scholarly journals N-(2'-deoxyguanosine-8-YL)-N-acetyl-2-aminofluorene induced translesion synthesis events in E.Coli: role of Y-family error-prone polymerases and the DNA sequence context

2004 ◽  
Author(s):  
M. Nokhbeh
Keyword(s):  
Dna Sequence ◽  
Translesion Synthesis ◽  
Sequence Context ◽  
Y Family

Effects of Base Sequence Context on Translesion Synthesis Past a Bulky (+)-trans-anti-B[a]P-N2-dG Lesion Catalyzed by the Y-family Polymerase pol κ†

Biochemistry ◽  
2003 ◽  
Vol 42 (8) ◽  
pp. 2456-2466 ◽  
Author(s):  
Xuanwei Huang ◽  
Alexander Kolbanovskiy ◽  
Xiaohua Wu ◽  
Yanbin Zhang ◽  
Zhigang Wang ◽  
...  
Keyword(s):  
Translesion Synthesis ◽  
Base Sequence ◽  
Sequence Context ◽  
Y Family

scholarly journals DNA Sequence Context as a Determinant of the Quantity and Chemistry of Guanine Oxidation Produced by Hydroxyl Radicals and One-electron Oxidants

2008 ◽  
Vol 283 (51) ◽  
pp. 35569-35578 ◽  
Author(s):  
Yelena Margolin ◽  
Vladimir Shafirovich ◽  
Nicholas E. Geacintov ◽  
Michael S. DeMott ◽  
Peter C. Dedon
Keyword(s):  
Dna Sequence ◽  
Hydroxyl Radicals ◽  
Sequence Context ◽  
Guanine Oxidation

scholarly journals Role of Translesion Synthesis DNA Polymerases in DNA Replication in the Presence of a Weak DNA Polymerase δ in Saccharomyces cerevisiae

2018 ◽  
Vol 8 (2) ◽  
pp. 754-754
Author(s):  
Likui Zhang ◽  
Yanchao Huang ◽  
Xinyuan Zhu ◽  
Yuxiao Wang ◽  
Haoqiang Shi ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Dna Replication ◽  
Dna Polymerase ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Dna Polymerase Δ

scholarly journals Functional role of a highly repetitive DNA sequence in anchorage of the mouse genome

1988 ◽  
Vol 16 (17) ◽  
pp. 8351-8360 ◽  
Author(s):  
Beatrice Neuer-Nitsche ◽  
Xiang Lu ◽  
Dieter Werner
Keyword(s):  
Dna Sequence ◽  
Repetitive Dna ◽  
Functional Role ◽  
Mouse Genome ◽  
Repetitive Dna Sequence ◽  
Highly Repetitive Dna

scholarly journals Polη, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress

2018 ◽  
Vol 131 (12) ◽  
pp. jcs212183 ◽  
Author(s):  
Kiminori Kurashima ◽  
Takayuki Sekimoto ◽  
Tsukasa Oda ◽  
Tsuyoshi Kawabata ◽  
Fumio Hanaoka ◽  
...  
Keyword(s):  
Translesion Synthesis ◽  
Replication Stress ◽  
Cellular Tolerance ◽  
Y Family

scholarly journals Y-family DNA polymerase-independent gap-filling translesion synthesis across aristolochic acid-derived adenine adducts in mouse cells

DNA Repair ◽  
2016 ◽  
Vol 46 ◽  
pp. 55-60 ◽  
Author(s):  
Keiji Hashimoto ◽  
Radha Bonala ◽  
Francis Johnson ◽  
Arthur P. Grollman ◽  
Masaaki Moriya
Keyword(s):  
Dna Polymerase ◽  
Aristolochic Acid ◽  
Translesion Synthesis ◽  
Gap Filling ◽  
Mouse Cells ◽  
Adenine Adducts ◽  
Y Family

scholarly journals Role of Double-Stranded DNA Translocase Activity of Human HLTF in Replication of Damaged DNA

2009 ◽  
Vol 30 (3) ◽  
pp. 684-693 ◽  
Author(s):  
András Blastyák ◽  
Ildikó Hajdú ◽  
Ildikó Unk ◽  
Lajos Haracska
Keyword(s):  
Translesion Synthesis ◽  
Dna Lesions ◽  
Template Switching ◽  
Replication Forks ◽  
Double Stranded Dna ◽  
Fork Regression ◽  
Dna Translocase ◽  
Damaged Dna

ABSTRACT Unrepaired DNA lesions can block the progression of the replication fork, leading to genomic instability and cancer in higher-order eukaryotes. In Saccharomyces cerevisiae, replication through DNA lesions can be mediated by translesion synthesis DNA polymerases, leading to error-free or error-prone damage bypass, or by Rad5-mediated template switching to the sister chromatid that is inherently error free. While translesion synthesis pathways are highly conserved from yeast to humans, very little is known of a Rad5-like pathway in human cells. Here we show that a human homologue of Rad5, HLTF, can facilitate fork regression and has a role in replication of damaged DNA. We found that HLTF is able to reverse model replication forks, a process which depends on its double-stranded DNA translocase activity. Furthermore, from analysis of isolated dually labeled chromosomal fibers, we demonstrate that in vivo, HLTF promotes the restart of replication forks blocked at DNA lesions. These findings suggest that HLTF can promote error-free replication of damaged DNA and support a role for HLTF in preventing mutagenesis and carcinogenesis, providing thereby for its potential tumor suppressor role.

Sign in / Sign up

Export Citation Format

Share Document