scholarly journals Uterine fibroids - clinical presentation and complications

2014 ◽  
Vol 61 (3) ◽  
pp. 41-48 ◽  
Author(s):  
Radmila Sparic ◽  
Milan Terzic ◽  
Antonio Malvasi ◽  
Andrea Tinelli
Keyword(s):  
Clinical Presentation ◽  
Treatment Options ◽  
Uterine Fibroids ◽  
Benign Tumors ◽  
Significant Morbidity ◽  
Childbearing Age ◽  
Invasive Treatment ◽  
Gynecological Examination ◽  
Adjacent Structures ◽  
Pain Symptoms

Fibroids are the most common benign tumors of the genital organs in women of childbearing age. In some women, fibroids can be present for years without any symptoms and then are discovered accidentally during a gynecological examination. In others, they can cause significant morbidity and necessitate the need for multiple surgical procedures. The scope of this clinical review is to provide information about the clinical data as well as the complications of uterine fibroids and their clinical presentation. The most common symptoms that may occur in women with uterine fibroids include: bleeding (menometrorrhagia, metrorrhagia or intermenstrual bleeding), pain, symptoms of compression of adjacent structures, changed appearance of the abdomen and infertility. Complications of uterine fibroids include: venous thromboembolism, torsion of pedunculated fibroids, acute urinary retention and renal insufficiency, vaginal and intraabdominal bleeding, mesenteric vein thrombosis and gangrene of the intestine. Complications of uterine fibroids fibroids are rare and though they may cause significant morbidity, and rarely, mortality, which indicates the need for further research in this area. Accurate diagnosis is an essential prerequisite for the evaluation of therapeutic options, especially recently, when medical and numerous non-invasive treatment options have become available.

scholarly journals Updated Costs of Uterine Fibroid Treatments Including Focused Ultrasound Surgery

2018 ◽  
Author(s):  
Bijan J. Borah ◽  
Elizabeth A. Stewart
Keyword(s):  
Magnetic Resonance ◽  
Focused Ultrasound ◽  
Treatment Options ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Invasive Treatment ◽  
Ultrasound Surgery ◽  
Non Invasive ◽  
Focused Ultrasound Surgery ◽  
Reproductive Age Women

Uterine leiomyomas (fibroids) affect 20–40% of reproductive age women and are the major indication for hysterectomy. Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) is a new, potentially disruptive, non-invasive and uterine-sparing treatment option that has been shown to yield similar or better clinical outcomes than other uterine-sparing interventions. However, the costs of MRgFUS and other minimally-invasive treatment options have not been studied using US practice data. This study attempts to fill this void. And since uterine fibroids are the first FDA-approved indication for MRgFUS treatment, this study may also have implications for other indications which are now investigational.

Highlights on Medical Treatment of Uterine Fibroids

2021 ◽  
Vol 26 ◽  
Author(s):  
Stefano Angioni ◽  
Maurizio N. D’Alterio ◽  
Angelos Daniilidis
Keyword(s):  
Medical Treatment ◽  
Treatment Effectiveness ◽  
Treatment Options ◽  
Uterine Fibroids ◽  
European Medicines Agency ◽  
Benign Tumors ◽  
Medical Treatments ◽  
Advantages And Disadvantages ◽  
Receptor Modulators ◽  
Progesterone Receptor Modulators

: Uterine fibroids (leiomyomas or myomas) are the most frequent benign tumors in women. Heavy menstrual bleeding with resultant anemia, dysmenorrhea, chronic pelvic pain, infertility urinary symptoms and constipation are generally associated with uterine fibroids (UFs). Although strategies mainly resort to surgical intervention, medical treatments are considered the first-line treatment to preserve fertility and avoid surgery. The aim of this review is to offer available and newest medical treatment options for symptomatic UFs. Various medical therapies are now available for women with uterine fibroids, although each therapy has its own advantages and disadvantages. Our topic specifically explores gonadotropin-releasing hormone (GnRH) analogs and selective progesterone receptor modulators (SPRMs), but also provides the reader with useful advice on the therapies for fibroids available after the recent European Medicines Agency (EMA) warning (EMA/160220/2020). The treatment options depend on the personal treatment objectives of the patients, in addition to treatment effectiveness and necessity for recurrent interventions.

scholarly journals A study of menstrual disturbance in cases of fibroid uterus

2017 ◽  
Vol 6 (6) ◽  
pp. 2494 ◽  
Author(s):  
Rajeshwari Laxman Khyade
Keyword(s):  
Negative Impact ◽  
Uterine Fibroids ◽  
Economic Cost ◽  
Reproductive Age ◽  
Benign Tumors ◽  
Public Health Burden ◽  
Fibrotic Tissue ◽  
Menstrual Disturbance ◽  
One Year ◽  
Pain Symptoms

