scholarly journals New viewpoint to histological classification of malignant epithelial tumors of nasopharynx

2005 ◽  
Vol 52 (3) ◽  
pp. 69-75 ◽  
Author(s):  
Svetlana Stosic-Divjak ◽  
Vladimir Kanjuh ◽  
V. Djukic ◽  
Alek Racic ◽  
V. Nesic ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Maxillofacial Surgery ◽  
Epithelial Tumor ◽  
Barr Virus ◽  
Serological Examination ◽  
Clinical Center ◽  
Important Correlation ◽  
Malignant Epithelial Tumor ◽  
Epstein Barr

Malignant tumors of nasopharyngeal epithelium differ clinically depending on the course of disease and applied therapy. They are presented in regard to the sex, age, smoking habits, alcohol usage and nutrition factors. Various studies already showed various etiological-causal links with Epstein- Barr virus (EBV). This leads to diversity of various morphological and histological types of diseases belonging to various classifications. In this work we presented 60 diagnosed and treated cases with malignant tumor of nasopharyngeal epithelium in the Institute for Otorynolaringology and maxillofacial surgery of Clinical Center of Serbia. All of them were pato-histologicaly examined and 24 of them received serological examination in regard to the concept of association between malignant epithelial tumor and EBV. An important correlation between histopathology and serology was found. Finally, the terminology used by WHO classification is not optimal for further histological determination of nasopharyngeal malignancy; therefore we recommend the French classification of C. Micheaua.

scholarly journals How immunologic and genetic biomarkers impact Hodgkin lymphoma classification, diagnosis, and management: a huge potential that yet needs to be exploited

2017 ◽  
Vol 33 (2) ◽  
pp. 137-140 ◽  
Author(s):  
Antonino Carbone ◽  
Annunziata Gloghini
Keyword(s):  
Hodgkin Lymphoma ◽  
Molecular Genetic ◽  
Scientific Basis ◽  
Grey Zone ◽  
Molecular Virology ◽  
Barr Virus ◽  
Long Time ◽  
Modern Classification ◽  
Epstein Barr

“Ne è passata di acqua sotto i ponti.” It has been a long time since the diagnosis of Hodgkin lymphoma (HL) was exclusively based on the detection of typical Reed-Sternberg cells and the recognition of the characteristic morpho-histological background, as well as on the pathologist’s skill. The discovery of immunologic, molecular genetic and virologic biomarkers has provided an objective contribution to the diagnosis and a scientific basis for a modern classification of HL. Recent updates have clarified the nature of the so-called nodular lymphocyte predominant HL and its link to the T-cell/histiocyte-rich large B-cell lymphomas as well as its relationship with the lymphocyte-rich subset of classical HL (CHL). Molecular virology studies assessed a role for the Epstein-Barr virus in the pathogenesis of a fraction of CHL of the general population, and virtually in all cases of CHL occurring in people infected by HIV. Finally, immunologic and genetic findings corroborated the existence of grey zone lymphomas at the edges of CHL. Overall, these advances provided additional and useful information to address the treatment of patients affected by HL.

scholarly journals Update on Gastrointestinal Lymphomas

2018 ◽  
Vol 142 (11) ◽  
pp. 1347-1351 ◽  
Author(s):  
Steven C. Weindorf ◽  
Lauren B. Smith ◽  
Scott R. Owens
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
World Health ◽  
Barr Virus ◽  
Not Otherwise Specified ◽  
Gastrointestinal Lymphomas ◽  
Epstein Barr ◽  
Health Organization

Herein we review the following selection of gastrointestinal lymphomas: monomorphic epitheliotropic intestinal T-cell lymphoma; indolent T-cell lymphoproliferative disorder of the gastrointestinal tract; intestinal T-cell lymphoma, not otherwise specified; duodenal-type follicular lymphoma; and Epstein-Barr virus–positive mucocutaneous ulcer. Definitions reflect the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Clinical, morphologic, and immunophenotypic characteristics of each entity are emphasized.

scholarly journals Epstein-Barr virus, human cytomegalovirus, human herpesvirus 6 and 7, human adenovirus, John Cunningham virus, and BK virus are not associated with gliomas in humans

