Human lymphoblastoid cell line panels: novel tools for assessing shared drug pathways

2010 ◽  
Vol 11 (3) ◽  
pp. 327-340 ◽  
Author(s):  
Ayelet Morag ◽  
Julia Kirchheiner ◽  
Moshe Rehavi ◽  
David Gurwitz
Keyword(s):  
Cell Line ◽  
Lymphoblastoid Cell Line ◽  
Human Lymphoblastoid Cell ◽  
Human Lymphoblastoid Cell Line

Quantitative analysis of cytotoxicity induced by HTLV-I carrying cells against a human lymphoblastoid cell line, molt-4

1987 ◽  
Vol 11 (4) ◽  
pp. 331-338 ◽  
Author(s):  
Ronko Kikukawa-Itamura ◽  
Shinji Harada ◽  
Nobuyuki Kobayashi ◽  
Masakazu Hatanaka ◽  
Naoki Yamamoto
Keyword(s):  
Quantitative Analysis ◽  
Cell Line ◽  
Lymphoblastoid Cell Line ◽  
Human Lymphoblastoid Cell ◽  
Human Lymphoblastoid Cell Line

Morphological modifications induced by HCV infection in the TOFE human lymphoblastoid cell line

1998 ◽  
Vol 149 (5) ◽  
pp. 299-305 ◽  
Author(s):  
A. Serafino ◽  
M.B. Valli ◽  
F. Andreola ◽  
G. Carloni ◽  
L. Bertolini
Keyword(s):  
Cell Line ◽  
Lymphoblastoid Cell Line ◽  
Hcv Infection ◽  
Human Lymphoblastoid Cell ◽  
Human Lymphoblastoid Cell Line

A Human Lymphoblastoid Cell Line Secreting Antiidiotypic Antibodies

1989 ◽  
pp. 489-491
Author(s):  
D. P. Singal ◽  
M. A. Blajchman ◽  
F. A. Ofosu ◽  
S. Joseph ◽  
B. Roberge ◽  
...  
Keyword(s):  
Cell Line ◽  
Lymphoblastoid Cell Line ◽  
Human Lymphoblastoid Cell ◽  
Human Lymphoblastoid Cell Line ◽  
Antiidiotypic Antibodies

The effect of anoxia on anthracycline-induced DNA damage in the RPMI-6410 human lymphoblastoid cell line

1982 ◽  
Vol 60 (9) ◽  
pp. 873-876 ◽  
Author(s):  
L. Brox ◽  
B. Gowans ◽  
R. To ◽  
A. Belch
Keyword(s):  
Cell Line ◽  
Lymphoblastoid Cell Line ◽  
Dna Strand Breaks ◽  
Primary Role ◽  
Alkaline Elution ◽  
Strand Breaks ◽  
Human Lymphoblastoid Cell ◽  
Strand Breakage ◽  
Human Lymphoblastoid Cell Line ◽  
Dna Strand

The alkaline elution procedure developed by Kohn and co-workers was used with the RPMI-6410 cultured human lymphoblastoid cell line to examine the hypothesis that anthracycline-induced DNA strand scission is mediated by oxygen- or superoxide-derived free radicals. Hypoxia was induced by gassing with nitrogen containing 5% carbon dioxide and less than 4 ppm oxygen. Alkaline elution studies showed hypoxia was induced, as the oxygen enhancement ratios for DNA strand breaks was 2.4 and 2.6 for the 250 R ± oxygen and the 500 R ± oxygen (1 R = 2.58 × 10−4 C/kg) experiments, respectively. The pattern of adriamycin-induced DNA strand breaks and cross-linking was not affected by hypoxia with 1-h adriamycin exposures between 0.05 and 1.0 μg/mL. Similarly, 1-h exposures of N-trifluoroacetyladriamycin-14-valerate at 3 or 10 μg/mL gave essentially identical alkaline elution profiles in the presence or absence of oxygen. These results do not support the hypothesis that oxygen-derived radicals play a primary role in anthracycline-induced DNA strand breakage.

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