Background: Leiomyoma’s also called fibroids due to their abundant fibrotic tissue have a 70-80% cumulative incidence in childbearing years. Fibroids are the most common occurring benign tumors. Fibroids represent a tremendous public health burden on women and economic cost on society.Methods: It is prospective study done over a period of one year, 50 cases presenting to the obstetrics and gynecology department. Women included were in their reproductive age between 30-55 yrs. of age and had experienced menstrual bleeding complaints.Results: The prevalence of uterine fibroids ranged from 46% in age group 41-45yrs, 24% in 46-50yrs, and 11% in 36-40yrs. Women with uterine fibroids complained of menorrhagia in 78%, dysmenorrhea in 30%, metrorrhagia in 10%, polymenorrhea 22%, pain in abdomen 22%, urinary problem 8%, SCOPV 6%, primary infertile 4%, leucorrhea 12% and lump in abdomen 4%.Conclusions: Uterine fibroid is a common problem in women of reproductive age causing various bleeding and pain symptoms that can have negative impact on various aspects of women’s life.

scholarly journals Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

2021 ◽  
Author(s):  
Qiwei Yang ◽  
Michal Ciebiera ◽  
Maria Victoria Bariani ◽  
Mohamed Ali ◽  
Hoda Elkafas ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Treatment Options ◽  
Uterine Fibroids ◽  
Current Treatment ◽  
Future Perspectives ◽  
Invasive Treatment ◽  
Treatment Interventions ◽  
Comprehensive Review ◽  
Non Invasive

Abstract Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the most common tumors in women worldwide. To date, no long-term or non-invasive treatment option exists for hormone-dependent uterine fibroids due to the limited knowledge about the molecular mechanisms underlying the initiation and development of uterine fibroids. This paper comprehensively summarizes the recent research advances on uterine fibroids, focusing on their risk factors, development origin, pathogenetic mechanisms, and treatment options. Additionally, we describe the current treatment interventions for uterine fibroids. Finally, future perspectives on uterine fibroids studies are summarized. Deeper mechanistic insights into tumor etiology and uterine fibroids’ complexity can contribute to the newer targeted therapies.

scholarly journals Clinical presentation and prevalence of uterine fibroids: a 3-year study in 3-decade rural South Indian women

2017 ◽  
Vol 6 (12) ◽  
pp. 5596 ◽  
Author(s):  
Mohanambal M. Munusamy ◽  
Wills G. Sheelaa ◽  
Vijaya P. Lakshmi
Keyword(s):  
Rural Women ◽  
Clinical Presentation ◽  
Uterine Fibroids ◽  
Pelvic Mass ◽  
Previous Treatment ◽  
Benign Tumors ◽  
Sonographic Examination ◽  
Nulliparous Women ◽  
South Indian

Background: Uterine fibroids are benign tumors arising from smooth muscle cells of myometrium. This study was conducted in rural women belonging to poor socio-economic class and primary school dropouts to find out clinical presentation, prevalence of uterine fibroids, their knowledge about health services and to develop modalities to improve awareness and early reporting to prevent morbidity and improve quality of life.Methods: Women ranging from 26-55 years age attending Gynecology OPD of SSSMCRI for abdominopelvic mass, pain, menstrual abnormalities over a period of 3 years were registered for the study. Socio-demographic profile, detailed menstrual history, reason for attending hospital and previous treatment taken prior to the hospital visit were recorded. Women with pregnancy with fibroids and fibroids detected by ultra-sonogram less than 12 weeks were excluded from the study. Clinical, local and ultra-sonographic examination was done for the morphology of the fibroids. Comparison was done with histological picture for accuracy in clinical and sonographic diagnosis.Results: 362 women who presented with uterine fibroids, menorrhagia or with abdomino pelvic mass were registered for this study. Of 136 patients who had uterine fibroids 66% had menorrhagia with severe anemia, 23% needed blood transfusion, 17 were nulliparous women. Menorrhagia was the commonest menstrual pattern seen in 58.8% women. Asymptomatic fibroids with huge abdomino pelvic mass was seen in 46 women (33%). The size was 12-28 weeks. The mean age was 46 years. Abdominal hysterectomy was done in 88 women, and 3 in-situ hysterectomies (91 cases) (67%), polypectomy in 16 and myomectomy in 22 nulliparous women. Laparotomy for torsion sub-serous fibroids was done in 7.Conclusions: Further research is needed to find out biological factors causing fibroids including diet, stress, environmental and racial influences. Routine screening, early detection, increase awareness by early reporting to the hospital will reduces morbidity and improves quality of life socioeconomically.

