scholarly journals Topical administration of Metamizole and its implications on vascular reactivity in Wistar rats- Experimental research

2017 ◽  
Vol 61 (1) ◽  
pp. 32-38
Author(s):  
Ioana-Cristina Coman ◽  
Horia Paunescu ◽  
Alina Cristina Stamate ◽  
Alina Popa Cherecheanu ◽  
Isabel Ghita ◽  
...  
Keyword(s):  
Experimental Research ◽  
Wistar Rats ◽  
Vascular Reactivity ◽  
Topical Administration

scholarly journals Sepiapterin Improves Vascular Reactivity and Insulin-Stimulated Glucose in Wistar Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
A. C. Keller ◽  
L. A. Knaub ◽  
R. L. Scalzo ◽  
S. E. Hull ◽  
A. E. Johnston ◽  
...  
Keyword(s):  
Mitochondrial Respiration ◽  
Wistar Rats ◽  
Vascular Reactivity ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Respiratory Control ◽  
Mitochondrial Activity ◽  
Insulin Tolerance ◽  
Male Wistar Rats ◽  
Endothelial Nitric Oxide

In the vasculature, sedentary behavior leads to endothelial abnormalities, resulting in elevated cardiovascular disease risk. Endothelial nitric oxide synthase (eNOS) aberrations characterize endothelial dysfunction; eNOS also regulates mitochondrial function. We hypothesized that sepiapterin (a precursor to eNOS cofactor tetrahydrobiopterin (BH4)) supplementation would improve endothelium-dependent vascular relaxation in sedentary animals via modulation of NOS function and mitochondrial activity. Sedentary male Wistar rats were fed ad libitum for a total of 10 weeks. Sepiapterin was administered in diet during the final 5 weeks. Intraperitoneal insulin and glucose tolerance tests (IP-ITT/IP-GTT) were conducted at baseline and endpoint. Aorta was assessed for vasoreactivity and mitochondrial respiration. Insulin tolerance, determined by IP-ITT, significantly improved in rats treated with sepiapterin (p<0.05, interaction of time and treatment). Acetylcholine- (ACh-) driven vasodilation was significantly greater in aorta from sepiapterin-treated rats as compared with control (76.4% versus 54.9% of phenylephrine contraction at 20 μM ACh, p<0.05). Sepiapterin treatment resulted in significantly elevated state 3 (9.00 oxygen pmol/sec∗mg versus 8.17 oxygen pmol/sec∗mg, p<0.05) and 4 (7.28 oxygen pmol/sec∗mg versus 5.86 oxygen pmol/sec∗mg, p<0.05) aortic mitochondrial respiration with significantly lower respiratory control ratio (p<0.05) during octanoylcarnitine-driven respiration. Vasodilation and insulin sensitivity were improved through targeting NOS via sepiapterin supplementation.

Altered Vascular Reactivity in Isolated Aortic Rings from Potassium-adapted Wistar Rats

2006 ◽  
Vol 2 (2) ◽  
pp. 193-200 ◽  
Author(s):  
R.I. Ozolua ◽  
E.E.I. Omogbai . ◽  
A.B. Ebeigbe .
Keyword(s):  
Wistar Rats ◽  
Vascular Reactivity

Evaluation of inositol phosphates in urine after topical administration of myo-inositol hexaphosphate to female Wistar rats

Life Sciences ◽  
2018 ◽  
Vol 192 ◽  
pp. 33-37 ◽  
Author(s):  
F. Grases ◽  
A. Costa-Bauzá ◽  
F. Berga ◽  
A. Rodríguez ◽  
R.M. Gomila ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Inositol Phosphates ◽  
Topical Administration ◽  
Inositol Hexaphosphate ◽  
Female Wistar Rats

scholarly journals Exercise training effects on vascular reactivity and metabolic parameters of high caloric-fed Wistar rats

2007 ◽  
Vol 7 (S1) ◽  
Author(s):  
Angelina Zanesco ◽  
Camila de Moraes ◽  
AP Davel ◽  
LV Rossoni ◽  
Gilberto de Nucci ◽  
...  
Keyword(s):  
Exercise Training ◽  
Wistar Rats ◽  
Vascular Reactivity ◽  
Metabolic Parameters ◽  
Training Effects

scholarly journals Hyperoxia blunts acute hypoxia- and PGF2α-induced pulmonary vasoconstriction in chronically hypoxic rats

2009 ◽  
pp. 917-920
Author(s):  
M Žaloudíková ◽  
M Vízek ◽  
J Herget
Keyword(s):  
Wistar Rats ◽  
Vascular Reactivity ◽  
Chronic Hypoxia ◽  
Acute Hypoxia ◽  
Gas Mixture ◽  
Pulmonary Vasoconstriction ◽  
Radical Production ◽  
Male Wistar Rats ◽  
Lung Preparation

