scholarly journals ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF DRACAENA CINNABARI BALF. RESIN ETHANOLIC EXTRACT OF SOQATRA ISLAND IN EXPERIMENTAL ANIMALS

2018 ◽  
Author(s):  
Nahed Al-Baoqai ◽  
Hassan Al-Mahbashi ◽  
Adnan Al-Adhal
Keyword(s):  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Albino Rats ◽  
Low Density ◽  
Experimental Animals ◽  
Socotra Island ◽  
Antihyperlipidemic Activity ◽  
Dracaena Cinnabari

Dracaena Cinnabari balfis a species plant in Abalfurn 1984e de la p pharmaciegavaceae family. It is a tree endemic to the Island of Socotra,Yemen. It was used as a dye and medicine in Socotra  and the Mediterranean basin. Some researches demonstrated both hypoglycemic and hypolipidemic of its resin of Dracaena Cochinchinensis, a traditional Chinese tree. Accordingly, this study aimed to evaluate the antidiabetic potential of the ethanolic extract of dracanea cinnabari balfresin (DCBR), endemic in Socotra Island, in Alloxan induced diabetes, and evaluation of possible antihyperlipidemic activity of the same extract in high-cholesterol diet-induced hyperlipidemia in male albino rats. Experimental diabetes was induced in rats with intraperitoneal injection a single dose of Alloxan (150 mg/kg). Hyperlipidemia was induced in rats by administration of 1% cholesterol in diet and 0.5 % Hydrogen Peroxide in drinking water for 14 days. Fasting blood glucose levels were measured at 1st day, 7th day and 14th day. Pancreas histopathology was done at the end. Estimation of serum lipid profile and liver   histopathology was done at the end of 14 day. The results were expressed as mean ± SD and differences among the groups of animals were compared using one-way ANOVA. Administration of ethanolic extract of resin of two doses (100mg and 300mg\kg) in alloxan induce diabetic rats resulted in a significant decrease in FBG levels with a recovery in destruction of pancreas cell compared with untreated group .Also the same doses of extract showed significant decrease in triglycerides, total cholesterol, low density lipoprotein, very low density lipoprotein and alkaline phospatase in comparing with untreated groups. From the results of present study we can conclude the ethanolic extract of Dracaena Cinnabari Balf. have a hypoglycemic and hypolipidemic activity in experimental animals  , these activity are time and dose dependent.  

scholarly journals Antidiabetic and Antioxidant Properties ofTriticum aestivumin Streptozotocin-Induced Diabetic Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Yogesha Mohan ◽  
Grace Nirmala Jesuthankaraj ◽  
Narendhirakannan Ramasamy Thangavelu
Keyword(s):  
Triticum Aestivum ◽  
Body Weight ◽  
Glycosylated Hemoglobin ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Low Density ◽  
Marker Enzyme

The antidiabetic and antioxidant potential ofTriticum aestivumwere evaluated by usingin vivomethods in normal and streptozotocin-induced diabetic rats. Diabetes was induced in the Wistar strain albino rats by injecting streptozotocin at a dose of 55 mg/kg body weight. Ethanolic extracts ofTriticum aestivumat doses of 100 mg/kg body weight were administered orally for 30 days. Various parameters were studied and the treatment group with the extract showed a significant increase in the liver glycogen and a significant decrease in fasting blood glucose, glycosylated hemoglobin levels, and serum marker enzyme levels. The total cholesterol and serum triglycerides levels, low density lipoprotein, and very low density lipoprotein were also significantly reduced and the high density lipoprotein level was significantly increased upon treatment with theTriticum aestivumethanol extract. A significant decrease in the levels of lipid peroxides, superoxide dismutase, and glutathione peroxidise and increase in the levels of vitamin E, catalase, and reduced glutathione were observed inTriticum aestivumtreated diabetic rats. Thus, from this study we conclude that ethanolic extract ofTriticum aestivumexhibited significant antihyperglycemic, hypolipidemic, and antioxidant activities in streptozotocin-induced diabetic rats.

