scholarly journals A bone fluid flow hypothesis for muscle pump-driven capillary filtration: ii proposed role for exercise in erodible scaffold implant incorporation

2003 ◽  
Vol 6 ◽  
pp. 1-11 ◽  
Author(s):  
H Winet ◽  
Keyword(s):  
Fluid Flow ◽  
Capillary Filtration ◽  
Muscle Pump ◽  
Bone Fluid Flow

In Vivo Mesenchymal Stem Cell Proliferation in Response to Dynamic Fluid Flow Stimulation

2012 ◽  
Author(s):  
M. Hu ◽  
R. Yeh ◽  
M. Lien ◽  
Y. X. Qin
Keyword(s):  
Fluid Flow ◽  
Bone Tissue ◽  
Bone Adaptation ◽  
Hindlimb Suspension ◽  
Osteoporotic Bone ◽  
Hydraulic Stimulation ◽  
Structural Deterioration ◽  
Bone Fluid Flow ◽  
Cord Injury

Osteoporosis is a debilitating disease characterized as decreased bone mass and structural deterioration of bone tissue. Osteoporotic bone tissue turns itself into altered structure, which leads to weaker bones that are more susceptible for fractures. While often happening in elderly, long-term bed-rest patients, e.g. spinal cord injury, and astronauts who participate in long-duration spaceflights, osteoporosis has been considered as a major public health thread and causes great medical cost impacts to the society. Mechanobiology and novel stimulation on regulating bone health have long been recognized. Loading induced bone fluid flow, as a critical mechanotransductive promoter, has been demonstrated to regulate cellular signaling, osteogenesis, and bone adaptation [4]. As one of the factors that mediate bone fluid flow, intromedullary pressure (ImP) creates a pressure gradient that further influence the magnitude of mechanotransductory signals [5]. As for a potential translational development of ImP, our group has recently introduced a novel, non-invasive dynamic hydraulic stimulation (DHS) on bone structural enhancement. Its promising effects on inhibition of disuse bone loss has been shown with 2 Hz loading through a 4-week hindlimb suspension rat study followed by microCT analysis. At the cellular level, mesenchymal stem cells (MSCs) are defined by their self-renewal ability and that to potentially differentiate into the cells that form tissues such as bone [1]. To further elucidate the cellular effects of DHS and its potential mechanism on bone quality enhancement, the objective of this study was to measure MSC quantification in response to the in vivo mechanical signals driven by DHS.

Induced Intramedullary Pressure by Dynamic Hydraulic Stimulation and Its Potential in Attenuation of Bone Loss

2011 ◽  
Author(s):  
M. Hu ◽  
J. Cheng ◽  
S. Ferreri ◽  
F. Serra-Hsu ◽  
W. Lin ◽  
...  
Keyword(s):  
Fluid Flow ◽  
Bone Loss ◽  
Bone Adaptation ◽  
Dependent Manner ◽  
Hydraulic Stimulation ◽  
Flow Coupling ◽  
Bone Fluid Flow ◽  
Intramedullary Pressure ◽  
New Treatments

Bone loss is a critical health problem of astronauts in long-term space missions. A growing number of evidence has pointed out bone fluid flow as a critical regulator in mechanotransductive signaling and bone adaptation. Intramedullary pressure (ImP) is a key mediator for bone fluid flow initiation and it influences the osteogenic signals within the skeleton. The potential ImP-induced bone fluid flow then triggers bone adaptation [1]. Previous in vivo study has demonstrated that ImP induced by oscillatory electrical stimulations can effectively mitigate disuse osteopenia in a frequency-dependent manner in a disuse rat model [2, 3]. In order to develop the translational potentials of ImP, a non-invasive intervention with direct fluid flow coupling is necessary to develop new treatments for microgravity-induced osteopenia/osteoporosis.

INTERSTITIAL FLUID FLOW BEHAVIOR IN OSTEON WALL UNDER NON-AXISYMMETRIC LOADING: A FINITE ELEMENT STUDY

2018 ◽  
Vol 18 (07) ◽  
pp. 1840007
Author(s):  
XIAO-GANG WU ◽  
TENG ZHAO ◽  
XIAO-HONG WU ◽  
JIANG-LAN XIE ◽  
KUI-JUN CHEN ◽  
...  
Keyword(s):  
Finite Element ◽  
Fluid Flow ◽  
Axial Compression ◽  
Flow Behavior ◽  
Pressure Amplitude ◽  
Interstitial Fluid Flow ◽  
Compression Loading ◽  
Velocity Amplitude ◽  
Bone Fluid Flow ◽  
Loading Case

Physiological loads are non-axisymmetric and can lead to interstitial bone fluid flow, particularly in osteon. According to research, interstitial bone fluid flow plays a key role in bone mechanotransduction. To evaluate the poroelastic responses of a non-axisymmetric loaded osteon, this paper presents a finite element osteon model that is bulit by using the Comsol Multiphysics software. Obtained results show that under the same loading amplitude, the generated pressure and velocity amplitudes in the axial compression loading case are the largest, followed by that in the compressive bending loading, and smallest in the bending case. Moreover, the induced pressure and velocity amplitudes in axial compression loading exhibit an axial symmetrical distribution and axial centrosymmetric distribution in the compressive bending. In the bend loading case, the pressure amplitude presents an antisymmetric distribution, but the velocity amplitude is axially symmetrically distributed. Therefore, the distributions of pressure and velocity are definitely affected by load types, which lead to different bone fluid stimuli in mechanotransduction.

