Pharmacogenetics of calcineurin inhibitors in Brazilian renal transplant patients

2011 ◽  
Vol 12 (9) ◽  
pp. 1293-1303 ◽  
Author(s):  
Ana Santoro ◽  
Claudia R Felipe ◽  
Helio Tedesco-Silva ◽  
Jose O Medina-Pestana ◽  
Claudio J Struchiner ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Calcineurin Inhibitors ◽  
Transplant Patients ◽  
Renal Transplant Patients

Long-term results after conversion from calcineurin inhibitors to sirolimus in renal transplant patients

2010 ◽  
Vol 24 (4) ◽  
pp. 467-473 ◽  
Author(s):  
Gustavo Martinez-Mier ◽  
Sandro F. Avila-Pardo ◽  
Marco T. Mendez-Lopez ◽  
Luis F. Budar-Fernandez
Keyword(s):  
Renal Transplant ◽  
Calcineurin Inhibitors ◽  
Long Term Results ◽  
Transplant Patients ◽  
Renal Transplant Patients

Effect of a new functionalCYP3A4polymorphism on calcineurin inhibitors’ dose requirements and trough blood levels in stable renal transplant patients

2011 ◽  
Vol 12 (10) ◽  
pp. 1383-1396 ◽  
Author(s):  
Laure Elens ◽  
Ron H van Schaik ◽  
Nadtha Panin ◽  
Martine de Meyer ◽  
Pierre Wallemacq ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Calcineurin Inhibitors ◽  
Blood Levels ◽  
Transplant Patients ◽  
Trough Blood ◽  
Renal Transplant Patients

scholarly journals TACROLIMUS INDUCED TREMORS AMONG POST RENAL TRANSPLANT PATIENTS: A CASE SERIES

2017 ◽  
Vol 10 (5) ◽  
pp. 9 ◽  
Author(s):  
Amita Priya ◽  
Balaji Ommurugan ◽  
Navin Patil
Keyword(s):  
Renal Transplant ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Case Series ◽  
Calcineurin Inhibitors ◽  
Neurological Complications ◽  
Care Hospital ◽  
Transplant Patients ◽  
Wide Range ◽  
Renal Transplant Patients

Triple immunosuppression in renal transplant has drastically changed the outcome of graft survival. However, concern always remains among thephysicians because of adverse effects produced due to triple immunosuppression. Calcineurin inhibitors are associated with wide range of side effects. Hence, we report a case series of tremors associated with tacrolimus among renal transplant patients in a tertiary care hospital in southern India.Keywords: Tacrolimus, Tremors, Neurological complications, Renal transplant, Triple immunosuppression.

scholarly journals Use of Belatacept as Alternative Immunosuppression in Three Renal Transplant Patients withDe NovoDrug-Induced Thrombotic Microangiopathy

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Federico Cicora ◽  
Marta Paz ◽  
Fernando Mos ◽  
Javier Roberti
Keyword(s):  
Renal Transplant ◽  
Thrombotic Microangiopathy ◽  
De Novo ◽  
Parvovirus B19 ◽  
Calcineurin Inhibitors ◽  
Immunosuppressive Drugs ◽  
Drug Induced ◽  
Transplant Patients ◽  
Proliferation Signal Inhibitors ◽  
Renal Transplant Patients

Thrombotic microangiopathy (TMA), a severe complication of renal transplantation, is a pathological process involving microvascular occlusion, thrombocytopenia, and microangiopathic hemolytic anemia. It generally appears within the first weeks after transplantation, when immunosuppressive drugs are used at high doses.De novoTMA may also be drug-induced when calcineurin inhibitors or proliferation signal inhibitors are used. We report three cases ofde novodrug-induced TMA in renal transplant patients who were managed by replacing calcineurin inhibitors or proliferation signal inhibitors with belatacept, a primary maintenance immunosuppressive drug, which blocks the CD28 costimulation pathway, preventing the activation of T lymphocytes. To identify the cause of TMA, we ruled out HUS, hepatitis C serology, HIV serology, parvovirus B19, cytomegalovirus, anti-HLA antibodies, and prolonged activated partial thromboplastin time. We suspect that the TMA was caused by the calcineurin inhibitors or proliferation signal inhibitors. Belatacept treatment was initiated at a dose of 10 mg/kg on days 1, 5, 14, 28, 60, and 90; maintenance treatment was 5 mg/kg once a month for 1 year. Belatacept, in combination with other agents, prevented graft rejection in three patients.

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