scholarly journals Effects of local application of platelet-rich plasma and guided tissue regeneration on stability of implants

2010 ◽  
Vol 60 (1) ◽  
pp. 89-101
Author(s):  
Duka Milos ◽  
Lazic Z. ◽  
Bubalo Marija ◽  
Tatic Z. ◽  
Djurdjevic D. ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Guided Tissue Regeneration ◽  
Local Application

scholarly journals Effect of local administration of platelet-rich plasma and guided tissue regeneration on the level of bone resorption in early dental implant insertion

2008 ◽  
Vol 65 (6) ◽  
pp. 462-468 ◽  
Author(s):  
Milos Duka ◽  
Zoran Lazic ◽  
Marija Bubalo
Keyword(s):  
Bone Resorption ◽  
Bone Defect ◽  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Guided Tissue Regeneration ◽  
Cellular Migration ◽  
Significant Difference ◽  
The Right ◽  
Defect Filling ◽  
Deproteinized Bone

Background/Aim. Osseointegration is a result of cellular migration, differentiation, bone formation, and bone remodeling on the surface of an implant. Each of these processes depends on platelets and blood coagulum. Platelet-rich plasma (PRP) is used to improve osseointegration and stability of implants. The aim of the research was to test the influence that PRP and guided tissue regeneration in bone defects have on bone defect filling and the level of bone resorption in early implant insertion. Methods. This experimental study included 10 dogs. A total of 40 BCT implants were inserted, 4 in each dog (two on the left side and two on the right side), with guided tissue regeneration. Radiologic analyses were done immediately after the insertion and 10 weeks after the insertion. Bone defect filling was measured by a graduated probe 10 weeks after the implant insertion. The following protocols were tested: I - PRP in combination with bovine deproteinized bone (BDB) and resorptive membrane of bovine origin (RBDM), II - BDB + RBDM, III - PRP + RBDM and IV - RBDM. Results. The applied protocols affected differently the bone defect filling and the level of bone resorption. Significantly better results (the lowest bone resorption) were achieved with protocol I (PRP + BDB + RBDM) in comparison with protocols III (PRP + RBDM) and IV (RBDM), but not with protocol II (BDB + RBDM). On the other hand, no significant difference was found among protocols II (BDB + RBDM), III (PRP + RBDM) and IV (RBDM) in the level of bone tissue resorption. Conslusion. The bone defect filling was largest and the level of bone resorption was lowest in the protocol with PRP applied in combination with BDB and RBDM.

scholarly journals Effects of local administration of platelet-rich plasma and guided tissue regeneration on bone healing in early inserted dental implants - a histomorphometric analysis

2020 ◽  
Vol 74 (1) ◽  
pp. 34-47
Author(s):  
Milos Duka ◽  
Zoran Lazic ◽  
Marija Bubalo ◽  
Branko Mihailovic ◽  
Milan Miladinovic ◽  
...  
Keyword(s):  
Growth Factors ◽  
Dental Implant ◽  
Tissue Regeneration ◽  
Bone Healing ◽  
Platelet Rich Plasma ◽  
Bone Defects ◽  
Tissue Growth ◽  
Guided Tissue Regeneration ◽  
Bovine Bone ◽  
Implant Loading

Introduction. In order to provide the most favorable conditions for bone healing following implant loading, new techniques such as the use of growth factors to directly or indirectly regulate cell and tissue growth are becoming increasingly popular. Simplicity in producing concentrated thrombocytes derived from platelet-rich plasma has led to increasing application of growth factors derived from thrombocytes, such as PDGF, TGF-?, IGF and VEGF, in order to increase the percentage of bone-to-implant contact that provides better implant stability and possibly earlier functional loading. The aim of the study was to determine the effects of platelet-rich plasma and guided tissue regeneration on bone regeneration in the case of bone defects in early dental implant insertion. Materials and Methods. This experimental study was conducted on 10 study dogs that received 40 BCT implants, i.e., 4 implants per dog. The study included early dental implant placement in the sites of the extracted premolars. Artificial bone defects, resembling peri-implantitis defects, were made on the mesial side of each site, and the defects were filled using suitable guided tissue regeneration protocols with platelet-rich plasma derived from each experimental animal an hour before surgery. Histopathologic and histomorphometric evaluations were performed 10 months following the implantation. Results and Conclusion. The applied protocols had different effects on bone healing. According to the results obtained, the use of platelet-rich plasma combined with deproteinized bovine bone and bovine-derived resorptive membrane provided superior bone defect ossification

Platelet-rich plasma and bovine porous bone mineral combined with guided tissue regeneration in the treatment of intrabony defects in humans

2002 ◽  
Vol 37 (4) ◽  
pp. 300-306 ◽  
Author(s):  
Paulo M. Camargo ◽  
Vojislav Lekovic ◽  
Michael Weinlaender ◽  
Nikola Vasilic ◽  
Miroslav Madzarevic ◽  
...  
Keyword(s):  
Bone Mineral ◽  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Guided Tissue Regeneration ◽  
Intrabony Defects

scholarly journals Complex Treatment of Patients With Chronic Generalized Periodontitis of a Medium Degree of Severity Using the Methods of Osteogygivoplasty With Biocomposite Materials and Guided Tissue Regeneration

2021 ◽  
Vol 7 (4) ◽  
pp. 154-163
Author(s):  
A. Imanalieva ◽  
P. Abaskanova ◽  
O. Tursunaliev ◽  
B. Bakiev ◽  
K. Kuttubaeva
Keyword(s):  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Interdisciplinary Approach ◽  
Guided Tissue Regeneration ◽  
Collagen Membrane ◽  
Complex Treatment ◽  
Surgical Interventions ◽  
X Ray ◽  
Combined Use

Improvement of methods of complex treatment of periodontium diseases continues to be an urgent problem of dentistry and requires an interdisciplinary approach. The severity of the course of periodontitis and the severity of destructive phenomena dictates the need to use osteoplastic agents to restore damaged periodontium tissues. It has been proven that the efficiency of membrane technology is significantly increased when membranes and substitute materials are used together. The positive effect of the combined use of Platelet Rich Plasma (PRP — autogenous growth factors), osteoplastic materials, and the method of Guided Tissue Regeneration (GTR) has been confirmed. To increase the efficiency of reconstructive treatment of patients with generalized periodontitis through the combined use of alloplasty, Platelet Rich Plasma, and the method of Guided Tissue Regeneration. Method of testing: clinical, X-ray. For the period 2018–2019, 34 patients with chronic generalized periodontal atrophy of moderate severity were under observation. All patients underwent professional oral hygiene, laser therapy, and antibacterial therapy with rovamycin. 6 patients in complex therapy underwent surgical interventions: osteogingivoplasty with biocomposite materials using GTR auto-allogenic membranes. Bone defects were filled with biocomposite material: hydroxylappatite granules (Polistom, RF) in combination with PRP, on top of an alto plasma membrane isolated from PRP and collagen membrane (Polistom, RF). The immediate and long-term periods of treatment were quite favorable. Control X-ray examination after 12 months showed restoration of a bone defect with an organotypic structure.

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