Correlation between prostate-specific antigen and histopathological difference of prostate carcinoma

BACKGROUND: Adenocarcinoma of prostate (ACP) is one of the most frequent tumors in men older than 50. Prostate specific antigen (PSA) is the most reliable serum marker in the diagnostics and following of prostate carcinoma, and Gleason's system of estimation of tumor differentiation, as well as classical estimation of tumor differentiation from 1 to 3, are generally accepted systems of prostate carcinoma evaluation. METHODS: Forty examined individuals with verified ACP and compared values of PSA and tumor differentiation as well as estimated comparability of these two systems are reported. RESULTS: Highly positive correlation between the values of PSA in serum and the degree of tumor differentiation determined by Gleason's system, as well as the low correlation between PSA and histological differentiation estimated using classical system from 1 to 3 were found. CONCLUSION: It could be concluded that Gleason's system for tumor differentiation determination is more superior system of histological grade determination than the other systems.