scholarly journals A large animal model for a failed two-stage revision of intramedullary nail-related infection by methicillin-resistant Staphylococcus aureus

2017 ◽  
Vol 34 ◽  
pp. 83-98 ◽  
Author(s):  
TF Moriarty ◽  
◽  
T Schmid ◽  
V Post ◽  
E Samara ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Animal Model ◽  
Intramedullary Nail ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Large Animal Model ◽  
Large Animal ◽  
Two Stage ◽  
Methicillin Resistant

scholarly journals A Hyaluronic Acid Hydrogel Loaded with Gentamicin and Vancomycin Successfully Eradicates Chronic Methicillin-Resistant Staphylococcus aureus Orthopedic Infection in a Sheep Model

2021 ◽  
Vol 65 (4) ◽  
Author(s):  
Willemijn Boot ◽  
Tanja Schmid ◽  
Matteo D’Este ◽  
Olivier Guillaume ◽  
Andrew Foster ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Animal Model ◽  
Hyaluronic Acid ◽  
Clinical Practice ◽  
Positive Impact ◽  
Treatment Success ◽  
Large Animal Model ◽  
Large Animal ◽  
Current Clinical Practice ◽  
Methicillin Resistant

ABSTRACT Implantable orthopedic devices have had an enormously positive impact on human health; however, despite best practice, patients are prone to developing orthopedic device-related infections (ODRI) that have high treatment failure rates. One barrier to the development of improved treatment options is the lack of an animal model that may serve as a robust preclinical assessment of efficacy. We present a clinically relevant large animal model of chronic methicillin-resistant Staphylococcus aureus (MRSA) ODRI that persists despite current clinical practice in medical and surgical treatment at rates equivalent to clinical observations. Furthermore, we showed that an injectable, thermoresponsive, hyaluronic acid-based hydrogel loaded with gentamicin and vancomycin outperforms current clinical practice treatment in this model, eliminating bacteria from all animals. These results confirm that local antibiotic delivery with an injectable hydrogel can dramatically increase treatment success rates beyond current clinical practice, with efficacy proven in a robust animal model.

scholarly journals Establishment of a new methicillin resistant staphylococcus aureus animal model of osteomyelitis

2013 ◽  
Vol 38 (4) ◽  
pp. 891-897 ◽  
Author(s):  
Lars Helbig ◽  
Hans Georg Simank ◽  
Helga Lorenz ◽  
Cornelia Putz ◽  
Christoph Wölfl ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Animal Model ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant
Sign in / Sign up

Export Citation Format

Share Document