scholarly journals Effect of fibrin on osteogenic differentiation and VEGF expression of bone marrow stromal cells in mineralised scaffolds: a three-dimensional analysis

2012 ◽  
pp. 413-424 ◽  
Author(s):  
N Lohse ◽  
◽  
J Schulz ◽  
H Schliephake
Keyword(s):  
Bone Marrow ◽  
Osteogenic Differentiation ◽  
Dimensional Analysis ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Three Dimensional ◽  
Marrow Stromal Cells ◽  
Vegf Expression

scholarly journals Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice

2021 ◽  
Author(s):  
Daqian Wan ◽  
Songtao Ai ◽  
Huoniu Ouyang ◽  
Liming Cheng
Keyword(s):  
Bone Marrow ◽  
Bone Loss ◽  
Osteogenic Differentiation ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Bone Marrow Microenvironment ◽  
Marrow Stromal Cells ◽  
Senile Osteoporosis ◽  
Aged Mice ◽  
Old Mice

AbstractSenile osteoporosis can cause bone fragility and increased fracture risks and has been one of the most prevalent and severe diseases affecting the elderly population. Bone formation depends on the proper osteogenic differentiation of bone marrow stromal cells (BMSCs) in the bone marrow microenvironment, which is generated by the functional relationship among different cell types in the bone marrow. With aging, bone marrow provides signals that repress osteogenesis. Finding the signals that oppose BMSC osteogenic differentiation from the bone marrow microenvironment and identifying the abnormal changes in BMSCs with aging are key to elucidating the mechanisms of senile osteoporosis. In a pilot experiment, we found that 4-1BBL and 4-1BB were more abundant in bone marrow from aged (18-month-old) mice than young (6-month-old) mice. Meanwhile, significant bone loss was observed in aged mice compared with young mice. However, very little data have been generated regarding whether high-level 4-1BB/4-1BBL in bone marrow was associated with bone loss in aged mice. In the current study, we found upregulation of 4-1BB in the BMSCs of aged mice, which resulted in the attenuation of the osteogenic differentiation potential of BMSCs from aged mice via the p38 MAPK-Dkk1 pathway. More importantly, bone loss of aged mice could be rescued through the blockade of 4-1BB signaling in vivo. Our study will benefit not only our understanding of the pathogenesis of age-related trabecular bone loss but also the search for new targets to treat senile osteoporosis.

STIMULATORY EFFECTS OF CARTILAGE-DERIVED MORPHOGENETIC PROTEINS 1 AND 2 ON OSTEOGENIC DIFFERENTIATION OF BONE MARROW STROMAL CELLS

Cytokine ◽  
2000 ◽  
Vol 12 (11) ◽  
pp. 1630-1638 ◽  
Author(s):  
Reinhard Gruber ◽  
Christian Mayer ◽  
Waltraud Schulz ◽  
Winfried Graninger ◽  
Meinrad Peterlik ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Osteogenic Differentiation ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells

Notch signaling enhances osteogenic differentiation while inhibiting adipogenesis in primary human bone marrow stromal cells

2009 ◽  
Vol 37 (7) ◽  
pp. 867-875.e1 ◽  
Author(s):  
Fernando Ugarte ◽  
Martin Ryser ◽  
Sebastian Thieme ◽  
Fernando A. Fierro ◽  
Katrin Navratiel ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Notch Signaling ◽  
Osteogenic Differentiation ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow

Differentiation-Dependent Up-Regulation of BMP-2, TGF-??1, and VEGF Expression by FGF-2 in Human Bone Marrow Stromal Cells

2005 ◽  
Vol 116 (5) ◽  
pp. 1379-1386 ◽  
Author(s):  
Jian Farhadi ◽  
Claude Jaquiery ◽  
Andrea Barbero ◽  
Marcel Jakob ◽  
Stefan Schaeren ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Vegf Expression
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