial And Antifungal ◽  
Microbial Study

New series of fused 1,2,4-triazoles, i.e., 3-(4-isopropylphenyl)-6-substituted phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (5a-5j) have been synthesized via a four-step procedure and using eco-friendly reaction condition at some steps of the synthesis. It was adopted by the formation of hydrazide of methyl 4-isopropylbenzoate (1) followed by reaction with CS2 in basic media to afford potassium salt, which on cyclized to our essential step, 4-amino-5-(4-isopropylphenyl)-4H-1,2,4-triazole-3-thiol (4). The desired adducts (5a-5j) were formed by (4) on reaction with various aromatic acids in POCl3 media. The newly synthesized triazolo- thiadiazoles have been characterized by different spectroscopic techniques and investigated for their in vitro antibacterial and antifungal activity. It was revealed that the compounds 5a, 5c, 5h, and 5i showed interesting antibacterial and antifungal activity compared to the used reference standard.

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