scholarly journals Serum activity of dipeptidylpeptidase IV and expression of CD26 antigen on immunocompetent cells of peripheral blood in patients with benign and malignant breast tumors

2012 ◽  
Author(s):  
Aleksandra Eric-Nikolic
Keyword(s):  
Peripheral Blood ◽  
Breast Tumors ◽  
Immunocompetent Cells ◽  
Dipeptidylpeptidase Iv ◽  
Serum Activity ◽  
Malignant Breast

scholarly journals Clinical value of peripheral blood M2/M1 like monocyte ratio in the diagnosis of breast cancer and the differentiation between benign and malignant breast tumors

2019 ◽  
Author(s):  
Mustafa Fadhil ◽  
Omar Abdul- Rasheed ◽  
Manwar Al-Naqqash
Keyword(s):  
Breast Cancer ◽  
Tumor Progression ◽  
Cancer Patients ◽  
Peripheral Blood ◽  
Breast Tumor ◽  
Healthy Subjects ◽  
Breast Tumors ◽  
Breast Cancer Patients ◽  
Cancer Tumor ◽  
Malignant Breast

Background: During tumor progression, circulating monocytes and macrophages are actively recruited into tumors where they alter the tumor microenvironment to accelerate tumor progression. In response to multiple microenvironmental signals from the tumor and stromal cells, macrophages change their functional phenotypes. Based on their function, macrophages are commonly classified into both, classical M1 and alternative M2 macrophages. M2-like tumor-associated macrophages promote breast tumor growth and survival, and may migrate into the peripheral blood. However, the level of circulating M2/M1-like monocyte ratio in the peripheral blood of breast cancer patients has not been yet clarified. Aim: To compare peripheral blood M2/M1 monocyte ratio among breast cancer patients, benign breast tumor patients and healthy subjects. Also, to investigate the role of peripheral blood M2/M1 monocyte ratio as a circulating breast cancer tumor marker and to asses the validity of this marker in differentiation between benign and malignant breast tumors. Methods: Flow cytometry technique was used to determine the peripheral blood M2/M1 monocyte ratio in three groups of subjects, i.e. 45 patients with breast cancer, 40 patients with benign breast tumor, and 40 healthy subjects as a control group. The results of carbohydrate antigen15-3 (CA15-3) determination were analyzed comparatively. Results: The peripheral blood M2/M1 monocyte ratio in patients with breast cancer (0.27±0.1) was significantly higher (P<0.001) than that in healthy subjects (0.07±0.05) and than in benign tumor subjects (0.08±0.04). The area under the receiver operating characteristic (ROC) curve of peripheral blood M2/M1 monocyte ratio determination was significantly higher (P≤0.001) than that of CA15-3 levels. Conclusion: M2/M1-like monocyte ratio is of a high diagnostic value for breast cancer and is a promising differentiating marker between benign and breast cancer tumor groups.

HISTOLOGICAL DIAGNOSTICS OF MAMMARY GLAND NEOPLASMS IN CATS

2020 ◽  
Keyword(s):  
Mammary Gland ◽  
Malignant Tumors ◽  
Breast Tumors ◽  
Domestic Animals ◽  
Breast Diseases ◽  
Microscopic Studies ◽  
Malignant Breast ◽  
Poorly Differentiated ◽  
Breast Adenocarcinomas

Mammary gland neoplasms in cats are at the top of the list of the most common nosological diseases among domestic animals; more than half of the tumors appear as malignant. Veterinary practitioners have many questions about the prevalence of breast tumors in cats, depending on age, breed and seasons of the year. The article presents the results of diseases prevalence of benign and malignant breast tumors in cats kept in the conditions of Bishkek. The characteristic of macroscopic and microscopic studies of benign and malignant breast tumors in cats at different periods of life and depending on the breed is also described. Studies were conducted in the period from March 2018 to March 2019. Morphological methods were used in the study of breast tumors. As a result of our research, we established the morphological forms of benign and malignant breast tumors in cats. Among benign neoplastic breast diseases in cats, breast lipoma was observed. Also among the malignant tumors of the breast met highly differentiated, moderately differentiated and poorly differentiated breast adenocarcinomas malnutrition and necrosis as well as the rare phylloid (leaf-shaped) fibroadenoma of the mammary gland which makes up only 0.3-0.5 % of all breast tumors.

scholarly journals Optically Measured Microvascular Blood Flow Contrast of Malignant Breast Tumors

