Association ofABCB1gene polymorphisms and their haplotypes with response to antiepileptic drugs: a systematic review and meta-analysis

2011 ◽  
Vol 12 (5) ◽  
pp. 713-725 ◽  
Author(s):  
Batoul Sadat Haerian ◽  
Kheng Seang Lim ◽  
Chong Tin Tan ◽  
Azman Ali Raymond ◽  
Zahurin Mohamed
Keyword(s):  
Systematic Review ◽  
Antiepileptic Drugs ◽  
Meta Analysis

scholarly journals Treatment Outcome of Epileptic Patients Receiving Antiepileptic Drugs in Ethiopia: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Taklo Simeneh Yazie ◽  
Belayneh Kefale ◽  
Mulugeta Molla
Keyword(s):  
Systematic Review ◽  
Treatment Outcome ◽  
Antiepileptic Drugs ◽  
Addis Ababa ◽  
Meta Analysis ◽  
Age Groups ◽  
Seizure Freedom ◽  
Pharmacoresistant Epilepsy ◽  
Pooled Prevalence ◽  
Epileptic Patients

Background. The prevalence and incidence rate of epilepsy were found to be higher in low- and middle-income countries. Uncontrolled epilepsy has a high risk of disability, stigma, discrimination, human rights violations, and premature death. The available studies of controlled seizure in Ethiopia have showed inconsistent results which calls for systematic review and meta-analysis. Therefore, this review intended to show the pooled prevalence of controlled seizure among people with epilepsy receiving antiepileptic drugs at outpatient department. Methods. A systematic literature search was conducted using PubMed/Medline, Science Direct, PsycINFO, Hinnarri databases, and Google Scholar for grey literatures. Data were extracted with structured format prepared using Microsoft Excel and exported to Stata/MP 16.0 software for analyses. The I 2 test was used to check the heterogeneity between primary studies with a corresponding 95% confidence interval (CI). Results. A total of 23 primary studies were included in the review showing the pooled prevalence of controlled seizure to be 46% (95% CI: 35, 56). A subgroup analysis of the primary studies showed a considerable variation in magnitude of seizure freedom by study regions, age groups, and seizure-free period. The highest prevalence was found in Addis Ababa 52% (95% CI: 29, 75), pediatric patients 77% (95% CI: 71, 83), and a seizure-free period of less than six months 58% (95% CI: 32, 83). On the other hand, the lowest prevalence of controlled seizure was found in Tigray 27% (95% CI: 11, 65), adult patients 43% (95% CI: 32, 54), and a seizure-free period of six or more 41% (95% CI: 32, 51). Higher frequency of seizure before treatment (2.23, 95% CI: 1.15, 3.31) and medication nonadherence (2.7, 95% CI: 1.25, 4.15) had statistically significant association with uncontrolled seizure. Conclusion. In this review, the prevalence of controlled seizure was found to be low. This warrants that clinicians should give more focus to epileptic patients regarding monitoring and evaluation of treatment outcome of epilepsy and factors that affect seizure control in routine clinical services. The use of standardized definition of controlled seizure, designing strategies to identify pharmacoresistant epilepsy and its treatment, and increasing medication adherence are recommended in Ethiopia. The review protocol has been registered with PROSPERO registration number CRD42021215302.

scholarly journals Relationship between ABCB1 3435TT genotype and antiepileptic drugs resistance in Epilepsy: updated systematic review and meta-analysis

BMC Neurology ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Malek Chouchi ◽  
Wajih Kaabachi ◽  
Hedia Klaa ◽  
Kalthoum Tizaoui ◽  
Ilhem Ben-Youssef Turki ◽  
...  
Keyword(s):  
Systematic Review ◽  
Antiepileptic Drugs ◽  
Meta Analysis

scholarly journals Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis

BMJ Open ◽  
2017 ◽  
Vol 7 (7) ◽  
pp. e017248 ◽  
Author(s):  
Areti Angeliki Veroniki ◽  
Patricia Rios ◽  
Elise Cogo ◽  
Sharon E Straus ◽  
Yaron Finkelstein ◽  
...  
Keyword(s):  
Systematic Review ◽  
Antiepileptic Drugs ◽  
Breast Feeding ◽  
Meta Analysis ◽  
Neurological Development ◽  
Comparative Safety

scholarly journals Vitamin D deficiency in pediatric patients using antiepileptic drugs: systematic review with meta‐analysis

2020 ◽  
Vol 96 (5) ◽  
pp. 559-568
Author(s):  
Cíntia Junges ◽  
Tania Diniz Machado ◽  
Paulo Ricardo Santos Nunes Filho ◽  
Rudimar Riesgo ◽  
Elza Daniel de Mello
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Antiepileptic Drugs ◽  
Pediatric Patients ◽  
Meta Analysis

Association between use of antiepileptic drugs and fracture risk: A systematic review and meta-analysis

Bone ◽  
2014 ◽  
Vol 64 ◽  
pp. 246-253 ◽  
Author(s):  
Chunhong Shen ◽  
Feng Chen ◽  
Yinxi Zhang ◽  
Yi Guo ◽  
Meiping Ding
Keyword(s):  
Systematic Review ◽  
Fracture Risk ◽  
Antiepileptic Drugs ◽  
Meta Analysis
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