scholarly journals Estimation of the Role of Apoptosis in Altering the Architecture of the Cells of Exocrine Pancreas in Mice Inoculated with Mammary Gland Carcinoma by Using Soft Laser

2018 ◽  
Vol 12 (2) ◽  
pp. 833-838
Author(s):  
Aida Al-Kaissy ◽  
Ahmed Albir
Keyword(s):  
Mammary Gland ◽  
Exocrine Pancreas ◽  
Mammary Gland Carcinoma ◽  
Gland Carcinoma

scholarly journals Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model

2014 ◽  
Vol 95 (6) ◽  
pp. 401-410 ◽  
Author(s):  
Peter Orendáš ◽  
Peter Kubatka ◽  
Bianka Bojková ◽  
Monika Kassayová ◽  
Karol Kajo ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Carcinoma ◽  
Rat Mammary Gland ◽  
Gland Carcinoma ◽  
Anti Tumour Effect

SEBACEOUS GLAND CARCINOMA AND MAMMARY GLAND CARCINOMA IN AN AFRICAN HEDGEHOG (ATELETRIX ALBIVENTRIS)

2014 ◽  
Vol 45 (3) ◽  
pp. 682-685 ◽  
Author(s):  
Alonso Reyes Matute ◽  
Adriana Mendez Bernal ◽  
José Ramírez Lezama ◽  
Manzano Pech Linaloe Guadalupe ◽  
Galicia Avalos Marco Antonio
Keyword(s):  
Mammary Gland ◽  
Sebaceous Gland ◽  
Sebaceous Gland Carcinoma ◽  
Mammary Gland Carcinoma ◽  
Gland Carcinoma

scholarly journals Efficacy of Palliative Radiation Therapy on Canine Inflammatory Mammary Gland Carcinoma

2000 ◽  
Vol 53 (11) ◽  
pp. 755-757
Author(s):  
Takahiko SAKAGUCHI ◽  
Takeo MINAMI ◽  
Nobuko MINAMI ◽  
Toshiyuki SUZUKI ◽  
Yasuhiro NAKANO ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Mammary Gland ◽  
Palliative Radiation ◽  
Mammary Gland Carcinoma ◽  
Palliative Radiation Therapy ◽  
Gland Carcinoma

scholarly journals Repurposing combination therapy of Voacamine with Vincristine for down regulation of HIF-1α/FASN co-axis and PHD2 activation in ER+ mammary neoplasia

2020 ◽  
Author(s):  
Lakhveer Singh ◽  
Manjari Singh ◽  
Dinesh Kumar ◽  
Mohd. Nazam Ansari ◽  
Abdulaziz S. Saeedan ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Fatty Acid ◽  
Combination Therapy ◽  
Fatty Acid Synthase ◽  
Hypoxia Inducible Factor ◽  
Prolyl Hydroxylase ◽  
Over Expression ◽  
Hypoxia Inducible Factor 1Α ◽  
Gland Carcinoma

Abstract Background The current study was attempted to inquest the role of combination therapy of Voacamine and Vincristine for the prevention of mammary gland carcinoma through prolyl hydroxylase-2 activation. The prolyl hydroxylase‐2 activation leads the downregulation of hypoxia‐inducible factor‐1α and fatty acid synthase. Over expression of hypoxia inducible factor-1α and fatty acid synthase is previously reported in solid tumor of mammary gland. Methods After screening a battery of natural compounds which were similar to vincristine, vocamine was selected as a possible prolyl hydroxylase-2 activator and justify its activity using 7, 12-Dimethylbenz[a]anthracene induced rat model. The combination therapy was evaluated for cardiac toxicity using hemodynamic profile. The angiogenic markers were evaluated using carmine staining. Monotherapy and combination therapy were also evaluated for liver and kidney toxicity through haematoxylin and eosin staining. The combination therapy also delineated the markers of oxidative stress favorably. Afterwards, the disruption of fatty acids was evaluated using gas chromatography. Results The immunoblotting analysis validated that combination therapy has a potential to switch on the prolyl hydroxylase-2 activity and thus initiate proteolytic degradation of hypoxia‐inducible factor‐1α and its consequence effects. The combination therapy also stimulated programmed cell death (apoptosis) in rapidly dividing cancer cells. Conclusion The present study explores the role of voacamine in activation of prolyl hydroxylase-2 which can decrease over expression of hypoxia‐inducible factor‐1α and fatty acid synthase in cells of mammary gland carcinoma.

scholarly journals Repurposing Combination Therapy of Voacamine with Vincristine for Down Regulation of HIF-1α/FASN Co-Axis and PHD2 Activation in ER+ Mammary Neoplasia

2020 ◽  
Author(s):  
Lakhveer Singh ◽  
Manjari Singh ◽  
Mohd. Nazam Ansari ◽  
Abdulaziz S. Saeedan ◽  
Gaurav Kaithwas
Keyword(s):  
Mammary Gland ◽  
Fatty Acid ◽  
Combination Therapy ◽  
Fatty Acid Synthase ◽  
Hypoxia Inducible Factor ◽  
Prolyl Hydroxylase ◽  
Over Expression ◽  
Hypoxia Inducible Factor 1Α ◽  
Gland Carcinoma

Abstract Background: The current study was attempted to inquest the role of combination therapy of Voacamine and Vincristine for the prevention of mammary gland carcinoma through prolyl hydroxylase‐2 activation. The prolyl hydroxylase‐2 activation leads the downregulation of hypoxia‐inducible factor‐1α and fatty acid synthase. Over expression of hypoxia inducible factor-1α and fatty acid synthase is previously reported in solid tumor of mammary gland. Methods: After screening a battery of natural compounds which were similar to vincristine, vocamine was selected as a possible prolyl hydroxylase‐2 activator and justify its activity using 7, 12-Dimethylbenz[a]anthracene induced rat model. The combination therapy was evaluated for cardiac toxicity using hemodynamic profile. The angiogenic markers were evaluated using carmine staining. Monotherapy and combination therapy were also evaluated for liver and kidney toxicity through haematoxylin and eosin staining. The combination therapy also delineated the markers of oxidative stress favorably. Afterwards, the disruption of fatty acids was evaluated using gas chromatography. Results: The immunoblotting analysis validated that combination therapy has a potential to switch on the prolyl hydroxylase‐2 activity and thus initiate proteolytic degradation of hypoxia‐inducible factor‐1α and its consequence effects. The combination therapy also stimulated programmed cell death (apoptosis) in rapidly dividing cancer cells.Conclusion: The present study explores the role of voacamine in activation of prolyl hydroxylase‐2 which can decrease over expression of hypoxia‐inducible factor‐1α and fatty acid synthase in cells of mammary gland carcinoma.

Grading in Canine Mammary Gland Carcinoma

2009 ◽  
Vol 9 (4) ◽  
pp. 333-338 ◽  
Author(s):  
A. Rezaie ◽  
A. Tavasoli ◽  
A. Bahonar ◽  
M. Mehrazma
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Carcinoma ◽  
Gland Carcinoma ◽  
Canine Mammary Gland

Immuno-histochemical staining expression of Ki67 protein in canine mammary gland carcinoma

2010 ◽  
Vol 20 (6) ◽  
pp. 557-561 ◽  
Author(s):  
Annahita Rezaie ◽  
Abbas Tavasoli ◽  
Mitra Mehrazma ◽  
Alireza Bahonar
Keyword(s):  
Mammary Gland ◽  
Histochemical Staining ◽  
Mammary Gland Carcinoma ◽  
Gland Carcinoma ◽  
Canine Mammary Gland
Sign in / Sign up

Export Citation Format

Share Document