scholarly journals Cyclic mechanical load causes global translational arrest in articular chondrocytes: a process which is partially dependent upon PKR phosphorylation

2011 ◽  
Vol 22 ◽  
pp. 178-189 ◽  
Author(s):  
C Lomas ◽  
◽  
XD Tang ◽  
A Chanalaris ◽  
J Saklatvala ◽  
...  
Keyword(s):  
Articular Chondrocytes ◽  
Mechanical Load ◽  
Translational Arrest ◽  
Cyclic Mechanical Load

Investigation of crack repair using piezoelectric material under thermo-mechanical loading

2020 ◽  
Vol 31 (19) ◽  
pp. 2243-2260
Author(s):  
Ritesh Kumar ◽  
Akhilendra Singh ◽  
Mayank Tiwari
Keyword(s):  
Piezoelectric Material ◽  
Mechanical Loading ◽  
Mechanical Load ◽  
Piezoelectric Sensor ◽  
Crack Location ◽  
Piezoelectric Patch ◽  
Optimal Value ◽  
Temperature Environment ◽  
Crack Repair ◽  
Cyclic Mechanical Load

This article presents an experimental investigation of repair of a crack in a structure using piezoelectric material under thermo-mechanical loading environment. The cyclic mechanical load is applied on a plate with a straight and angular crack under uniform temperature environment. Two cases have been considered for the repair of crack under (a) mechanical loading and (b) thermo-mechanical loading environment. A piezoelectric sensor is utilized to measure voltage. The measured voltage is used to calculate the stress intensity factor in passive and active modes. The effect of a single and double piezoelectric patch in the repair of the plate is investigated. The double piezoelectric patch is found to be more effective as compared to single patch when placed symmetrically offset from the crack. An optimal value of voltage and phase difference is evaluated for most effective crack repair. Location of the piezoelectric patch is varied with respect to crack location, and best-suited position for effective crack repair is proposed. The viability of piezoelectric used for repair under thermo-mechanical loading is discussed. The active mode of repair by piezoelectric is found to be effective under thermo-mechanical loading environment.

scholarly journals Fatigue and Structural Deformation of Aged Engineering Plastics by Cyclic Mechanical Load.

1997 ◽  
Vol 54 (2) ◽  
pp. 61-68 ◽  
Author(s):  
Shigeki TAKAYAMA ◽  
Tomoyuki ISHIKAWA ◽  
Kunihiko TAKEDA
Keyword(s):  
Mechanical Load ◽  
Structural Deformation ◽  
Engineering Plastics ◽  
Cyclic Mechanical Load

Development of a Novel Model System to Study Remodeling of ECM Scaffolds in Response to Cyclic Stretching

2003 ◽  
Author(s):  
Thomas W. Gilbert ◽  
James H.-C. Wang ◽  
Stephen F. Badylak ◽  
Savio L.-Y. Woo
Keyword(s):  
Mechanical Load ◽  
Complex Loading ◽  
Biological Tissues ◽  
In Vitro Models ◽  
Matrix Remodeling ◽  
Cyclic Stretching ◽  
A Cell ◽  
Cyclic Mechanical Load

In an effort to better understand the role of mechanical loading on the healing and remodeling of biological tissues, a number of in vitro models have been developed to apply either static or cyclic mechanical load to cell-seeded scaffolds (Huang 1993, Langelier 1999, Cacou 2000). The current study describes the validation of a new system designed to facilitate the study of matrix remodeling in cell seeded scaffolds, as well as the formation of tissue engineered scaffolds for potential use in repair of healing ligaments and tendons. Our objective was to develop a system that would allow a cell seeded scaffold to remain viable under cyclic loading for long periods of time, with the capability to apply complex loading regimes to the scaffold while monitoring the load in the scaffold.

Critical currents of Nb/sub 3/Sn superconductors for generators under cyclic mechanical load

1994 ◽  
Vol 30 (4) ◽  
pp. 1927-1930 ◽  
Author(s):  
H. Kasahara ◽  
S. Torii ◽  
S. Akita ◽  
K. Uyeda ◽  
T. Ogawa ◽  
...  
Keyword(s):  
Mechanical Load ◽  
Critical Currents ◽  
Cyclic Mechanical Load

Connexin 32 and 43 gap junctions differentially modulate tenocyte response to cyclic mechanical load

2006 ◽  
Vol 85 (11) ◽  
pp. 1145-1154 ◽  
Author(s):  
Andrew D. Waggett ◽  
Michael Benjamin ◽  
James R. Ralphs
Keyword(s):  
Gap Junctions ◽  
Mechanical Load ◽  
Connexin 32 ◽  
Cyclic Mechanical Load

scholarly journals The potential role of mechanically sensitive ion channels in the physiology, injury, and repair of articular cartilage

2020 ◽  
Vol 28 (3) ◽  
pp. 230949902095026
Author(s):  
Bo-Yang Xu ◽  
Yu Jin ◽  
Xiao-Hui Ma ◽  
Chi-Yu Wang ◽  
Yi Guo ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Ion Channels ◽  
Articular Chondrocytes ◽  
Mechanical Load ◽  
Biological Responses ◽  
Intracellular Signals ◽  
Biophysical Mechanism ◽  
Mechanical Factors ◽  
Injury And Repair ◽  
Biomechanical Factors

Biomechanical factors play an extremely important role in regulating the function of articular chondrocytes. Understanding the mechanical factors that drive chondrocyte biological responses is at the heart of our interpretation of cascade events leading to changes in articular cartilage osteoarthritis. The mechanism by which mechanical load is transduced into intracellular signals that can regulate chondrocyte gene expression remains largely unknown. The mechanically sensitive ion channel (MSC) may be one of its specific mechanisms. This review focuses on four ion channels involved in the mechanotransduction of chondrocytes, exploring their properties and the main factors that activate the associated pathways. The upstream and downstream potential relationships between the protein pathways were also explored. The specific biophysical mechanism of the chondrocyte mechanical microenvironment is becoming the focus of research. Elucidating the mechanotransduction mechanism of MSC is essential for the research of biophysical pathogenesis and targeted drugs in cartilage injury-related diseases.

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