scholarly journals The seventieth anniversary of the hormonal treatment of prostatic carcinoma

2011 ◽  
Vol 19 (1-2) ◽  
pp. 28-30
Author(s):  
Lela Milovanovic
Keyword(s):  
Pancreatic Cancer ◽  
Hormonal Therapy ◽  
Theoretical Basis ◽  
Prostatic Carcinoma ◽  
Systemic Treatment ◽  
Fatal Outcome ◽  
Hormonal Treatment ◽  
Lhrh Agonists ◽  
Initial Results

Hormonal treatment of prostatic carcinoma was initiated in the first half of twentieth century. Theoretical basis of hormonal treatment was established with the work of Charles Brenton Huggins published in 1941. Initial results were encouraging, but fatal outcome occurred anyway. There are four directions of hormonal treatment of pancreatic cancer: orchiectomy, estrogens, LHRH agonists, or antiandrogens. Refinements of hormonal therapy were constant and resulted in prolonged survival time and fairly improved quality of life. These results rank hormonal therapy of pancreatic cancer as the most successful systemic treatment of metastatic disease.

Health-Related Quality of Life and Survival in Prostate Cancer Patients in a Real-World Setting

2020 ◽  
Vol 104 (11-12) ◽  
pp. 939-947
Author(s):  
Susanne Bergius ◽  
Risto P. Roine ◽  
Kimmo Taari ◽  
Harri Sintonen
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Hormonal Therapy ◽  
Real World ◽  
Hormonal Treatment ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

<b><i>Objective:</i></b> To analyze the health-related quality of life (HRQoL) and survival of real-world prostate cancer (PC) patients and to calculate quality-adjusted life-years (QALYs) experienced under different treatment strategies. <b><i>Materials and Methods:</i></b> PC patients undergoing active surveillance (<i>n</i> = 226), radiation treatment (<i>n</i> = 280), surgery (<i>n</i> = 299), or hormonal treatment (<i>n</i> = 62) responded to the generic 15-dimensional (15D) HRQoL questionnaire at the time of the diagnosis and were followed up 3, 6, 12, and 24 months later. QALYs experienced during the follow-up were calculated for each treatment group, and variables associated with survival were analyzed using Cox proportional hazards models. <b><i>Results:</i></b> HRQoL was stable during the first 2 years after diagnosis in all other treatment groups, except in patients treated with hormonal therapy. The overall survival within 6.5-year follow-up time was 84.4%. The number of QALYs experienced during the 2-year follow-up was similar in patients in active surveillance (1.790), surgery (1.784), and radiation groups (1.767), but significantly lower in the hormonal therapy group (1.665). <b><i>Conclusions:</i></b> Patients receiving hormonal treatment had significantly impaired HRQoL and survival compared with other treatments. Although the number of QALYs experienced was similar in the 3 other treatment lines, there were marked differences between treatment lines on some 15D dimensions.

scholarly journals Prolongation of survival time and improvement of the quality of life after treatment with irinotecan liposomal in the patient with metastatic pancreatic adenocarcinoma

Oncoreview ◽  
2021 ◽  
Vol 11 (3(43)) ◽  
pp. 77-79
Author(s):  
Wojciech Rogowski ◽  
Przemysław Będkowski
Keyword(s):  
Quality Of Life ◽  
Pancreatic Cancer ◽  
Survival Time ◽  
Response Rate ◽  
Systemic Treatment ◽  
Advanced Disease ◽  
Locally Advanced ◽  
Malignant Neoplasms ◽  
Metastatic Pancreatic Adenocarcinoma

Pancreatic cancer is one of the malignant neoplasms with the worst prognosis. It is most often diagnosed at an advanced stage, which relates to unsatisfactory results of the therapy. Only about 15–20% of patients with pancreatic cancer qualify for surgery. The remaining patients are diagnosed with locally advanced disease or much more frequently in the generalized stage. Systemic treatment (chemotherapy) remains the mainstay of therapy in these patients, but both the response rate and progression-free time are unsatisfactory [1, 2]. This paper presents a case of a patient with metastatic pancreatic cancer, in whom three lines of systemic treatment were applied sequentially, which allowed to extend the survival time and improve the quality of life.

Systematic literature review of clinical outcomes in adults with metastatic or advanced synovial sarcoma

2020 ◽  
Vol 16 (35) ◽  
pp. 2997-3013
Author(s):  
Kentaro Kogushi ◽  
Michael LoPresti ◽  
Shunya Ikeda
Keyword(s):  
Synovial Sarcoma ◽  
High Frequency ◽  
Clinical Evidence ◽  
Systemic Treatment ◽  
Progression Free Survival ◽  
Treatment Modalities ◽  
Free Survival ◽  
New Treatment ◽  
Poor Outcomes

