scholarly journals Rodent animal models of delayed bone healing and non-union formation: a comprehensive review

2013 ◽  
Vol 26 ◽  
pp. 1-14 ◽  
Author(s):  
P Garcia ◽  
◽  
T Histing ◽  
JH Holstein ◽  
W Klein ◽  
...  
Keyword(s):  
Animal Models ◽  
Bone Healing ◽  
Union Formation ◽  
Comprehensive Review ◽  
Non Union ◽  
Delayed Bone Healing

scholarly journals Value of SPECT/CT in the assessment of necrotic bone fragments in patients with delayed bone healing or non-union after traumatic fractures

2020 ◽  
Vol 93 (1114) ◽  
pp. 20200300
Author(s):  
Ujwal Bhure ◽  
Christoph Agten ◽  
Dirk Lehnick ◽  
Maria del Sol Perez-Lago ◽  
Frank Beeres ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Healing ◽  
Predictive Value ◽  
Bone Fractures ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Necrotic Bone ◽  
Non Union ◽  
Bone Fragments ◽  
Delayed Bone Healing

Objective: To evaluate the value of single-photon emission computed tomography / computed tomography (SPECT/CT) compared with planar bone scintigraphy (BS) in the assessment of necrotic bone fragments in patients with delayed bone healing or non-union after traumatic fractures. Methods: Retrospective evaluation of patients with traumatic fractures and suspected delayed healing or non-union and/or persistent pain or suspected infection who had undergone planar late phase BS and SPECT/CT between 2011 and 2018. On the BS and SPECT/CT images, a necrotic fragment was considered if there was an area of absent radiotracer uptake (photopenia) related to bone at the fracture site. Histology served as a reference standard (presence or absence of necrotic bone fragments). If histology was not available, intraoperative findings and combined clinical and imaging follow-up served as reference standards. Results: In 37 consecutive patients with traumatic fractures (femur (n = 18), tibia (11), humerus (6), radius (1), jaw (1)), necrotic bone fragments were suspected in 11 fractures (29.7%) on BS and in 16 fractures (43.2%) on SPECT/CT. 35 fractures (94.6%) had metallic implants. Histology showed necrotic fragments in 10/11 (90.9%) patients. For the detection of necrotic bone fragments, SPECT/CT showed sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 100%, 95%, 94%, 100%, and 97%, respectively, and BS 67%, 95%, 91%, 81%, and 83%, respectively. SPECT/CT significantly outperformed BS with better area under curve (AUC) for SPECT/CT (0.9773) compared to planar imaging (0.8106) (p-value < 0.01). Conclusions: SPECT/CT is an accurate tool in the assessment of necrotic bone fragments in patients with delayed bone healing or non-union after traumatic bone fractures and is superior to conventional planar BS. Advances in knowledge: SPECT/CT is accurate and superior to planar BS in identification of necrotic bone fragments, responsible for delayed bone healing/non-union after fractures.

scholarly journals Profiling microRNA expression in murine bone healing and non-union formation: Role of miR-140 during the early stage of bone healing

PLoS ONE ◽  
2019 ◽  
Vol 14 (7) ◽  
pp. e0218395
Author(s):  
Marcel Orth ◽  
Claudia Scheuer ◽  
Christina Backes ◽  
Andreas Keller ◽  
Mika F. Rollmann ◽  
...  
Keyword(s):  
Bone Healing ◽  
Early Stage ◽  
Microrna Expression ◽  
Union Formation ◽  
Non Union

Mechanical Failure of Angle Locking Plates in Distal Comminuted Tibial Fractures

2016 ◽  
Vol 695 ◽  
pp. 118-122 ◽  
Author(s):  
Razvan Ene ◽  
Zsombor Panti ◽  
Mihai Nica ◽  
Marian Pleniceanu ◽  
Patricia Ene ◽  
...  
Keyword(s):  
Internal Fixation ◽  
Bone Healing ◽  
Tibial Fracture ◽  
Weight Bearing ◽  
Healing Process ◽  
Biomechanical Properties ◽  
Implant Failure ◽  
Locking Plates ◽  
Non Union ◽  
Tibial Pilon

Distal comminuted tibial fracture with or without intra-articular involvement is a very common injury of the lower limb, especially in younger patients due to high energy trauma. The anatomical and biomechanical properties of this segment of tibia, makes this pathology a major surgical challenge with a preserved clinical outcome. The aim of this study is to present different outcome of tibial fracture, treated with open reduction and internal fixation (ORIF) with titanium angle locking plates (ALP) and to underline the physiological and non-physiological bone healing effects on implants. In this study we included 48 patients with tibial pilon fracture who underwent to ORIF, applying ALP in the Orthopedics and Trauma department of the University Emergency Hospital in Bucharest. Due to preserved biomechanical properties of ALP and this anatomical region, weight bearing is not allowed till 6 to 8 weeks. Comminuted fracture of this part of tibia often have de-vascularized bony fragments which leads to delayed union or non-union. These complications often lead to implant failure, improper bone healing or non-union. Internal fixation with angle stable screws, offers a good stability of reduction in the early postoperative period. Titanium angle locking plates offers good anatomical reduction and stable fixation in the early period of healing process. Due to its rigid, fixed position of the screws in the plates, bone remodelling during healing process and early weight bearing, increases the mechanical failure of implant.Keywords: tibial pilon fractures, angle locking plates, implant failure.