Numerical Simulation of Cryosurgery as a Potential Treatment for Uterine Fibroids

2010 ◽  
Author(s):  
Katherine McCaffrey ◽  
Karen Rose ◽  
John P. Abraham
Keyword(s):  
Solid Phase ◽  
Treatment Options ◽  
Fibrous Tissue ◽  
Uterine Fibroids ◽  
Blood Perfusion ◽  
Bioheat Transfer ◽  
Benign Tumors ◽  
Transfer Model ◽  
Bioheat Equation ◽  
Survival Studies

Nearly 80% of all women may suffer from menorrhagia caused by uterine fibroids (leiomyomas) which are benign tumors made up of muscle and fibrous tissue that grow from the muscular wall of the uterus. The vast majority of women whose symptoms are strong enough to require treatment obtain a hysterectomy. Other treatment options which are less invasive than hysterectomy include thermal therapies such as thermal ablation or cryosurgical removal of tissue. This project numerically evaluates the efficacy of a liquid-nitrogen-based cryotherapy for the treatment of uterine fibroids. A bioheat transfer model was utilized which includes both the effects of blood perfusion and the impacts of liquid-to-solid phase change. Changes in all physical properties including thermal conductivity, heat capacity, and perfusion rate were taken into account as the tissue passed through a range of temperatures where it would be transitioning from unfrozen to fully frozen. The numerical model was based on a one-dimensional unsteady bioheat equation. The results show that even for the direct-contact cooling, it is unlikely that intracellular ice would form during the procedure. On the other hand, based on data obtained from previous cell-survival studies, it was found that necrosis would occur when the cooling rates exceeded 30°/min. According to the present numerical results, necrosis would occur within the tissue up to a depth of approximately 5.8 mm, thereby ensuring that sufficient tissue would be cryosurgically destroyed to result in effective treatment.

scholarly journals MINIMALLY INVASIVE TREATMENT OF ABDOMINAL LYMPHOCELE: A REVIEW OF CONTEMPORARY OPTIONS AND HOW TO APPROACH THEM

Lymphology ◽  
2021 ◽  
Vol 54 (2) ◽  
Author(s):  
F. Khorshidi ◽  
B.S. Majdalany ◽  
G. Peters ◽  
A.N. Tran ◽  
J. Shaikh ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Treatment Options ◽  
Mass Effect ◽  
Percutaneous Treatment ◽  
Minimally Invasive Treatment ◽  
Invasive Treatment ◽  
Adjacent Structures ◽  
Limb Edema ◽  
Fluid Collections ◽  
Lymphatic Fluid

Lymphoceles are lymphatic fluid collections resulting from lymphatic vessel disruption after surgery or trauma. They are most often described following retroperitoneal surgeries such as cystectomies, prostatectomies, renal transplants, and gynecologic surgeries. Most lymphoceles are asymptomatic and resolve spontaneously without treatment. If persistent, they can become infected or exert mass effect on adjacent structures causing pain, urinary, or lower limb edema particularly for lymphoceles in the pelvis Symptomatic lymphoceles should be treated to relieve symptoms and prevent functional compromise of vital adjacent structures. Although surgery has been traditionally accepted as the gold standard treatment, advances in imaging and interventional technology allow for less invasive, percutaneous treatment. Available minimally invasive treatment options include percutaneous aspiration, catheter drainage, sclerotherapy, and lymphangiography with lymphatic embolization. A review of these treatment options and a suggested algorithm for managing lymphoceles is presented.

An Overview of Dementias

2012 ◽  
Vol 21 (3) ◽  
pp. 75-84
Author(s):  
Venkata Vijaya K. Dalai ◽  
Jason E. Childress ◽  
Paul E Schulz
Keyword(s):  
Clinical Presentation ◽  
Treatment Options ◽  
Current Treatment ◽  
Great Variability ◽  
Health Concern ◽  
Public Health Concern ◽  
Life Threatening ◽  
The Common ◽  
Neurodegenerative Dementias ◽  
Made In

Dementia is a major public health concern that afflicts an estimated 24.3 million people worldwide. Great strides are being made in order to better diagnose, prevent, and treat these disorders. Dementia is associated with multiple complications, some of which can be life-threatening, such as dysphagia. There is great variability between dementias in terms of when dysphagia and other swallowing disorders occur. In order to prepare the reader for the other articles in this publication discussing swallowing issues in depth, the authors of this article will provide a brief overview of the prevalence, risk factors, pathogenesis, clinical presentation, diagnosis, current treatment options, and implications for eating for the common forms of neurodegenerative dementias.

Phlegmasia cerulea dolens – an uncommon but alarming manifestation of deep vein thrombosis

VASA ◽  
2020 ◽  
Vol 49 (5) ◽  
pp. 422-426
Author(s):  
Manuela Nickler ◽  
Sebastian Haubitz ◽  
Adriana Méndez ◽  
Martin Gissler ◽  
Peter Stierli ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Treatment Options ◽  
Bleeding Risk ◽  
Venous Intervention ◽  
Aggressive Treatment ◽  
Vein Thrombosis ◽  
Prompt Treatment ◽  
Surgical Thrombectomy ◽  
Deep Vein ◽  
Phlegmasia Cerulea Dolens

Summary: In phlegmasia cerulea dolens (PCD), immediate diagnosis and prompt treatment is crucial for limb salvage. Aggressive treatment options including venous intervention, thrombolysis and/or surgical thrombectomy should be considered. Due to the lack of data, the most appropriate intervention depends upon etiology of PCD, clinical presentation and patient’s bleeding risk.

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