scholarly journals A Review of Limbal Stem Cell Deficiency

2019 ◽  
Vol 2 (1) ◽  
pp. e4-e11
Author(s):  
John E. Conto
Keyword(s):  
Stem Cell ◽  
Contact Lenses ◽  
Systemic Disease ◽  
Anterior Segment ◽  
Treatment Strategies ◽  
Limbal Stem Cell Deficiency ◽  
Contact Lens Wear ◽  
Limbal Stem Cell Transplantation ◽  
Limbal Stem Cell ◽  
Amniotic Membranes

Limbal stem cell deficiency (LSCD) can be secondary to multiple etiologies including contact lens wear, chemical or thermal trauma, and systemic disease, any of which can result in the reduction of the number of stem cells or their decreased functionality. Primary LSCD is seen with a variety of congenital anterior segment disorders. Often LSCD can be stabilized and timely diagnosis is the key. The use of topical corticosteroids and artificial tear lubricants, along with treatment of any underlying conditions, and discontinuation of contact lenses are important initial treatment strategies. Advance treatments include amniotic membranes, limbal stem cell transplantation and keratoprostheses.

Management of Focal Limbal Stem Cell Deficiency Associated With Soft Contact Lens Wear

Cornea ◽  
2011 ◽  
Vol 30 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Bennie H Jeng ◽  
Colleen P Halfpenny ◽  
David M Meisler ◽  
E Lee Stock
Keyword(s):  
Stem Cell ◽  
Contact Lens ◽  
Limbal Stem Cell Deficiency ◽  
Soft Contact ◽  
Contact Lens Wear ◽  
Soft Contact Lens ◽  
Limbal Stem Cell ◽  
Lens Wear

scholarly journals High-Resolution Optical Coherence Tomography Angiography Characteristics of Limbal Stem Cell Deficiency

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1130
Author(s):  
Shobhit Varma ◽  
Swapna S. Shanbhag ◽  
Pragnya Rao Donthineni ◽  
Dilip Kumar Mishra ◽  
Vivek Singh ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Stem Cell ◽  
High Resolution ◽  
Imaging Modality ◽  
Multiple Logistic Regression Analysis ◽  
Anterior Segment ◽  
Limbal Stem Cell Deficiency ◽  
Vascular Density ◽  
Optical Coherence ◽  
Limbal Stem Cell

This study aimed to identify the anterior segment high-resolution optical coherence tomography (HR-OCT) and HR-OCT angiography (HR-OCTA) features suggestive of limbal stem cell deficiency (LSCD) as confirmed by both impression cytology (IC) and in vivo confocal microscopy (IVCM). This was a single-centre prospective cross-sectional study including 24 eyes of 22 patients with clinical suspicion of LSCD based on peripheral superficial corneal vascularisation and scarring. On IC and IVCM, performed and interpreted by blinded observers, 12 eyes each were diagnosed with and without LSCD. Additionally, 10 eyes of 5 healthy volunteers with no ocular pathology were also imaged. The 136 HR-OCT/A images of these 34 eyes were analysed with respect to 12 imaging parameters; the parameters most suggestive of LSCD were identified and the sensitivity and specificity were calculated. In the LSCD group, the most common aetiology was ocular chemical burns (83%), whereas in the non-LSCD group, the most common aetiology was viral keratitis (67%). Multiple logistic regression analysis revealed that mean epithelial reflectivity, mean stromal reflectivity, and mean superficial vascular density were the parameters that were diagnostic of LSCD on HR-OCT/A (p < 0.0001). A ratio of the mean epithelial reflectivity to stromal reflectivity of >1.29 corresponded with a high sensitivity (91.7%) and specificity (98.75%); while a mean superficial vascular density score of >0.38 corresponded with a sensitivity of 97.9% and specificity of 73.8%. In conclusion, HR-OCT/A as a non-invasive imaging modality could prove to be a useful tool for confirming the diagnosis of LSCD, with potential clinical and research applications.

Focal limbal stem cell deficiency associated with soft contact lens wear

2017 ◽  
Vol 52 (6) ◽  
pp. 552-558 ◽  
Author(s):  
Karolien Termote ◽  
Steven Schendel ◽  
Gregory Moloney ◽  
Simon P. Holland ◽  
Alex P. Lange
Keyword(s):  
Stem Cell ◽  
Contact Lens ◽  
Limbal Stem Cell Deficiency ◽  
Soft Contact ◽  
Contact Lens Wear ◽  
Soft Contact Lens ◽  
Limbal Stem Cell ◽  
Lens Wear

scholarly journals Treatment of limbal stem cell deficiency with autologous cultivated oral mucosal epithelial transplantation

2019 ◽  
Author(s):  
yuqi jin ◽  
huicheng zhang ◽  
huimin wang ◽  
yufeng ye
Keyword(s):  
Stem Cell ◽  
Ex Vivo ◽  
Limbal Stem Cell Deficiency ◽  
Safe Alternative ◽  
Clinical Safety ◽  
The Mean ◽  
Limbal Stem Cell ◽  
Amniotic Membranes ◽  
Persistent Epithelial Defects

Abstract Background: To evaluate the feasibility of autologous cultivated oral mucosal epithelial transplantation (COMET) for the treatment of limbal stem cell deficiency (LSCD).Methods: Seven eyes from seven different patients with monocular LSCD were included in this study. Autologous oral mucosal epithelial cells were fabricated on ex vivo using amniotic membranes as a substrate. Clinical efficacy was evaluated by the coefficient of best-corrected visual acuity (BCVA). Clinical formation of the conjunctiva and symblepharon was evaluated and graded on a scale from 0 to 3. Clinical safety was evaluated by the presence of persistent epithelial defects, infection, and ocular hypertension.Results: Autologous COMET was successfully performed in all seven patients. The mean follow-up period was 10.7 months, during which time the postoperative formation of the conjunctiva and symblepharon was inhibited. BCVA was improved more than two lines in six eyes (86%) during the follow-up period. Complete reepithelialization of the corneal surfaces occurred in all treated eyes. No persistent epithelial defects, corneal infection, or postoperative ocular hypertension were observed. Conclusions: Autologous COMET offers a viable and safe alternative for the reconstruction of a stable ocular surface and improves vision in patients with LSCD.

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