Background: Synovial sarcoma (SS) is a rare, aggressive soft tissue sarcoma with a poor prognosis after metastasis. The objective of this study was to conduct a systematic review of the clinical evidence for therapeutic options for adults with metastatic or advanced SS. Materials & methods: Relevant databases were searched with predefined keywords. Results: Thirty-nine publications reported clinical data for systemic treatment and other interventions. Data on survival outcomes varied but were generally poor (progression-free survival: 1.0–7.7 months; overall survival: 6.7–29.2 months) for adults with metastatic and advanced SS. A high frequency of neutropenia with systemic treatment and low quality of life post-progression were reported. Conclusion: Reported evidence suggests poor outcomes in adults with metastatic and advanced SS and the need for the development of new treatment modalities.

scholarly journals Obvious Reduction of the Tumor Size in Dedifferentiated Liposarcoma in a Lung Metastasis Patient Receiving Individualized Treatment

2021 ◽  
pp. 1080-1084
Author(s):  
Xin-Li Wang ◽  
Jia-Yao Gong ◽  
Yan Xue
Keyword(s):  
Quality Of Life ◽  
Therapeutic Effect ◽  
Tumor Size ◽  
Systemic Treatment ◽  
Treatment Method ◽  
Palliative Surgery ◽  
Dedifferentiated Liposarcoma ◽  
Comprehensive Treatment ◽  
Back Surgery

Abdominal metastasis is relatively rare in dedifferentiated liposarcoma of the shoulder and back. Surgery is the best treatment option, whether it is radical or palliative surgery. Chemotherapy is the standard systemic treatment for advanced unresectable/metastatic patients, but the therapeutic effect is limited. Here, we treat advanced abdominal dedifferentiated liposarcoma through a comprehensive treatment method of targeting, surgery, and chemotherapy, which improves the quality of life of the patient, and shrinks the tumor significantly.

scholarly journals Exercise efficacy and prescription during treatment for pancreatic ductal adenocarcinoma: a systematic review

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dominic O’Connor ◽  
Malcolm Brown ◽  
Martin Eatock ◽  
Richard C. Turkington ◽  
Gillian Prue
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Pancreatic Cancer ◽  
Adjuvant Therapy ◽  
Physical Function ◽  
Meta Analysis ◽  
Ductal Adenocarcinoma ◽  
Key Stakeholders ◽  
The Impact

Abstract Background Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-adjuvant therapy before surgery or adjuvant therapy afterward, inherently exposing them to toxicity. As such, optimizing physical function through exercise during treatment remains imperative to optimize quality of life either before surgery or during rehabilitation. However, current exercise efficacy and prescription in pancreatic cancer is unknown. Therefore, this study aims to summarise the published literature on exercise studies conducted in patients with pancreatic cancer undergoing treatment with a focus on determining the current prescription and progression patterns being used in this population. Methods A systematic review of four databases identified studies evaluating the effects of exercise on aerobic fitness, muscle strength, physical function, body composition, fatigue and quality of life in participants with pancreatic cancer undergoing treatment, published up to 24 July 2020. Two reviewers independently reviewed and appraised the methodological quality of each study. Results Twelve studies with a total of 300 participants were included. Heterogeneity of the literature prevented meta-analysis. Exercise was associated with improvements in outcomes; however, study quality was variable with the majority of studies receiving a weak rating. Conclusions High quality evidence regarding the efficacy and prescription of exercise in pancreatic cancer is lacking. Well-designed trials, which have received feedback and input from key stakeholders prior to implementation, are required to examine the impact of exercise in pancreatic cancer on key cancer related health outcomes.

scholarly journals Systematic Review of the Integrative Medicine Recommendations for Patients with Pancreatic Cancer

Surgeries ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 216-230
Author(s):  
Andrew A. Gumbs ◽  
Manana Gogol ◽  
Gaya Spolverato ◽  
Hebatallah Taher ◽  
Elie K. Chouillard
Keyword(s):  
Systematic Review ◽  
Pancreatic Cancer ◽  
Integrative Medicine ◽  
Lifestyle Changes ◽  
Randomized Controlled ◽  
Nutrition Supplementation ◽  
Traditional Therapies ◽  
Traditional Approaches

Introduction: Integrative medicine (IM) is a relatively new field where non-traditional therapies with peer-reviewed evidence are incorporated or integrated with more traditional approaches. Methods: A systematic review of the literature from the last 10 years was done by searching clinical trials and randomized-controlled trials on Pubmed that discuss nutrition, supplementation, and lifestyle changes associated with “Pancreatic Cancer.” Results: Only 50 articles ultimately met the inclusion criteria for this review. A total of 15 articles discussed the role of obesity and 10 discussed the influence of stress in increasing the risk of pancreatic cancer. Six discussed the potential beneficial role of Vitamins, 5 of cannabinoids, 4 an anti-inflammatory diet, 3 of nut consumption, 2 of green tea consumption, 2 of curcumin supplementation, 1 role of melatonin, and 1 of probiotics. One article each was found on the theoretical benefits of adhering to either a Mediterranean or ketogenic diet. Discussion: As more surgeons become interested in IM, it is hoped that more diseases where the curative treatment is mainly surgical can benefit from the all-encompassing principles of IM in an effort to improve quality of life and survival in patients with pancreatic cancer.

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