2021 ◽  
Author(s):  
Bożena Czarkowska-Pączek ◽  
Rafal Górski ◽  
Aleksandra Wyczałkowska-Tomasik ◽  
Maciej Bujko ◽  
Leszek Pączek
Keyword(s):  
Epstein Barr Virus ◽  
Human Herpesvirus ◽  
Human Adenovirus ◽  
Bk Virus ◽  
John Cunningham Virus ◽  
Barr Virus ◽  
Risk Of Death ◽  
Course Material ◽  
Epstein Barr

Introduction: The literature points to several viruses associated with brain carcinogenesis, including gliomas. Aim: The aim of this study was to assess the presence of several viruses in gliomas and plasma from patients with brain tumor and the possible association of viral positivity with the clinical course. Material and methods: The study group consisted of 37 patients with gliomas who were subjected to surgery. Mean patient age was 54.59 (SD 15.85) years. The presence of viral DNA was assessed using real-time polymerase chain reaction. Results and discussion: We did not confirm any BK virus, John Cunningham virus, or human adenovirus-positive gliomas. The percentage of patients with gliomas positive for Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpesvirus (HHV) 6 and 7 was 18.9%, 8.1%, 2.7%, and 10.8%, respectively. We did not confirm the co-occurrence of glioma and plasma viral positivity. Fisher’s test did not reveal the influence of viral infection on the risk of death. We did not detect any differences regarding sex, WHO classification of gliomas, or the functional impairment evaluated by the Karnofsky scale index at admission to the hospital in the group of patients positive or negative for EBV, CMV, or HHV6. Conclusions: We cannot confirm an association of the investigated viruses with gliomas.

scholarly journals Detección del Virus de Epstein-Barr en linfoma mediante qPCR //Detection of Epstein-Barr Virus (EBV) in lymphoma through qPCR

Ciencia Unemi ◽  
2018 ◽  
Vol 11 (26) ◽  
pp. 126 ◽  
Author(s):  
Sunny Sánchez-Giler ◽  
Alan Herrera-Vásquez ◽  
Claudia Castillo-Zambrano ◽  
Luis Solórzano-Alava ◽  
Dolores Zambrano-Castro ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Malignant Tumors ◽  
Tissue Samples ◽  
Virus Identification ◽  
Barr Virus ◽  
Non Hodgkin Lymphoma ◽  
Latently Infected ◽  
Infected Cells ◽  
Epstein Barr

Virus Epstein Barr (VEB) ha sido relacionado con una serie de tumores malignos de origen epitelial y linfoide. Existe una clara correlación entre este virus y enfermedades linfoproliferativas como Linfoma de Burkitt (LB), Linfoma Hodgkin (LH), Linfoma no Hodgkin (LNH) y carcinoma gástrico. Se han desarrollado diversas técnicas para la detección de VEB en células tumorales: hibridación in situ (RISH) que detecta RNAs (ácido ribonucleico) pequeños codificados para VEB (EBERs) en las células con infección latente, considerado el estándar de oro para la identificación del virus; la reacción en cadena de la polimerasa (PCR) que permite la detección de la cepa viral y representa un ensayo importarte en el diagnóstico del virus. Se realizó un estudio retrospectivo a partir de muestras de tejidos en parafina de pacientes con linfoma y se buscó al virus mediante PCR y RISH. La prevalencia del virus fue de 58,82%, el género más afectado fue el masculino y el grupo más afectado fue el de 31/40 años. La presencia del virus fue similar en ambos tipos de linfoma: Hodking y No Hodking. La técnica de RISH se mostró más eficiente para detectar la presencia del virus. AbstractEpstein Barr Virus (EBV) is linked to a number of malignant tumors of epithelial and lymphoid origin. There is a strong correlation between this virus and lymphoproliferative diseases such as Burkitt's lymphoma (BL), Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL) and gastric carcinoma. There are various techniques developed to detect EBV in tumor cells: in situ hybridization (ISH) detects small coded RNAs (ribonucleic acid) to VEB (EBERs) in latently infected cells. This is considered the gold standard for virus identification. The polymerase chain reaction (PCR) allows the detection of the viral strain and represents an important fact in the virus diagnose. We conducted a retrospective study in paraffin from tissue samples of patients with lymphoma and we sought the virus through PCR and RISH. The virus prevalence was 58.82%, the most affected gender was male and the most affected group was 31/40 years. The virus was similar in both types of lymphoma: Hodgkin and non-Hodgkin. RISH technique seemed to be more efficient to detect the virus.

