scholarly journals The influence of vitamin E supplementation on the oxidative status of rat liver

2010 ◽  
Vol 62 (3) ◽  
pp. 677-681 ◽  
Author(s):  
S.F. Djurasevic ◽  
Jelena Djordjevic ◽  
N. Jasnic ◽  
Iva Lakic ◽  
P. Vujovic ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Liver Lipid ◽  
Oxidative Status ◽  
Activity Level ◽  
Sod Activity ◽  
Peroxide Content ◽  
Tocopheryl Succinate ◽  
Liver Lipid Peroxidation ◽  
Vitamin E Supplementation

We tested to see if the additional intake of vitamin E in the form of ?-tocopheryl-succinate would improve liver antioxidative protection. Thus, we studied the tissue oxidative status in rats supplemented by two doses of the antioxidant over a four week period of time. Our results confirmed that the additional intake of vitamin E decreased the liver lipid peroxidation level and SOD activity level and preserved its vitamin C content. However, the hydrogen peroxide content and catalase activity remained unchanged, probably due to the mechanism of vitamin E liver metabolism. .

scholarly journals The influence of vitamin e supplementation on the oxidative status of rat interscapular brown adipose tissue

2010 ◽  
Vol 62 (4) ◽  
pp. 993-997
Author(s):  
S.F. Djurasevic ◽  
Jelena Djordjevic ◽  
N. Jasnic ◽  
Iva Lakic ◽  
P. Vujovic ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Adipose Tissue ◽  
Vitamin E ◽  
Brown Adipose Tissue ◽  
Oxidative Status ◽  
Activity Levels ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose ◽  
Tocopheryl Succinate ◽  
Vitamin E Supplementation

We tested whether the additional intake of vitamin E in the form of ?-tocopheryl-succinate would improve the interscapular brown adipose tissue (IBAT) antioxidative protection. Thus, we studied the tissue oxidative status in rats supplemented by two doses of vitamin E over a four-week period. Our results confirmed that vitamin E supplementation decreased the IBAT lipid peroxidation level, SOD and catalase activity levels, the hydrogen peroxide concentration and spared its vitamin C content.

Metallothionein response to stress in rats: role in free radical scavenging

1988 ◽  
Vol 255 (4) ◽  
pp. E518-E524 ◽  
Author(s):  
J. Hidalgo ◽  
L. Campmany ◽  
M. Borras ◽  
J. S. Garvey ◽  
A. Armario
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Liver Lipid ◽  
Radical Scavenging ◽  
Antioxidant Vitamin ◽  
Response To Stress ◽  
Liver Lipid Peroxidation

The possibility that liver metallothionein (MT) can function as an antioxidant in vivo has been studied in the rat. It was found that the stress of food and water deprivation with or without physical immobilization consistently increased liver lipid peroxidation (LLP), suggesting that liver MT induction by stress might be related to the stress-induced LLP. This was supported by results with the lipid peroxidation promoter dimethyl sulfoxide (DMSO) and the natural antioxidant vitamin E. Whereas DMSO administration increased LLP levels in basal and stress situations, vitamin E decreased them. Liver MT levels were increased by DMSO in basal and stress situations, whereas they were decreased by vitamin E during stress. These in vivo results are consistent with an antioxidant role of liver MT suggested by previous in vitro results. However, liver MT preinduction by Zn treatment did not result in a lower MT response to stress. Instead a positive synergistic effect between Zn and stress appeared to be present. This result indicates that the mechanism of action of MT as antioxidant remains unclear.

Vitamin E decreases hepatic levels of aldehyde-derived peroxidation products in rats with iron overload

1996 ◽  
Vol 270 (2) ◽  
pp. G376-G384 ◽  
Author(s):  
S. Parkkila ◽  
O. Niemela ◽  
R. S. Britton ◽  
K. E. Brown ◽  
S. Yla-Herttuala ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Iron Overload ◽  
Kupffer Cells ◽  
Laser Scanning ◽  
Laser Scanning Microscopy ◽  
Alpha Tocopherol ◽  
Confocal Laser ◽  
Hepatocellular Injury ◽  
Vitamin E Supplementation

Hepatic iron overload can cause lipid peroxidation with the formation of aldehydic products, hepatocellular injury, and fibrosis. Vitamin E (alpha-tocopherol) may prevent peroxidation-induced hepatic damage. We used confocal laser scanning microscopy, digital image analysis, and immunohistochemical methods to quantitate aldehyde-derived peroxidation products in the liver of rats with experimental iron overload with or without supplemental vitamin E. A strong autofluorescent reaction colocalizing with iron deposits was present in the livers of iron-loaded rats. Fluorescent granules were unevenly distributed in the cytosol of both hepatocytes and Kupffer cells in the periportal regions. Immunohistochemical studies revealed the presence of malon-dialdehyde adducts in the periportal regions of the ironloaded rats. Vitamin E supplementation markedly reduced the fluorescence intensity and the amount of aldehyde-derived peroxidation products and changed the distribution of stainable iron and iron-associated peroxidation products such that their levels were much decreased in Kupffer cells. These results indicate that aldehyde-derived covalent chemical addition products are formed in the liver in iron overload. Vitamin E supplementation markedly reduces the amount of these compounds and changes their cellular distribution. These findings should be implicated in the role of antioxidant therapy in conditions causing iron overload and lipid peroxidation.

Dietary trans-resveratrol bioavailability and effect on CCl4-induced liver lipid peroxidation

2009 ◽  
Vol 24 (4) ◽  
pp. 618-622 ◽  
Author(s):  
Paola Vitaglione ◽  
Barbara Ottanelli ◽  
Stefano Milani ◽  
Filomena Morisco ◽  
Nicola Caporaso ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Liver Lipid ◽  
Liver Lipid Peroxidation
Sign in / Sign up

Export Citation Format

Share Document