Antioxidant potentials of Terminalia catappa leaf extractin Streptozotocin induced diabetes in rats

2016 ◽  
Author(s):  
Natarajan Divya ◽  
Arumugam Vijaya Anand
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Serum Levels ◽  
Albino Rats ◽  
Low Density ◽  
Subsequent Increase ◽  
Terminalia Catappa ◽  
Percolation Method

The objective of this study to evaluate the antioxidant capacity of the ethanolic extract of Terminalia catappa in vivo in Wistar albino rats. Streptozotocin (STZ) used as toxin it induces diabetes, damages the cell membrane and causes oxidative stress. The leaves (T. catappa) were extracted using 95 % ethanol by hot continuous percolation method. The extracts were concentrated by rotaevaporador. The residues extract were administrated orally to the STZ induced diabetes animals. After 45th day the animals were sacrificed and blood, liver tissues were collected and various antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), were reduced in the STZ alone treated animals with subsequent increase in LPO. The serum levels of total cholesterol (TC), triglycerides (TG), free fatty acids (FFA), phospholipids, low density lipoprotein (LDL), very low density lipoprotein (VLDL), and high density lipoprotein (HDL) was found out. Treatment with ethanolic extract of T. catappa at a dose of 300, 500 mg/kg once in a day has altered the levels of biochemical markers and brings back to near normal levels. Among which the dose 500 mg/kg having scavenging action to eradicate free radicals and maintained antioxidant status. The statistical data of P Values less than 0.001 were considered as level of significance.

scholarly journals Comparative Analysis of the Hypoglycaemic and Hypolipidemic Effects of Aqueous Extract of some Ethno medicinal Plants in Alloxan Induced Diabetic Rats

2021 ◽  
pp. 40-48
Author(s):  
Idris Aliyu Kankara ◽  
Akos Noel Ibrahim ◽  
Haruna Ade
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Diabetic Control ◽  
Albino Rats ◽  
Low Density ◽  
Fasting Blood Glucose Level

Diabetes mellitus is a complex metabolic disorder associated with the development of metabolic complications. This research evaluated the hypoglycemic and hypolipidaemic effects of Moringa oleifera (MO), Treculia africana (TA) and Albizzia chevalieri (AC) plant extracts on diabetes. Albino rats were randomly divided into six (six) main groups; MC, MO, TA, AC, Normal Control (NC) and Diabetic Control (DC) groups. Group MO, TA and AC were further subdivide into three sub groups. Diabetes mellitus was induced by a single dose intraperitoneal injection of alloxan 150 mg/kg body weight. Fasting blood glucose level and lipid profile were assayed using standard methods. Intraperitoneal injection of 150 mg/kg of Alloxan in the albino rats resulted in significant (p<0.05) elevation of serum glucose, total cholesterol (TC), triglyceride (TG), very low density lipoprotein (VLDL-C), and low density lipoprotein (LDL-C). Also, there was significant decrease (p<0.05) in HDL-C and body weight of the albino rats compared with that of the NC group. Oral administration of MO, TA and AC to diabetic albino rats for 21 days significantly (p<0.05) reduced fasting blood glucose level, normalized lipid profile and restore body weight of the albino rats in treated groups compared to diabetic control groups. All the plant extracts studied in this research significantly (p<0.05) increase the regeneration of damaged pancreatic β cells. Treatment with MO (800 mg/kg) confirmed highly significant (p<0.05) effect compared to TA and AC.

scholarly journals Effect of Some Strains of Lactic Acid Bacteria and Their Mixture on the Level of Fats and Cholesterol in Albino Rats (Rattus norvegicus) Male with Hypothyroidism Induced Using Carbimazole

2021 ◽  
Vol 34 (1) ◽  
pp. 139-146
Author(s):  
Elham K. Nasser ◽  
Kithar R. Majeed ◽  
Hayder I. Ali
Keyword(s):  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Control Sample ◽  
Density Lipoprotein ◽  
High Density ◽  
Control Group ◽  
Albino Rats ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Fortified Milk

