scholarly journals Genetic association study of tumor necrosis factor-alpha with sepsis and septic shock in Thai pediatric patients

2012 ◽  
Vol 88 (5) ◽  
Author(s):  
Suwannee Phumeetham ◽  
Nunthawut Chat-uthai ◽  
Manutham Manavathongchai ◽  
Vip Viprakasit
Keyword(s):  
Septic Shock ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Genetic Association Study ◽  
Tumor Necrosis ◽  
Pediatric Patients ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Sepsis And Septic Shock ◽  
Necrosis Factor

scholarly journals Correlation between tumor necrosis factor-alpha and septic shock in children

2013 ◽  
Vol 53 (1) ◽  
pp. 1 ◽  
Author(s):  
Khrisanti Dinata ◽  
Ari L. Runtunuwu ◽  
Jose M. Mandei ◽  
Julius H. Lolombulan
Keyword(s):  
Septic Shock ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Strong Positive Correlation ◽  
Necrosis Factor Alpha ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Factor Alpha ◽  
Necrosis Factor

Background The crucial role cytokines play in the pathophysiologyof sepsis is widely accepted. Infection stimulates the productionof cytokines in various cell types. Tumor necrosis factor-alpha(TNF-a) is one of the most extensively investigated cytokines inexperimental and clinical sepsis. Tumor necrosis factor-alpha hasbeen shown to mediate lethality in experimental sepsis.Objective To evaluate for a possible correlation between TNF-alevel and septic shock in children.Methods This cross-sectional study was conducted in Manadofrom June to September 2011. A total of 40 patients with arecent diagnosis of sepsis or septic shock were included. Plasmaspecimens were collected from subjects for measurement ofTNF-a concentration. Logistic regression analysis was used toassess the correlation between TNF-a level and sepsis, as well asthe probability of shock in children with sepsis, with P<0.05 asstatistically significant.Results There was a strong positive correlation betweenTNF-a level and the probability of shock in children with sepsis(regression coefficient = 0. 78, P = 0.002).Conclusions There is a strong positive correlation betweenTNF-a level with the probability of shock in children with sepsis.Higher plasma level ofTNF-a is associated with higher probabilityof septic shock.

scholarly journals P444 Fecal calprotectin response to anti-tumor necrosis factor alpha induction and maintenance in Pediatric Inflammatory Bowel Disease

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S442-S443
Author(s):  
M Matar ◽  
R Levi ◽  
M Zvuloni ◽  
R Shamir ◽  
A Assa
Keyword(s):  
Inflammatory Bowel Disease ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Pediatric Patients ◽  
Fecal Calprotectin ◽  
Necrosis Factor Alpha ◽  
Inflammatory Bowel ◽  
Factor Alpha ◽  
Necrosis Factor

Abstract Background Fecal calprotectin (FC) is a sensitive surrogate marker of mucosal inflammation in inflammatory bowel disease (IBD). Our aim was to asses the effect of anti-tumor necrosis factor alpha (TNFα) induction and maintenance therapy on FC levels in children with IBD. Methods The medical records of pediatric patients with IBD who were treated with anti-TNFα agents from 2015 to 2020 were reviewed retrospectively. We identified 63 patients who had FC levels measured prior to anti TNFα induction with sequential measurements during the first months of therapy. The main outcome measures were time to FC response according to cut-offs of 250,150,100 and 50µgr/gr. Variables affecting FC response were analyzed using multivariate analysis. Results Out of 63 patients, mean age 13.6 (±3) years, females 28(44.4%),54 (85.7%) had Crohn’s disease. The median (interquartile range) FC at baseline was 715 µgr/gr (312–1700). The outcomes of &lt;250, &lt;150, &lt;100 and &lt;50 µgr/gr were achieved by 52 (82%), 51 (81%), 44 (70%) and 32 (50%) patients, respectively. The mean time (± standard error) for achieving these cut-offs were 4.8 ±0.8, 7.9±1.3, 10±1.8 and 18.5±7.2 months, respectively. There was no statistically significant correlation between age, gender, type of disease, Paris classification, extra-intestinal manifestation, albumin levels, erythrocyte sedimentation rate, C-reactive protein and the pediatric disease activity indexes at baseline and FC response. Furthermore, there was no statistically significant correlation between anti TNFα trough concentration during induction and FC response. Conclusion In pediatric patients with IBD, FC response (&lt;250µgr/gr) was achieved by the majority of patients within a relatively short period of time. Nevertheless, calprotectin normalization (&lt;100µgr/gr) required an average period of approximately one year in responders.

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