scholarly journals Peripapillary Perfused Capillary Density in Exfoliation Syndrome and Exfoliation Glaucoma versus POAG and Healthy Controls: An OCTA Study

2019 ◽  
Keyword(s):  
Capillary Density ◽  
Healthy Controls ◽  
Exfoliation Syndrome ◽  
Exfoliation Glaucoma

scholarly journals Reduced Superficial Capillary Density in Cerebral Infarction Is Inversely Correlated With the NIHSS Score

2021 ◽  
Vol 13 ◽  
Author(s):  
William Robert Kwapong ◽  
Yuying Yan ◽  
Zilong Hao ◽  
Bo Wu
Keyword(s):  
Cerebral Infarction ◽  
Capillary Density ◽  
Foveal Avascular Zone ◽  
Healthy Controls ◽  
Operating Characteristics ◽  
Microvascular Changes ◽  
Receiver Operating Characteristics Curve ◽  
Capillary Plexus ◽  
Magnetic Resonance Imaging Mri

Purpose: The retina and the brain share similar neuronal and microvascular features, therein we aimed to assess the structural and microvascular changes in the macula and choriocapillaris (CC) in patients with cerebral infarction when compared with healthy controls using optical coherence tomography angiography (OCTA).Methods: OCTA was used to image and measure the capillary density in the radial peripapillary capillaries (RPC), superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC), and mean area of the foveal avascular zone (FAZ) in all participants. Twenty-two cerebral infarction patients based on their magnetic resonance imaging (MRI) and 25 healthy controls were included in our study.Results: Density of the RPC (P < 0.001), SCP (P = 0.001), DCP (P < 0.001) and CC (P < 0.001) were significantly reduced in cerebral infarction patients when compared with healthy controls, respectively. Retinal thickness measurements (P < 0.05) were significantly reduced in cerebral infarction patients when compared with healthy controls. The mean FAZ area was significantly larger (P = 0.012) in cerebral infarction patients when compared with healthy controls. National Institute of HealthStroke Scale (NIHSS) inversely correlated with SCP density in cerebral infarction patients (Rho = −0.409, P = 0.001). Receiver operating characteristics curve analysis showed that the blood flow of the choriocapillaris had the highest index [area under the receiver operatingcharacteristic (AUROC) = 0.964] to discriminate cerebral infarction patients from the healthy controls.Conclusions: Our study suggests that cerebral microcirculation dysfunction which occurs in cerebral infarction is mirrored in the macula and choroidal microcirculation. OCTA has the potential to non-invasively characterize the macula and choroidal changes in cerebral infarction in vivo.

scholarly journals Nailfold capillary density is associated with the presence and severity of pulmonary arterial hypertension in systemic sclerosis

2008 ◽  
Vol 68 (2) ◽  
pp. 191-195 ◽  
Author(s):  
H M A Hofstee ◽  
A Vonk Noordegraaf ◽  
A E Voskuyl ◽  
B A C Dijkmans ◽  
P E Postmus ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Capillary Density ◽  
Total Width ◽  
Healthy Controls ◽  
Mean Pulmonary Arterial Pressure ◽  
Microvascular Changes ◽  
Pulmonary Arterial ◽  
Disease Specificity

Objective:The aim of this study was to investigate whether there are differences in capillary nailfold changes in patients with systemic sclerosis (SSc) with and without pulmonary arterial hypertension (PAH), and whether these changes are associated with PAH severity and disease specificity.Methods:Capillary density and loop dimensions were studied in 21 healthy controls, 20 patients with idiopathic PAH (IPAH) and 40 patients with SSc. Of the 40 patients with SSc, 19 had no PAH (SSc–nonPAH) and 21 had PAH (SSc–PAH), of whom eight had PAH during exercise.Results:Capillary density was lower in SSc–PAH compared with patients who had SSc–nonPAH (4.33/mm vs 6.56/mm respectively, p = 0.001), but loop dimensions were equal. In comparison with IPAH, patients with SSc–PAH had reduced capillary density (4.33/mm vs 7.86/mm, p<0.001) and larger loop dimensions (total width 101.05 µm vs 44.43 µm, p<0.001). Capillary density in healthy controls (9.87/mm) was significantly higher when compared with SSc–nonPAH (6.56/mm), SSc–PAH (4.33/mm) and with IPAH (7.86/mm). No differences in capillary dimensions were present between healthy controls and IPAH.Capillary density correlated with mean pulmonary arterial pressure (PAP) at rest in SSc–PAH at rest (r = −0.58, p = 0.039) and IPAH (r = −0.67, p = 0.001).Conclusions:Reduction of nailfold capillary density, but not capillary loop dimensions is associated with PAH, and correlates with the severity of PAH in both SSc and IPAH. This suggests that either systemic microvascular changes play a part in the development of PAH, or that PAH itself contributes to systemic microvascular changes.