Fortified milk containing Lactobacillus plantarum, L. casei, and L. acidophilus isolates and their mixture were used in dosing the male albino rats at an age of 9-12 weeks at an average of 23 g with induced hypothyroidism at a concentration of 0.6 g.kg-1 of carbimazole. Total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) were estimated. The results showed a significant increase in the level of triglycerides (TG), cholesterol and triglycerides. Low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL), with a significant decrease in the level of high-density lipoprotein (HDL) in infected male mice, compared to the control sample, and upon dosing with liquid milk fortified, it returned to its normal level without significant differences from the control group.

scholarly journals Effects of Ethanolic Extract of Metracaria chamomela on Some Physiological Parameters in Male Rabbits

2015 ◽  
Vol 39 (2) ◽  
pp. 26-31
Author(s):  
Alia Hussein Ali
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Blood Cell Count

     The aim of this study is to explain the effect of Ethanolic extract 70% of Metracaria chamomella on some physiological parameters in male rabbits. Twelve adult male rabbits were used in this study and were divided equally into two groups: First group was control (C) and received normal saline for four weeks, the second group (Treated group) was intubated orally with ethanolic extract of Metracaria chamomella in a dose 70 mg/kg B.W. for four weeks. Blood samples were collected by heart puncture from each animal at the end of experiment. Blood sample was divided into a part for hematological study and a part for biochemical analysis. The value of serum urea, and creatinine were reduced in animals that received Metracaria chamomella extract at dose of 70 mg/ kg B.W. as compared with the control group. Significant decrease in serum activity of aspartate aminotransferase alanine aminotransferase and alkaline phosphatase activity was observed in Metracaria treated animal as compared with the control group. This study explained that there was significant increase in serum total protein, serum albumin and serum globulin in treated animals as compared with the control group. The value of total cholesterol, serum triacylglycerol, serum low density lipoprotein cholesterol and very low density lipoprotein cholesterol concentration were reduced significantly in animal received Metracaria chamomella extract while the high density lipoprotein cholesterol was elevated significantly as compared with control group. While the effect of Metracaria chamomella extract on blood picture showed no changes in red blood cell count, hemoglobin concentration and hematocrit value but showed significant decrease in platelet count, and significant   increase in white blood cell count as compared with control group. Over all this study explained that Metracaria chamomella extract had Reno protective and hypolipidimic effect in male rabbit.  

scholarly journals Determinants of Cardiovascular Disease among Urban Women with Psoriasis: A Case–Control Study

2020 ◽  
Vol 5 (02) ◽  
pp. 102-108 ◽  
Author(s):  
Sudha Bala ◽  
Archana Mavoori ◽  
Harshal Pandve ◽  
Chinmayee Biswal ◽  
Vijay Prasanna ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Case Control Study ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Case Control ◽  
Low Density ◽  
Control Study

Abstract Background and Aim Psoriasis have a direct impact on development of cardiovascular risk factors leading to atherosclerosis and metabolic abnormalities. In order to prevent the complications, early and prompt identification of factors through various parameters help in primary and secondary prevention of cardiovascular diseases (CVDs) among these psoriatic patients. Therefore the aim of this study is to determine the prevalence of various determinants for cardiovascular diseases among cases and controls. Methods A hospital based case control study at a tertiary care hospital included women from the out patient department, aged above 18 years who were known cases of psoriasis. 114 patients were recruited with 1:1 ratio between cases and controls. All patients were evaluated using semi structured interview schedule with socio demographic variables, duration of disease, family history, and usage of drugs. Severity of disease was assessed through the psoriasis area severity index (PASI). Body surface area (BSA), body mass index (BMI), waist circumference and blood pressure measurement were done using standard methods. Lipid profile, high sensitivity C-Reactive protein (HsCRP) and blood sugar through calibrated analyzers having quality control. Carotid intima media thickness (CIMT) was assessed by using carotid Doppler technique to measure atherosclerosis. Results One hundred fourteen patients, means 57 pairs of cases and controls were analyzed in this study. Significant determinants among cases were raised such as waist circumference (p = 0.025), diastolic blood pressure (p = 0.0001), low density lipoprotein (p = 0.002) and fasting blood glucose (p = 0.004) when compared to controls. HsCRP and CIMT were also raised among cases but only CIMT was statistically significant when compared to controls (p = 0.0001). We also found raised determinants among psoriatic arthritis patients compared to psoriasis. Conclusion Psoriasis patients had high waist circumference, diastolic blood pressure, low density lipoprotein, fasting blood glucose, and CIMT when compared to controls. Early identification of these determinants make them amenable for prevention.