Mechanical induction of critically delayed bone healing in sheep: Radiological and biomechanical results

2008 ◽  
Vol 41 (14) ◽  
pp. 3066-3072 ◽  
Author(s):  
Hanna Schell ◽  
Mark S. Thompson ◽  
Hermann J. Bail ◽  
Jan-Erik Hoffmann ◽  
Alexander Schill ◽  
...  
Keyword(s):  
Bone Healing ◽  
Delayed Bone Healing

Animal models in the neurotoxicology of 2,4-D

2019 ◽  
Vol 38 (10) ◽  
pp. 1178-1182 ◽  
Author(s):  
LM Freitas ◽  
LP de Assis Valadares ◽  
MGM Camozzi ◽  
PG de Oliveira ◽  
MR Ferreira Machado ◽  
...  
Keyword(s):  
Nervous System ◽  
Animal Models ◽  
Motor Activity ◽  
Biochemical Analysis ◽  
Brain Area ◽  
Behavioral Effect ◽  
Comprehensive Review ◽  
Locomotor Patterns ◽  
Chicken Eggs ◽  
The Brain

2,4-D is a selective pre- and postemergence herbicide used for several crops. It is hazardous for the environment and risk for humans; therefore, several studies attempt to evaluate its effects and consequences of its use. The nervous system is supposedly a target for this herbicide, and this comprehensive review gathers the information about animal models that have been used for the study of the neurotoxicity of 2,4-D. The studies used several methods to evaluate the neurotoxicity of this herbicide, most of which used rodents, mainly rats, two used fish, and one used chicken eggs. The main behavioral effect observed concerned alterations in locomotor patterns and reduced motor activity. Biochemical analysis showed decreased levels of serotonin (5-HT) and increased levels of its metabolites and increased or decreased levels of DA and its metabolites depending on the brain area analyzed. Hypomyelination is also a possible effect of 2,4-D when the exposure occurs during the proliferation and development of the oligodendrocytes. The worst neuropathologic effects were observed in fish. Since most studies focused on the neurotoxicity of 2,4-D in rodents, the effect it may have on other species and groups of animals, especially with different physiology, is unclear and it should be researched.

Non-steroidal anti-inflammatory drugs inhibit bone healing: A review

2010 ◽  
Vol 23 (06) ◽  
pp. 385-392 ◽  
Author(s):  
S. Barry
Keyword(s):  
Animal Models ◽  
Heterotopic Ossification ◽  
Mechanism Of Action ◽  
Bone Healing ◽  
Clinical Importance ◽  
Human Medicine ◽  
Experimental Animal Models ◽  
Domestic Species ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryThe ability of non-steroidal anti-inflammatory drugs (NSAID) to inhibit bone healing has been established in experimental animal models using mice, rats, and rabbits. The mechanism of action is largely unknown but stems from prostaglandin inhibition and is likely multifactorial. In human medicine NSAID are known to prevent heterotopic ossification, however the clinical importance of their effects on bone healing remains controversial. Although a small handful of reports suggest that NSAID suppress bone healing in dogs and horses, there is little published information to direct veterinary practice in domestic species.

Design of a stability-detecting device for dental implants

2005 ◽  
Vol 219 (3) ◽  
pp. 203-211 ◽  
Author(s):  
H-M Huang ◽  
K-Y Cheng ◽  
C-F Chen ◽  
K-L Ou ◽  
C-T Lin ◽  
...  
Keyword(s):  
Animal Models ◽  
Dental Implant ◽  
Bone Healing ◽  
Test Apparatus ◽  
Implant Stability ◽  
Left Tibia ◽  
Vibrational Signals ◽  
Acoustic Receiver ◽  
Rf Values

Resonance frequency (RF) analysis technology was used to design a dental implant stability detector. The device uses a miniature-sized electromagnetic triggering rod to elicit vibration in a dental implant. Vibrational signals were recorded via an acoustic receiver. To assess the in vivo performance of the test apparatus, animal models were used. Implants were placed in the left tibia of 12 rabbits using a conventional surgical procedure. Standard 3.2 mm × 8 mm implants were placed in each test tibia with pre-tapping cavities of 3.2 mm and 3.7 mm diameters to simulate either a ‘well-fitting’ or a ‘loosely fitting’ situation. The RF values of the test implants were detected by the newly developed device which was directly mounted on the healing abutments of the implants. The results showed that the RF values of the implants under well-fitting conditions significantly increased (p<0.01) 3 weeks after surgery and reached a plateau at around 6-7 weeks. Meanwhile implants with higher initial RF values had shorter healing times and higher final RF values at the plateau. Based on these findings, it was concluded that the idea of using the current designed device for detecting the degree of bone healing during the osseointegration process seems feasible.

Delayed bone healing following high tibial osteotomy related to increased implant stiffness in locked plating

Injury ◽  
2014 ◽  
Vol 45 (10) ◽  
pp. 1648-1652 ◽  
Author(s):  
Götz Röderer ◽  
Florian Gebhard ◽  
Lutz Duerselen ◽  
Anita Ignatius ◽  
Lutz Claes
Keyword(s):  
High Tibial Osteotomy ◽  
Bone Healing ◽  
Tibial Osteotomy ◽  
Locked Plating ◽  
Delayed Bone Healing
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