Center variability in risk of adjusted length of stay for very low birth weight infants in the Neocosur South American Network

2012 ◽  
Vol 88 (6) ◽  
pp. 524-30 ◽  
Author(s):  
Guillermo Marshall ◽  
Maria J. Luque ◽  
Alvaro Gonzalez ◽  
Ivonne D´Apremont ◽  
Gabriel Musante ◽  
...  
Keyword(s):  
Birth Weight ◽  
Length Of Stay ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
South American ◽  
Low Birth Weight Infants

Effect of Breast Milk on Hospital Costs and Length of Stay Among Very Low-Birth-Weight Infants in the NICU

2012 ◽  
Vol 12 (4) ◽  
pp. 254-259 ◽  
Author(s):  
Leslie A. Parker ◽  
Charlene Krueger ◽  
Sandra Sullivan ◽  
Teresa Kelechi ◽  
Martina Mueller
Keyword(s):  
Birth Weight ◽  
Breast Milk ◽  
Length Of Stay ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Hospital Costs ◽  
Low Birth Weight Infants

scholarly journals Maternal Interleukin Genotypes Are Associated With NICU Outcomes Among Low-Birth-Weight Infants

2016 ◽  
Vol 19 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Kelley L. Baumgartel ◽  
Maureen W. Groer ◽  
Susan M. Cohen ◽  
Dianxu Ren ◽  
Diane L. Spatz ◽  
...  
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Length Of Stay ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Fecal Calprotectin ◽  
Minor Allele ◽  
Neonatal Outcomes ◽  
Nucleotide Polymorphisms ◽  
Low Birth Weight Infants

Background: Maternal interleukin (IL) single nucleotide polymorphisms (SNPs) are associated with obstetrical outcomes. Conversely, infant SNPs are associated with subsequent neonatal intensive care unit (NICU) outcomes. Little is known about relationships between maternal SNPs and neonatal outcomes. Purpose: To examine the relationships between maternal IL genotypes and neonatal outcomes. Methods: An ancillary study was conducted among mothers ( N = 63) who delivered very low-birth-weight infants ( N = 74). Maternal DNA was extracted from breast milk and genotyped. Outcomes included fecal calprotectin, length of stay, scores for neonatal acute physiology with perinatal extension (SNAPPE-II), weight gain, oxygen needs, necrotizing enterocolitis, intraventricular hemorrhage, sepsis, retinopathy of prematurity, blood transfusions, and feeding intolerance. Multivariate analyses examined the relationships between maternal IL SNPs and outcomes, controlling for gestational age and the ratio of maternal milk to total milk. Results: Absence of a minor allele in 2 IL6 SNPs was associated with fecal calprotectin ( p = .0222, p = .0429), length of stay ( p = .0158), SNAPPE-II ( p = .0497), weight gain ( p = .0272), and days on oxygen ( p = .0316). IL6 genotype GG (rs1800795) was associated with length of stay ( p = .0034) and calprotectin ( p = .0213). Minor-allele absence in 2 IL10 SNPs was associated with days on oxygen ( p = .0320). There were associations between IL10 genotype TT (rs1800871) and calprotectin ( p = .0270) and between IL10 genotypes AA (rs1800872 and rs1800896) and calprotectin ( p = .0158, p = .0045). Conclusion: Maternal IL SNPs are associated with NICU outcomes. A potential clinical application includes an antenatal risk profile to identify neonatal needs.

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