scholarly journals Clear cell sarcoma of the nuchal region with metastasis in stomach

2011 ◽  
Vol 19 (3-4) ◽  
pp. 76-78
Author(s):  
Dragana Tegeltija ◽  
Aleksandra Lovrenski ◽  
Milana Panjkovic ◽  
Slavica Knezevic-Usaj ◽  
Zivka Eri ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Soft Tissues ◽  
Clear Cell ◽  
Neck Region ◽  
Surgical Excision ◽  
Clear Cell Sarcoma ◽  
Lower Limbs ◽  
Medical Attention ◽  
Cell Sarcoma ◽  
Complete Surgical Excision

Clear cell sarcoma/malignant melanoma of soft parts is a rare malignant tumor that originates from the neural crest. It is most common in young men in the lower limbs, grows slowly in the form of deep localized nodes around the tendons, fascia, and aponeurosis. Prognosis is poor, local recurrences and metastases are common. We present a case of a 53-year-old patient who sought medical attention due to the presence of a tumefaction in the nuchal neck region, followed by pain, heightened sensitivity, and numbness in his right hand. After excision, histological examination, and application of immunohistochemical and histochemical methods, malignant melanoma of soft tissues was diagnosed. Fourteen months after the excision of the neck tumor, a metastatic stomach disease was diagnosed. Larger tumors with necrosis, expressed pleomorphisam, and increased mitotic activity give metastases before local recurrence. Diagnosis is set using immunohistochemical methods after surgical excision of the tumor and the prognosis of the disease depends on the size of tumor and complete surgical excision.

Epithelial-Type and Neural-Type Cadherin Expression in Malignant Noncarcinomatous Neoplasms With Epithelioid Features That Involve the Soft Tissues

2002 ◽  
Vol 126 (4) ◽  
pp. 425-431 ◽  
Author(s):  
William B. Laskin ◽  
Markku Miettinen
Keyword(s):  
Malignant Melanoma ◽  
Synovial Sarcoma ◽  
Soft Tissues ◽  
Clear Cell ◽  
Epithelioid Sarcoma ◽  
Clear Cell Sarcoma ◽  
Extraskeletal Myxoid Chondrosarcoma ◽  
Cell Sarcoma ◽  
Myxoid Chondrosarcoma ◽  
Poorly Differentiated

Abstract Context.—Transmembrane adhesion molecules, epithelial-type cadherin (ECAD) and neural-type cadherin (NCAD), help in regulating transformations between epithelial and mesenchymal cells in the developing embryo and in maintaining the epithelioid phenotype. Consequently, the presence of epithelioid cells in certain malignant noncarcinomatous neoplasms raises speculation that the expression of ECAD and NCAD in these neoplasms may have diagnostic significance. Objective.—To investigate the utility of ECAD and NCAD immunoexpression in distinguishing malignant (noncarcinomatous) neoplasms with epithelioid features that involve the soft tissues. Design.—Membranous immunoreactivity of anti-ECAD and anti-NCAD was evaluated on archived cases selected from the files of the Armed Forces Institute of Pathology. Results.—Epithelial-type cadherin was found in biphasic synovial sarcoma (35 of 35 cases), malignant melanoma (13/21), monophasic fibrous synovial sarcoma (13/26), clear cell sarcoma (4/9), poorly differentiated synovial sarcoma (3/13), diffuse mesothelioma (4/20), malignant epithelioid peripheral nerve sheath tumor (1/6), and epithelioid sarcoma (5/62). Neural-type cadherin was observed in chordoma (11/11), biphasic synovial sarcoma (30/35), diffuse mesothelioma (14/20), malignant melanoma (14/25), epithelioid sarcoma (24/63), epithelioid angiosarcoma (1/4), poorly differentiated synovial sarcoma (2/13), clear cell sarcoma (1/10), and monophasic fibrous synovial sarcoma (1/26). Eighteen cases of primary cutaneous squamous cell carcinomas all tested positive for ECAD, whereas NCAD was focally observed in 5 cases. No expression of either molecule was observed in cases of epithelioid hemangioendothelioma (n = 9), alveolar soft part sarcoma (n = 8), and extraskeletal myxoid chondrosarcoma (n = 7). Conclusions.—Epithelial-type and neural-type cadherins are found in a variety of noncarcinomatous neoplasms with epithelioid features that involve the soft tissues and can be utilized, in association with other immunomarkers, in distinguishing chordoma (100% NCAD) from extraskeletal myxoid chondrosarcoma and conventional chondrosarcoma of bone (0% NCAD), squamous cell carcinoma (100% ECAD) from epithelioid sarcoma (8% ECAD), and biphasic synovial sarcoma (100% ECAD) from diffuse mesothelioma (20% ECAD).

