scholarly journals Determination of total antioxidant status (TAS) as a biochemical parameter in control of workers' health

2009 ◽  
Vol 61 (3) ◽  
pp. 375-382 ◽  
Author(s):  
Olga Jozanov-Stankov ◽  
Jovanka Djuric ◽  
Branislava Dobutovic ◽  
Esma Isenovic
Keyword(s):  
Biochemical Parameters ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Biochemical Parameter ◽  
Defense System ◽  
Working Population ◽  
Regular Control ◽  
Total Antioxidant ◽  
Biochemical Analyses

Despite its importance for human health, the capacity of the antioxidative defense system (AOS) is still not included among regular biochemical analyses. In this study, we estimated the blood plasma level of the total antioxidant status (TAS) as an appropriate parameter for AOS monitoring with the aim of including it among other biochemical parameters in the regular control of health of the working population. We have applied a method developed by Randox Laboratories (England) that can be routinely performed on automatic chemical analyzers. The TAS level, in correlation with corresponding biochemical parameters, could contribute to better evaluation of the health of individuals and the working population.

scholarly journals The antioxidant defense system of Varroa destructor mites facilitates the infestation of Apis mellifera

2016 ◽  
Vol 60 (1) ◽  
pp. 163-166
Author(s):  
Kamila Dmochowska-Ślęzak ◽  
Małgorzata Dmitryjuk ◽  
Ewa Zaobidna ◽  
Krystyna Żółtowska
Keyword(s):  
Antioxidant Enzymes ◽  
Varroa Destructor ◽  
Antioxidant Status ◽  
Antioxidant Defense ◽  
Total Antioxidant Status ◽  
Antioxidant Defense System ◽  
Low Molecular Weight ◽  
Defense System ◽  
Total Antioxidant ◽  
Parasitic Mite

Abstract Varroa destructor is a parasitic mite of the Western honey bee. The activity of five antioxidant enzymes of V. destructor were analysed. Glutathione content and total antioxidant status was also evaluated. Our results suggest that antioxidant enzymes constitute the main line of defense against ROS in V. destructor, whereas low-molecular-weight antioxidants play a limited role in the antioxidant system of mites.

A Suggested Method for the Prediction of the Oxidation Resistance of Low Density Lipoprotein by Determination of the Lag Time

2002 ◽  
Vol 16 (2) ◽  
pp. 107-112 ◽  
Author(s):  
M.R. Naghii
Keyword(s):  
Antioxidant Status ◽  
Healthy Adult ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Total Antioxidant Status ◽  
Lag Time ◽  
Lag Phase ◽  
Adult Males ◽  
Total Antioxidant

A simple clinical blood test, which measures the total antioxidant status of Low Density Lipoprotein (LDL) and therefore its vulnerability to oxidative stress is suggested, and as a first stage this was tried on a small sample of eight healthy adult males. The body's natural defence and repair systems try to handle all free radicals, but these systems are not hundred percent effective. Thereby, the role of antioxidants (particularly natural antioxidants) becomes evident and vitamins such as Vitamin C, Vitamin E, and compounds like beta-carotene are under especially extensive study. Vitamin C is the most abundant water-soluble antioxidant acting in extracellular fluid, while Vitamin E is the most abundant fat-soluble antioxidant, and it protects the polyunsaturated fatty acids within the LDL from oxidation and helps to prevent the process of atherogenesis. The determination of ‘lag-phase’ during continuous monitoring of oxidation of LDL in vitro is a convenient and objective procedure for determining the susceptibility of LDL from different donors towards oxidation as well as of pro- and anti-oxidants. The Lag-time for LDL samples, obtained from eight healthy adult males was found to be between 40–50 minutes. The measurement of this Lag-phase could be a highly promising routine method for measuring the total antioxidant status of LDL.

Effect of Piperine on the Pharmacokinetics and Pharmacodynamics of Glimepiride in Normal and Streptozotocin - Induced Diabetic Rats

2012 ◽  
Vol 7 (10) ◽  
pp. 1934578X1200701 ◽  
Author(s):  
Ciddi Veeresham ◽  
Samala Sujatha ◽  
Thatipamula Sandya Rani
Keyword(s):  
Biochemical Parameters ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Diabetic Rats ◽  
Pharmacokinetic Parameters ◽  
Control Group ◽  
Diabetic Patients ◽  
Significant Protection ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Total Antioxidant

The effect of piperine on the pharmacokinetics and pharmacodynamics of glimepiride in normal as well as diabetic rats was studied. In normal and streptozotocin induced diabetic rats the combination of glimepiride with piperine increased all the pharmacokinetic parameters, such as Cmax, AUC0-n, AUCtotal, t½, and MRT, and decreased the clearance, Vd, markedly as compared with the control group. In pharmacodynamic studies, the combination of glimepiride with piperine provided significant protection against the diabetes induced alterations in the biochemical parameters. In addition, the combination of glimepiride with piperine also improved the total antioxidant status significantly in diabetic rats compared with piperine and glimepiride treated groups. The results revealed that a combination of glimepiride with piperine led to the enhancement of the bioavailability of glimepiride by inhibiting the CYP2C9 enzyme, which suggested that piperine might be beneficial as an adjuvant to glimepiride in a proper dose, in diabetic patients.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

Antioxidant status of blood in patients with vibration disease

2019 ◽  
pp. 978-982 ◽  
Author(s):  
N. N. Malyutina ◽  
A. F. Bolotova ◽  
R. B. Eremeev ◽  
A. Zh. Gilmanov ◽  
D. Yu. Sosnin
Keyword(s):  
Antioxidant Activity ◽  
Blood Serum ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Main Group ◽  
Biologically Active ◽  
Antioxidant Systems ◽  
Control Group ◽  
Vibration Disease ◽  
Total Antioxidant

Introduction. The overwhelming number of publications contains only data on the content of individual antioxidants, but not on the overall antioxidant activity of the blood in patients with vibration disease.The aim of the study was to determine the total antioxidant activity of blood serum in patients with vibration disease.Materials and methods. Th e main group consisted of 30 people diagnosed with “Vibration disease” of 1 degree (n=21) and 2 degrees (n=9). Th e control group consisted of 30 clinically healthy men, comparable in age with the main group (p=0.66). Th e total activity of antioxidant systems of blood plasma was evaluated photometrically using the test system “Total antioxidant status-Novo” (“Vector-best”, Russia).Results. The indicator of the total antioxidant status (TAS) was 1,038±0.232 mmol/l in the examined main group, against 1,456±0.225 mmol/l in the examined control group (p<0.000001). Th e coefficient of variation (CV) in patients with vibration disease was 22.35%, 1.45 times higher than in the control group (15.45%). In the main group there was a positive correlation between age and TAS (R=0.525), in the control group there was no such relationship (R=0.095). Th e degree of decrease depended on the severity of vibration disease.Conclusions. 1. The development of vibration disease is accompanied by a decrease in the antioxidant status of blood serum. 2. Th e degree of decrease in the antioxidant status of blood serum correlates with the severity of vibration disease. 3. Reduction of TAS can serve as a pathogenetic justification of the need to include drugs and/or biologically active additives with antioxidant activity in therapy

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