We investigated the influence of oxygenation of in vitro lung preparation on the pulmonary vascular reactivity. Small pulmonary vessels isolated from adult male Wistar rats exposed for 4 days to hypoxia (FiO2 = 0.1, group CH) were compared with those of normoxic controls (group N). The bath in the chamber of small vessel myograph was saturated with gas mixture containing either 21 % or 95 % of O2 with 5 % CO2 and we measured the reactions of vessels to acute hypoxic challenge with 0 % O2 or to PGF2α. We did not observe any difference of the contractile responses between both groups when the normoxic conditions were set in the bath. When the bath oxygenation was increased to 95 % O2, the contractions induced by hypoxic challenge and PGF2α decreased in chronically hypoxic rats and did not change in normoxic controls. We hypothesize that reduced reactivity of vessels from hypoxic rats in hyperoxia results from the effect of chronic hypoxia on Ca2+ signaling in the vascular smooth muscle, which is modulated by increased free radical production during the exposure to chronic hypoxia and further hyperoxia.

scholarly journals Histopathology of The Muscle Corpus Kavernosum Wistar Rat (Rattus norvegicus) Hyperlipidemia

2018 ◽  
Vol 5 (2) ◽  
pp. 254
Author(s):  
Anak Agung Ayu Putri Permatasari ◽  
Ni Kadek Yunita Sari ◽  
I Gede Widhiantara
Keyword(s):  
Risk Factor ◽  
Erectile Dysfunction ◽  
Muscle Atrophy ◽  
Experimental Research ◽  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Wistar Rat ◽  
Tissue Abnormalities ◽  
Collagen Tissue ◽  
Treatment Surgery

This study aims to see the histopathology of muscle corvus cavernosum penis wistar rats (Rattus novergicus) hyperlipidemia seen in terms of thickness and picture of tissue abnormalities. Hyperlipidemia is a risk factor for erectile dysfunction ateriosklerosis in men. This research is an experimental research with one group prettest - posttest design. Samples in this study were 10 adult male aged 3-4 months wistar rats with a weight range 150-200 grams. Prior to treatment, surgery was performed for histopathology of 5-tailed rat samples at pretest. After that, sample were made with hyperhidemia by feeding fat for 50 days. Then performed surgery for histopathological preparation of corvus cavernosum muscle in posttest. The results showed that the thickness of the corvus cavernosum of the penile mouse of hyperlipidemia decreased significantly (P?0,05) when compared with the pretest group. In the histopathologic picture occurs muscle atrophy and the existence of abnormal structures of fibrotic and collagen tissue.

Effect of Physical Preconditioning on Vascular Reactivity and Metabolic Parameters of Wistar Rats Treated with Cafeteria Diet

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S3-S4
Author(s):  
Angelina Zanesco ◽  
Camila de Moraes ◽  
Mario Angelo Claudino ◽  
Carla Franco Penteado ◽  
Emerielle C. Vanzela ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Vascular Reactivity ◽  
Cafeteria Diet ◽  
Metabolic Parameters

Enhanced Na+, K+-ATPase activity and endothelial modulation decrease phenylephrine-induced contraction in aorta from ouabain-treated normotensive and hypertensive rats

2014 ◽  
Vol 18 (2) ◽  
Author(s):  
Ana Paula Davel ◽  
Gisele Kruger Couto ◽  
Camilla Ferreira Wenceslau ◽  
Emilia Cristina Peres ◽  
Fabiano Elias Xavier ◽  
...  
Keyword(s):  
Protein Expression ◽  
Wistar Rats ◽  
Vascular Reactivity ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Vasoconstrictor Response ◽  
Adrenergic Response ◽  
Male Wistar Rats ◽  
Cox 2

AbstractThe purpose of this study was to compare the effect of long-term ouabain treatment on the vascular reactivity and NaMale Wistar rats were treated with ouabain (~8.0 µg/day, subcutaneously) or vehicle for 5 and 20 weeks, and spontaneously hypertensive rats (SHRs) for 5 weeks. Vasoconstrictor response to phenylephrine (10The phenylephrine-induced contraction was reduced, whereas the relaxation to KCl was enhanced in the aorta of ouabain-treated Wistar rats and SHRs. In both strains, endothelial modulation of α-adrenergic response was enhanced, related to an increased NO and reduced COX-derived vasoconstrictor factor modulation. Aortas from 20-week ouabain-treated Wistar rats showed reduced COX-2 and enhanced eNOS protein expression. In SHRs, 5-week ouabain treatment reduced COX-2 and increased nNOS protein expression.The results suggest that long-term ouabain treatment reduces the α-adrenergic response of aorta from normotensive rats and SHRs, associated with an increase of NO synthesis, reduced COX-2-derived vasoconstrictor factors, and enhanced ouabain-sensitive Na

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