scholarly journals Burkitt Lymphoma with Multiorgan Involvement

2018 ◽  
Vol 04 (01) ◽  
pp. 024-028
Author(s):  
Venus Kumar ◽  
H R Chandrashekhar ◽  
Suresh Hanagavadi
Keyword(s):  
B Lymphocytes ◽  
Burkitt Lymphoma ◽  
Epstein Barr Virus ◽  
Malignant Tumors ◽  
Indian Children ◽  
Barr Virus ◽  
Poorly Differentiated ◽  
Epstein Barr ◽  
Rare Malignancy ◽  
Solid Malignant Tumors

AbstractBurkitt lymphoma (BL) is classified as a poorly differentiated lymphocytic lymphoma of B lymphocytes. It mainly affects children. It is one of the rapidly growing tumors in humans, with profuse proliferation. It is a rare malignancy comprised of only 0.76% of solid malignant tumors among Indian children.Symptoms occur because of rapid turnover of the mature B lymphocytes with involvement of the extranodal sites and involvement of adjacent organs. Initially, this tumor was identified in Africans. The cause of this tumor is uncertain, but shows strong evidence with Epstein–Barr virus (EBV) in its development. A case of BL with multiorgan involvement in a 7-year-old girl was reported, which was confirmed by immunohistochemistry (IHC).

Classification of Epstein–Barr Virus–Positive Gastric Cancers by Definition of DNA Methylation Epigenotypes

2011 ◽  
Vol 71 (23) ◽  
pp. 7187-7197 ◽  
Author(s):  
Keisuke Matsusaka ◽  
Atsushi Kaneda ◽  
Genta Nagae ◽  
Tetsuo Ushiku ◽  
Yasuko Kikuchi ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Epstein Barr Virus ◽  
Gastric Cancers ◽  
Barr Virus ◽  
Epstein Barr ◽  
Definition Of

scholarly journals Significance of confirming Epstein-Barr virus nuclear antibody as tumor marker

2007 ◽  
Vol 64 (7) ◽  
pp. 459-462 ◽  
Author(s):  
Svetlana Stosic-Divjak ◽  
Vojko Djukic ◽  
Ivan Boricic ◽  
Alek Racic ◽  
Isidora Divjak ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Blood Donors ◽  
Malignant Tumors ◽  
Barr Virus ◽  
Group A ◽  
Causal Treatment ◽  
Nasopharyngeal Tumors ◽  
Epstein Barr ◽  
Group B ◽  
Group D

Backgrounnd/Aim. Study of the association between Epstein-Barr virus (EBV) and the tumors of the nasopharynx renders an opportunity to introduce causal treatment. Already have been proven the anti-EBV (anti-Epstein-Barr nucleus antigene) antibodies in the blood serum of the patients infected with EBV, while over 91% of the patients with nasopharyngeal malignant tumors also have a detectable anti-EBV marker. The aim of this research was to determine if there were anti-EBV antibodies in the serum of the patients with the already verified nasopharyngeal malignant tumors, and, if there were, to determine the quantitative ratio to the values in the serum of the healthy controls. Methods. The study involved 74 individuals in the period from 1994?2001 divided into four groups: group A counting 11 patients with undifferentiated carcinome of nasopharyngeal type (UCNT); group B counting 25 patients with UCNT Xray treated at least three years before the onset of the study; group C including 28 healthy subjecets (blood donors), and the group D with 10 patients with planocellular nasopharyngeal carcinoma. Serologic diagnostics of the patients serum was performed using the techniques of Reedman and Klein for the detection of anti-EBV antibodies in the serum. Results. The presence of the statistically significantly higher values of the mean geometric titer (MGT) of the anti- EBNA antibodies was determined in 36 patients with histologically verified UCNT as compared with the control groups including 10 patients with planocellular carcinomas of the nasopharynx and 28 blood donors. Presented were anti-EBNA titers with 95% confidence interval for any participants according to the Hoo clinical classification of nasopharyngeal tumors, as well as according to the fact if they had been radiotreated within the previous three years. Conclusion. The results of this study confirm the conclusions of the recent literature on the possible etiopathogenesis of nasopharyngeal tumors and the use of viral anti-EBNA antibodies as viral markers in the diagnostics of UCNT diseases. .

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