scholarly journals Metformin reduces circulating malondialdehyde-modified low-density lipoprotein in type 2 diabetes mellitus

2014 ◽  
Vol 37 (4) ◽  
pp. 243 ◽  
Author(s):  
Masahiro Ohira ◽  
Takashi Yamaguchi ◽  
Atsuhito Saiki ◽  
Noriko Ban ◽  
Hidetoshi Kawana ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Hypoglycemic Agents ◽  
Low Density

Purpose: Type 2 diabetes is known to be associated with increasing cardiovascular mortality. Malondialdehyde-modified LDL (MDA-LDL) is an oxidized LDL and is increased in patients with diabetes or hypertriglyceridemia. Elevated MDA-LDL has been reported to be a risk factor of atherosclerosis or cardiovascular disease. Sitagliptin is a dipeptidyl peptidase-4 inhibitor and a new class of hypoglycemic agents. In this study, the effects of increasing the dose of metformin and add-on sitagliptin on MDA-LDL were examined in type 2 diabetes patients. Methods: Seventy patients with type 2 diabetes, inadequately controlled despite on-going treatment with metformin 500 mg/day, were enrolled in this randomized controlled trial. The patients received additional metformin (500 mg/day) or sitagliptin (50 mg/day) for 6 months, and changes in metabolic parameters including MDA-LDL were evaluated. Results: After 6 months of treatment, add-on sitagliptin (n=35) improved fasting blood glucose (FBG) and hemoglobin A1c (HbA1c) to significantly greater extent than increasing the dose of metformin (n=35). There were no differences in total cholesterol and low-density lipoprotein cholesterol levels between two groups. MDA-LDL levels (mean±S.E.) decreased significantly with increasing the dose of metformin (from 94.40±6.35 to 77.83±4.74 U/L, P < 0.005), but remained unchanged with add-on sitagliptin treatment (from 89.94±5.59 to 98.46±6.78 U/L, p > 0.05). Multiple linear regression analysis identified increasing the dose of metformin treatment as the only independent factor associated with decreased MDA-LDL (β coefficient 0.367, P < 0.0119), and no significant correlation between change in MDA-LDL and fasting blood glucose or HbA1c. Conclusion: These results suggest that increasing the dose of metformin improves serum MDA-LDL levels in type 2 diabetes mellitus.

scholarly journals ASSOCIATION OF SUBCLINICAL HYPOTHYROIDISM IN METABOLIC SYNDROME PATIENTSASSOCIATION OF SUBCLINICAL HYPOTHYROIDISM IN METABOLIC SYNDROME PATIENTS

2018 ◽  
Vol 11 (9) ◽  
pp. 188
Author(s):  
Jennifer S Suhashini ◽  
Savitha G
Keyword(s):  
Metabolic Syndrome ◽  
Subclinical Hypothyroidism ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Significant Difference ◽  
Tsh Levels

Objectives: Subclinical hypothyroidism (SCH) is also the major risk for cardiovascular disease like metabolic syndrome (MetS). Hence, the aim of this study is to assess the association of SCH in MetS patients.Materials and Methods: Ninety patients reporting to Saveetha Dental College and Hospitals were enrolled in the study which includes 40 patients with MetS and 40 healthy individuals. 5 ml of venous blood was collected and centrifuged. Then, it is analyzed for fasting blood sugar, serum triglycerides, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and very low-density lipoprotein (VLDL) using the standard kit method. Then, Free T3, Free T4, and thyroid-stimulating hormone (TSH) were estimated by ELISA method. The data obtained were subjected to statistical analysis using the SPSS software.Results: SCH is 20% in cases when compared to 4.4% in controls, which was significant, p=0.024. The biochemical parameters were compared between the study population fasting blood glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol, and VLDL cholesterol was statistically significant, with p<0.001. TSH levels showed significant difference between two groups with the p=0.002.Conclusion: MetS patients should be screened for the SCH as an important risk factor in evaluation protocol. Mere correction of TSH levels can reverse the associated morbidity in these patients rather than leaving them untreated pushing them to a state of overt hypothyroidism with its attendant complications.

