scholarly journals Clinical manifestations and progression, seasonal variation, and environmental factors associated with Paederus dermatitis among patients attending the outpatient dermatology clinic of Thailand's largest national tertiary referral center: a prospective cohort study

2021 ◽  
Author(s):  
Sukhum Jiamton ◽  
Nuttagarn Jantanapornchai ◽  
Ya-Nin Nokdhes ◽  
Poramin Patthamalai ◽  
Ploypailin Tantrapornpong ◽  
...  
Keyword(s):  
Cohort Study ◽  
Seasonal Variation ◽  
Environmental Factors ◽  
Prospective Cohort ◽  
Clinical Manifestations ◽  
Tertiary Referral ◽  
Tertiary Referral Center ◽  
Factors Associated ◽  
Dermatology Clinic ◽  
Paederus Dermatitis

scholarly journals Australia IBD Microbiome (AIM) Study: protocol for a multicentre longitudinal prospective cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e042493
Author(s):  
Astrid-Jane Williams ◽  
Ramesh Paramsothy ◽  
Nan Wu ◽  
Simon Ghaly ◽  
Steven Leach ◽  
...  
Keyword(s):  
Cohort Study ◽  
Environmental Factors ◽  
Prospective Cohort Study ◽  
Clinical Data ◽  
Prospective Cohort ◽  
Response To Therapy ◽  
Psychological State ◽  
Local Health ◽  
Microbial Composition ◽  
Patient Reported

IntroductionCrohn’s disease and ulcerative colitis are common chronic idiopathic inflammatory bowel diseases (IBD), which cause considerable morbidity. Although the precise mechanisms of disease remain unclear, evidence implicates a strong multidirectional interplay between diet, environmental factors, genetic determinants/immune perturbations and the gut microbiota. IBD can be brought into remission using a number of medications, which act by suppressing the immune response. However, none of the available medications address any of the underlying potential mechanisms. As we understand more about how the microbiota drives inflammation, much interest has focused on identifying microbial signals/triggers in the search for effective therapeutic targets. We describe the establishment of the Australian IBD Microbiota (AIM) Study, Australia’s first longitudinal IBD bioresource, which will identify and correlate longitudinal microbial and metagenomics signals to disease activity as evaluated by validated clinical instruments, patient-reported surveys, as well as biomarkers. The AIM Study will also gather extensive demographic, clinical, lifestyle and dietary data known to influence microbial composition in order to generate a more complete understanding of the interplay between patients with IBD and their microbiota.MethodsThe AIM Study is an Australian multicentre longitudinal prospective cohort study, which will enrol 1000 participants; 500 patients with IBD and 500 healthy controls over a 5-year period. Assessment occurs at 3 monthly intervals over a 24-month period. At each assessment oral and faecal samples are self-collected along with patient-reported outcome measures, with clinical data also collected at baseline, 12 and 24 months. Intestinal tissue will be sampled whenever a colonoscopy is performed. Dietary intake, general health and psychological state will be assessed using validated self-report questionnaires. Samples will undergo metagenomic, transcriptomic, proteomic, metabolomic and culturomic analyses. Omics data will be integrated with clinical data to identify predictive biomarkers of response to therapy, disease behaviour and environmental factors in patients with IBD.Ethics and disseminationEthical approval for this study has been obtained from the South Eastern Sydney Local Health District Research Ethics Committee (HREC 2019/ETH11443). Findings will be reported at national and international gastroenterology meetings and published in peer-reviewed journals.Trial registration numberACTRN12619000911190.

scholarly journals Racial Differences in Hepatocellular Carcinoma Incidence and Risk Factors among a Low Socioeconomic Population

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3710
Author(s):  
Sylvie Muhimpundu ◽  
Rebecca Baqiyyah N. Conway ◽  
Shaneda Warren Andersen ◽  
Loren Lipworth ◽  
Mark D. Steinwandel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Cohort Study ◽  
African Americans ◽  
Racial Differences ◽  
Prospective Cohort ◽  
White Americans ◽  
Low Socioeconomic ◽  
Factors Associated ◽  
Southeastern Us

The purpose of this study was to examine differences in risk factors associated with hepatocellular carcinoma (HCC) among White and African Americans from low socioeconomic backgrounds in the Southern Community Cohort Study (SCCS). The SCCS is a prospective cohort study with participants from the southeastern US. HCC incidence rates were calculated. Multivariable Cox regression was used to calculate HCC-adjusted hazard ratios (aHR) associated with known baseline HCC risk factors for White and African Americans, separately. There were 294 incident HCC. The incidence rate ratio for HCC was higher (IRR = 1.4, 95%CI: 1.1–1.9) in African Americans compared to White Americans. White Americans saw a stronger association between self-reported hepatitis C virus (aHR = 19.24, 95%CI: 10.58–35.00) and diabetes (aHR = 3.55, 95%CI: 1.96–6.43) for the development of HCC compared to African Americans (aHR = 7.73, 95%CI: 5.71–10.47 and aHR = 1.48, 95%CI: 1.06–2.06, respectively) even though the prevalence of these risk factors was similar between races. Smoking (aHR = 2.91, 95%CI: 1.87–4.52) and heavy alcohol consumption (aHR = 1.59, 95%CI: 1.19–2.11) were significantly associated with HCC risk among African Americans only. In this large prospective cohort, we observed racial differences in HCC incidence and risk factors associated with HCC among White and African Americans.

scholarly journals Psychological Factors Associated With Development of TMD: The OPPERA Prospective Cohort Study

2013 ◽  
Vol 14 (12) ◽  
pp. T75-T90 ◽  
Author(s):  
Roger B. Fillingim ◽  
Richard Ohrbach ◽  
Joel D. Greenspan ◽  
Charles Knott ◽  
Luda Diatchenko ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Psychological Factors ◽  
Prospective Cohort ◽  
Factors Associated
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