Association of ATP-binding cassette transporter variants with the risk of Alzheimer’s disease

2013 ◽  
Vol 14 (5) ◽  
pp. 485-494 ◽  
Author(s):  
Ingolf Cascorbi ◽  
Charlotte Flüh ◽  
Cornelia Remmler ◽  
Sierk Haenisch ◽  
Frank Faltraco ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

Increased ATP-Binding Cassette Transporter A1 Expression in Alzheimer's Disease Hippocampal Neurons

2010 ◽  
Vol 21 (1) ◽  
pp. 193-205 ◽  
Author(s):  
Woojin Scott Kim ◽  
Surabhi Bhatia ◽  
David A. Elliott ◽  
Lotta Agholme ◽  
Katarina Kågedal ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hippocampal Neurons ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

P3-053: ATP-binding cassette transporter A7 (ABCA7) effects on amyloid processing and relevance to Alzheimer's disease

2012 ◽  
Vol 8 (4S_Part_13) ◽  
pp. P473-P473 ◽  
Author(s):  
Kanayo Satoh ◽  
Sumiko Abe-Dohmae ◽  
Shinji Yokoyama ◽  
Peter St. George-Hyslop ◽  
Paul Fraser
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

scholarly journals Abca7 deletion does not affect adult neurogenesis in the mouse

2016 ◽  
Vol 36 (2) ◽  
Author(s):  
Hongyun Li ◽  
Tim Karl ◽  
Brett Garner
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Adult Neurogenesis ◽  
Abc Transporters ◽  
Atp Binding ◽  
Wild Type ◽  
Atp Binding Cassette Transporter ◽  
The Brain ◽  
Deficient Mice ◽  
Atp Binding Cassette

ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and linked with Alzheimer's disease. Since other ABC transporters regulate adult neurogenesis, we assessed neurogenesis in wild-type (WT) and Abca7 deficient mice. Abca7 deletion did not affect adult neurogenesis in the mouse.

Meta-analysis on association between the ATP-binding cassette transporter A1 gene (ABCA1) and Alzheimer's disease

Gene ◽  
2012 ◽  
Vol 510 (2) ◽  
pp. 147-153 ◽  
Author(s):  
Mei Jiang ◽  
Lei Lv ◽  
Hairong Wang ◽  
Xuelian Yang ◽  
Haifeng Ji ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Meta Analysis ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

No Genetic Association between ATP Binding Cassette Proteins and Japanese Sporadic Alzheimer’s Disease

2005 ◽  
Vol 20 (2-3) ◽  
pp. 95-98 ◽  
Author(s):  
Taku Ohkubo ◽  
Nobuto Shibata ◽  
Tohru Ohnuma ◽  
Shinji Higashi ◽  
Chie Usui ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Association ◽  
Atp Binding ◽  
Sporadic Alzheimer’S Disease ◽  
Atp Binding Cassette

scholarly journals The Function and Expression of ATP-Binding Cassette Transporters Proteins in the Alzheimer's Disease

2021 ◽  
Author(s):  
Asli Aykac ◽  
Ahmet Özer Sehirli
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Choroid Plexus ◽  
Abc Transporters ◽  
Amyloid Β ◽  
Neuronal Cell ◽  
Tau Proteins ◽  
Atp Binding ◽  
Aβ Peptide ◽  
Atp Binding Cassette

AbstractDespite many years of research, radical treatment of Alzheimer's disease (AD) has still not been found. Amyloid-β (Aβ) peptide is known to play an important role in the pathogenesis of this disease. AD is characterized by three main changes occurring in the central nervous system: (1) Aβ plaque accumulation that prevents synaptic communication, (2) the accumulation of hyperphosphorylated tau proteins that inhibit the transport of molecules inside neurons, and (3) neuronal cell loss of the limbic system. Mechanisms leading to Aβ accumulation in AD are excessive Aβ production as a result of mutations in amyloid precursor protein or genes, and impairment of clearance of Aβ due to changes in Aβ aggregation properties and/or Aβ removal processes. Human ATP-binding cassette (ABC) transporters are expressed in astrocyte, microglia, neuron, brain capillary endothelial cell, choroid plexus, choroid plexus epithelial cell, and ventricular ependymal cell. ABC transporters have essential detoxification and neuroprotective roles in the brain. The expression and functional changes in ABC transporters contribute to the accumulation of Aβ peptide. In conclusion, the review was aimed to summarize and highlight accumulated evidence in the literature focusing on the changing functions of human ABC transporter members, in AD pathogenesis and progression.

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