Oscillatory Bone Fluid Flow and its Role in Initiating Remodeling in the Absence of Matrix Strain

2001 ◽  
Author(s):  
Yixian Qin ◽  
Anita Saldanha ◽  
Tamara Kaplan
Keyword(s):  
Fluid Flow ◽  
Cellular Response ◽  
Fluid Shear Stress ◽  
Bone Matrix ◽  
Fluid Pressure ◽  
Streaming Potential ◽  
Bone Adaptation ◽  
Interstitial Fluid Flow ◽  
Bone Fluid Flow ◽  
Matrix Deformation

Abstract Load-generated intracortical fluid flow is proposed to be an important mediator for regulating bone mass and morphology [1]. Although the mechanism of cellular response to induced flow parameters, i.e., fluid pressure, pressure gradient, velocity, and fluid shear stress, are not yet clear, interstitial fluid flow driven by loading may be necessary to explain the adaptive response of bone, which is either coupled with load-induced strain magnitude or independent with matrix strain per se [2]. It has been demonstrated that load-induced intracortical fluid flow is contributed by both bone matrix deformation and induced intramedullary (IM) pressure [3]. To examine the hypothesis of fluid flow generated adaptation, it is necessary to test the mechanism under the circumstances of solely fluid induced bone adaptation in the absence of matrix deformation. While our previous data has demonstrated that bone fluid flow and its associated streaming potential product can be influenced by the dynamic IM pressure quantitatively [4], the objective of this study was to evaluate fluid induced bone adaptation in an avian ulna model using oscillatory IM fluid pressure loading in the absence of bone matrix strain. The potential fluid pathway was measured in the model.

scholarly journals Calf Muscle Pump Stimulation Increases Lower Limb Bone Density in Perimenopausal Women

2018 ◽  
Vol 4 (1) ◽  
pp. 89-93
Author(s):  
Kenneth James McLeod ◽  
Carolyn Pierce
Keyword(s):  
Bone Mineral Density ◽  
Fluid Flow ◽  
Lower Limb ◽  
Calf Muscle ◽  
Muscle Stimulation ◽  
Mineral Density ◽  
Nutrient Delivery ◽  
Muscle Pump ◽  
Calf Muscle Pump ◽  
Perimenopausal Women

Nutrient delivery to bone tissue, as for all tissues in the body, is provided through interstitial fluid flow. This flow is driven by the differential fluid pressures between the intramedullary canal and the tissues outside of the bone. Correspondingly, reductions in tissue fluid pressure should enhance interstitial bone fluid flow, nutrient delivery, and thereby increase bone mineral density. This hypothesis was tested in a one year long pilot clinical study of healthy, employed, perimenopausal women (42 - 68 years). Soleus muscle (calf muscle pump) stimulation was utilized with the intent of increasing lower limb fluid return to the heart, serving to both reduce lower limb tissue pressures and to increase intramedullary pressures by increasing cardiac output. Dual-energy x-ray absorptiometry (DXA) assessments of bone mineral density (BMD) were obtained at 12 month intervals. Muscle stimulation usage ranged from 0.7 to 4.8 hours/work-day. Dose dependent responses between duration of daily soleus muscle stimulation and changes in both proximal femur BMD (+0.5% per hour of daily use; p = 0.05) and proximal tibia BMD (+1.5% per hour of daily use; p = 0.0004), were observed; no significant effect was observed at the lumbar spine. These results are consistent with the hypothesis that calf muscle pump stimulation, which is sufficient to reduce lower limb fluid pooling, is capable of significantly reducing the rate of bone loss in perimenopausal women as well as enhancing new bone formation.

Water in hydroxyapatite nanopores: Possible implications for interstitial bone fluid flow

2015 ◽  
Vol 48 (12) ◽  
pp. 3066-3071 ◽  
Author(s):  
T. Lemaire ◽  
T.T. Pham ◽  
E. Capiez-Lernout ◽  
N.H. de Leeuw ◽  
S. Naili
Keyword(s):  
Fluid Flow ◽  
Bone Fluid Flow

Bone Formation and Inhibition of Bone Loss by Dynamic Muscle Stimulation With Altered Interstitial Fluid Pressure

2007 ◽  
Author(s):  
Yi-Xian Qin ◽  
Hoyan Lam
Keyword(s):  
Fluid Flow ◽  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Tissue Level ◽  
Bone Strain ◽  
Bone Fluid Flow ◽  
Muscle Dynamics ◽  
Key Players ◽  
Flow Through ◽  
Bone Physiology

Tissue-level mechanisms and functions, including bone strain and muscle, are the potential key players in bone physiology and adaptation [1,2,3]. However, the mechanisms are not yet fully understood. Exercise such as muscle contraction appears to increase blood flow to the skeletal tissues, i.e., bone and muscle. These evidences imply that bone fluid flow induced by muscle dynamics may be an important role in regulating fluid flow through coupling of muscle and bone via microvascular system.

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