Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids

2014 ◽  
Vol 15 (6) ◽  
pp. 799-806 ◽  
Author(s):  
Susanne JH Vijverberg ◽  
Roger Tavendale ◽  
Maarten Leusink ◽  
Leo Koenderman ◽  
Jan AM Raaijmakers ◽  
...  
Keyword(s):  
Inhaled Corticosteroids ◽  
Pediatric Asthma

scholarly journals Association among Fraction of Exhaled Nitrous Oxide, Bronchodilator Response and Inhaled Corticosteroid Type

2015 ◽  
Vol 22 (3) ◽  
pp. 153-156 ◽  
Author(s):  
Ryan W Smith ◽  
Kim Downey ◽  
Nadia Snow ◽  
Sharon Dell ◽  
W Gary Smith
Keyword(s):  
Nitrous Oxide ◽  
Inhaled Corticosteroids ◽  
Pediatric Asthma ◽  
Persistent Asthma ◽  
Forced Expiratory Volume ◽  
Parental Smoking ◽  
Type B ◽  
Bronchodilator Response ◽  
Percent Change ◽  
Forced Expiratory Flow

BACKGROUND: Fraction of exhaled nitrous oxide (FeNO) is a known marker of airway inflammation and a topic of recent investigation for asthma control in children.OBJECTIVE: To investigate the relationship among FeNO and bronchodilator response measured by spirometry and types of inhaled corticosteroids (ICS).METHODS: A one-year review of children tested with spirometry and FeNO in a regional pediatric asthma centre was conducted.RESULTS: A total of 183 children were included (mean [± SD] age 12.8±2.8 years). Fluticasone was used most commonly (n=66 [36.1%]), followed by ciclesonide (n=50 [27.3%]). Most children (n=73 [39.9%]) had moderate persistent asthma. Increased FeNO was associated with percent change in forced expiratory volume in 1 s (FEV1) after bronchodilator adjusted for allergic rhinitis, parental smoking and ICS type (B=0.08 [95% CI 0.04 to 0.12]; P<0.001). Similarly, FeNO was associated with percent change in forced expiratory flow at 25% to 75% of the pulmonary volume (FEF25–75) after bronchodilator adjusted for parental smoking and ICS type (B=0.13 [95% CI 0.01 to 0.24]; P=0.03). FeNO accounted for only 16% and 9% of the variability in FEV1and FEF25–75, respectively. Mean-adjusted FeNO was lowest in fluticasone users compared with no ICS (mean difference 18.6 parts per billion [ppb] [95% CI 1.0 to 36.2]) and there was no difference in adjusted FeNO level between ciclesonide and no ICS (5.9 ppb [95% CI −9.0 to 20.8]).CONCLUSION: FeNO levels correlated with bronchodilator response in a regional pediatric asthma centre. However, FeNO accounted for only 16% and 9% of the variability in FEV1and FEF25–75, respectively. Mean adjusted FeNO varied according to ICS type, suggesting a difference in relative efficacy between ICS beyond their dose equivalents.

scholarly journals A study on HbA1c profile in children with asthma using inhaled corticosteroids

2017 ◽  
Vol 4 (3) ◽  
pp. 796 ◽  
Author(s):  
Sunil Daniel ◽  
Jose O.
Keyword(s):  
Blood Sugar ◽  
Inhaled Corticosteroids ◽  
Glycosylated Hemoglobin ◽  
Venous Blood ◽  
Pediatric Asthma ◽  
Total Study Population ◽  
Asthmatic Children ◽  
Children With Asthma ◽  
Study Population

Background: Inhaled corticosteroids (ICS) are the mainstay of treatment for persistent bronchial asthma in children. Even though ICS is comparatively safe, few systemic toxicities have been reported. We have conducted a study on HbA1c profile of 170 asthmatic children who are on ICS for atleast 6 months. Glycosylated hemoglobin (HbA1c), fasting blood sugar (FBS), Postprandial blood sugar (PPBS) levels were measured before initiating ICS and after 6 months using venous blood samples. HbA1c measured using immunoassay. The objective of the study was to detect prevalence of significant hyperglycemia among children with asthma who are on inhaled corticosteroids. Study design used as a prospective follow up study, setting of the study was to Pediatric asthma clinic, Govt. TDMCH, Alappuzha, Study population used Children between 3 to 12 years attending pediatric asthma clinic.Methods: Cumulative doses of ICS and bronchodialators were measured by providing an asthma diary to mark the dose of medication. FBS, PPBS, and HbA1c levels were measured before initiating ICS and after 6 months. To elucidate the assosiations comparisons between different parameters Chi-square test was used as non-parametric test. Student’s T- test was used to compare mean values between 2 groups and different groups. Initial and follow up two groups of HbA1c and ICS administrations were compared using paired and unpaired T-test.Results: There is a significant increase in the mean HbA1c of the total study population before and after treatment with ICS.Conclusions: Long term use of ICS can affect glucose metabolism of asthmatic children. 

scholarly journals The use of inhaled corticosteroids in pediatric asthma: update

2016 ◽  
Vol 9 ◽  
pp. 26 ◽  
Author(s):  
Elham Hossny ◽  
Nelson Rosario ◽  
Bee Wah Lee ◽  
Meenu Singh ◽  
Dalia El-Ghoneimy ◽  
...  
Keyword(s):  
Inhaled Corticosteroids ◽  
Pediatric Asthma
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