Blue-field entoptic simulation in exfoliation syndrome and exfoliation glaucoma

2001 ◽  
Vol 33 (4) ◽  
pp. 309-314 ◽  
Author(s):  
Eija Vesti ◽  
Mika Harju ◽  
Päivi Puska ◽  
Ilkka Immonen
Keyword(s):  
Exfoliation Syndrome ◽  
Exfoliation Glaucoma

Abstract 3321: Gender Impacts Capillary Density and Skeletal Muscle Composition in Patients With Peripheral Arterial Disease

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
William S Jones ◽  
Brian D Duscha ◽  
Jennifer L Robbins ◽  
Amy J Aldrich ◽  
Judy G Regensteiner ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Gender Differences ◽  
Endothelial Cells ◽  
Muscle Fiber ◽  
Fiber Type ◽  
Capillary Density ◽  
Arterial Disease ◽  
Healthy Controls ◽  
Muscle Composition ◽  
Peripheral Arterial

Background : Peripheral arterial disease (PAD) is a disorder characterized by impaired blood flow to the legs and maladaptive changes in the skeletal muscle. It is generally accepted that the skeletal muscle characteristics in patients with PAD include decreased capillary density and an altered percentage of oxidative myofibers. The scientific literature is conflicting, and it is based on studies with small sample size and older methodologies of skeletal muscle analysis. In addition, women are under-represented or not included at all in these studies. Hypothesis : We hypothesized that there would be differences in skeletal muscle composition in PAD patients compared to healthy controls. We further hypothesized that there would be gender differences in skeletal muscle composition in PAD patients versus healthy controls. Methods : Thirty -one patients with PAD and 31 age-, gender-, and activity-matched healthy controls underwent gastrocnemius muscle biopsy. Capillary density analysis and muscle fiber type determination were performed using immunohistochemistry techniques. Capillary density was measured as endothelial cells per muscle fiber and endothelial cells per area (mm 2 ). Results : There was no significant difference in capillary density in patients with PAD versus healthy controls when measured as endothelial cells per fiber (mean = 1.45 ± 0.43 vs. 1.50 ± 0.35, NS) or area (mean = 1.20 ± 0.29 vs. 1.29 ± 0.33, NS). There was also no difference in muscle fiber type composition between the groups. In the PAD cohort, capillary density was significantly lower in the men versus the women (mean = 1.36 ± 0.35 vs. 1.59 ± 0.51, p=0.005). In our cohort of women, there was no difference in capillary density in patients with PAD versus healthy controls (N=12). In men, capillary density was significantly lower in the PAD group versus healthy controls (N=19, mean = 1.09 ± 0.20 vs. 1.28 ± 0.34, p=0.043). Conclusions : Our data fail to confirm the belief that patients with PAD have a decreased capillary density and an altered percentage of oxidative myofibers. However, we did find that gender has an important impact on these characteristics. Further study of skeletal muscle composition in PAD may help to better understand the functional relevance of the gender differences.

scholarly journals A Role for Clusterin in Exfoliation Syndrome and Exfoliation Glaucoma?

2018 ◽  
Vol 27 ◽  
pp. S61-S66 ◽  
Author(s):  
Janey L. Wiggs ◽  
Jae Hee Kang ◽  
BaoJian Fan ◽  
Hani Levkovitch-Verbin ◽  
Louis R. Pasquale
Keyword(s):  
Exfoliation Syndrome ◽  
Exfoliation Glaucoma

scholarly journals Retrobulbar hemodynamics and aqueous humor levels of endothelin-1 in exfoliation syndrome and exfoliation glaucoma

2018 ◽  
Vol Volume 12 ◽  
pp. 1199-1204 ◽  
Author(s):  
Stavroula Koukoula ◽  
Andreas Katsanos ◽  
Ioannis Tentes ◽  
Georgios Labiris ◽  
Vassilios Kozobolis
Keyword(s):  
Aqueous Humor ◽  
Exfoliation Syndrome ◽  
Endothelin 1 ◽  
Exfoliation Glaucoma ◽  
Retrobulbar Hemodynamics

Aqueous humour levels of ghrelin in exfoliation syndrome and exfoliation glaucoma patients

2014 ◽  
Vol 58 (4) ◽  
pp. 348-352
Author(s):  
Ayşe Vural Özeç ◽  
Ayhan Dursun ◽  
Mustafa İlker Toker ◽  
Yüksel Demirci ◽  
Aysen Topalkara ◽  
...  
Keyword(s):  
Aqueous Humour ◽  
Exfoliation Syndrome ◽  
Exfoliation Glaucoma

Hemodynamic evaluation of the posterior ciliary circulation in exfoliation syndrome and exfoliation glaucoma

2006 ◽  
Vol 245 (4) ◽  
pp. 516-521 ◽  
Author(s):  
Efstathios T. Detorakis ◽  
Athanassios K. Achtaropoulos ◽  
Eleni E. Drakonaki ◽  
Vassilios P. Kozobolis
Keyword(s):  
Exfoliation Syndrome ◽  
Exfoliation Glaucoma ◽  
Hemodynamic Evaluation
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