Pharmacogenetics of drug transporters in modulating imatinib disposition and treatment outcomes in chronic myeloid leukemia & gastrointestinal stromal tumor patients

2016 ◽  
Vol 17 (17) ◽  
pp. 1941-1955 ◽  
Author(s):  
Sylvia Chen ◽  
Natalia Sutiman ◽  
Balram Chowbay
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Gastrointestinal Stromal Tumor ◽  
Treatment Outcomes ◽  
Myeloid Leukemia ◽  
Drug Transporters ◽  
Stromal Tumor ◽  
Tumor Patients

scholarly journals Effect of imatinib on plasma glucose concentration in subjects with chronic myeloid leukemia and gastrointestinal stromal tumor

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Miguel Ángel Gómez-Sámano ◽  
Jorge Enrique Baquerizo-Burgos ◽  
Melissa Fabiola Coronel Coronel ◽  
Buileng Daniela Wong-Campoverde ◽  
Fernando Villanueva-Martinez ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Gastrointestinal Stromal Tumor ◽  
Plasma Glucose ◽  
Glucose Concentration ◽  
Myeloid Leukemia ◽  
Stromal Tumor ◽  
Plasma Glucose Concentration

scholarly journals Development of hypogammaglobulinemia in patients treated with imatinib for chronic myeloid leukemia or gastrointestinal stromal tumor

Haematologica ◽  
2008 ◽  
Vol 93 (8) ◽  
pp. 1252-1255 ◽  
Author(s):  
R. Santachiara ◽  
R. Maffei ◽  
S. Martinelli ◽  
A. Arcari ◽  
F. Piacentini ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Gastrointestinal Stromal Tumor ◽  
Myeloid Leukemia ◽  
Stromal Tumor

scholarly journals Chai For Cancer: A Fundraiser and Advocacy Model for Chronic Myeloid Leukemia/Gastrointestinal Stromal Tumor Patients and Caregivers in India

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 184s-184s
Author(s):  
P. George
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Gastrointestinal Stromal Tumor ◽  
Myeloid Leukemia ◽  
Extended Family ◽  
Stromal Tumor ◽  
Radio Stations ◽  
Fm Radio ◽  
Institute Of Design ◽  
Long Time ◽  
Fund Raiser

Amount raised: During 2017, funds from Chai for Cancer Addas totaled approximately US$ 28,000 (IRS 18 lacs). Background and context: Chai for Cancer ( www.chaiforcancer.org ) is in a sense, a satellite brand of Friends of Max ( www.friendsofmax.info ). Friends of Max is a registered Public Charitable Trust and the support group arm of The Max Foundation in India. In India chai or tea is a household drink. At its best in an informal setting, an Adda serves a dual purpose as a fund-raiser and advocacy platform. It is based on the concept of an informal gathering among well-wishers and caregivers supporting underserved cancer patients suffering from chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST). The chronic condition is made manageable by life-long treatment. Aim: Chai For Cancer is a dynamic fundraiser and advocacy model for CML/GIST patients and caregivers in India. Strategy/Tactics: In 4 years, now on the cusp of the 5th year, Chai for Cancer has built up a creditable legacy of trust and an extended family of volunteers that networks throughout the year with the ability to attract new segments of donors/well-wishers and patient/caregiver participants. Funds thus raised support patient group meetings which facilitate various patient-related activities and patient–physician interactions which form the bedrock of FOM's dictum “Together We Share And Learn”. Potential donors are approached and educated informally about how to host an Adda. Once the host expresses interest, support is provided to the host in terms of tea bags and paper cups (from Society Tea), literature (printed leaflets, brochures elaborating the concept, newsletters) and receipts (U/s 80 G of the Indian Income Tax Act, 1961). Program process: An Adda is usually hosted by members/volunteers belonging to Friends of Max although it is not unusual for persons who have simply heard of Chai for Cancer to get in touch and express interest in hosting an Adda. The emergence of new hosts like D Y Patil University and IDEAL (Institute of Design Expression Art and Learning) in Ahmedabad, Jayanth Jayaprakash's India To Excellence 2020 in addition to long-time supporters Society Tea, Being Human-The Salman Khan Foundation, Manish Mandhana Retail Ventures, Mahotsaav Entertainment, Radio One and Red FM is testimony to the strength of the fundraising/advocacy model and a platform to encourage openness, empowering patients and caregivers. HNIs from various industries have also been donors. Costs and returns: The entire process is manned by senior, experienced people who volunteer their time and professional skills. Year-long publicity is generated through social media (FM radio stations, Web site www.chaiforcancer.org Twitter, Instagram and Facebook). What was learned: This is a personalised and intimate approach to raising funds for patient-related activity. This approach ensures known and accepted sources of funds within a growing family. It is different from crowd-funding techniques.

Chronic Myeloid Leukemia in Two Patients with Gastrointestinal Stromal Tumor.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4767-4767
Author(s):  
Erina Sakamoto ◽  
Hirohisa Nakamae ◽  
Ki Ryang Koh ◽  
Takahisa Yamane ◽  
Masayuki Hino
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Tyrosine Kinase ◽  
Gastrointestinal Stromal Tumor ◽  
Myeloid Leukemia ◽  
Philadelphia Chromosome ◽  
Stromal Tumor ◽  
Pathological Examination ◽  
Aberrant Expression ◽  
First Case ◽  
Old Japanese

Abstract Imatinib competitively binds to the ATP binding site of Bcr-Abl kinase and inhibits Abl tyrosine kinase activity. Most patients with chronic myeloid leukemia (CML) achieve clinically relevant hematologic and cytogenetic responses to imatinib. It is also a potent inhibitor of a receptor-type c-Kit tyrosine kinase. Therefore, it was examined for therapeutic efficacy against malignant Gastrointestinal Stromal Tumor (GIST), which is a rare tumor of the gastrointestinal tract and is mainly caused by aberrant expression of a mutated c-Kit that is constitutively active without binding of a ligand, stem cell factor. We report two rare cases of double cancer involving CML and GIST. The first case is a 66-year-old Japanese male patient who was presented to our hospital with leukothrombocytosis on February 27, 2006. The patient was diagnosed to be suffering from CML by the presence of Philadelphia chromosome. Several days later, he was admitted with acute peritonitis. A ruptured tumor on 80 cm oral side of ileum end was found by an emergency partial ilectomy. Microscopically, spindle-shaped and round epithelioid cells were growing externally from the intestinal muscular propia. Immunohistochemical analysis showed that the tumor cells were positive for c-kit and CD34 and negative for S-100 protein and desmin. The tumors were identified as GIST. Imatinib was administered to treat CML on the 8th postoperative day. The second case is a 57-year-old Japanese female patient who was presented to our hospital with marked thrombocytosis on March 6, 2006. The patient was diagnosed to be suffering from CML by the presence of Philadelphia chromosome. One year ago, she underwent distal gastrectomy for submucosal tumor. Pathological examination revealed proliferation of submucosal spindle-shaped cells with elongated cigar-shaped nuclei arranged in fascicles. Immunohistochemical stains confirmed the diagnosis of GIST. These two cases provided a valuable opportunity for treating GIST with CML. We look forward to active effect of imatinib, not only in CML treatment but also in preventing recurrence of GIST. The occurrence mechanism of either CML or GIST at the biomolecular level has been established. However, we can show no relation between these malignancies. Therefore, it is natural for us to understand accidental coincidence. We should follow-up these patients carefully. Accumulation of such cases may contribute to clarify more precise mechanism of tumorgenesis.

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