Primary Clear Cell Sarcoma of the Tongue

2013 ◽  
Vol 137 (11) ◽  
pp. 1680-1683 ◽  
Author(s):  
Stefan Kraft ◽  
Cristina R. Antonescu ◽  
Andrew E Rosenberg ◽  
Daniel G. Deschler ◽  
G. Petur Nielsen
Keyword(s):  
Soft Tissues ◽  
Clear Cell ◽  
S100 Protein ◽  
Neck Region ◽  
Clear Cell Sarcoma ◽  
Giant Cells ◽  
Cell Sarcoma ◽  
Node Metastases ◽  
Type Giant

Clear cell sarcoma shares features with melanoma, but frequently shows EWSR1 rearrangements. It is an aggressive tumor typically occurring in the soft tissues of the extremities, with a gastrointestinal variant with less consistent melanocytic differentiation. It is extremely rare in the head and neck region, with no reported cases in the oral cavity. We report a case of an 82-year-old woman with a clear cell sarcoma arising in the tongue, with cervical lymph node metastases. Histologically, the tumor showed some features of gastrointestinal clear cell sarcoma. No osteoclast-type giant cells were present. The tumor cells were positive for S100 protein and negative for other melanocytic markers. Fluorescence in situ hybridization showed rearrangements of EWSR1 and ATF1. This case expands the spectrum of clear cell sarcoma with a gastrointestinal-like variant in a novel site, emphasizing the need to consider it as a differential diagnosis to melanoma in mucosal sites.

Malignant Melanoma of Soft Parts (Clear Cell Sarcoma): A Case Report

2003 ◽  
Vol 30 (7) ◽  
pp. 550-555 ◽  
Author(s):  
Takuya Seike ◽  
Kazuya Matsumoto ◽  
Hideki Nakanishi ◽  
Ichiro Hashimoto ◽  
Yoshiaki Kubo ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma

scholarly journals Is clear cell sarcoma a malignant form of psammomatous melanotic schwannoma?

2006 ◽  
Vol 21 (6) ◽  
pp. 1-4 ◽  
Author(s):  
Ahmet Şengöz ◽  
Erol Taşdemiroğlu ◽  
Halit Togay
Keyword(s):  
Malignant Melanoma ◽  
Nerve Root ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Histopathological Diagnosis ◽  
Total Resection ◽  
Cell Sarcoma ◽  
Melanotic Schwannoma ◽  
Psammomatous Melanotic Schwannoma

✓The authors present a case of clear cell sarcoma (CCS) in which the tumor originated in the S-1 nerve root and had been previously diagnosed as psammomatous melanotic schwannoma (PMS). This is the third case of a spinal nerve root origin for CCS reported in the English-language literature. The similar histogenesis of CCS and malignant melanoma supports the hypothesis that biological agents or immunotherapy are potentially important areas of investigation. The patient underwent S1–3 laminectomy and gross-total resection of the mass lesion. The border of the resection was extended 1 cm distal to the tumor margin. The postoperative period was uneventful. The new histopathological diagnosis was CCS (malignant melanoma of soft tissue). Despite total resection, the patient returned with disseminated disease at the 18-month follow-up visit. His follow-up magnetic resonance image of the lumbar spine revealed sacral L5–S3 involvement of the vertebral bodies along with disseminated cauda equina seeding. A CCS originating from peripheral nerves is quite rare. The histopathological and immunohistochemical appearance of CCSs resembles those of PMSs. Surgery should be the first choice of treatment.

Clear cell sarcoma with intraepidermal nests requiring the differential diagnosis of malignant melanoma

2017 ◽  
Vol 45 (1) ◽  
pp. 115-116 ◽  
Author(s):  
Takayuki Fusumae ◽  
Koji Kamiya ◽  
Takeo Maekawa ◽  
Mayumi Komine ◽  
Satoru Murata ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Malignant Melanoma ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma

scholarly journals A Rare Case of Clear Cell Sarcoma (Malignant Melanoma of Soft Parts) Diagnosed in Pleural Effusion Cytology

2016 ◽  
Vol 146 (suppl_1) ◽  
Author(s):  
Khurram Shafique ◽  
Afra Samad ◽  
Arslan Ahmad ◽  
Flores Alfonso ◽  
Arbaz Samad
Keyword(s):  
Pleural Effusion ◽  
Malignant Melanoma ◽  
Rare Case ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma

scholarly journals Primary malignant melanoma (clear cell sarcoma) of bone: Report of a case arising in the ulna

Cancer ◽  
1996 ◽  
Vol 77 (12) ◽  
pp. 2471-2475 ◽  
Author(s):  
Ryohei Yokoyama ◽  
Kiyoshi Mukai ◽  
Teruyuki Hirota ◽  
Yasuo Beppu ◽  
Hisatoshi Fukuma
Keyword(s):  
Malignant Melanoma ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Primary Malignant Melanoma ◽  
Cell Sarcoma

Clear cell sarcoma of tendons and aponeuroses with t(12;22) (q13;q12) diagnosed initially as malignant melanoma

1996 ◽  
Vol 91 (1) ◽  
pp. 37-39 ◽  
Author(s):  
Bogusław Nedoszytko ◽  
Krzysztof Mrózek ◽  
Andrzej Roszkiewicz ◽  
Andrzej Kopacz ◽  
Maciej Świerblewski ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma

Identification of biomarkers to distinguish clear cell sarcoma from malignant melanoma

2012 ◽  
Vol 43 (9) ◽  
pp. 1463-1470 ◽  
Author(s):  
Linlin Yang ◽  
Yuan Chen ◽  
Tiantian Cui ◽  
Thomas Knösel ◽  
Qing Zhang ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Clear Cell ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma
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