DRD2haplotype is associated with dyskinesia induced by levodopa therapy in Parkinson’s disease patients

2012 ◽  
Vol 13 (15) ◽  
pp. 1701-1710 ◽  
Author(s):  
Mariana Rieck ◽  
Artur F Schumacher-Schuh ◽  
Vivian Altmann ◽  
Carolina LM Francisconi ◽  
Paulo TB Fagundes ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Levodopa Therapy

scholarly journals Impact of levodopa treatment in the voice pattern of Parkinson’s disease patients: a systematic review and meta-analysis

CoDAS ◽  
2018 ◽  
Vol 30 (5) ◽  
Author(s):  
Patrícia Pinho ◽  
Larissa Monteiro ◽  
Maria Francisca de Paula Soares ◽  
Lorena Tourinho ◽  
Ailton Melo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Acoustic Analysis ◽  
Meta Analysis ◽  
Speech Disorders ◽  
Levodopa Therapy ◽  
Eligibility Criteria ◽  
Perceptual Analysis ◽  
Vocal Intensity

Abstract Purpose Investigate the association between levodopa therapy and vocal characteristics in Parkinson’s disease patients. Search strategy Studies published at MEDLINE, LILACS, and SciELO, from 1960 to December 2016. A systematic review and meta-analysis was performed using the following keywords: Parkinson’s disease; levodopa; L-dopa; voice; speech disorders; dysphonia; dysarthria. After analyzing titles and abstracts, two independent reviewers selected all clinical trials that met the eligibility criteria and selected the articles and the data recorded in a previously standardized table. Selection criteria Trials published in English between 1960 and December 2016 individuals with clinical diagnosis of Parkinson’s disease; use of levodopa therapy in stable doses; acoustic analysis combined or not with auditory-perceptual analysis to evaluate the vocal parameters under investigation. Data analysis The following vocal parameters were analyzed: fundamental frequency (F 0), jitter, and vocal intensity. Standardized mean differences (SMD) were calculated using the Comprehensive Meta-analysis V2 software. Results Nine articles met the eligibility criteria and were selected, with a total of 119 individuals. From these, six articles with 83 individuals were included in the meta-analysis. During the levodopa therapy “on” state, modifications in F 0 (SMD=0.39; 95% CI - 0.21-0.57) and jitter (SMD=0.23; 95% CI - 0.02-0.45) were observed. Vocal intensity was not affected (SMD=0.09; 95% CI - 0.22-0.39) by levodopa ingestion. Data of the included studies were controversial in the auditory-perceptual analysis of voice. Conclusion Levodopa therapy modifies F0 and jitter. No changes in vocal intensity were observed in either the “on” or “off” states of levodopa therapy.

Factors Predictive of the Need for Levodopa Therapy in Early, Untreated Parkinson's Disease

1995 ◽  
Vol 52 (6) ◽  
pp. 565-570 ◽  
Author(s):  
M. P. McDermott ◽  
J. Jankovic ◽  
J. Carter ◽  
S. Fahn ◽  
S. Gauthier ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Levodopa Therapy

The influence of SLC6A3 and DRD2 polymorphisms on levodopa-therapy in patients with sporadic Parkinson's disease

2018 ◽  
Vol 71 (2) ◽  
pp. 206-212 ◽  
Author(s):  
Erinaldo Ubirajara Damasceno dos Santos ◽  
Tiago F. Sampaio ◽  
Aléxia D. Tenório dos Santos ◽  
Fernanda C. Bezerra Leite ◽  
Ronaldo C. da Silva ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Levodopa Therapy ◽  
Sporadic Parkinson’S Disease

Initiating levodopa therapy for Parkinson's disease

2014 ◽  
Vol 29 (3) ◽  
pp. 430-430 ◽  
Author(s):  
C. Warren Olanow ◽  
Karl Kieburtz ◽  
Fabrizio Stocchi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Levodopa Therapy

scholarly journals Enteral Levodopa Therapy in Advanced Parkinson's Disease with Gastroparesis

2015 ◽  
Vol 2 (3) ◽  
pp. 321-322 ◽  
Author(s):  
Anil Venkitachalam ◽  
Adriana Lazarescu ◽  
Oksana Suchowersky
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Levodopa Therapy ◽  
Advanced Parkinson’S Disease
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