scholarly journals 'Virus and Interferon' Molecular mechanisms for suppression of interferon signal transduction pathway caused by viral infections

Uirusu ◽  
2004 ◽  
Vol 54 (2) ◽  
pp. 169-178 ◽  
Author(s):  
Nobuhiro Fujii ◽  
Shin-ichi Yokota ◽  
Noriko Yokosawa ◽  
Tamaki Okabayashi
Keyword(s):  
Signal Transduction ◽  
Molecular Mechanisms ◽  
Viral Infections ◽  
Signal Transduction Pathway ◽  
Transduction Pathway

scholarly journals An Efficient Method to Identify Conditionally Activated Transcription Factors and their Corresponding Signal Transduction Pathway Segments

2009 ◽  
Vol 3 ◽  
pp. BBI.S3485
Author(s):  
Haiyan Hu
Keyword(s):  
Signal Transduction ◽  
Transcription Factors ◽  
Efficient Method ◽  
Molecular Mechanisms ◽  
Target Genes ◽  
Signal Transduction Pathway ◽  
Protein Interaction Data ◽  
Transduction Pathway ◽  
Binding Data ◽  
Microarray Datasets

A signal transduction pathway (STP) is a cascade composed of a series of signal transferring steps, which often activate one or more transcription factors (TFs) to control the transcription of target genes. Understanding signaling pathways is important to our understanding of the molecular mechanisms of disease. Many condition-annotated pathways have been deposited in public databases. However, condition-annotated pathways are far from complete, considering the large number of possible conditions. Computational methods to assist in the identification of conditionally activated pathways are greatly needed. In this paper, we propose an efficient method to identify conditionally activated pathway segments starting from the identification of conditionally activated TFs, by incorporating protein-DNA binding data, gene expression data and protein interaction data. Applying our methods on several microarray datasets, we have discovered many significantly activated TFs and their corresponding pathway segments, which are supported by evidence in the literature.

scholarly journals The Mechanism of MAPK Signal Transduction Pathway Involved with Electroacupuncture Treatment for Different Diseases

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Weibin Du ◽  
Huahui Hu ◽  
Jiangsong Zhang ◽  
Guanai Bao ◽  
Rongliang Chen ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Electrical Stimulation ◽  
Molecular Mechanisms ◽  
Signal Transduction Pathway ◽  
Cerebrovascular Diseases ◽  
Mitogen Activated Protein Kinase ◽  
Signal Pathways ◽  
Transduction Pathway ◽  
Analgesic Effects ◽  
Electroacupuncture Treatment

The mitogen-activated protein kinase (MAPK) signal transduction pathway plays an important role in the regulation of various diseases, such as cardiovascular and cerebrovascular diseases, and takes part in anti-inflammatory effects, analgesic effects, protection against injury, and maintenance of gastrointestinal functions. Electroacupuncture therapy is an external therapy used in traditional Chinese medicine. By adding external electrical stimulation to traditional acupuncture, the stimulus gets doubled and the therapeutic efficacy gets enhanced accordingly. It combines the benefits of both acupuncture and electrical stimulation. In recent years, some studies have explored the molecular mechanisms of MAPK signal pathways involved with electroacupuncture treatment. Based on these recent studies, this article summarizes the mechanisms of MAPK signal transduction pathways involved with electroacupuncture treatment. This adds great value to the studies of molecular mechanisms of electroacupuncture treatment and also provides an effective reference for its clinical use.

A Mutation in an HSP90 Gene Affects the Sexual Cycle and Suppresses Vegetative Incompatibility in the Fungus Podospora anserina

Genetics ◽  
1997 ◽  
Vol 147 (2) ◽  
pp. 581-588
Author(s):  
Gabriel Loubradou ◽  
Joel Bégueret ◽  
Béatrice Turcq
Keyword(s):  
Signal Transduction ◽  
Molecular Mechanisms ◽  
Biological Function ◽  
Molecular Level ◽  
Signal Transduction Pathway ◽  
Podospora Anserina ◽  
Sexual Cycle ◽  
Transduction Pathway ◽  
Vegetative Incompatibility ◽  
Developmental Defects

Vegetative incompatibility is widespread in fungi but its molecular mechanism and biological function are still poorly understood. A way to study vegetative incompatibility is to investigate the function of genes whose mutations suppress this phenomenon. In Podospora anserina, these genes are known as mod genes. In addition to suppressing vegetative incompatibility, mod mutations cause some developmental defects. This suggests that the molecular mechanisms of vegetative incompatibility and development pathways are interconnected. The mod-E1 mutation was isolated as a suppressor of the developmental defects of the mod-D2 strain. We show here that mod-E1 also partially suppresses vegetative incompatibility, strengthening the link between development and vegetative incompatibility. mod-E1 is the first suppressor of vegetative incompatibility characterized at the molecular level. It encodes a member of the Hsp90 family, suggesting that development and vegetative incompatibility use common steps of a signal transduction pathway. The involvement of mod-E in the sexual cycle has also been further investigated.

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