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99683 ◽  
Author(s):  
Regine Choe ◽  
Mary E. Putt ◽  
Peter M. Carlile ◽  
Turgut Durduran ◽  
Joseph M. Giammarco ◽  
...  
Keyword(s):  
Blood Flow ◽  
Breast Tumors ◽  
Microvascular Blood Flow ◽  
Malignant Breast

scholarly journals Morphological predictors of nipple areola involvement in malignant breast tumors

2010 ◽  
Vol 53 (2) ◽  
pp. 232 ◽  
Author(s):  
Kalyan Khan ◽  
Subrata Chakraborti ◽  
Sukanta Mondal
Keyword(s):  
Breast Tumors ◽  
Malignant Breast

scholarly journals Expression analisis of the ITSN2 and TKS5 mRNA isoforms in human malignant breast tumors

2018 ◽  
Vol 16 (1) ◽  
pp. 20-27
Author(s):  
S. V. Kropyvko ◽  
L. O. Tsyba ◽  
O. V. Novokhatska ◽  
L. A. Syvak ◽  
T. Ye. Tarasenko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Expression Analysis ◽  
Rna Isolation ◽  
Breast Tumors ◽  
Quantitative Real Time Pcr ◽  
Mrna Isoforms ◽  
Extensive Experience ◽  
Great Progress ◽  
Malignant Breast ◽  
The Many

Aim. Despite the great progress in cancer treating, the breast cancer remains lethal in 15 % cases. Regardless of the many years of research and extensive experience in the treatment of this type of cancer, one of the main problems in diagnosis and therapy is its high clinical and genetic heterogeneity. Thereby the identification of markers for personalized treatment of patients is still an actual issue. Methods. Collection of clinical material, RNA isolation, and expression analysis of ITSN2 and TKS5 isoforms using quantitative real time PCR with fluorescence-labeled probes. Results. We have found that ITSN2-S expression is reliably reduced in HER2/neu-positive tumors with poor prognosis. There were no significant differences in the expression of ITSN2-L and TKS5-L in the analyzed samples. Conclusions. These studies have demonstrated the possible use of ITSN2 short isoform (ITSN2-S) as a prognostic marker for breast cancer. Keywords: breast cancer, ITSN2, TKS5, expression analysis.

scholarly journals Classification of benign and malignant breast tumors on the basis of 36 radiographic properties

Cancer ◽  
1973 ◽  
Vol 31 (2) ◽  
pp. 342-352 ◽  
Author(s):  
Laurens V. Ackerman ◽  
Anthony N. Mucciardi ◽  
Earl E. Gose
Keyword(s):  
Breast Tumors ◽  
Malignant Breast

scholarly journals Primary breast lymphoma: a case report and review of the literature

2017 ◽  
Vol 7 (3) ◽  
Author(s):  
Kamal E.H. Mohamed ◽  
Rusha A.E. Ali
Keyword(s):  
Breast Cancer ◽  
Rare Case ◽  
Breast Tumors ◽  
Review Of The Literature ◽  
Primary Breast Lymphoma ◽  
Breast Lymphoma ◽  
First Case ◽  
High Prevalence ◽  
Malignant Breast ◽  
Hodgkin's Lymphomas

Primary breast lymphoma (PBL) represents 0.04-0.5% of all malignant breast tumors, &lt;1% of all patients with non-Hodgkin’s lymphomas and 1.7-2.2% of all patients with extra nodal lymphomas. Despite the high prevalence of breast cancer, primary breast lymphoma is very rare. We report a rare case of PBL, successfully treated with surgery, chemotherapy and radiotherapy. This is the first case of PBL to be reported from Sudan to our knowledge.

Experience in performing organ-preserving and reconstructive plastic surgeries for malignant breast tumors at the Regional Clinical Center of Oncology in Khabarovsk

2021 ◽  
Vol 87 (1) ◽  
pp. 32-36
Author(s):  
A.A. Chernyayeva ◽  
◽  
A.S. Zenyukov ◽  
S.M. Korneyev ◽  
Ye.G. Lokalov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Local Recurrence ◽  
Clinical Oncology ◽  
Breast Tumors ◽  
Clinical Center ◽  
Malignant Breast ◽  
Oncology Center ◽  
Reconstructive Plastic

The article presents the experience of the Oncology department No. 1 of the Regional Clinical Oncology Center in Khabarovsk in performing organ-preserving and reconstructive plastic surgeries for breast cancer in the period 2014–2019. An assessment was made of the incidence of local recurrence or distant progression of the disease, as well as risk factors for their occurrence

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