scholarly journals In vitro Resistance Pattern of Selected Antifungal Azoles against Candida albicans Biofilms on Silicone Nasogastric Tube

2019 ◽  
Vol 13 (4) ◽  
pp. 1881-1891
Author(s):  
Derick Erl P. Sumalapao ◽  
Pauline Bridgette D. Salazar ◽  
Frederico Martin D. Alegre ◽  
Nelson R. Villarante ◽  
Nina G. Gloriani
Keyword(s):  
Candida Albicans ◽  
Nasogastric Tube ◽  
Resistance Pattern ◽  
Candida Albicans Biofilms

scholarly journals In Vitro Activity of Caspofungin against Candida albicans Biofilms

2002 ◽  
Vol 46 (11) ◽  
pp. 3591-3596 ◽  
Author(s):  
Stefano P. Bachmann ◽  
Kacy VandeWalle ◽  
Gordon Ramage ◽  
Thomas F. Patterson ◽  
Brian L. Wickes ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Inhibitory Effect ◽  
Vitro Activity ◽  
Confocal Scanning Laser Microscopy ◽  
In Vitro Activity ◽  
Confocal Scanning ◽  
Confocal Scanning Laser ◽  
Biofilm Development ◽  
Candida Albicans Biofilms

ABSTRACT Most manifestations of candidiasis are associated with biofilm formation on biological or inanimate surfaces. Candida albicans biofilms are recalcitrant to treatment with conventional antifungal therapies. Here we report on the activity of caspofungin, a new semisynthetic echinocandin, against C. albicans biofilms. Caspofungin displayed potent in vitro activity against sessile C. albicans cells within biofilms, with MICs at which 50% of the sessile cells were inhibited well within the drug's therapeutic range. Scanning electron microscopy and confocal scanning laser microscopy were used to visualize the effects of caspofungin on preformed C. albicans biofilms, and the results indicated that caspofungin affected the cellular morphology and the metabolic status of cells within the biofilms. The coating of biomaterials with caspofungin had an inhibitory effect on subsequent biofilm development by C. albicans. Together these findings indicate that caspofungin displays potent activity against C. albicans biofilms in vitro and merits further investigation for the treatment of biofilm-associated infections.

scholarly journals Gallic acid/hydroxypropyl-β-cyclodextrin complex: Improving solubility for application on in vitro/ in vivo Candida albicans biofilms

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0181199 ◽  
Author(s):  
Guilherme Rodrigues Teodoro ◽  
Aline Vidal Lacerda Gontijo ◽  
Aline Chiodi Borges ◽  
Márcia Hiromi Tanaka ◽  
Gabriela de Morais Gouvêa Lima ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Gallic Acid ◽  
Cyclodextrin Complex ◽  
Candida Albicans Biofilms

In vitro activity of eugenol against Candida albicans biofilms

2007 ◽  
Vol 163 (3) ◽  
pp. 137-143 ◽  
Author(s):  
Miao He ◽  
Minquan Du ◽  
Mingwen Fan ◽  
Zhuan Bian
Keyword(s):  
Candida Albicans ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Candida Albicans Biofilms

In vitro effectiveness of 455-nm blue LED to reduce the load of Staphylococcus aureus and Candida albicans biofilms in compact bone tissue

2015 ◽  
Vol 31 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Luciano Pereira Rosa ◽  
Francine Cristina da Silva ◽  
Magda Souza Viana ◽  
Giselle Andrade Meira
Keyword(s):  
Staphylococcus Aureus ◽  
Candida Albicans ◽  
Bone Tissue ◽  
Compact Bone ◽  
Compact Bone Tissue ◽  
Blue Led ◽  
Candida Albicans Biofilms

P1956 In vitro activity of amphotericin B and anidulafungin against Candida albicans biofilms

2007 ◽  
Vol 29 ◽  
pp. S562
Author(s):  
A. Valentín ◽  
E. Cantóon ◽  
J. Pemáan ◽  
M. Bosch ◽  
E. Eraso ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Amphotericin B ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Candida Albicans Biofilms

scholarly journals In Vitro Pharmacodynamic Properties of Three Antifungal Agents against Preformed Candida albicans Biofilms Determined by Time-Kill Studies

2002 ◽  
Vol 46 (11) ◽  
pp. 3634-3636 ◽  
Author(s):  
Gordon Ramage ◽  
Kacy VandeWalle ◽  
Stefano P. Bachmann ◽  
Brian L. Wickes ◽  
José L. López-Ribot
Keyword(s):  
Candida Albicans ◽  
Amphotericin B ◽  
Antifungal Agents ◽  
Pharmacokinetic Properties ◽  
Time Kill ◽  
Candida Albicans Biofilms

ABSTRACT We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with ≥99% killing at physiological concentrations.

scholarly journals Addition of DNase improves the in vitro activity of antifungal drugs against Candida albicans biofilms

Mycoses ◽  
2011 ◽  
Vol 55 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Margarida Martins ◽  
Mariana Henriques ◽  
José L. Lopez-Ribot ◽  
Rosário Oliveira
Keyword(s):  
Candida Albicans ◽  
Antifungal Drugs ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Candida Albicans Biofilms
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