scholarly journals Cynanchum wilfordii Etanolic Extract Controls Blood Cholesterol: A Double-blind, Randomized, Placebo-Controlled, Parallel Trial

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 836 ◽  
Author(s):  
Youn ◽  
Ham ◽  
Yoon ◽  
Choi ◽  
Lee ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Low Dose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Blood Cholesterol ◽  
High Dose ◽  
Low Density ◽  
Double Blind ◽  
Cynanchum Wilfordii

We evaluated the effects of Cynanchum wilfordii (CW) ethanolic extract on blood cholesterol levels in adults with high low-density lipoprotein cholesterol (LDL-C) levels. In a double-blind, randomized, placebo-controlled, parallel trial, 84 subjects were recruited. Participants were randomly divided into two groups with a low-dose (300 mg/d) or high-dose (600 mg/d) of CW. Levels of very low-density lipoprotein (p = 0.022) and triglycerides (p = 0.022) were significantly lower in the low-dose CW group than in the placebo group after 8 weeks. In a subgroup of participants with LDL-C≥ 150 mg/dL (n = 33), there was a significant decrease in total cholesterol (low-dose, p = 0.012; high-dose, p = 0.021), apolipoprotein B (low-dose, p = 0.022; high-dose, p = 0.016), and cholesteryl ester transfer protein (low-dose, p = 0.037; high-dose, p = 0.016) after 8 weeks of CW. The correlation between changes in total cholesterol and baseline LDL-C levels was significant in the groups that received both doses of CW (low-dose, p = 0.010; high-dose, p = 0.015). These results show that the CW ethanolic extract can regulate blood cholesterol in subjects with LDL-C≥ 150 mg/dL.

Protective effect of Psidium guajava leaf ethanolic extract against streptozotocin-induced diabetes and lipidosis in rats

2017 ◽  
Author(s):  
R. Manikandan ◽  
A. Vijaya Anand ◽  
P. Sampathkumar ◽  
N. Manoharan
Keyword(s):  
Blood Glucose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Psidium Guajava ◽  
Pancreatic Tissue ◽  
Diabetic Rat ◽  
Hypolipidemic Effect ◽  
Low Density ◽  
Standard Drug

This study was conducted to find out the anti-diabetic and hypolipidemic potential of ethanolic extract of Psidium guajava Linn leaves and its one of the important compound of caryophyllene in a streptozotocin (STZ) induced diabetic rats. The rats were divided into eight groups. Diabetes was induced by STZ at a dosage of 60 mg/kg b.w. The various dosages of extract (100, 200, 300 mg/kg b.w), caryophyllene (300 mg/kg b.w) were injected and glibenclamide (3 mg/kg b.w) is used as a standard drug. After the treatment of the extract and caryophyllene the levels of blood glucose, HbA1c, glucose-6-phosphatase, fructose-1,6-bis phosphatase, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), high density lipoprotein (HDL) were determined. Pancreatic tissue changes were noticed in all the groups. The present study showed that there was a significant reduction in blood glucose, HbA1c, glucose-6-phosphatase, fructose-1,6-bis phosphatase, TC, TG, LDL, VLDL and the enhancement was noticed in the level of insulin, glucokinase and HDL. Pancreas was damaged in diabetic induced rats and it altered to normal size and shape in the plant extract treated and caryophyllene treated groups. The results proved that the STZ induced diabetic rat models had revealed anti-diabetic and hypolipidemic effect treated with ethanolic leaf extract of P. guajava and caryophyllene.

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